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Publication bias

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be less prone to publication bias. For example, an intervention found to be ineffective would be easier to publish as part of a megastudy as just one of many studied interventions. In contrast, it might go unreported due to the file-drawer problem if it were the sole focus of a contemplated paper. For the same reason, the megastudy research design may encourage researchers to study not only the interventions they consider more likely to be effective but also those interventions that researchers are less sure about and that they would not pick as the sole focus of the study due to the perceived high risk of a null effect.
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Enhanced research standards such as the pre-registration of protocols, the registration of data collections, and adherence to established protocols are other techniques. To avoid false-positive results, the experimenter must consider the chances that they are testing a true or non-true relationship. This can be undertaken by properly assessing the false positive report probability based on the statistical power of the test and reconfirming (whenever ethically acceptable) established findings of prior studies known to have minimal bias.
209: 182:. The study showed that statistically positive significant findings are 27% more likely to be included in meta-analyses of efficacy than other findings. Results showing no evidence of adverse effects have a 78% greater probability of inclusion in safety studies than statistically significant results showing adverse effects. Evidence of publication bias was found in meta-analyses published in prominent medical journals. 439: 123:
which "successful" research is more likely to be published. As a result, "the literature of such a field consists in substantial part of false conclusions resulting from errors of the first kind in statistical tests of significance". In the worst case, false conclusions could canonize as being true if the publication rate of negative results is too low.
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In a megastudy, a large number of treatments are tested simultaneously. Given the inclusion of different interventions in the study, a megastudy's publication likelihood is less dependent on the statistically significant effect of any specific treatment, so it has been suggested that megastudies may
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regression test, and may adopt a multiplicative or additive dispersion parameter to adjust for the presence of between-study heterogeneity. Some approaches may even attempt to compensate for the (potential) presence of publication bias, which is particularly useful to explore the potential impact on
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demonstrated attempts to detect publication bias in clinical trials. Based on positive trial data, reboxetine was originally passed as a treatment for depression in many countries in Europe and the UK in 2001 (though in practice it is rarely used for this indication). A 2010 meta-analysis concluded
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on publication bias in the biomedical field. Investigators following clinical trials from the submission of their protocols to ethics committees (or regulatory authorities) until the publication of their results observed that those with positive results are more likely to be published. In addition,
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Publication bias occurs when the publication of research results depends not just on the quality of the research but also on the hypothesis tested, and the significance and direction of effects detected. The subject was first discussed in 1959 by statistician Theodore Sterling to refer to fields in
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The presence of publication bias can be detected by Time-lag bias tests, where time-lag bias occurs when larger or statistically significant effects are published more quickly than smaller or non-statistically significant effects. It can manifest as a decline in the magnitude of the overall effect
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Positive-results bias, a type of publication bias, occurs when authors are more likely to submit, or editors are more likely to accept, positive results than negative or inconclusive results. Outcome reporting bias occurs when multiple outcomes are measured and analyzed, but the reporting of these
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in which the estimate of the reported effect size is plotted against a measure of precision or sample size. The premise is that the scatter of points should reflect a funnel shape, indicating that the reporting of effect sizes is not related to their statistical significance. However, when small
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Meta-analyses (reviews) have been performed in the field of ecology and environmental biology. In a study of 100 meta-analyses in ecology, only 49% tested for publication bias. While there are multiple tests that have been developed to detect publication bias, most perform poorly in the field of
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Publication bias can be contained through better-powered studies, enhanced research standards, and careful consideration of true and non-true relationships. Better-powered studies refer to large studies that deliver definitive results or test major concepts and lead to low-bias meta-analysis.
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In the social sciences, a study of published papers exploring the relationship between corporate social and financial performance found that "in economics, finance, and accounting journals, the average correlations were only about half the magnitude of the findings published in Social Issues
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In ecology and environmental biology, a study found that publication bias impacted the effect size, statistical power, and magnitude. The prevalence of publication bias distorted confidence in meta-analytic results, with 66% of initially statistically significant meta-analytic means becoming
134:. This term suggests that negative results, those that do not support the initial hypotheses of researchers are often "filed away" and go no further than the researchers' file drawers, leading to a bias in published research. The term "file drawer problem" was coined by psychologist 300:
argues that "claimed research findings may often be simply accurate measures of the prevailing bias." He lists the following factors as those that make a paper with a positive result more likely to enter the literature and suppress negative-result papers:
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An analysis comparing studies of gene-disease associations originating in China to those originating outside China found that those conducted within the country reported a stronger association and a more statistically significant result.
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Because an inevitable degree of subjectivity exists in the interpretation of funnel plots, several tests have been proposed for detecting funnel plot asymmetry. These are often based on linear regression including the popular
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Meta-analyses and systematic reviews can account for publication bias by including evidence from unpublished studies and the grey literature. The presence of publication bias can also be explored by constructing a
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non-significant after correcting for publication bias. Ecological and evolutionary studies consistently had low statistical power (15%) with a 4-fold exaggeration of effects on average (Type M error rates = 4.4).
