553:
541:
342:
40:
281:
Aneurysmal bone cyst has been widely regarded a reactive process of uncertain cause since its initial description by Jaffe and
Lichtenstein in 1942. Many hypotheses have been proposed to explain the cause and pathogenesis of aneurysmal bone cyst, and until very recently the most commonly accepted
207:
The afflicted may have relatively small amounts of pain that will quickly increase in severity over a time period of 6–12 weeks. The skin temperature around the bone may increase, a bony swelling may be evident, and movement may be restricted in adjacent joints.
440:
Aneurysmal bone cysts may be intraosseous, staying inside of the bone marrow. Or they may be extraosseous, developing on the surface of the bone, and extending into the marrow. A radiograph will reveal a soap bubble appearance.
1783:
1113:
1098:
525:
It is rare. The incidence is around 0.15 cases per one million per year. 80% occur in people age less than 20 years. It is second most common tumor of spine and most common benign tumor of pelvis in
1776:
282:
idea was that aneurysmal bone cyst was the consequence of an increased venous pressure and resultant dilation and rupture of the local vascular network. However, studies by
Panoutsakopoulus
196:
Treatment is usually by curettage, bone grafting or surgically removing the part of bone. 20–30% may recur, usually in the first couple of years after treatment, particularly in children.
1769:
497:
is performed on some people, and is sufficient for inactive lesions. The recurrence rate with curettage is significant in active lesions, and marginal resection has been advised.
806:
Tomasik, Patryk; Spindel, Jerzy; Miszczyk, Leszek; Chrobok, Adam; Koczy, Bogdan; Widuchowski, Jerzy; Mrozek, Tomasz; Matysiakiewicz, Jacek; Pilecki, Bolesław (September 2009).
716:
Muratori, Francesco; Mondanelli, Nicola; Rizzo, Anna Rosa; Beltrami, Giovanni; Giannotti, Stefano; Capanna, Rodolfo; Campanacci, Domenico Andrea (10 November 2019).
174:. It generally presents with pain and swelling in the affected bone. Pressure on neighbouring tissues may cause compression effects such as neurological symptoms.
552:
845:
Zadik, Yehuda; AktaĹź Alper; Drucker Scott; Nitzan W Dorrit (2012). "Aneurysmal bone cyst of mandibular condyle: A case report and review of the literature".
456:
show lytic expansion lesions with clear borders. Expansion of cortex gives the lesion a balloon-like appearance. Larger lesions may appear septated.
199:
It is rare. The incidence is around 0.15 cases per one million per year. Aneurysmal bone cyst was first described by Jaffe and
Lichtenstein in 1942.
540:
1850:
1832:
1216:
1035:
293:
The lesion may arise de novo or may arise secondarily within a pre-existing bone tumor, because the abnormal bone causes changes in
290:
uncovered the clonal neoplastic nature of aneurysmal bone cyst. Primary cause has been regarded arteriovenous fistula within bone.
935:"TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB"
1449:
660:
1647:
1991:
1128:
2001:
1944:
681:
1018:
917:
888:
790:
317:. A giant cell tumor is the most common cause, occurring in 19–39% of cases. Less frequently, it results from some
1510:
1209:
1955:
1797:
1444:
994:
987:
Who Manual Of
Diagnostic Imaging: Radiographic Anatomy And Interpretation Of The Muskuloskeletal System, VOlume
1761:
2025:
1960:
1896:
1479:
655:. Vol. 3 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 437–439.
1659:
1474:
2065:
1940:
1904:
1815:
2035:
1981:
1375:
1202:
375:
According to
Buraczewski and Dabska, the development of the aneurysmal bone cyst follows three stages.
1837:
1615:
1469:
1403:
1705:
1565:
1437:
1264:
1139:
575:
310:
1730:
1977:
1891:
1326:
1283:
1065:
649:
WHO Classification of
Tumours Editorial Board, ed. (2020). "3. Bone tumours: simple bone cyst".
33:
Not recommended: Giant cell reparative granuloma of small bone, giant cell lesion of small bones
1886:
1793:
1340:
1253:
111:
2060:
1581:
1358:
302:
2009:
1861:
1454:
330:
166:
in a bone which are filled with blood. The term is a misnomer, as the lesion is neither an
1182:
808:"Treatment and differential diagnosis of aneurysmal bone cyst based on our own experience"
8:
2030:
1664:
1413:
1117:
580:
506:
47:
A. X-ray: osteolytic lesion in tibia near knee. B/C/D/E. MRI with E showing fluid levels.
1827:
1679:
1486:
1432:
1122:
959:
934:
341:
64:
1970:
1914:
1846:
1225:
1057:
1014:
990:
964:
913:
884:
862:
827:
819:
786:
737:
729:
656:
461:
314:
103:
82:
52:
1674:
844:
360:
The classic (or standard) form (95%) has blood filled clefts among bony trabeculae.
