19:
116:
molecule and each of the types vary in its longevity in the cell. Ribosomal RNA exists longer in the cell before degradation so utilizing 2'-O-Met would aid in stabilizing its structure. The epitranscriptomics of this particular RNA modification occurs post-translation, causing a change in the resulting protein without the DNA being altered.
60:(rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the outcome of the protein as well. This modification to the rRNA is done via
115:
This modification is able to stabilize the structure of RNA while preventing it from undergoing hydrolysis as the hydroxyl group is replaced. A technique was developed based on this property called RiboMethSeq to quantify the amount of modifications existing in a sample of rRNA. RNA is a short lived
123:-methylation is presumed to have been one of the reactive group of RNA molecules on early Earth that would have given rise to DNA.
413:"Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes"
80:
group. The modification of one Nm creates more stabilization in the structure by 0.2kcal/mol which is more
472:"RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data"
69:
315:"2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states"
692:
132:
109:
313:
Abou Assi H, Rangadurai AK, Shi H, Liu B, Clay MC, Erharter K, et al. (December 2020).
585:
424:
411:
Erales J, Marchand V, Panthu B, Gillot S, Belin S, Ghayad SE, et al. (December 2017).
8:
213:"2'-O-Methylation of Ribosomal RNA: Towards an Epitranscriptomic Control of Translation?"
137:
589:
428:
659:
632:
608:
569:
545:
520:
496:
471:
447:
412:
339:
314:
290:
263:
239:
212:
185:
160:
61:
388:
363:
664:
613:
550:
501:
452:
393:
344:
295:
244:
190:
108:-methylations have been identified in yeast alone and 106 in humans and deposited in
93:
654:
644:
603:
593:
540:
532:
491:
483:
442:
432:
383:
375:
334:
326:
285:
275:
234:
224:
180:
172:
53:
633:"Reviving the RNA World: An Insight into the Appearance of RNA Methyltransferases"
568:
Khoshnevis S, Dreggors-Walker RE, Marchand V, Motorin Y, Ghalei H (March 2022).
578:
Proceedings of the
National Academy of Sciences of the United States of America
417:
Proceedings of the
National Academy of Sciences of the United States of America
379:
364:"Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs"
681:
649:
89:
57:
598:
521:"Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA"
437:
687:
668:
617:
554:
505:
456:
397:
348:
299:
248:
194:
65:
487:
330:
280:
176:
536:
101:
18:
567:
229:
470:
Sun WJ, Li JH, Liu S, Wu J, Zhou H, Qu LH, et al. (January 2016).
50:
27:
519:
Marchand V, Blanloeil-Oillo F, Helm M, Motorin Y (September 2016).
97:
81:
574:-methylations regulate translation by impacting ribosome dynamics"
518:
77:
119:
Having chemical properties intermediate between RNA and DNA, 2'-
88:-methylated nucleotides are mostly found in post-translational
73:
410:
264:"RNA 2'-O-Methylation (Nm) Modification in Human Diseases"
312:
211:
Monaco PL, Marcel V, Diaz JJ, Catez F (October 2018).
261:
210:
262:Dimitrova DG, Teysset L, Carré C (February 2019).
161:"Transcription: the epicenter of gene expression"
679:
206:
204:
469:
201:
165:Journal of Zhejiang University. Science. B
154:
152:
76:moiety of any nucleotide (Nm) producing a
658:
648:
630:
624:
607:
597:
544:
495:
446:
436:
387:
338:
289:
279:
238:
228:
184:
17:
149:
680:
361:
158:
13:
14:
704:
561:
512:
463:
404:
355:
306:
255:
26:-methyl-adenosine, a modified
1:
143:
7:
126:
10:
709:
631:Rana AK, Ankri S (2016).
104:. Currently, about 55 2'-
650:10.3389/fgene.2016.00099
380:10.1093/emboj/20.14.3617
599:10.1073/pnas.2117334119
438:10.1073/pnas.1707674114
525:Nucleic Acids Research
476:Nucleic Acids Research
319:Nucleic Acids Research
31:
637:Frontiers in Genetics
281:10.3390/genes10020117
177:10.1631/jzus.B1400113
133:Nucleic acid analogue
110:RNA Modification Base
21:
362:Kiss T (July 2001).
590:2022PNAS..11917334K
584:(12): e2117334119.
488:10.1093/nar/gkv1036
429:2017PNAS..11412934E
423:(49): 12934–12939.
331:10.1093/nar/gkaa928
325:(21): 12365–12379.
230:10.3390/biom8040106
138:Small nucleolar RNA
112:(RMBase) database.
570:"Ribosomal RNA 2'-
537:10.1093/nar/gkw547
159:Guo J (May 2014).
54:epitranscriptomics
32:
482:(D1): D259–D265.
374:(14): 3617–3622.