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Conceptual illustration of how publication bias affects effect estimates in a meta-analysis. When negative effects are not published, the overall effect estimate tends to be inflated. From Nilsonne (2023).
260:. A subsequent meta-analysis published in 2011, based on the original data, found flaws in the 2010 analyses and suggested that the data indicated reboxetine was effective in severe depression (see 2208:
Yang, Yefeng; Sánchez-Tójar, Alfredo; O’Dea, Rose E.; Noble, Daniel W. A.; Koricheva, Julia; Jennions, Michael D.; Parker, Timothy H.; Lagisz, Malgorzata; Nakagawa, Shinichi (3 April 2023).
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Nakagawa, Shinichi; Lagisz, Malgorzata; Jennions, Michael D.; Koricheva, Julia; Noble, Daniel W. A.; Parker, Timothy H.; Sánchez-Tójar, Alfredo; Yang, Yefeng; O'Dea, Rose E. (January 2022).
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Tkachenko, Y., Jedidi, K. A megastudy on the predictability of personal information from facial images: Disentangling demographic and non-demographic signals. Sci Rep 13, 21073 (2023).
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Many factors contribute to publication bias. For instance, once a scientific finding is well established, it may become newsworthy to publish reliable papers that fail to reject the
408:(WHO) agreed that basic information about all clinical trials should be registered at the study's inception and that this information should be publicly accessible through the WHO 99:
Attempts to find unpublished studies often prove difficult or are unsatisfactory. In an effort to combat this problem, some journals require studies submitted for publication
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that reboxetine was ineffective and that the preponderance of positive-outcome trials reflected publication bias, mostly due to trials published by the drug manufacturer
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Where publication bias is present, published studies are no longer a representative sample of the available evidence. This bias distorts the results of meta-analyses and
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Vickers, Andrew; Goyal, Niraj; Harland, Robert; Rees, Rebecca (1998). "Do Certain Countries Produce Only Positive Results? A Systematic Review of Controlled Trials".
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studies are predominately in one direction (usually the direction of larger effect sizes), asymmetry will ensue and this may be indicative of publication bias.
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One example cited as an instance of publication bias is the refusal to publish attempted replications of Bem's work that claimed evidence for precognition by
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Luijendijk, HJ; Koolman, X (May 2012). "The incentive to publish negative studies: how beta-blockers and depression got stuck in the publication cycle".
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Hedges L, Vevea J (1996). "Estimating effect size under publication bias: small sample properties and robustness of a random effects selection model".
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over time. The key feature of time-lag bias tests is that, as more studies accumulate, the mean effect size is expected to converge on its true value.
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Sterling, Theodore D. (March 1959). "Publication decisions and their possible effects on inferences drawn from tests of significance—or vice versa".
2352:"Institutional Logics in the Study of Organizations: The Social Construction of the Relationship between Corporate Social and Financial Performance" 2145: 3430: 2210:"Publication bias impacts on effect size, statistical power, and magnitude (Type M) and sign (Type S) errors in ecology and evolutionary biology" 409: 2351: 1458:
Kicinski, M; Springate, D. A.; Kontopantelis, E (2015). "Publication bias in meta-analyses from the Cochrane Database of Systematic Reviews".
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studies often fail to report negative results when published, as demonstrated by research comparing study protocols with published articles.
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RĂĽcker, Gerta; Carpenter, James R.; Schwarzer, Guido (1 March 2011). "Detecting and adjusting for small-study effects in meta-analysis".
382: 412:. Additionally, the public availability of complete study protocols, alongside reports of trials, is becoming more common for studies. 1185:
Flore P. C.; Wicherts J. M. (2015). "Does stereotype threat influence performance of girls in stereotyped domains? A meta-analysis".
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Jin, Zhi-Chao; Zhou, Xiao-Hua; He, Jia (30 January 2015). "Statistical methods for dealing with publication bias in meta-analysis".
2161:"How does under-reporting of negative and inconclusive results affect the false-positive rate in meta-analysis? A simulation study" 1752:"Detecting small-study effects and funnel plot asymmetry in meta-analysis of survival data: a comparison of new and existing tests" 1148: 3435: 2691:"Recognizing, investigating and dealing with incomplete and biased reporting of clinical research: from Francis Bacon to the WHO" 2268: 142:
outcomes is dependent on the strength and direction of its results. A generic term coined to describe these post-hoc choices is
178:. The largest such analysis investigated the presence of publication bias in systematic reviews of medical treatments from the 2774:
Register of clinical trials conducted in the US and around the world, maintained by the National Library of Medicine, Bethesda
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finding disturbs the balance of findings in favor of positive results. The study of publication bias is an important topic in
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Song, F.; Parekh, S.; Hooper, L.; Loke, Y. K.; Ryder, J.; Sutton, A. J.; Hing, C.; Kwok, C. S.; Pang, C.; Harvey, I. (2010).
