924:
31:
329:
Chen, Chang-jie; Chin, Janice E.; Ueda, Kazumitsu; Clark, Douglas P.; Pastan, Ira; Gottesman, Michael M.; Roninson, Igor B. (1986), "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells",
1005:
1000:
375:
Thiebaut, F.; Tsuruo, T.; Hamada, H.; Gottesman, M. M.; Pastan, I.; Willingham, M. C. (1987), "Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues",
176:, a research associate at the NIH, and an assistant professor at Harvard before taking a permanent position at the NIH in 1976. On August 1, 2022, Gottesman was succeeded as director of the
595:
545:
620:
610:
645:
304:
600:
873:
691:
605:
650:
531:
615:
590:
1010:
696:
630:
221:
585:
1055:
377:
635:
275:. Accessed April 20, 2023. "Michael Marc Gottesman was born on October 7, 1946 in Jersey City, New Jersey, and grew up in Flushing, New York."
1045:
747:
706:
1015:
722:
432:
Kimchi-Sarfaty, Chava; Oh, Jung Mi; Kim, In-Wha; Sauna, Zuben E.; Calcagno, Anna Maria; Ambudkar, Suresh V.; Gottesman, Michael M. (2007),
524:
1030:
995:
660:
1040:
1035:
961:
570:
575:
287:
272:
990:
883:
655:
517:
1025:
264:
233:
888:
868:
686:
893:
858:
732:
640:
200:
efflux transporter associated with clinical resistance to anti-cancer agents. In 2007, he reported for the first time in
229:
676:
930:
This biography of a person who has held a non-elected position in the federal government of the United States is a
625:
1050:
863:
177:
169:
109:
1020:
954:
541:
141:
113:
681:
237:
225:
84:
580:
765:
560:
145:
947:
878:
800:
790:
701:
129:
54:
985:
785:
565:
165:
935:
805:
727:
923:
509:
980:
447:
386:
197:
8:
810:
137:
451:
390:
284:
835:
473:
357:
209:
66:
409:
795:
775:
760:
755:
465:
438:
414:
349:
345:
201:
477:
361:
305:"Dr. Nina Schor appointed as the NIH Acting Deputy Director for Intramural Research"
144:(NIH) in the United States, and also Chief of the Laboratory of Cell Biology at the
820:
737:
455:
404:
394:
341:
261:
30:
830:
815:
770:
291:
268:
205:
161:
157:
931:
825:
332:
193:
1006:
Fellows of the
American Society for Pharmacology and Experimental Therapeutics
974:
181:
460:
399:
160:
in biochemical sciences in 1966 from
Harvard College, and received his M.D.
469:
418:
353:
192:
His areas of expertise includes a major contribution to the discovery of
434:"A "silent" polymorphism in the MDR1 gene changes substrate specificity"
852:
780:
133:
596:
National
Institute of Arthritis and Musculoskeletal and Skin Diseases
433:
1001:
Fellows of the
American Association for the Advancement of Science
76:
Impact of silent polymorphisms on tertiary structure and function
621:
National
Institute of Diabetes and Digestive and Kidney Diseases
611:
National
Institute on Deafness and Other Communication Disorders
173:
539:
374:
646:
National
Institute on Minority Health and Health Disparities
601:
National
Institute of Biomedical Imaging and Bioengineering
504:
168:
in 1970. He then worked as an intern and resident at the
692:
606:
National
Institute of Child Health and Human Development
431:
651:
National Institute of Neurological Disorders and Stroke
874:
National Institutes of Health Director's Pioneer Award
616:
National Institute of Dental and Craniofacial Research
591:
National Institute of Allergy and Infectious Diseases
499:
494:
697:
National Center for Advancing Translational Sciences
631:
National Institute of Environmental Health Sciences
222:
American Association for the Advancement of Science
586:National Institute on Alcohol Abuse and Alcoholism
328:
140:. He was the deputy director (Intramural) of the
972:
378:Proceedings of the National Academy of Sciences
636:National Institute of General Medical Sciences
955:
707:National Institutes of Health Clinical Center
525:
723:Advanced Research Projects Agency for Health
1011:Members of the National Academy of Medicine
962:
948:
532:
518:
29:
571:National Heart, Lung, and Blood Institute
459:
408:
398:
1056:United States government biography stubs
576:National Human Genome Research Institute
495:NIH Intramural Research Program website
973:
884:National Center for Research Resources
656:National Institute of Nursing Research
257:
255:
253:
220:Gottesman is an elected member of the
513:
234:American Academy of Arts and Sciences
1046:National Institutes of Health people
918:
889:National Institutes of Health Police
869:National Institutes of Health campus
687:John E. Fogarty International Center
273:Office of Research on Women's Health
1016:People from Jersey City, New Jersey
894:Office of Laboratory Animal Welfare
859:United States Public Health Service
733:National Diabetes Education Program
641:National Institute of Mental Health
505:NIH Institutes, Centers and Offices
309:National Institutes of Health (NIH)
250:
13:
230:Association of American Physicians
14:
1067:
1031:21st-century American biochemists
996:20th-century American biochemists
677:Center for Information Technology
488:
1041:21st-century American physicians
1036:20th-century American physicians
922:
626:National Institute on Drug Abuse
262:Pharmacology Conference Speakers
864:Division of Intramural Research
215:
178:NIH Intramural Research Program
16:American biochemist (born 1946)
425:
368:
322:
297:
278:
112:, Boston; Harvard University;
1:
991:Harvard Medical School alumni
907:indicate acting officeholders
542:National Institutes of Health
243:
142:National Institutes of Health
114:National Institutes of Health
1026:American medical researchers
934:. You can help Knowledge by
682:Center for Scientific Review
661:National Library of Medicine
346:10.1016/0092-8674(86)90595-7
294:, NCI, retrieved 2010-02-28.
238:National Academy of Sciences
226:National Academy of Medicine
85:National Academy of Sciences
7:
581:National Institute on Aging
212:and function of a protein.
187:
170:Peter Dent Brigham Hospital
110:Peter Dent Brigham Hospital
10:
1072:
917:
128:(born October 7, 1946, in
902:
844:
746:
715:
669:
561:National Cancer Institute
553:
267:January 16, 2009, at the
180:by pediatric neurologist
151:
146:National Cancer Institute
119:
105:
97:
90:
80:
72:
62:
37:
28:
21:
879:NIH Public Access Policy
791:James Augustine Shannon
702:Vaccine Research Center
461:10.1126/science.1135308
400:10.1073/pnas.84.21.7735
148:(NCI) within the NIH.
130:Jersey City, New Jersey
55:Jersey City, New Jersey
1051:Harvard College alumni
786:William H. Sebrell, Jr
566:National Eye Institute
166:Harvard Medical School
806:Donald S. Fredrickson
728:Visible Human Project
1021:Physician-scientists
206:silent polymorphisms
198:multidrug resistance
126:Michael M. Gottesman
23:Michael M. Gottesman
811:James B. Wyngaarden
452:2007Sci...315..525K
391:1987PNAS...84.7735T
196:(MDR1, ABCB1), the
138:physician-scientist
836:Monica Bertagnolli
290:2010-05-27 at the
210:tertiary structure
67:Harvard University
943:
942:
912:
911:
796:Robert Q. Marston
776:Lewis R. Thompson
761:Milton J. Rosenau
756:Joseph J. Kinyoun
446:(5811): 525–528,
385:(21): 7735–7738,
132:) is an American
123:
122:
92:Scientific career
1063:
964:
957:
950:
926:
919:
821:Harold E. Varmus
766:John F. Anderson
738:BRAIN Initiative
534:
527:
520:
511:
510:
482:
480:
463:
429:
423:
421:
412:
402:
372:
366:
364:
326:
320:
319:
317:
316:
301:
295:
282:
276:
259:
236:(2010), and the
202:Science magazine
51:
47:
45:
33:
19:
18:
1071:
1070:
1066:
1065:
1064:
1062:
1061:
1060:
971:
970:
969:
968:
915:
913:
908:
898:
840:
831:Francis Collins
816:Bernadine Healy
771:George W. McCoy
742:
711:
665:
549:
538:
491:
486:
485:
430:
426:
373:
369:
327:
323:
314:
312:
303:
302:
298:
292:Wayback Machine
283:
279:
269:Wayback Machine
260:
251:
246:
218:
208:can impact the
190:
162:magna cum laude
158:summa cum laude
154:
58:
52:
49:
48:October 7, 1946
43:
41:
24:
17:
12:
11:
5:
1069:
1059:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
967:
966:
959:
952:
944:
941:
940:
927:
910:
909:
903:
900:
899:
897:
896:
891:
886:
881:
876:
871:
866:
861:
856:
848:
846:
842:
841:
839:
838:
833:
828:
826:Elias Zerhouni
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
752:
750:
744:
743:
741:
740:
735:
730:
725:
719:
717:
713:
712:
710:
709:
704:
699:
694:
689:
684:
679:
673:
671:
667:
666:
664:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
598:
593:
588:
583:
578:
573:
568:
563:
557:
555:
551:
550:
537:
536:
529:
522:
514:
508:
507:
502:
497:
490:
489:External links
487:
484:
483:
424:
367:
340:(3): 381–389,
321:
296:
277:
248:
247:
245:
242:
217:
214:
194:P-glycoprotein
189:
186:
153:
150:
121:
120:
117:
116:
107:
103:
102:
99:
95:
94:
88:
87:
82:
78:
77:
74:
73:Known for
70:
69:
64:
60:
59:
53:
39:
35:
34:
26:
25:
22:
15:
9:
6:
4:
3:
2:
1068:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
986:Living people
984:
982:
979:
978:
976:
965:
960:
958:
953:
951:
946:
945:
939:
937:
933:
928:
925:
921:
920:
916:
906:
901:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
854:
850:
849:
847:
843:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
753:
751:
749:
745:
739:
736:
734:
731:
729:
726:
724:
721:
720:
718:
714:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
674:
672:
668:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
558:
556:
552:
547:
543:
535:
530:
528:
523:
521:
516:
515:
512:
506:
503:
501:
498:
496:
493:
492:
479:
475:
471:
467:
462:
457:
453:
449:
445:
441:
440:
435:
428:
420:
416:
411:
406:
401:
396:
392:
388:
384:
380:
379:
371:
363:
359:
355:
351:
347:
343:
339:
335:
334:
325:
310:
306:
300:
293:
289:
286:
285:Staff profile
281:
274:
270:
266:
263:
258:
256:
254:
249:
241:
239:
235:
231:
227:
223:
213:
211:
207:
203:
199:
195:
185:
183:
182:Nina F. Schor
179:
175:
171:
167:
163:
159:
156:He graduated
149:
147:
143:
139:
135:
131:
127:
118:
115:
111:
108:
104:
100:
96:
93:
89:
86:
83:
79:
75:
71:
68:
65:
61:
56:
50:(age 77)
40:
36:
32:
27:
20:
936:expanding it
929:
914:
904:
851:
801:Robert Stone
500:NIH homepage
443:
437:
427:
382:
376:
370:
337:
331:
324:
313:. Retrieved
311:. 2022-07-13
308:
299:
280:
232:(2006), the
228:(2003), the
224:(1988), the
219:
216:Distinctions
191:
155:
125:
124:
106:Institutions
101:Biochemistry
91:
981:1946 births
975:Categories
853:NIH Record
781:Rolla Dyer
554:Institutes
315:2022-07-29
244:References
134:biochemist
44:1946-10-07
748:Directors
63:Education
716:Programs
478:15146955
470:17185560
362:20431107
288:Archived
265:Archived
240:(2018).
188:Research
905:Italics
845:Related
670:Centers
448:Bibcode
439:Science
419:2444983
387:Bibcode
354:2876781
476:
468:
417:
410:299375
407:
360:
352:
174:Boston
152:Career
98:Fields
81:Awards
57:, U.S.
540:U.S.
474:S2CID
358:S2CID
204:that
164:from
932:stub
546:list
466:PMID
415:PMID
350:PMID
333:Cell
136:and
38:Born
456:doi
444:315
405:PMC
395:doi
342:doi
172:in
977::
472:,
464:,
454:,
442:,
436:,
413:,
403:,
393:,
383:84
381:,
356:,
348:,
338:47
336:,
307:.
271:,
252:^
184:.
46:)
963:e
956:t
949:v
938:.
548:)
544:(
533:e
526:t
519:v
481:.
458::
450::
422:.
397::
389::
365:.
344::
318:.
42:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.