94:small nuclear RNA
64:(snoRNP) where a
62:ribonucleoprotein
700:
673:
672:
662:
652:
628:
622:
621:
611:
601:
565:
559:
558:
548:
516:
510:
509:
499:
467:
461:
460:
450:
440:
408:
402:
401:
391:
368:The EMBO Journal
359:
353:
352:
342:
310:
304:
303:
293:
283:
259:
253:
252:
242:
232:
208:
199:
198:
188:
156:
72:hydroxyl of the
68:is added to the
56:modification of
708:
707:
703:
702:
701:
699:
698:
697:
678:
677:
676:
629:
625:
566:
562:
517:
513:
468:
464:
409:
405:
360:
356:
311:
307:
260:
256:
209:
202:
157:
150:
146:
129:
96:located in the
12:
11:
5:
706:
696:
695:
690:
675:
674:
623:
560:
511:
462:
403:
354:
305:
254:
200:
171:(5): 409–411.
147:
145:
142:
141:
140:
135:
128:
125:
84:favorable. 2'-
49:) is a common
9:
6:
4:
3:
2:
705:
694:
693:O-methylation
691:
689:
686:
685:
683:
670:
666:
661:
656:
651:
646:
642:
638:
634:
627:
619:
615:
610:
605:
600:
595:
591:
587:
583:
579:
575:
573:
564:
556:
552:
547:
542:
538:
534:
530:
526:
522:
515:
507:
503:
498:
493:
489:
485:
481:
477:
473:
466:
458:
454:
449:
444:
439:
434:
430:
426:
422:
418:
414:
407:
399:
395:
390:
385:
381:
377:
373:
369:
365:
358:
350:
346:
341:
336:
332:
328:
324:
320:
316:
309:
301:
297:
292:
287:
282:
277:
273:
269:
265:
258:
250:
246:
241:
236:
231:
226:
222:
218:
214:
207:
205:
196:
192:
187:
182:
178:
174:
170:
166:
162:
155:
153:
148:
139:
136:
134:
131:
130:
124:
122:
117:
113:
111:
107:
103:
99:
95:
91:
90:ribosomal RNA
87:
83:
82:enthalpically
79:
75:
71:
67:
63:
59:
58:ribosomal RNA
55:
52:
48:
46:
40:
38:
29:
25:
20:
16:
640:
636:
626:
581:
577:
571:
563:
531:(16): e135.
528:
524:
514:
479:
475:
465:
420:
416:
406:
371:
367:
357:
322:
318:
308:
271:
267:
257:
220:
217:Biomolecules
216:
168:
164:
120:
118:
114:
105:
85:
66:methyl group
44:
42:
39:-methylation
36:
34:
33:
23:
15:
102:spliceosome
682:Categories
274:(2): 117.
223:(4): 106.
144:References
51:nucleotide
28:adenosine
669:27375676
618:35294285
555:27302133
506:26464443
457:29158377
398:11447102
349:33104789
300:30764532
249:30282949
195:24793758
127:See also
98:ribosome
660:4893491
609:8944910
586:Bibcode
546:5027498
497:4702777
448:5724255
425:Bibcode
340:7708057
291:6409641
240:6316387
186:4076597
78:methoxy
667:
657:
643:: 99.
616:
606:
553:
543:
504:
494:
455:
445:
396:
389:125535
386:
347:
337:
298:
288:
247:
237:
193:
183:
74:ribose
268:Genes
665:PMID
614:PMID
551:PMID
502:PMID
453:PMID
394:PMID
345:PMID
296:PMID
245:PMID
191:PMID
100:and
92:and
688:RNA
655:PMC
645:doi
604:PMC
594:doi
582:119
541:PMC
533:doi
492:PMC
484:doi
443:PMC
433:doi
421:114
384:PMC
376:doi
335:PMC
327:doi
286:PMC
276:doi
235:PMC
225:doi
181:PMC
173:doi
47:-Me
43:2'-
35:2'-
22:2'-
684::
663:.
653:.
639:.
635:.
612:.
602:.
592:.
580:.
576:.
549:.
539:.
529:44
527:.
523:.
500:.
490:.
480:44
478:.
474:.
451:.
441:.
431:.
419:.
415:.
392:.
382:.
372:20
370:.
366:.
343:.
333:.
323:48
321:.
317:.
294:.
284:.
272:10
270:.
266:.
243:.
233:.
219:.
215:.
203:^
189:.
179:.
169:15
167:.
163:.
151:^
70:2'
671:.
647::
641:7
620:.
596::
588::
572:O
557:.
535::
508:.
486::
459:.
435::
427::
400:.
378::
351:.
329::
302:.
278::
251:.
227::
221:8
197:.
175::
121:O
106:O
86:O
45:O
41:(
37:O
30:.
24:O
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
