85:
470:
487:
504:
520:
469:
549:
654:
486:
557:
Switzerland in 2017 (BMA2017). The statues were then signed at the fourth international meeting, held in 2018 again in Lille (BMA2018). As discussed in the following section, there have since been three further international meetings, held in Odense, Denmark in 2019 (BMA2019), virtually in 2020 (BMA2020), and in Athens, Greece in 2022 (BMA2022). The first BMAS Summer School was held virtually in the summer of 2021.
545:
meeting was a great success and led to a second international meeting (BMA2016) in August 2016 held in
Rotterdam, The Netherlands. Both meetings were a success in that they for the first time brought together scientists and physicians from different backgrounds (bone metabolism, cancer, obesity and diabetes) to share ideas and advance research into, and our understanding of, the patho/physiological role of BMAds.
556:
This success led to a network of researchers discussing the formation of a new society, focusing on bone marrow adiposity (BMA). This network worked together in 2016–2017 to lay the foundations for this society, which was then discussed further during the third international meeting held in
Lausanne,
544:
Because of the increasing interest in BMAT from both researchers and clinicians, in 2018 The
International Bone Marrow Adiposity Society (BMAS) was founded. Work to build the society began in Lille, France in 2015, when the first International Meeting on Bone Marrow Adiposity (BMA2015) was held. The
477:
This figure demonstrates the use of the osmium- μCT method with advanced image processing to quantify BMAT. In this figure, running exercise is shown to suppress BMAT despite PPARγ agonist. Fat binder osmium is imaged via μCT (A ) in n =5 per group overlaid images. Quantification of osmium as BMAT/
451:
of osmium-bound lipid volume (in mm) relative to bone volume. This technique provides reproducible quantification and visualization of BMAT, enabling the ability to consistently quantify changes in BMAT with diet, exercise, and agents that constrain precursor lineage allocation. Although the osmium
455:
Several studies have also analysed BMAT function in vivo using positron emission tomography - computed tomography (PET-CT) combined with the tracer 18F-Fluorodeoxyglucose (FDG). This allows glucose uptake, a measure of metabolic activity, to be quantified in living organisms, including humans. Two
139:
therapies. BMAT decreases in anaemia, leukaemia, and hypertensive heart failure; in response to hormones such as oestrogen, leptin, and growth hormone; with exercise-induced weight loss or bariatric surgery; in response to chronic cold exposure; and in response to pharmacological agents such as
494:
This figure demonstrates the use of MRI imaging (9.4T scanner) along with advanced image processing to quantify BMAT. The images and graph demonstrate that BMAT is higher in obese compared with lean mice. B6 mice were fed HFD from age 4 wk until age 16 wk. BMAT was quantified by MRI. A) n=10
415:
quantification can be used to purify adipocytes from the stromal vascular fraction of most fat depots. Early research with such machinery cited adipocytes as too large and fragile for cytometer-based purification, rendering them susceptible to lysis; however, recent advances have been made to
196:
was published in 2014; Now, exercise regulation of BMAT has been confirmed in a human, adding clinical importance. Several studies demonstrated exercise reduction of BMAT which occurs along with an increase in bone quantity. Since exercise increases bone quantity, reduces BMAT and increases
564:
have published three position papers relating to nomenclature, methodologies and biobanking for BMA research. These working groups remain active, with other working groups also focussing on clinical and translational issues, public engagement, and young researchers (Next
Generation BMAS)
452:
method is quantitatively precise, osmium is toxic and cannot be compared across batched experiments. Recently, researchers developed and validated a 9.4T MRI scanner technique that allows localization and volumetric (3D) quantification that can be compared across experiments, as in.
456:
recent studies found that, unlike brown adipose tissue, BMAT does not increase glucose uptake in response to cold exposure, demonstrating that BMAT is functionally distinct from BAT. The full extent of BMAT's impact on systemic metabolic homeostasis remains to be determined.
519:
503:
3191:
Rosen CJ, Ackert-Bicknell CL, Adamo ML, Shultz KL, Rubin J, Donahue LR, et al. (November 2004). "Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program".
399:
and cannot adequately quantify the volume of fat in the marrow. Nevertheless, histological techniques and fixation make possible visualization of BMAT, quantification of BMAd size, and BMAT's association with the surrounding
3785:"Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society"
3664:
Scheller EL, Troiano N, Vanhoutan JN, Bouxsein MA, Fretz JA, Xi Y, et al. (2014). "Use of Osmium
Tetroxide Staining with Microcomputerized Tomography to Visualize and Quantify Bone Marrow Adipose Tissue in Vivo".
277:+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. Recently, BMAT was noted to "produce a greater proportion of
257:(VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of
321:
also decrease BMAT while increasing bone density, supporting an inverse relationship between bone quantity and BMAT. During aging, bone quantity declines and fat redistributes from subcutaneous to
727:
Meunier P, Aaron J, Edouard C, Vignon G (October 1971). "Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies".
205:. A notable exception occurs in the setting of caloric restriction: exercise suppression of BMAT does not yield an increase in bone formation and even appears to cause bone loss. Indeed,
2866:"Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways"
1040:"Standardised Nomenclature, Abbreviations, and Units for the Study of Bone Marrow Adiposity: Report of the Nomenclature Working Group of the International Bone Marrow Adiposity Society"
4178:
387:
In order to understand the physiology of BMAT, various analytic methods have been applied. BMAds are difficult to isolate and quantify because they are interspersed with bony and
4205:
3286:"Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis"
527:
Representative distal femur histologic section of a 16-week-old C57BL/6 mouse after 6 weeks of calorie restriction demonstrating an increased quantity of marrow adipocytes.
3836:"Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society"
3885:
Hardouin P, Marie PJ, Rosen CJ (December 2016). "New insights into bone marrow adipocytes: Report from the First
European Meeting on Bone Marrow Adiposity (BMA 2015)".
337:
expression or decreased Wnt10b. Thus, bone fragility, osteoporosis, and osteoporotic fractures are thought to be linked to mechanisms which promote BMAT accumulation.
301:
based on the inverse relationship between bone and BMAT in bone-fragile osteoporotic states. An increase in BMAT is noted in osteoporosis clinical studies measured by
333:
is associated with lower osteogenic and greater adipogenic biasing of MSC. This aging-related biasing of MSC away from osteoblast lineage may represent higher basal
2155:
Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS (December 2001). "A transgenic model of visceral obesity and the metabolic syndrome".
237:
fat. However, more-recent functional and -omics studies have shown that BMAT is a unique adipose depot that is molecularly and functionally distinct to WAT or BAT.
297:
BMAT increases in states of bone fragility. BMAT is thought to result from preferential MSC differentiation into an adipocyte, rather than osteoblast lineage in
171:, rather than osteoblast, lineage in the setting of osteoporosis. Since BMAT is increased in the setting of obesity and is suppressed by endurance exercise, or
2588:"Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis"
2355:"Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential"
439:-based marrow density measurements. A volumetric method to identify, quantify, and localize BMAT in rodent bone has been recently developed, requiring
953:"Effects of rosiglitazone vs metformin on circulating osteoclast and osteogenic precursor cells in postmenopausal women with type 2 diabetes mellitus"
302:
334:
2257:"Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study"
478:
bone volume in the whole femur is shown. a, significant due to Rosi. b, significant due to exercise. Rosi=rosiglizaone, CTL=control, E=exercise.