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on girls' math scores showing asymmetry typical of publication bias. From Flore, P. C., & Wicherts, J. M. (2015)
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ecology because of high levels of heterogeneity in the data and that often observations are not fully independent.
3507: 3425: 3235: 2400: 2336: 1357:"Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors" 364: 135: 3540: 3354: 1306:"Extent of publication bias in different categories of research cohorts: a meta-analysis of empirical studies" 3560: 3240: 2894: 57:, papers with statistically significant results are three times more likely to be published than those with 3530: 2889: 2594:"Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies" 154: 2118:
Sutton AJ, Song F, Gilbody SM, Abrams KR (2000). "Modelling publication bias in meta-analysis: a review".
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analysis and disfavoring small and non-randomized studies due to high susceptibility to error and bias.
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K. Dickersin (March 1990). "The existence of publication bias and risk factors for its occurrence".
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As of 1998, "No trial published in China or Russia/USSR found a test treatment to be ineffective."
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Simonsohn, Uri; Nelson, Leif D.; Simmons, Joseph P. (2014). "P-curve: A key to the file-drawer".
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the decision to publish or otherwise distribute it. Publishing only results that show a
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Silliman N (1997). "Hierarchical selection models with applications in meta-analysis".
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Nissen, Silas Boye; Magidson, Tali; Gross, Kevin; Bergstrom, Carl (20 December 2016).
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Wacholder, S.; Chanock, S; Garcia-Closas, M; El Ghormli, L; Rothman, N (March 2004).
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The scientific field is hot and there are more scientific teams pursuing publication.
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There is greater flexibility in designs, definitions, outcomes, and analytical modes.
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Song F, Parekh-Bhurke S, Hooper L, Loke Y, Ryder J, Sutton A, et al. (2009).
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Psychfiledrawer.org: Archive for replication attempts in experimental psychology
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McShane, Blakeley B.; Böckenholt, Ulf; Hansen, Karsten T. (29 September 2016).
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There is both a greater number and lesser preselection of tested relationships.
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Other proposed strategies to detect and control for publication bias include
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Riveros C, Dechartres A, Perrodeau E, Haneef R, Boutron I, Ravaud P (2013).
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Chopra, Felix; Haaland, Ingar; Roth, Christopher; Stegmann, Andreas (2023).
72:. Most commonly, investigators simply decline to submit results, leading to 3360: 3122: 3107: 2724: 2631: 2591: 2578: 2521: 2468: 2324: 2253: 2194: 2104: 1936: 1920: 1885: 1793: 1676: 1546: 1479: 1441: 1390: 1341: 1322: 1290: 1206: 1171: 1007: 866: 797: 576: 488: 265: 2612: 2316: 2001: 1704: 1241: 1067:
Rosenthal R (1979). "File drawer problem and tolerance for null results".
911: 813:"On doing better science: From thrill of discovery to policy implications" 672: 624: 96:, a proclivity to produce many redundant, trivial, and incoherent works." 3277: 3047: 3037: 3027: 2923: 2370: 1125: 754: 725:
Publication bias in meta-analysis: prevention, assessment and adjustments
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Pan, Zhenglun; Trikalinos, Thomas A.; Kavvoura, Fotini K.; Lau, Joseph;
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Egger, M.; Smith, G. D.; Schneider, M.; Minder, C. (13 September 1997).
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Easterbrook, P. J.; Berlin, J. A.; Gopalan, R.; Matthews, D. R. (1991).
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In September 2004, editors of prominent medical journals (including the
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Higher probability of publishing results showing a significant finding
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There are prejudices (financial interest, political, or otherwise).
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Debray, Thomas P.A.; Moons, Karel G.M.; Riley, Richard D. (2018).
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Management, Business Ethics, or Business and Society journals".
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Reinvention: An International Journal of Undergraduate Research
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Nakagawa, Shinichi; Santos, Eduardo S. A. (1 September 2012).
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is increasingly reliant on meta-analysis to assess evidence.
1960:"Bias in meta-analysis detected by a simple, graphical test" 959: 80:, an inordinate focus on statistically significant results; 2841: 2598: 2207: 1303: 39: 38:
occurs when the outcome of an experiment or research study
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database from the start. Furthermore, some journals (e.g.
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The studies conducted in a field have small sample sizes.
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One effect of publication bias is sometimes called the
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What doctors don't know about the drugs they prescribe
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H. Rothstein, A. J. Sutton and M. Borenstein. (2005).