1951:
1693:
1380:
1179:
1047:
1034:
Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J, Gebhardt MC (September 2005).
1011:
Differential
Diagnosis in Surgical Pathology: Expert Consult - Online and Print, 2e
954:
946:
854:
569:
371:
proliferation, osteoid production and degenerated calcifying fibromyxoid elements.
1878:
1625:
1607:
1586:
1560:
1529:
1464:
1390:
1144:
780:
650:
498:
298:
178:
87:
756:
1922:
1791:
1740:
1522:
1517:
1459:
1316:
858:
326:
1107:
2054:
1294:
823:
733:
648:
306:
1052:
807:
717:
1965:
1543:
1505:
1370:
1353:
1348:
1311:
1233:
1061:
968:
866:
831:
741:
689:
349:
322:
294:
216:
1321:
1269:
1194:
950:
57:
1090:
1552:
1398:
1365:
1304:
1299:
392:
368:
345:
236:
228:
163:
159:
39:
1932:
1492:
1174:
1150:
526:
494:
472:
Following conditions are excluded before diagnosis can be confirmed:
318:
142:
Rare, ~0.15 cases per one million per year. 80% age <20 years. M=F
129:
1811:
1242:
1033:
232:
167:
1155:
509:
are considered for use to kill cells at margins of resected cyst.
453:
361:
212:
182:
91:
1133:
558:
Intermediate magnification micrograph of an aneurysmal bone cyst
1408:
1102:
715:
502:
156:
1857:
1654:
805:
449:
244:
240:
186:
95:
1821:
652:
Soft Tissue and Bone
Tumours: WHO Classification of Tumours
433:
171:
464:
shows outer radiotracer uptake, with a central dark area.
881:
Rosai and
Ackerman's surgical pathology, Volume 2, 9th ed
457:
297:. An aneurysmal bone cyst can arise from a pre-existing
190:
99:
755:
Stevens, Kyle J.; Stevens, James A. (5 September 2020).
546:
High magnification micrograph of an aneurysmal bone cyst
69:
Pain, swelling, pressure related neurological symptoms
356:
Histologically, they are classified in two variants.
1080:
1013:. Elsevier Health Sciences. 2010. pp. 878–879.
782:
Imaging in
Treatment Planning for Sinonasal Diseases
529:
population. Males and females are equally affected.
219:
and patients with skull lesions may have headaches.
933:Ye Y, Pringle LM, Lau AW, et al. (June 2010).
247:. Approximate percentages by sites are as shown:
189:show lytic expansion lesions with clear borders.
2052:
1036:"Aneurysmal bone cyst: a review of 150 patients"
411:Formation of shell around central part of lesion
1851:Leukoencephalopathy with vanishing white matter
989:. World Health Organization. pp. 168–186.
754:
718:"Aneurysmal Bone Cyst: A Review of Management"
711:
709:
707:
1777:
1210:
676:
674:
672:
1027:
932:
926:
1833:Fragile X-associated tremor/ataxia syndrome
704:
1784:
1770:
1224:
1217:
1203:
748:
669:
644:
642:
640:
638:
636:
634:
632:
630:
628:
626:
624:
622:
620:
618:
616:
38:
1051:
958:
614:
612:
610:
608:
606:
604:
602:
600:
598:
596:
467:
405:Rapid increase in size of osseous erosion
177:The cause is unknown. Diagnosis involves
340:
1450:Hypertrophic pulmonary osteoarthropathy
812:Ortopedia, Traumatologia, Rehabilitacja
778:
2053:
984:
980:
978:
799:
682:"Bone tumours. What are Bone Tumours?"
593:
162:composed of multiple varying sizes of
1992:Multiple familial trichoepithelioma 1
1765:
1198:
904:
902:
900:
421:Fully developed radiological pattern
202:
16:Benign bone tumor consisting of blood
1003:
912:. Springer. 2007. pp. 151–155.
873:
774:
772:
770:
532:
975:
427:They can also be associated with a
13:
1945:X-linked spinal muscular atrophy 2
897:
838:
364:tissue is found in stromal matrix.
14:
2077:
1076:
910:Pediatric Orthopedics in Practice
767:
722:Surgical Technology International
551:
539:
1511:Infantile cortical hyperostosis
520:
1871:Posttranslational modification
1798:posttranslational modification
1445:Complex regional pain syndrome
785:. Springer. pp. 114–116.
517:20–70% recur after curettage.
485:Secondary aneurysmal bone cyst
1:
2026:Multiple sulfatase deficiency
1905:3-Methylglutaconic aciduria 5
586:
134:20-70% recur after curettage.
883:. Mosby. 2004. p. 148.
512:
489:
444:
408:Enlargement of involved bone
348:of an aneurysmal bone cyst.