407:
Recent advances in cell surface and intracellular marker identification and single-cell analyses led to greater resolution and high-throughput
511:
Representative distal femur histologic section of a 16-week-old healthy C57BL/6 mouse demonstrating a typical quantity of marrow adipocytes.
416:
mitigate this; nevertheless, this methodology continues to pose technical challenges and is inaccessible to much of the research community.
363:, a microenvironment that contains cells and secreted factors that promote appropriate renewal and differentiation of HSC. The study of the
4182:
3374:
Majka SM, Miller HL, Helm KM, Acosta AS, Childs CR, Kong R, Klemm DJ (2014). "Analysis and
Isolation of Adipocytes by Flow Cytometry".
1512:"Mechanical Signals As a Non-Invasive Means to Influence Mesenchymal Stem Cell Fate, Promoting Bone and Suppressing the Fat Phenotype"
2539:"Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study"
2447:"Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction"
84:
1299:"A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice"
424:
306:
132:
2494:
Duque G, Li W, Adams M, Xu S, Phipps R (May 2011). "Effects of risedronate on bone marrow adipocytes in postmenopausal women".
3103:"Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats"
1011:
869:"Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma"
17:
2686:"Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment"
351:
cells (also known as blood cells) reside in the bone marrow along with BMAds. These hematopoietic cells are derived from
3468:"Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women"
197:
expression of markers of fatty acid oxidation in bone, BMAT is thought to be providing needed fuel for exercise-induced
2915:"Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells"
1091:"Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program"
3682:
3391:
2112:
Wronska A, Kmiec Z (June 2012). "Structural and biochemical characteristics of various white adipose tissue depots".
355:(HSC) which give rise to diverse cells: cells of the blood, immune system, as well as cells that break down bone (
2069:
Tilg H, Moschen AR (October 2006). "Adipocytokines: mediators linking adipose tissue, inflammation and immunity".
427:
has been used with success to quantify vertebral BMAT in humans, it is difficult to employ in laboratory animals.
4242:
2774:
Tchkonia T, Morbeck DE, Von
Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, et al. (October 2010).
1617:"Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue"
209:
availability appears to be a factor in the ability of exercise to regulate BMAT. Another exception occurs in
916:
Wronski TJ, Morey ER (1982-01-01). "Skeletal abnormalities in rats induced by simulated weightlessness".
376:
310:
238:
1758:"Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes"
1297:
Doucette CR, Horowitz MC, Berry R, MacDougald OA, Anunciado-Koza R, Koza RA, Rosen CJ (September 2015).
613:
has published hundreds of presentations and articles on BMAT featured in the ASBMR annual meetings, The
175:, it is likely that BMAT physiology, in the setting of mechanical input/exercise, approximates that of
762:
Fazeli PK, Horowitz MC, MacDougald OA, Scheller EL, Rodeheffer MS, Rosen CJ, Klibanski A (March 2013).
658:
428:
3517:"VDR haploinsufficiency impacts body composition and skeletal acquisition in a gender-specific manner"
1867:"Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling"
3718:"Human Bone Marrow Adipose Tissue is a Metabolically Active and Insulin-Sensitive Distinct Fat Depot"
3564:
Fazeli PK, Bredella MA, Freedman L, Thomas BJ, Breggia A, Meenaghan E, et al. (September 2012).
3515:
de Paula FJ, Dick-de-Paula I, Bornstein S, Rostama B, Le P, Lotinun S, et al. (September 2011).
3101:
Bielohuby M, Matsuura M, Herbach N, Kienzle E, Slawik M, Hoeflich A, Bidlingmaier M (February 2010).
2353:
Al-Nbaheen M, Vishnubalaji R, Ali D, Bouslimi A, Al-Jassir F, Megges M, et al. (February 2013).
1922:
Scheller EL, Khandaker S, Learman BS, Cawthorn WP, Anderson LM, Pham HA, et al. (January 2019).
1808:
Suchacki KJ, Tavares AA, Mattiucci D, Scheller EL, Papanastasiou G, Gray C, et al. (June 2020).
951:
Rubin MR, Manavalan JS, Agarwal S, McMahon DJ, Nino A, Fitzpatrick LA, Bilezikian JP (October 2014).
1353:"Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice"
3834:
Lucas S, Tencerova M, von der Weid B, Andersen TL, Attané C, Behler-Janbeck F, et al. (2021).
3566:"Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa"
3054:"Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF"
1810:"Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis"
820:"Exercise Degrades Bone in Caloric Restriction, Despite Suppression of Marrow Adipose Tissue (MAT)"
3325:
Majka SM, Miller HL, Sullivan T, Erickson PF, Kong R, Weiser-Evans M, et al. (October 2012).
818:
McGrath C, Sankaran JS, Misaghian-Xanthos N, Sen B, Xie Z, Styner MA, et al. (January 2020).
4227:
4190:
3716:
Pham TT, Ivaska KK, Hannukainen JC, Virtanen KA, Lidell ME, Enerbäck S, et al. (July 2020).
352:
4124:"Next Generation Bone Marrow Adiposity Researchers: Report From the 1st BMAS Summer School 2021"
3466:
Bredella MA, Torriani M, Ghomi RH, Thomas BJ, Brick DJ, Gerweck AV, et al. (January 2011).
1924:"Bone marrow adipocytes resist lipolysis and remodeling in response to β-adrenergic stimulation"
1705:
McGrath C, Little-Letsinger SE, Sankaran JS, Sen B, Xie Z, Styner MA, et al. (2022-01-25).
1248:"Changes in Skeletal Integrity and Marrow Adiposity during High-Fat Diet and after Weight Loss"
67:
4122:
Labella R, Little-Letsinger S, Avilkina V, Sarkis R, Tencerova M, Vlug A, Palmisano B (2022).
3284:
David V, Martin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, et al. (May 2007).
2684:
Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, et al. (January 2006).
2445:
Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, et al. (August 2014).
2206:
Bredella MA, Lin E, Gerweck AV, Landa MG, Thomas BJ, Torriani M, et al. (November 2012).
1865:
Craft CS, Robles H, Lorenz MR, Hilker ED, Magee KL, Andersen TL, et al. (November 2019).
2402:
Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME (May 2006). "Playing with bone and fat".
444:
436:
164:
153:
2637:"Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women"
1971:
Attané C, Estève D, Chaoui K, Iacovoni JS, Corre J, Moutahir M, et al. (January 2020).
1666:"Energy Deficiency Suppresses Bone Turnover in Exercising Women With Menstrual Disturbances"
1151:"The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians"
678:
Cohen A, Dempster DW, Stein EM, Nickolas TL, Zhou H, McMahon DJ, et al. (August 2012).
495:
superimposed group average images are shown B) BMAT normalized to bone volume in each group.
4222:
3783:
Tratwal J, Labella R, Bravenboer N, Kerckhofs G, Douni E, Scheller EL, et al. (2020).
3240:
2164:
1878:
1821:
322:
286:
282:
262:
258:
242:
241:
contain excess energy, indicating a clear evolutionary advantage during times of scarcity.