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Journal of Articles in Support of the Null Hypothesis
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The presence of publication bias was investigated in
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Pages displaying wikidata descriptions as a fallback
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Pages displaying wikidata descriptions as a fallback
434: 1808: 1102:D.L. Sackett (1979). "Bias in analytic research". 1020: 2688: 2079:"Adjusting for Publication Bias in Meta-Analysis" 775: 3522: 2543:"Why most published research findings are false" 2044:Journal of Educational and Behavioral Statistics 1749: 282:The Journal of Personality and Social Psychology 2533: 2531: 2017:Journal of the American Statistical Association 1453: 1451: 927:Journal of the American Statistical Association 719: 717: 715: 688:"Preliminary testing: The devil of statistics?" 410:International Clinical Trials Registry Platform 146:("Hypothesizing After the Results are Known"). 1807:Light, Richard J.; Pillemer, David B. (1984). 1559: 524: â€“ Type of bias in public health research 2826: 2481: 1811:Summing Up: The Science of Reviewing Research 1806: 685: 590: 588: 586: 264:). Examples of publication bias are given by 2528: 2152: 2144:: CS1 maint: DOI inactive as of June 2024 ( 1711: 1448: 1255:Decullier E, Lheritier V, Chapuis F (2005). 1219: 1101: 887: 712: 475:Conflicts of interest in academic publishing 2779:Skeptic's Dictionary: positive outcome bias 2537: 2401:"Backwards step on looking into the future" 2041: 1717: 1066: 847:Journal of Experimental Psychology: General 506: â€“ Phenomenon in scientific publishing 285:(the original publisher of Bem's article). 3489:Heuristics in judgment and decision-making 2833: 2819: 2791:Journal of Negative Results in Biomedicine 2739:https://doi.org/10.1038/s41598-023-42054-9 2295: 2014: 1503:"Publication bias in recent meta-analyses" 1500: 1354: 1222:"NIH clinical trials and publication bias" 727:. Wiley. 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(1993). 1031:Journal of Scientific Exploration 811:Antonakis, John (February 2017). 2298:"Dishonesty in Medical Research" 1624:Methods in Ecology and Evolution 437: 2682: 2638: 2475: 2418: 2399:Goldacre, Ben (23 April 2011). 2392: 2343: 2289: 2260: 2201: 2111: 2070: 2035: 2008: 1951: 1900: 1849: 1800: 1553: 1494: 1397: 1348: 1297: 1248: 1213: 1132: 1095: 1060: 1014: 953: 918: 881: 365:New England Journal of Medicine 2029:10.1080/01621459.1997.10474047 838: 804: 790:10.1016/j.jclinepi.2011.06.022 769: 730: 705:10.31273/reinvention.v12i2.339 686:Pearce, J; Derrick, B (2019). 679: 639: 415: 311:in a field tend to be smaller. 1: 1697:10.1016/S0197-2456(97)00150-5 535: 117: 2560:10.1371/journal.pmed.0020124 2503:10.1371/journal.pmed.0020409 2450:10.1371/journal.pmed.0020334 1528:10.1371/journal.pone.0081823 1423:10.1371/journal.pmed.1001566 1118:10.1016/0021-9681(79)90012-2 832:10.1016/j.leaqua.2017.01.006 665:10.1016/0197-2456(87)90155-3 616:10.1016/0140-6736(91)90201-Y 555:Health Technology Assessment 7: 3355:DĂ©formation professionnelle 2267:Goldacre, Ben (June 2012). 2177:10.1136/bmjopen-2014-004831 1373:10.1136/bmj.38356.424606.8f 1355:Chan AW, Altman DG (2005). 1273:10.1136/bmj.38488.385995.8f 1163:10.1207/s15327957pspr0203_4 1021:Jeffrey D. Scargle (2000). 561:(8): iii, iix–xi, iix–193. 430: 377:Annals of Internal Medicine 358:Clinical trial registration 338: 149: 10: 3582: 3349:Basking in reflected glory 2840: 2296:Wilmshurst, Peter (2007). 