234:
230:
176:
3615:"Differential effects of exercise on tibial shaft marrow density in young female athletes"
3142:
Spatz JM, Ellman R, Cloutier AM, Louis L, van Vliet M, Suva LJ, et al. (April 2013).
662:
653:
8:
2913:
Stevens JR, Miranda-Carboni GA, Singer MA, Brugger SM, Lyons KM, Lane TF (October 2010).
1707:"Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity"
124:
3244:
2735:"Age-related changes in trabecular architecture differ in female and male C57BL/6J mice"
2168:
1882:
1825:
1115:
1090:
1038:
Bravenboer N, Bredella MA, Chauveau C, Corsi A, Douni E, Ferris WF, et al. (2020).
4232:
4150:
4123:
4099:
4072:
4048:
4021:
3997:
3970:
3946:
3921:
3862:
3835:
3811:
3784:
3742:
3717:
3693:
3674:
3590:
3565:
3541:
3516:
3492:
3467:
3402:
3383:
3351:
3326:
3261:
3228:
3168:
3144:"Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading"
3143:
3078:
3053:
3029:
3004:
2939:
2914:
2890:
2865:
2800:
2775:
2710:
2685:
2661:
2636:
2612:
2587:
2568:
2519:
2471:
2446:
2427:
2379:
2354:
2330:
2305:
2281:
2256:
2255:
Cohen A, Dempster DW, Recker RR, Lappe JM, Zhou H, Zwahlen A, et al. (June 2013).
2232:
2207:
2188:
2137:
2094:
2046:
2021:
2002:
1948:
1923:
1899:
1866:
1842:
1809:
1782:
1757:
1733:
1706:
1641:
1616:
1536:
1511:
1487:
1462:
1435:
1410:
1377:
1352:
1351:
Styner M, Pagnotti GM, Galior K, Wu X, Thompson WR, Uzer G, et al. (August 2015).
1323:
1298:
1274:
1247:
1246:
Scheller EL, Khoury B, Moller KL, Wee NK, Khandaker S, Kozloff KM, et al. (2016).
1223:
1198:
1128:
1066:
1039:
1017:
1003:
898:
844:
819:
788:
763:
704:
679:
372:
254:
3229:"Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment"
1463:"Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity"
1461:
Pagnotti GM, Styner M, Uzer G, Patel VS, Wright LE, Ness KK, et al. (June 2019).
285:", suggesting an endocrine function for this depot, akin, but different, from that of
4247:
4155:
4104:
4053:
4002:
3971:"Brief Report From the 3rd International Meeting on Bone Marrow Adiposity (BMA 2017)"
3951:
3902:
3867:
3816:
3747:
3698:
3678:
3646:
3641:
3595:
3546:
3497:
3448:
3407:
3387:
3356:
3307:
3266:
3209:
3173:
3124:
3083:
3034:
2985:
2962:
Bennett CN, Ouyang H, Ma YL, Zeng Q, Gerin I, Sousa KM, et al. (December 2007).
2944:
2895:
2881:
2846:
2841:
2824:
2805:
2791:
2756:
2715:
2666:
2635:
Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S (September 2008).
2617:
2560:
2511:
2476:
2419:
2384:
2335:
2286:
2237:
2180:
2129:
2125:
2086:
2051:
2006:
1994:
1953:
1904:
1847:
1787:
1738:
1687:
1646:
1592:
1587:
1541:
1492:
1440:
1382:
1328:
1279:
1228:
1199:"Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise"
1172:
1120:
1071:
1021:
1007:
993:
974:
933:
929:
890:
849:
793:
744:
740:
709:
136:
4022:"Brief Report From the 4th International Meeting on Bone Marrow Adiposity (BMA2018)"
2523:
2431:
2141:
2098:
1559:
Belavy DL, Quittner MJ, Ridgers ND, Shiekh A, Rantalainen T, Trudel G (April 2018).
1411:"Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice"
902:
88:
Bone marrow adipocytes are derived from mesenchymal stem cell (MSC) differentiation.
4237:
4145:
4135:
4094:
4084:
4043:
4033:
3992:
3982:
3941:
3933:
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3857:
3847:
3806:
3796:
3737:
3729:
3688:
3670:
3636:
3626:
3613:
Rantalainen T, Nikander R, Heinonen A, Cervinka T, Sievänen H, Daly RM (May 2013).
3585:
3577:
3536:
3528:
3487:
3479:
3438:
3397:
3379:
3346:
3338:
3297:
3256:
3248:
3201:
3163:
3155:
3114:
3073:
3065:
3024:
3016:
2975:
2964:"Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation"
2934:
2926:
2885:
2877:
2836:
2795:
2787:
2746:
2705:
2697:
2656:
2648:
2607:
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2503:
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2411:
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2366:
2325:
2317:
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2227:
2219:
2172:
2121:
2078:
2041:
2033:
1984:
1943:
1935:
1894:
1886:
1837:
1829:
1777:
1769:
1728:
1718:
1677:
1636:
1628:
1582:
1572:
1531:
1523:
1482:
1474:
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1422:
1372:
1364:
1318:
1310:
1269:
1259:
1218:
1210:
1162:
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1110:
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999:
964:
925:
880:
839:
831:
783:
775:
736:
699:
691:
432:
423:
techniques have been developed as a means to visualize and quantify BMAT. Although
120:
3937:
2192:
1409:
Styner M, Pagnotti GM, McGrath C, Wu X, Sen B, Uzer G, et al. (August 2017).
1197:
Styner M, Thompson WR, Galior K, Uzer G, Wu X, Kadari S, et al. (July 2014).
163:, among other cell types. Thus, it is thought that BMAT results from preferential
2037:
1989:
1972:
420:
364:
360:
318:
274:
156:
1756:
Krings A, Rahman S, Huang S, Lu Y, Czernik PJ, Lecka-Czernik B (February 2012).
680:"Increased marrow adiposity in premenopausal women with idiopathic osteoporosis"
3898:
3205:
2586:
Li X, Kuo D, Schafer AL, Porzig A, Link TM, Black D, Schwartz AV (April 2011).
2462:
2208:"Determinants of bone microarchitecture and mechanical properties in obese men"
1939:
1890:
1833:
1773:
1632:
1214:
885:
868:
625:
448:
412:
396:
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elements. Until recently, qualitative measurements of BMAT have relied on bone
214:
128:
108:
4140:
4089:
4073:"Report From the 6th International Meeting on Bone Marrow Adiposity (BMA2020)"
3852:
3532:
3052:
Zhou BO, Yu H, Yue R, Zhao Z, Rios JJ, Naveiras O, Morrison SJ (August 2017).
2652:
2507:
2370:
1723:
1478:
1106:
4216:
4038:
3987:
3801:
3733:
1973:"Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism"
1561:"Specific Modulation of Vertebral Marrow Adipose Tissue by Physical Activity"
1264:
1056:
388:
348:
266:
210:
3227:
Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ (July 2009).
2176:
629:
4159:
4108:
4057:
4006:
3955:
3906:
3871:
3820:
3751:
3702:
3650:
3599:
3550:
3501:
3443:
3426:
3425:
Bernstein RL, Hyun WC, Davis JH, Fulwyler MJ, Pershadsingh HA (July 1989).
3411:
3360:
3311:
3270:
3213:
3177:
3128:
3087:
3038:
2989:
2948:
2899:
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2515:
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2090:
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1998:
1957:
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1851:
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1742:
1691:
1650:
1596:
1545:
1496:
1444:
1386:
1332:
1283:
1232:
1176:
1124:
1075:
978:
894:
853:
797:
713:
598:
298:
198:
116:
40:
4206:"Why are our bones full of fat? The secrets of bone marrow adipose tissue"
4191:"Another reason to exercise: Burning bone fat a key to better bone health"
3452:
3003:
Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, et al. (July 2016).
2537:
Yeung DK, Griffith JF, Antonio GE, Lee FK, Woo J, Leung PC (August 2005).
1682:
1665:
937:
748:
614:
561:
73:
3631:
3614:
3483:
3302:
3285:
3020:
2272:
2223:
1368:
1167:
1150:
969:
952:
779:
695:
630:
Primer on the
Metabolic Bone Diseases and Disorders of Mineral Metabolism
539:
326:
314:
278:
270:
250:
206:
112:
3252:
3119:
3102:
2980:
2963:
2751:
2734:
2701:
3342:
2825:"Senescence-associated intrinsic mechanisms of osteoblast dysfunctions"
2773:
2603:
2555:
2538:
1615:
Little-Letsinger SE, Pagnotti GM, McGrath C, Styner M (December 2020).
356:
246:
160:
4179:"Bone marrow fat tissue secretes hormone that helps body stay healthy"
3581:
3159:
2415:
2022:"Adiponectin, driver or passenger on the road to insulin sensitivity?"
1577:
1560:
1426:
1314:
1144:
1142:
835:
4121:
3514:
3005:"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?"
2930:
1614:
1527:
1033:
1031:
610:
401:
392:
218:
202:
172:
168:
149:
3327:"Adipose lineage specification of bone marrow-derived myeloid cells"
3069:
2082:
1664:
Southmayd EA, Williams NI, Mallinson RJ, De Souza MJ (August 2019).
4070:
3612:
2912:
2864:
Moerman EJ, Teng K, Lipschitz DA, Lecka-Czernik B (December 2004).
1139:
817:
586:
368:
3833:
1704:
1663:
1149:
Paccou J, Hardouin P, Cotten A, Penel G, Cortet B (October 2015).
1028:
253:) and negative effects on metabolic and cardiovascular endpoints.
3969:
Corsi A, Palmisano B, Tratwal J, Riminucci M, Naveiras O (2019).
3782:
2863:
2352:
867:
Ahdjoudj S, Lasmoles F, Holy X, Zerath E, Marie PJ (April 2002).
605:
3663:
1921:
1807:
761:
661: by Gabriel M. Pagnotti and Maya Styner available under the
3283:
3190:
3100:
2306:"Adaptive thermogenesis in adipocytes: is beige the new brown?"
1296:
1037:
462:
440:
193:
3968:
2154:
548:
345:
BMAds secrete factors that promote HSC renewal in most bones.
192:
The first study to demonstrate exercise regulation of BMAT in
3715:
2732:
2444:
640:
330:
55:
3563:
2733:
Glatt V, Canalis E, Stadmeyer L, Bouxsein ML (August 2007).
2634:
1510:
Luu YK, Pessin JE, Judex S, Rubin J, Rubin CT (April 2009).
950:
3465:
3324:
3226:
1558:
3922:"Meeting report of the 2016 bone marrow adiposity meeting"
3765:
3424:
1970:
1803:
1801:
866:
677:
340:
281:– an adipokine associated with improved metabolism – than
3669:. Methods in Enzymology. Vol. 537. pp. 123–39.
3378:. Methods in Enzymology. Vol. 537. pp. 281–96.
1148:
726:
249:
and inflammatory markers which have both positive (e.g.,
4071:
Scheller EL, McGee-Lawrence ME, Lecka-Czernik B (2021).
3919:
3141:
2683:
2254:
1196:
552:
Logo for The International Bone Marrow Adiposity Society
2536:
2401:
2205:
1864:
1798:
1460:
1408:
1245:
115:. It increases in states of low bone density, such as
4019:
1350:
1088:
540:
The International Bone Marrow Adiposity Society (BMAS)
224:
4181:. University of Michigan. 3 July 2014. Archived from
3373:
379:, there is interest in improving the renewal of HSC.
3722:
The Journal of Clinical Endocrinology and Metabolism
3619:
The Journal of Clinical Endocrinology and Metabolism
2261:
The Journal of Clinical Endocrinology and Metabolism
2212:
The Journal of Clinical Endocrinology and Metabolism
1670:
The Journal of Clinical Endocrinology and Metabolism
1155:
The Journal of Clinical Endocrinology and Metabolism
957:
The Journal of Clinical Endocrinology and Metabolism
768:
The Journal of Clinical Endocrinology and Metabolism
684:
The Journal of Clinical Endocrinology and Metabolism
2961:
1755:
1509:
1089:Muruganandan S, Roman AA, Sinal CJ (January 2009).
3884:
3002:
2585:
643:features many presentations and articles on BMAT.
3766:"The International Bone Marrow Adiposity Society"
2303:
992:Cawthorn W (2020). "Bone Marrow Adipose Tissue".
273:location, and its adipocyte origin from at least
229:BMAT has been reported to have qualities of both
4214:
998:. Oxford, UK: Academic Press. pp. 156–177.
3920:van der Eerden B, van Wijnen A (October 2017).
3427:"Flow cytometric analysis of mature adipocytes"
425:proton magnetic resonance spectroscopy (1H-MRS)
2493:
2304:Wu J, Cohen P, Spiegelman BM (February 2013).
606:American Society for Bone and Mineral Research
140:bisphosphonates, teriparatide, and metformin.
3051:
918:Metabolic Bone Disease & Related Research
2776:"Fat tissue, aging, and cellular senescence"
2111:
915:
313:reduces BMAT. Antiresorptive therapies like
221:is possible, even with minimal BMAT stores.
2822:
2068:
729:Clinical Orthopaedics and Related Research
265:as by a group of proteins that help BAT's
4208:. Society for Endocrinology. Winter 2017.
4149:
4139:
4098:
4088:
4047:
4037:
4020:Penel G, Kerckhofs G, Chauveau C (2019).
3996:
3986:
3945:
3861:
3851:
3810:
3800:
3741:
3692:
3667:Methods of Adipose Tissue Biology, Part A
3640:
3630:
3589:
3540:
3491:
3442:
3401:
3376:Methods of Adipose Tissue Biology, Part A
3350:
3301:
3260:
3167:
3118:
3077:
3028:
2979:
2938:
2889:
2840:
2799:
2750:
2709:
2660:
2611:
2554:
2470:
2378:
2329:
2280:
2231:
2045:
2019:
1988:
1947:
1898:
1841:
1781:
1732:
1722:
1681:
1640:
1586:
1576:
1535:
1486:
1434:
1376:
1322:
1273:
1263:
1222:
1166:
1114:
1065:
1055:
968:
884:
843:
787:
703:
419:To improve quantification of BMAT, novel
404:, milieu of cells, and secreted factors.