2227:10.1186/s12915-022-01485-y 2132:10.1191/096228000701555244 1756:Research Synthesis Methods 1720:"Figure: Publication bias" 1685:Controlled Clinical Trials 1081:10.1037/0033-2909.86.3.638 652:Controlled Clinical Trials 419: 351: 88:, a mania for new theory; 18: 3497: 3479:Cognitive bias mitigation 3471: 3336: 3211: 2848: 2359:Business Ethics Quarterly 2056:10.3102/10769986021004299 1586:10.1007/s10682-012-9555-5 1226:Online J Curr Clin Trials 1199:10.1016/j.jsp.2014.10.002 739:"The Null Result Penalty" 460:Adversarial collaboration 406:World Health Organization 397:encourage publication of 3063:Illusion of transparency 2796:The All Results Journals 2707:10.1258/jrsm.2011.11k042 2134:(inactive 23 June 2024). 2096:10.1177/1745691616662243 1976:10.1136/bmj.315.7109.629 904:10.1001/jama.263.10.1385 820:The Leadership Quarterly 388:clinical trials registry 292: 19:Not to be confused with 2350:Orlitzky, Marc (2011). 1644:10.1111/2041-210X.13724 231:meta-analysis results. 203:evidence-based medicine 193:Impact on meta-analysis 105:Center for Open Science 2482:Ling Tang Jin (2005). 1921:10.1002/bimj.201000151 1858:Statistics in Medicine 1460:Statistics in Medicine 1323:10.1186/1471-2288-9-79 327:Other factors include 213: 163: 30:In published academic 3541:Criticism of academia 3431:Arab–Israeli conflict 3158:Social influence bias 3103:Out-group homogeneity 2756:"The Truth Wears Off" 2317:10.1258/rsmmlj.75.1.3 420:Further information: 352:Further information: 262:Reboxetine § Efficacy 243:Compensation examples 211: 157: 3561:Academic terminology 3073:Mere-exposure effect 3003:Extrinsic incentives 2949:Selective perception 2427:Ioannidis, John P.A. 2371:10.5840/beq201121325 2305:Medico-Legal Journal 2159:Kicinski, M (2014). 2120:Stat Methods Med Res 1718:Nilsonne G. (2023). 1566:Evolutionary Ecology 1310:BMC Med Res Methodol 743:The Economic Journal 3531:Academic publishing 3298:Social desirability 3193:von Restorff effect 3068:Mean world syndrome 3043:Hostile attribution 2613:10.1093/jnci/djh075 2388:on 25 January 2018. 1909:Biometrical Journal 1825:10.2307/j.ctvk12px9 1636:2022MEcEv..13....4N 1578:2012EvEco..26.1253N 1519:2013PLoSO...881823K 1501:Kicinski M (2013). 1054:1999physics...9033S 989:10.7554/eLife.21451 401:in their journals. 166:There is extensive 132:file-drawer problem 3213:Statistical biases 2991:Curse of knowledge 1733:10.53962/w0d6-9kwa 1139:N.L. Kerr (1998). 755:10.1093/ej/uead060 510:Replication crisis 504:Proteus phenomenon 348:Study registration 214: 199:systematic reviews 164: 128:file-drawer effect 3546:Systematic review 3516: 3515: 3153:Social comparison 2934:Choice-supportive 2678:on 2 August 2007. 1970:(7109): 629–634. 1768:10.1002/jrsm.1266 609:(8746): 867–872. 469:Confirmation bias 445:Psychology portal 354:Registered report 329:experimenter bias 160:stereotype threat 74:non-response bias 3573: 3313:Systematic error 3268:Omitted-variable 3183:Trait ascription 3023:Frog pond effect 2851:Cognitive biases 2835: 2828: 2821: 2812: 2811: 2770: 2768: 2766: 2741: 2735: 2729: 2728: 2718: 2686: 2680: 2679: 2668: 2662: 2661: 2659: 2657: 2642: 2636: 2635: 2625: 2615: 2589: 2583: 2582: 2572: 2562: 2535: 2526: 2525: 2515: 2505: 2479: 2473: 2472: 2462: 2452: 2422: 2416: 2415: 2413: 2411: 2396: 2390: 2389: 2387: 2381:. Archived from 2356: 2347: 2341: 2340: 2335:. Archived from 2302: 2293: 2287: 2286: 2284: 2282: 2264: 2258: 2257: 2247: 2229: 2205: 2199: 2198: 2188: 2156: 2150: 2149: 2143: 2135: 2115: 2109: 2108: 2098: 2074: 2068: 2067: 2039: 2033: 2032: 2023:(439): 926–936. 2012: 2006: 2005: 1995: 1955: 1949: 1948: 1904: 1898: 1897: 1870:10.1002/sim.6342 1853: 1847: 1846: 1814: 1804: 1798: 1797: 1787: 1747: 1738: 1737: 1735: 1715: 1709: 1708: 1680: 1674: 1673: 1655: 1615: 1606: 1605: 1572:(5): 1253–1274. 1557: 1551: 1550: 1540: 1530: 1498: 1492: 1491: 1472:10.1002/sim.6525 1455: 1446: 1445: 1435: 1425: 1416:(12): e1001566. 1401: 1395: 1394: 1384: 1352: 1346: 1345: 1335: 1325: 1301: 1295: 1294: 1284: 1252: 1246: 1245: 1217: 1211: 1210: 1182: 1176: 1175: 1165: 1145: 1136: 1130: 1129: 1099: 1093: 1092: 1064: 1058: 1057: 1047: 1027: 1018: 1012: 1011: 1001: 991: 981: 957: 951: 950: 922: 916: 915: 885: 879: 878: 859:10.1037/a0033242 842: 836: 835: 817: 808: 802: 801: 778:J Clin Epidemiol 773: 767: 766: 749:(657): 193–219. 734: 728: 721: 710: 709: 707: 683: 677: 676: 643: 637: 636: 618: 592: 581: 580: 570: 568:10.3310/hta14080 546: 500: 485: 465: 447: 442: 441: 440: 309:The effect sizes 270:Peter Wilmshurst 180:Cochrane Library 136:Robert Rosenthal 36:publication bias 3581: 3580: 3576: 3575: 3574: 3572: 3571: 3570: 3521: 3520: 3517: 3512: 3493: 3467: 3332: 3207: 3188:Turkey illusion 2956:Compassion fade 2853: 2844: 2839: 2764: 2762: 2750: 2745: 2744: 2736: 2732: 2701:(12): 532–538. 2687: 2683: 2670: 2669: 2665: 2655: 2653: 2651:Washington Post 2643: 2639: 2590: 2586: 2536: 2529: 2480: 2476: 2423: 2419: 2409: 2407: 2397: 2393: 2385: 2354: 2348: 2344: 2339:on 21 May 2013. 2300: 2294: 2290: 2280: 2278: 2265: 2261: 2206: 2202: 2157: 2153: 2137: 2136: 2116: 2112: 2075: 2071: 2040: 2036: 2013: 2009: 1956: 1952: 1905: 1901: 1854: 1850: 1835: 1805: 1801: 1748: 1741: 1716: 1712: 1681: 1677: 1616: 1609: 1558: 1554: 1499: 1495: 1466:(20): 2781–93. 1456: 1449: 1402: 1398: 1353: 1349: 1302: 1298: 1267:(7507): 19–22. 1253: 1249: 1228:. 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For example, 195: 152: 120: 70:null hypothesis 28: 17: 12: 11: 5: 3579: 3569: 3568: 3563: 3558: 3553: 3548: 3543: 3538: 3533: 3514: 3513: 3511: 3510: 3505: 3498: 3495: 3494: 3492: 3491: 3486: 3481: 3475: 3473: 3472:Bias reduction 3469: 3468: 3466: 3465: 3460: 3455: 3450: 3448:Political bias 3445: 3440: 3439: 3438: 3433: 3428: 3423: 3418: 3413: 3408: 3403: 3393: 3388: 3383: 3378: 3376:Infrastructure 3373: 3368: 3363: 3358: 3351: 3346: 3340: 3338: 3334: 3333: 3331: 3330: 3325: 3320: 3315: 3310: 3305: 3300: 3295: 3293:Self-selection 3290: 3285: 3280: 3275: 3270: 3265: 3260: 3255: 3250: 3245: 3244: 3243: 3233: 3228: 3223: 3217: 3215: 3209: 3208: 3206: 3205: 3200: 3195: 3190: 3185: 3180: 3175: 3170: 3165: 3160: 3155: 3150: 3145: 3140: 3135: 3130: 3128:Pro-innovation 3125: 3120: 3115: 3113:Overton window 3110: 3105: 3100: 3095: 3090: 3085: 3080: 3075: 3070: 3065: 3060: 3055: 3050: 3045: 3040: 3035: 3030: 3025: 3020: 3015: 3010: 3005: 3000: 2995: 2994: 2993: 2983: 2981:Dunning–Kruger 2978: 2973: 2968: 2963: 2958: 2953: 2952: 2951: 2941: 2936: 2931: 2926: 2921: 2920: 2919: 2909: 2904: 2899: 2898: 2897: 2895:Correspondence 2892: 2890:Actor–observer 2882: 2877: 2872: 2867: 2862: 2856: 2854: 2849: 2846: 2845: 2838: 2837: 2830: 2823: 2815: 2809: 2808: 2803: 2798: 2793: 2788: 2782: 2776: 2771: 2760:The New Yorker 2749: 2748:External links 2746: 2743: 2742: 2730: 2681: 2663: 2637: 2584: 2527: 2474: 2417: 2391: 2365:(3): 409–444. 2342: 2288: 2259: 2200: 2171:(8): e004831. 2151: 2126:(5): 421–445. 2110: 2089:(5): 730–749. 2069: 2050:(4): 299–332. 2034: 2007: 1950: 1915:(2): 351–368. 1899: 1864:(2): 343–360. 1848: 1833: 1799: 1739: 1724:ResearchEquals 1710: 1691:(2): 159–166. 1675: 1607: 1552: 1513:(11): e81823. 1493: 1447: 1396: 1347: 1296: 1247: 1212: 1177: 1156:(3): 196–217. 1131: 1112:(1–2): 51–63. 1094: 1059: 1013: 952: 933:(285): 30–34. 917: 898:(10): 1385–9. 880: 853:(2): 534–547. 837: 803: 768: 729: 711: 678: 659:(4): 343–353. 