375:. As such cancers are often treated with
371:in order to improve therapy for multiple
991:
547:
292:
83:
764:"Marrow fat and bone--new perspectives"
534:
341:Maintenance of hematopoietic stem cells
14:
4215:
187:
2592:Journal of Magnetic Resonance Imaging
2543:Journal of Magnetic Resonance Imaging
1610:
1608:
1606:
1456:
1454:
1404:
1402:
1400:
1398:
1396:
1346:
1344:
1342:
1192:
1190:
1188:
1186:
3570:Journal of Bone and Mineral Research
3148:Journal of Bone and Mineral Research
3107:Journal of Bone and Mineral Research
2968:Journal of Bone and Mineral Research
2919:Journal of Bone and Mineral Research
2739:Journal of Bone and Mineral Research
2690:Journal of Bone and Mineral Research
1565:Journal of Bone and Mineral Research
1415:Journal of Bone and Mineral Research
1095:Cellular and Molecular Life Sciences
873:Journal of Bone and Mineral Research
824:Journal of Bone and Mineral Research
813:
811:
809:
807:
635:
616:Journal of Bone and Mineral Research
359:). HSC renewal occurs in the marrow
225:Relationships to other types of fat
213:, a condition with reduced overall
24:
4170:
3675:10.1016/b978-0-12-411619-1.00007-0
3384:10.1016/b978-0-12-411619-1.00015-x
1603:
1451:
1393:
1339:
1183:
1004:10.1016/B978-0-12-801238-3.11207-3
25:
4259:
2823:Kassem M, Marie PJ (April 2011).
804:
2882:10.1111/j.1474-9728.2004.00127.x
2842:10.1111/j.1474-9726.2011.00669.x
2792:10.1111/j.1474-9726.2010.00608.x
2404:Journal of Cellular Biochemistry
2126:10.1111/j.1748-1716.2012.02409.x
741:10.1097/00003086-197110000-00021
657: This article incorporates
652:
595:BMA Summer School 2021 (virtual)
577:BMA2016 (Rotterdam, Netherlands)
568:
518:
502:
485:
468:
431:provides BMAT assessment in the
429:Magnetic resonance imaging (MRI)
4115:
4064:
4013:
3962:
3913:
3878:
3827:
3776:
3758:
3709:
3657:
3606:
3557:
3508:
3459:
3418:
3367:
3318:
3277:
3220:
3184:
3135:
3094:
3045:
2996:
2955:
2906:
2857:
2816:
2767:
2726:
2677:
2628:
2579:
2530:
2487:
2438:
2395:
2346:
2297:
2248:
2199:
2148:
2105:
2062:
2020:Ye R, Scherer PE (April 2013).
2013:
1964:
1915:
1858:
1749:
1698:
1657:
1552:
1503:
1290:
1239:
1082:
580:BMA2017 (Lausanne, Switzerland)
3521:Calcified Tissue International
3009:Cell Death and Differentiation
1303:Journal of Cellular Physiology
985:
944:
909:
860:
755:
720:
671:
447:imaging, followed by advanced
382:
45:Musculoskeletal (or locomotor)
13:
1:
3938:10.1080/21623945.2017.1313374
2359:Stem Cell Reviews and Reports
1467:Nature Reviews. Endocrinology
646:
592:BMA2020 (virtual BMA meeting)
269:role. BMAT, by its "specific
182:
131:such as that which occurs in
2038:10.1016/j.molmet.2013.04.001
1990:10.1016/j.celrep.2019.12.089
1621:Current Osteoporosis Reports
995:Encyclopedia of Bone Biology
930:10.1016/0221-8747(82)90011-X
367:is relevant to the field of
99:), sometimes referred to as
7:
395:, which is subject to site
377:bone marrow transplantation
311:postmenopausal osteoporosis
154:mesenchymal stem cell (MSC)
10:
4264:
4128:Frontiers in Endocrinology
4077:Frontiers in Endocrinology
4026:Frontiers in Endocrinology
3975:Frontiers in Endocrinology
3899:10.1016/j.bone.2015.11.013
3840:Frontiers in Endocrinology
3789:Frontiers in Endocrinology
3206:10.1016/j.bone.2004.07.008
2641:Osteoporosis International
2496:Osteoporosis International
2463:10.1016/j.cmet.2014.06.003
2071:Nature Reviews. Immunology
1940:10.1016/j.bone.2018.01.016
1891:10.1038/s41598-019-54036-x
1834:10.1038/s41467-020-16878-2
1774:10.1016/j.bone.2011.06.016
1711:Frontiers in Endocrinology
1633:10.1007/s11914-020-00634-y
1252:Frontiers in Endocrinology
1215:10.1016/j.bone.2014.03.044
1044:Frontiers in Endocrinology
886:10.1359/jbmr.2002.17.4.668
263:brown adipose tissue (BAT)
261:substantially differ from
217:stores: exercise- induced
143:
93:Bone marrow adipose tissue
30:Bone marrow adipose tissue
4141:10.3389/fendo.2022.879588
4090:10.3389/fendo.2021.712088
3853:10.3389/fendo.2021.744527
3533:10.1007/s00223-011-9505-1
2653:10.1007/s00198-008-0574-6
2508:10.1007/s00198-010-1353-8
2371:10.1007/s12015-012-9365-8
1724:10.3389/fendo.2021.782194
1479:10.1038/s41574-019-0170-1
1107:10.1007/s00018-008-8429-z
167:differentiation into the
66:
54:
49:
39:
34:
29:
4039:10.3389/fendo.2019.00691
3988:10.3389/fendo.2019.00336
3802:10.3389/fendo.2020.00065
1265:10.3389/fendo.2016.00102
1057:10.3389/fendo.2019.00923
353:hematopoietic stem cells
2310:Genes & Development
2177:10.1126/science.1066285
583:BMA2018 (Lille, France)
574:BMA2015 (Lille, France)
159:that also give rise to
152:(BMAds) originate from
4243:Musculoskeletal system
3734:10.1210/clinem/dgaa216
3444:10.1002/cyto.990100416
2322:10.1101/gad.211649.112
560:Since its foundation,
553:
443:staining of bones and
255:Visceral abdominal fat
245:is also the source of
239:Subcutaneous white fat
89:
68:Anatomical terminology
61:adipose ossium medulla
3642:10536/DRO/DU:30060423
1814:Nature Communications
1683:10.1210/jc.2019-00089
1588:10536/DRO/DU:30106029
551:
329:, muscle, and liver.
293:Impact on bone health
101:marrow adipose tissue
87:
18:Marrow Adipose Tissue
3632:10.1210/jc.2012-3748
3484:10.1038/oby.2010.106
3303:10.1210/en.2006-1704
3021:10.1038/cdd.2015.168
2273:10.1210/jc.2013-1047
2224:10.1210/jc.2012-2246
2026:Molecular Metabolism
1369:10.1210/en.2015-1213
1168:10.1210/jc.2015-2338
970:10.1210/jc.2013-3666
780:10.1210/jc.2012-3634
696:10.1210/jc.2012-1477
535:Scientific societies
435:in conjunction with
177:white adipose tissue
3253:10.1038/nature08099
3245:2009Natur.460..259N
3120:10.1359/jbmr.090813
3058:Nature Cell Biology
2981:10.1359/jbmr.070810
2752:10.1359/jbmr.070507
2702:10.1359/jbmr.050916
2169:2001Sci...294.2166M
2163:(5549): 2166–2170.