638: 582: 540: 539: 537: 534: 532: 531: 525: 522:White hat bias 519: 516:Selection bias 513: 507: 501: 492: 486: 477: 472: 466: 457: 450: 449: 448: 432: 429: 417: 414: 349: 346: 340: 337: 333:white hat bias 325: 324: 321: 318: 315: 312: 306: 298:John Ioannidis 294: 291: 253:antidepressant 244: 241: 194: 191: 151: 148: 119: 116: 94:disjunctivitis 21:Reporting bias 15: 9: 6: 4: 3: 2: 3578: 3567: 3564: 3562: 3559: 3557: 3554: 3552: 3551:Meta-analysis 3549: 3547: 3544: 3542: 3539: 3537: 3534: 3532: 3529: 3528: 3526: 3519: 3509: 3506: 3504: 3500: 3499: 3496: 3490: 3487: 3485: 3482: 3480: 3477: 3476: 3474: 3470: 3464: 3461: 3459: 3456: 3454: 3451: 3449: 3446: 3444: 3441: 3437: 3434: 3432: 3429: 3427: 3426:United States 3424: 3422: 3419: 3417: 3414: 3412: 3409: 3407: 3404: 3402: 3401:False balance 3399: 3398: 3397: 3394: 3392: 3389: 3387: 3384: 3382: 3379: 3377: 3374: 3372: 3369: 3367: 3364: 3362: 3359: 3357: 3356: 3352: 3350: 3347: 3345: 3342: 3341: 3339: 3335: 3329: 3326: 3324: 3321: 3319: 3316: 3314: 3311: 3309: 3306: 3304: 3301: 3299: 3296: 3294: 3291: 3289: 3286: 3284: 3281: 3279: 3276: 3274: 3273:Participation 3271: 3269: 3266: 3264: 3261: 3259: 3256: 3254: 3251: 3249: 3246: 3242: 3241:Psychological 3239: 3238: 3237: 3234: 3232: 3229: 3227: 3224: 3222: 3219: 3218: 3216: 3214: 3210: 3204: 3201: 3199: 3196: 3194: 3191: 3189: 3186: 3184: 3181: 3179: 3176: 3174: 3171: 3169: 3166: 3164: 3161: 3159: 3156: 3154: 3151: 3149: 3146: 3144: 3141: 3139: 3136: 3134: 3131: 3129: 3126: 3124: 3121: 3119: 3116: 3114: 3111: 3109: 3106: 3104: 3101: 3099: 3096: 3094: 3091: 3089: 3086: 3084: 3081: 3079: 3076: 3074: 3071: 3069: 3066: 3064: 3061: 3059: 3056: 3054: 3051: 3049: 3046: 3044: 3041: 3039: 3036: 3034: 3031: 3029: 3026: 3024: 3021: 3019: 3016: 3014: 3011: 3009: 3008:Fading affect 3006: 3004: 3001: 2999: 2996: 2992: 2989: 2988: 2987: 2984: 2982: 2979: 2977: 2974: 2972: 2969: 2967: 2964: 2962: 2959: 2957: 2954: 2950: 2947: 2946: 2945: 2942: 2940: 2937: 2935: 2932: 2930: 2927: 2925: 2922: 2918: 2915: 2914: 2913: 2910: 2908: 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1388: 1383: 1378: 1374: 1370: 1367:(7494): 753. 1366: 1362: 1358: 1351: 1343: 1339: 1334: 1329: 1324: 1319: 1315: 1311: 1307: 1300: 1292: 1288: 1283: 1278: 1274: 1270: 1266: 1262: 1258: 1251: 1243: 1239: 1235: 1231: 1227: 1223: 1216: 1208: 1204: 1200: 1196: 1192: 1188: 1187:J Sch Psychol 1181: 1173: 1169: 1164: 1159: 1155: 1151: 1150: 1142: 1135: 1127: 1123: 1119: 1115: 1111: 1107: 1106: 1105:J Chronic Dis 1098: 1090: 1086: 1082: 1078: 1075:(3): 638–41. 1074: 1070: 1063: 1055: 1051: 1046: 1041: 1038:(1): 91–106. 1037: 1033: 1032: 1024: 1017: 1009: 1005: 1000: 995: 990: 985: 980: 975: 971: 967: 963: 956: 948: 944: 940: 936: 932: 928: 921: 913: 909: 905: 901: 897: 893: 892: 884: 876: 872: 868: 864: 860: 856: 852: 848: 841: 833: 829: 825: 821: 814: 807: 799: 795: 791: 787: 784:(5): 488–92. 783: 779: 772: 764: 760: 756: 752: 748: 744: 740: 733: 726: 720: 718: 716: 706: 701: 697: 693: 689: 682: 674: 670: 666: 662: 658: 654: 653: 648: 647:Dickersin, K. 642: 634: 630: 626: 622: 617: 612: 608: 604: 603: 598: 591: 589: 587: 578: 574: 569: 564: 560: 556: 552: 545: 541: 529: 528:Woozle effect 526: 523: 520: 517: 514: 511: 508: 505: 502: 496: 493: 490: 487: 481: 478: 476: 473: 470: 467: 461: 458: 455: 454:Academic bias 452: 451: 446: 435: 428: 423: 413: 411: 407: 402: 400: 396: 394: 389: 385: 384: 379: 378: 373: 372: 367: 366: 359: 355: 345: 336: 334: 330: 322: 319: 316: 313: 310: 307: 304: 303: 302: 299: 290: 286: 284: 283: 277: 273: 271: 267: 263: 259: 254: 250: 240: 236: 232: 229: 223: 220: 210: 206: 204: 200: 190: 187: 183: 181: 177: 176:meta-analyses 172: 169: 168:meta-research 161: 156: 147: 145: 139: 137: 133: 129: 124: 115: 113: 108: 106: 102: 97: 95: 91: 87: 83: 79: 75: 71: 66: 64: 63:data dredging 60: 56: 51: 49: 45: 41: 37: 33: 26: 22: 3518: 3452: 3386:In education 3353: 3337:Other biases 3323:Verification 3308:Survivorship 3258:Non-response 3231:Healthy user 3173:Substitution 3148:Self-serving 2944:Confirmation 2912:Availability 2860:Acquiescence 2763:. 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Retrieved 2269: 2262: 2217: 2213: 2203: 2168: 2164: 2154: 2140:cite journal 2123: 2119: 2113: 2086: 2082: 2072: 2047: 2043: 2037: 2020: 2016: 2010: 1967: 1963: 1953: 1912: 1908: 1902: 1861: 1857: 1851: 1810: 1802: 1762:(1): 41–50. 1759: 1755: 1723: 1713: 1688: 1684: 1678: 1627: 1623: 1569: 1565: 1555: 1510: 1506: 1496: 1463: 1459: 1413: 1409: 1399: 1364: 1360: 1350: 1313: 1309: 1299: 1264: 1260: 1250: 1225: 1215: 1193:(1): 25–44. 1190: 1186: 1180: 1153: 1147: 1134: 1109: 1103: 1097: 1072: 1069:Psychol Bull 1068: 1062: 1035: 1029: 1016: 969: 965: 955: 930: 926: 920: 895: 889: 883: 850: 846: 840: 823: 819: 806: 781: 777: 771: 746: 742: 732: 724: 695: 691: 681: 656: 650: 641: 606: 600: 558: 554: 544: 489:Funding bias 425: 403: 391: 381: 375: 369: 363: 361: 342: 326: 296: 287: 280: 278: 274: 266:Ben Goldacre 246: 237: 233: 224: 215: 196: 188: 184: 173: 165: 140: 131: 127: 125: 121: 109: 101:pre-register 98: 93: 89: 85: 81: 78:significosis 77: 67: 59:null results 52: 35: 29: 3566:Metascience 3453:Publication 3406:Vietnam War 3253:Length time 3236:Information 3178:Time-saving 3038:Horn effect 3028:Halo effect 2976:Distinction 2885:Attribution 2880:Attentional 2695:J R Soc Med 2553:(8): e124. 2539:Ioannidis J 2311:(1): 3–12. 2214:BMC Biology 1653:1885/294436 1630:(1): 4–21. 826:(1): 5–21. 480:Counternull 416:Megastudies 219:funnel plot 48:metascience 44:significant 3556:Publishing 3525:Categories 3416:South Asia 3391:Liking gap 3203:In animals 3168:Status quo 3083:Negativity 2986:Egocentric 2961:Congruence 2939:Commitment 2929:Blind spot 2917:Mean world 2907:Automation 2765:30 January 2656:3 February 2281:3 February 2273:(Speech). 1843:1036880624 979:1609.00494 972:: e21451. 536:References 495:FUTON bias 371:The Lancet 249:reboxetine 118:Definition 25:Media bias 3484:Debiasing 3463:White hat 3458:Reporting 3371:Inductive 3288:Selection 3248:Lead time 3221:Estimator 3198:Zero-risk 3163:Spotlight 3143:Restraint 3133:Proximity 3118:Precision 3078:Narrative 3033:Hindsight 3018:Frequency 2998:Emotional 2971:Declinism 2902:Authority 2875:Anchoring 2865:Ambiguity 2379:147466849 2236:1741-7007 2220:(1): 71. 2064:123680599 1984:0959-8138 1929:1521-4036 1878:1097-0258 1776:1759-2887 1670:241159497 1662:2041-210X 1602:254466150 1594:1573-8477 1234:1059-2725 763:0013-0133 422:Megastudy 138:in 1979. 90:arigorium 86:theorrhea 82:neophilia 3381:Inherent 3344:Academic 3318:Systemic 3303:Spectrum 3283:Sampling 3263:Observer 3226:Forecast 3138:Response 3098:Optimism 3093:Omission 3088:Normalcy 3058:In-group 3053:Implicit 2966:Cultural 2870:Affinity 2725:22179297 2632:15026468 2579:16060722 2547:PLOS Med 2541:(2005). 2522:16363911 2469:16285839 2429:(2005). 2410:11 April 2333:26915448 2325:17506338 2254:37013585 2245:10071700 2195:25168036 2165:BMJ Open 2105:27694467 1945:24560718 1937:21374698 1894:12341436 1886:25363575 1794:28975717 1547:24363797 1507:PLOS ONE 1488:25560005 1480:25988604 1442:24311990 1410:PLOS Med 1391:15681569 1342:19941636 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Index

Reporting bias
Media bias
research
biases
significant
metascience
design
null results
data dredging
null hypothesis
non-response bias
pre-register
Center for Open Science
p-curve
Robert Rosenthal
HARKing

stereotype threat
meta-research
meta-analyses
Cochrane Library
systematic reviews
evidence-based medicine

funnel plot
Eggers
reboxetine
antidepressant
Pfizer
Reboxetine § Efficacy

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