1883:2019NatSR...917427C
1826:2020NatCo..11.3097S
1516:BoneKEy Osteovision
963:(10): E1933–E1942.
562:BMAS working groups
373:hematologic cancers
188:Exercise regulation
125:caloric restriction
3343:10.4161/adip.21496
2604:10.1002/jmri.22489
2556:10.1002/jmri.20367
1871:Scientific Reports
554:
433:vertebral skeleton
90:
4185:on 15 March 2015.
3582:10.1002/jbmr.1640
3239:(7252): 259–263.
3160:10.1002/jbmr.1807
2974:(12): 1924–1932.
2925:(10): 2138–2147.
2416:10.1002/jcb.20777
2218:(11): 4115–4122.
2114:Acta Physiologica
1983:(4): 949–958.e6.
1578:10.1002/jbmr.3357
1427:10.1002/jbmr.3159
1315:10.1002/jcp.24954
1161:(10): 3613–3621.
1013:978-0-12-814082-6
836:10.1002/jbmr.3872
641:Endocrine society
636:Endocrine Society
589:(Odense, Denmark)
82:
81:
77:
16:(Redirected from
4255:
4209:
4198:
4186:
4164:
4163:
4153:
4143:
4119:
4113:
4112:
4102:
4092:
4068:
4062:
4061:
4051:
4041:
4017:
4011:
4010:
4000:
3990:
3966:
3960:
3959:
3949:
3917:
3911:
3910:
3882:
3876:
3875:
3865:
3855:
3831:
3825:
3824:
3814:
3804:
3780:
3774:
3773:
3762:
3756:
3755:
3745:
3728:(7): 2300–2310.
3713:
3707:
3706:
3696:
3661:
3655:
3654:
3644:
3634:
3625:(5): 2037–2044.
3610:
3604:
3603:
3593:
3576:(9): 1864–1871.
3561:
3555:
3554:
3544:
3512:
3506:
3505:
3495:
3463:
3457:
3456:
3446:
3422:
3416:
3415:
3405:
3371:
3365:
3364:
3354:
3322:
3316:
3315:
3305:
3296:(5): 2553–2562.
3281:
3275:
3274:
3264:
3224:
3218:
3217:
3200:(5): 1046–1058.
3188:
3182:
3181:
3171:
3139:
3133:
3132:
3122:
3098:
3092:
3091:
3081:
3049:
3043:
3042:
3032:
3015:(7): 1128–1139.
3000:
2994:
2993:
2983:
2959:
2953:
2952:
2942:
2931:10.1002/jbmr.118
2910:
2904:
2903:
2893:
2861:
2855:
2854:
2844:
2820:
2814:
2813:
2803:
2771:
2765:
2764:
2754:
2745:(8): 1197–1207.
2730:
2724:
2723:
2713:
2681:
2675:
2674:
2664:
2647:(9): 1323–1330.
2632:
2626:
2625:
2615:
2583:
2577:
2576:
2558:
2534:
2528:
2527:
2502:(5): 1547–1553.
2491:
2485:
2484:
2474:
2442:
2436:
2435:
2399:
2393:
2392:
2382:
2350:
2344:
2343:
2333:
2301:
2295:
2294:
2284:
2267:(6): 2562–2572.
2252:
2246:
2245:
2235:
2203:
2197:
2196:
2152:
2146:
2145:
2109:
2103:
2102:
2066:
2060:
2059:
2049:
2017:
2011:
2010:
1992:
1968:
1962:
1961:
1951:
1919:
1913:
1912:
1902:
1862:
1856:
1855:
1845:
1805:
1796:
1795:
1785:
1753:
1747:
1746:
1736:
1726:
1702:
1696:
1695:
1685:
1676:(8): 3131–3145.
1661:
1655:
1654:
1644:
1612:
1601:
1600:
1590:
1580:
1556:
1550:
1549:
1539:
1528:10.1138/20090371
1507:
1501:
1500:
1490:
1458:
1449:
1448:
1438:
1421:(8): 1692–1702.
1406:
1391:
1390:
1380:
1363:(8): 2753–2761.
1348:
1337:
1336:
1326:
1309:(9): 2032–2037.
1294:
1288:
1287:
1277:
1267:
1243:
1237:
1236:
1226:
1194:
1181:
1180:
1170:
1146:
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1136:
1118:
1086:
1080:
1079:
1069:
1059:
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1026:
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989:
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858:
857:
847:
815:
802:
801:
791:
759:
753:
752:
724:
718:
717:
707:
690:(8): 2782–2791.
675:
656:
601:(Athens, Greece)
522:
506:
489:
472:
411:quantification.
121:anorexia nervosa
107:), is a type of
74:edit on Wikidata
71:
27:
26:
21:
4263:
4262:
4258:
4257:
4256:
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4171:Further reading
4168:
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3099:
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3070:10.1038/ncb3570
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2451:Cell Metabolism
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2347:
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2253:
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2204:
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2149:
2110:
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2083:10.1038/nri1937
2077:(10): 772–783.
2067:
2063:
2018:
2014:
1969:
1965:
1920:
1916:
1863:
1859:
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1799:
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986:
949:
945:
914:
910:
865:
861:
816:
805:
760:
756:
725:
721:
676:
672:
649:
638:
608:
571:
542:
537:
530:
529:
523:
514:
513:
507:
498:
497:
490:
481:
480:
473:
463:
413:Flow cytometric
385:
365:stem cell niche
361:stem cell niche
343:
303:MR spectroscopy
295:
227:
190:
185:
146:
78:
23:
22:
15:
12:
11:
5:
4261:
4251:
4250:
4245:
4240:
4235:
4230:
4228:Bone fractures
4225:
4211:
4210:
4200:
4199:
4197:. 18 May 2017.
4187:
4174:
4172:
4169:
4166:
4165:
4114:
4063:
4012:
3961:
3932:(4): 304–313.
3912:
3877:
3826:
3775:
3757:
3708:
3683:
3656:
3605:
3556:
3527:(3): 179–191.
3507:
3458:
3437:(4): 469–474.
3417:
3392:
3366:
3337:(4): 215–229.
3317:
3276:
3219:
3183:
3154:(4): 865–874.
3134:
3113:(2): 275–284.
3093:
3064:(8): 891–903.
3044:
2995:
2954:
2905:
2876:(6): 379–389.
2856:
2835:(2): 191–197.
2815:
2786:(5): 667–684.
2766:
2725:
2696:(1): 124–131.
2676:
2627:
2598:(4): 974–979.
2578:
2549:(2): 279–285.
2529:
2486:
2457:(2): 368–375.
2437:
2410:(2): 251–266.
2394:
2345:
2316:(3): 234–250.
2296:
2247:
2198:
2147:
2120:(2): 194–208.
2104:
2061:
2032:(3): 133–141.
2012:
1963:
1914:
1857:
1797:
1768:(2): 546–552.
1748:
1697:
1656:
1627:(6): 774–789.
1602:
1571:(4): 651–657.
1551:
1522:(4): 132–149.
1502:
1473:(6): 339–355.
1450:
1392:
1338:
1289:
1238:
1182:
1138:
1101:(2): 236–253.
1081:
1027:
1012:
984:
943:
908:
879:(4): 668–677.
859:
830:(1): 106–115.
803:
774:(3): 935–945.
754:
719:
669:
668:
648:
645:
637:
634:
607:
604:
603:
602:
596:
593:
590:
584:
581:
578:
575:
570:
567:
541:
538:
536:
533:
532:
531:
525:
524:
517:
515:
509:
508:
501:
499:
492:
491:
484:
482:
475:
474:
467:
465:
461:
449:image analysis
397:selection bias
384:
381:
342:
339:
325:sites such as
294:
291:
226:
223:
199:bone formation
189:
186:
184:
181:
145:
142:
80:
79:
70:
64:
63:
58:
52:
51:
47:
46:
43:
37:
36:
32:
31:
9:
6:
4:
3:
2:
4260:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4220:
4218:
4207:
4203:
4202:
4196:
4195:Science Daily
4192:
4188:
4184:
4180:
4176:
4175:
4161:
4157:
4152:
4147:
4142:
4137:
4133:
4129:
4125:
4118:
4110:
4106:
4101:
4096:
4091:
4086:
4082:
4078:
4074:
4067:
4059:
4055:
4050:
4045:
4040:
4035:
4031:
4027:
4023:
4016:
4008:
4004:
3999:
3994:
3989:
3984:
3980:
3976:
3972:
3965:
3957:
3953:
3948:
3943:
3939:
3935:
3931:
3927:
3923:
3916:
3908:
3904:
3900:
3896:
3892:
3888:
3881:
3873:
3869:
3864:
3859:
3854:
3849:
3845:
3841:
3837:
3830:
3822:
3818:
3813:
3808:
3803:
3798:
3794:
3790:
3786:
3779:
3771:
3767:
3761:
3753:
3749:
3744:
3739:
3735:
3731:
3727:
3723:
3719:
3712:
3704:
3700:
3695:
3690:
3686:
3684:9780124116191
3680:
3676:
3672:
3668:
3660:
3652:
3648:
3643:
3638:
3633:
3628:
3624:
3620:
3616:
3609:
3601:
3597:
3592:
3587:
3583:
3579:
3575:
3571:
3567:
3560:
3552:
3548:
3543:
3538:
3534:
3530:
3526:
3522:
3518:
3511:
3503:
3499:
3494:
3489:
3485:
3481:
3477:
3473:
3469:
3462:
3454:
3450:
3445:
3440:
3436:
3432:
3428:
3421:
3413:
3409:
3404:
3399:
3395:
3393:9780124116191
3389:
3385:
3381:
3377:
3370:
3362:
3358:
3353:
3348:
3344:
3340:
3336:
3332:
3328:
3321:
3313:
3309:
3304:
3299:
3295:
3291:
3290:Endocrinology
3287:
3280:
3272:
3268:
3263:
3258:
3254:
3250:
3246:
3242:
3238:
3234:
3230:
3223:
3215:
3211:
3207:
3203:
3199:
3195:
3187:
3179:
3175:
3170:
3165:
3161:
3157:
3153:
3149:
3145:
3138:
3130:
3126:
3121:
3116:
3112:
3108:
3104:
3097:
3089:
3085:
3080:
3075:
3071:
3067:
3063:
3059:
3055:
3048:
3040:
3036:
3031:
3026:
3022:
3018:
3014:
3010:
3006:
2999:
2991:
2987:
2982:
2977:
2973:
2969:
2965:
2958:
2950:
2946:
2941:
2936:
2932:
2928:
2924:
2920:
2916:
2909:
2901:
2897:
2892:
2887:
2883:
2879:
2875:
2871:
2867:
2860:
2852:
2848:
2843:
2838:
2834:
2830:
2826:
2819:
2811:
2807:
2802:
2797:
2793:
2789:
2785:
2781:
2777:
2770:
2762:
2758:
2753:
2748:
2744:
2740:
2736:
2729:
2721:
2717:
2712:
2707:
2703:
2699:
2695:
2691:
2687:
2680:
2672:
2668:
2663:
2658:
2654:
2650:
2646:
2642:
2638:
2631:
2623:
2619:
2614:
2609:
2605:
2601:
2597:
2593:
2589:
2582:
2574:
2570:
2566:
2562:
2557:
2552:
2548:
2544:
2540:
2533:
2525:
2521:
2517:
2513:
2509:
2505:
2501:
2497:
2490:
2482:
2478:
2473:
2468:
2464:
2460:
2456:
2452:
2448:
2441:
2433:
2429:
2425:
2421:
2417:
2413:
2409:
2405:
2398:
2390:
2386:
2381:
2376:
2372:
2368:
2364:
2360:
2356:
2349:
2341:
2337:
2332:
2327:
2323:
2319:
2315:
2311:
2307:
2300:
2292:
2288:
2283:
2278:
2274:
2270:
2266:
2262:
2258:
2251:
2243:
2239:
2234:
2229:
2225:
2221:
2217:
2213:
2209:
2202:
2194:
2190:
2186:
2182:
2178:
2174:
2170:
2166:
2162:
2158:
2151:
2143:
2139:
2135:
2131:
2127:
2123:
2119:
2115:
2108:
2100:
2096:
2092:
2088:
2084:
2080:
2076:
2072:
2065:
2057:
2053:
2048:
2043:
2039:
2035:
2031:
2027:
2023:
2016:
2008:
2004:
2000:
1996:
1991:
1986:
1982:
1978:
1974:
1967:
1959:
1955:
1950:
1945:
1941:
1937:
1933:
1929:
1925:
1918:
1910:
1906:
1901:
1896:
1892:
1888:
1884:
1880:
1876:
1872:
1868:
1861:
1853:
1849:
1844:
1839:
1835:
1831:
1827:
1823:
1819:
1815:
1811:
1804:
1802:
1793:
1789:
1784:
1779:
1775:
1771:
1767:
1763:
1759:
1752:
1744:
1740:
1735:
1730:
1725:
1720:
1716:
1712:
1708:
1701:
1693:
1689:
1684:
1679:
1675:
1671:
1667:
1660:
1652:
1648:
1643:
1638:
1634:
1630:
1626:
1622:
1618:
1611:
1609:
1607:
1598:
1594:
1589:
1584:
1579:
1574:
1570:
1566:
1562:
1555:
1547:
1543:
1538:
1533:
1529:
1525:
1521:
1517:
1513:
1506:
1498:
1494:
1489:
1484:
1480:
1476:
1472:
1468:
1464:
1457:
1455:
1446:
1442:
1437:
1432:
1428:
1424:
1420:
1416:
1412:
1405:
1403:
1401:
1399:
1397:
1388:
1384:
1379:
1374:
1370:
1366:
1362:
1358:
1357:Endocrinology
1354:
1347:
1345:
1343:
1334:
1330:
1325:
1320:
1316:
1312:
1308:
1304:
1300:
1293:
1285:
1281:
1276:
1271:
1266:
1261:
1257:
1253:
1249:
1242:
1234:
1230:
1225:
1220:
1216:
1212:
1208:
1204:
1200:
1193:
1191:
1189:
1187:
1178:
1174:
1169:
1164:
1160:
1156:
1152:
1145:
1143:
1134:
1130:
1126:
1122:
1117:
1112:
1108:
1104:
1100:
1096:
1092:
1085:
1077:
1073:
1068:
1063:
1058:
1053:
1049:
1045:
1041:
1034:
1032:
1023:
1019:
1015:
1009:
1005:
1001:
997:
996:
988:
980:
976:
971:
966:
962:
958:
954:
947:
939:
935:
931:
927:
923:
919:
912:
904:
900:
896:
892:
887:
882:
878:
874:
870:
863:
855:
851:
846:
841:
837:
833:
829:
825:
821:
814:
812:
810:
808:
799:
795:
790:
785:
781:
777:
773:
769:
765:
758:
750:
746:
742:
738:
734:
730:
723:
715:
711:
706:
701:
697:
693:
689:
685:
681:
674:
670:
667:
666:
664:
660:
655:
644:
642:
633:
631:
627:
623:
621:
617:
612:
600:
597:
594:
591:
588:
585:
582:
579:
576:
573:
572:
569:BMAS meetings
566:
563:
558:
550:
546:
528:
521:
516:
512:
505:
500:
496:
488:
483:
479:
471:
466:
464:
459:
458:
457:
453:
450:
446:
442:
438:
434:
430:
426:
422:
417:
414:
410:
405:
403:
398:
394:
390:
389:hematopoietic
380:
378:
374:
370:
366:
362:
358:
354:
350:
349:Hematopoietic
346:
338:
336:
332:
328:
324:
320:
316:
312:
308:
304:
300:
290:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
222:
220:
216:
212:
211:lipodystrophy
208:
204:
200:
195:
180:
178:
174:
170:
166:
162:
158:
155:
151:
141:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
86:
75:
69:
65:
62:
59:
57:
53:
48:
44:
42:
38:
33:
28:
19:
4194:
4183:the original
4131:
4127:
4117:
4080:
4076:
4066:
4029:
4025:
4015:
3978:
3974:
3964:
3929:
3925:
3915:
3890:
3886:
3880:
3843:
3839:
3829:
3792:
3788:
3778:
3770:BMAS Website
3769:
3760:
3725:
3721:
3711:
3666:
3659:
3622:
3618:
3608:
3573:
3569:
3559:
3524:
3520:
3510:
3478:(1): 49–53.
3475:
3471:
3461:
3434:
3430:
3420:
3375:
3369:
3334:
3330:
3320:
3293:
3289:
3279:
3236:
3232:
3222:
3197:
3193:
3186:
3151:
3147:
3137:
3110:
3106:
3096:
3061:
3057:
3047:
3012:
3008:
2998:
2971:
2967:
2957:
2922:
2918:
2908:
2873:
2869:
2859:
2832:
2828:
2818:
2783:
2779:
2769:
2742:
2738:
2728:
2693:
2689:
2679:
2644:
2640:
2630:
2595:
2591:
2581:
2546:
2542:
2532:
2499:
2495:
2489:
2454:
2450:
2440:
2407:
2403:
2397:
2365:(1): 32–43.
2362:
2358:
2348:
2313:
2309:
2299:
2264:
2260:
2250:
2215:
2211:
2201:
2160:
2156:
2150:
2117:
2113:
2107:
2074:
2070:
2064:
2029:
2025:
2015:
1980:
1977:Cell Reports
1976:
1966:
1931:
1927:
1917:
1877:(1): 17427.
1874:
1870:
1860:
1817:
1813:
1765:
1761:
1751:
1714:
1710:
1700:
1673:
1669:
1659:
1624:
1620:
1568:
1564:
1554:
1519:
1515:
1505:
1470:
1466:
1418:
1414:
1360:
1356:
1306:
1302:
1292:
1255:
1251:
1241:
1206:
1202:
1158:
1154:
1098:
1094:
1084:
1047:
1043:
994:
987:
960:
956:
946:
924:(1): 69–75.
921:
917:
911:
876:
872:
862:
827:
823:
771:
767:
757:
732:
728:
722:
687:
683:
673:
651:
650:
639:
619:
615:
609:
559:
555:
543:
526:
510:
493:
476:
460:
454:
418:
408:
406:
386:
347:
344:
299:osteoporosis
296:
228:
191:
148:Bone marrow
147:
133:space travel
117:osteoporosis
104:
100:
96:
92:
91:
60:
4223:Bone marrow
3893:: 212–215.
1820:(1): 3097.
735:: 147–154.
383:Measurement
357:osteoclasts
327:bone marrow
319:zoledronate
315:risedronate
309:therapy in
279:adiponectin
267:thermogenic
251:adiponectin
161:osteoblasts
157:progenitors
135:, and anti-
129:unweighting
127:, skeletal
113:bone marrow
109:fat deposit
50:Identifiers
4217:Categories
4134:: 879588.
4083:: 712088.
3846:: 744527.
2870:Aging Cell
2829:Aging Cell
2780:Aging Cell
1717:: 782194.
647:References
628:, and the
247:adipokines
183:Physiology
150:adipocytes
4233:Histology
3926:Adipocyte
3431:Cytometry
3331:Adipocyte
2007:210949460
1934:: 32–41.
1209:: 39–46.
1022:213762507
663:CC BY 4.0
402:endosteum
393:histology
219:anabolism
203:anabolism
173:vibration
169:adipocyte
4248:Mesoderm
4160:35498418
4109:34335478
4058:31681168
4007:31191458
3956:28410005
3907:26608519
3872:34646237
3821:32180758
3752:32311037
3703:24480344
3651:23616150
3600:22508185
3551:21637996
3502:20467419
3412:24480352
3361:23700536
3312:17317771
3271:19516257
3214:15542029
3178:23109229
3129:19653818
3088:28714970
3039:26868907
2990:17708715
2949:20499361
2900:15569355
2851:21210937
2810:20701600
2761:17488199
2720:16355281
2671:18274695
2622:21448966
2565:16028245
2524:27850362
2516:20661545
2481:24998914
2432:19746472
2424:16479589
2389:22529014
2340:23388824
2291:23515452
2242:22933540
2185:11739957
2142:22915022
2134:22226221
2099:29865593
2091:16998510
2056:24049728
1999:31995765
1958:29360620
1909:31758074
1852:32555194
1792:21723971
1743:35145475
1692:30896746
1651:33068251
1597:29336053
1546:22241295
1497:30814687
1445:28436105
1387:26052898
1333:25663195
1284:27512386
1233:24709686
1177:26244490
1125:18854943
1116:11131547
1076:32038486
979:24905061
903:23060094
895:11918224
854:31509274
798:23393168
714:22701013
665:license.
626:JBMRPlus
369:oncology
307:Estrogen
137:diabetes
4238:Anatomy
4151:9043644
4100:8323480
4049:6813723
4032:: 691.
3998:6546805
3981:: 336.
3947:5736244
3863:8503265
3812:7059536
3743:7247553
3694:4097010
3591:3415584
3542:3157554
3493:3593350
3472:Obesity
3453:2766892
3403:4143162
3352:3609111
3262:2831539
3241:Bibcode
3169:4076162
3079:5536858
3030:4946886
2940:3153316
2891:1850101
2801:2941545
2711:1352156
2662:2652842
2613:3072841
2573:2941430
2472:4126847
2380:3563956
2331:3576510
2282:3667251
2233:3485587
2165:Bibcode
2157:Science
2047:3773837
1949:6062480
1900:6874537
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