336:
227:Commonly affected sites are
7:
1838:Premature ovarian failure 1
563:
482:Telangiectatic osteosarcoma
116:Telangiectatic osteosarcoma
10:
2082:
1956:Johanson–Blizzard syndrome
1648:Legg–Calvé–Perthes disease
859:10.1016/j.jcms.2011.10.026
395:without peculiar findings
367:The solid form (5%) shows
2018:
2000:
1961:Von Hippel–Lindau disease
1931:
1913:
1897:Creutzfeldt–Jakob disease
1877:
1870:
1804:
1716:
1690:
1633:
1624:
1616:Osteochondritis dissecans
1606:
1599:
1574:
1551:
1542:
1422:
1389:
1339:
1280:
1250:
1241:
1232:
1165:
1084:
779:Maroldi, Roberto (2005).
418:Stabilization phase (III)
276:
138:
128:
120:
110:
81:
73:
63:
51:
46:
37:
29:
24:
2036:Ehlers–Danlos syndrome 6
1660:Osgood–Schlatter disease
1566:Relapsing polychondritis
1438:Osteonecrosis of the jaw
1265:Osteitis fibrosa cystica
763:. StatPearls Publishing.
576:Giant cell tumor of bone
222:
1978:Deubiquitinating enzyme
1862:Retinitis pigmentosa 33
1816:Diamond–Blackfan anemia
1376:Paget's disease of bone
1327:Vertebral osteomyelitis
1053:10.1200/JCO.2005.15.255
985:Davies, Arthur (2002).
847:J Craniomaxillofac Surg
757:"Aneurysmal Bone Cysts"
263:Pelvis and sacrum (12%)
251:Skull and mandible (4%)
1982:Machado–Joseph disease
1226:Bone and joint disease
468:Differential diagnosis
460:reveals fluid levels.
353:
257:Clavicle and ribs (5%)
193:reveals fluid levels.
112:Differential diagnosis
1706:Scheuermann's disease
1582:Slipping rib syndrome
1404:Hajdu–Cheney syndrome
344:
303:chondromyxoid fibroma
260:Upper extremity (21%)
1987:Aneurysmal bone cyst
1892:Huntington's disease
1499:Aneurysmal bone cyst
1455:Nonossifying fibroma
951:10.1038/onc.2010.116
476:Unicameral bone cyst
331:hemangioendothelioma
149:Aneurysmal bone cyst
25:Aneurysmal bone cyst
2031:Hyperproinsulinemia
1887:Alzheimer's disease
581:Traumatic bone cyst
507:methyl methacrylate
2066:Vascular neoplasia
1828:Fragile X syndrome
1731:Kienböck's disease
1487:Skeletal fluorosis
1433:Avascular necrosis
1166:External resources
354:
203:Signs and symptoms
2048:
2047:
2044:
2043:
1971:Angelman syndrome
1915:Protein targeting
1847:Initiation factor
1759:
1758:
1755:
1754:
1751:
1750:
1595:
1594:
1538:
1537:
1470:Fibrous dysplasia
1335:
1334:
1192:
1191:
662:978-92-832-4503-2
533:Additional images
425:
424:
400:Growth phase (II)
389:Initial phase (I)
315:fibrous dysplasia
146:
145:
83:Diagnostic method
19:Medical condition
2073:
1875:
1874:
1786:
1779:
1772:
1763:
1762:
1721:
1697:
1665:Blount's disease
1638:
1631:
1630:
1604:
1603:
1549:
1548:
1414:Gorham's disease
1381:Hypophosphatasia
1288:
1258:
1248:
1247:
1239:
1238:
1219:
1212:
1205:
1196:
1195:
1082:
1081:
1070:
1069:
1064:. Archived from
1055:
1031:
1025:
1024:
1007:
1001:
1000:
982:
973:
972:
962:
930:
924:
923:
906:
895:
894:
877:
871:
870:
842:
836:
835:
803:
797:
796:
776:
765:
764:
752:
746:
745:
713:
702:
701:
699:
697:
692:on 24 April 2021
688:. Archived from
678:
667:
666:
646:
570:Simple bone cyst
555:
543:
479:Giant cell tumor
378:
377:
321:tumors, such as
311:giant cell tumor
42:
22:
21:
2081:
2080:
2076:
2075:
2074:
2072:
2071:
2070:
2051:
2050:
2049:
2040:
2014:
1996:
1927:
1909:
1879:Protein folding
1866:
1800:
1790:
1760:
1747:
1717:
1712:
1691:
1686:
1680:Sever's disease
1634:
1620:
1608:Osteochondritis
1591:
1587:Tietze syndrome
1570:
1561:Costochondritis
1534:
1530:Pycnodysostosis
1465:Stress fracture
1418:
1391:Bone resorption
1385:
1331:
1281:
1276:
1251:
1228:
1223:
1193:
1188:
1187:
1183:article/1254784
1161:
1160:
1093:
1079:
1074:
1073:
1046:(27): 6756–62.
1032:
1028:
1021:
1009:
1008:
1004:
997:
983:
976:
945:(25): 3619–29.
931:
927:
920:
908:
907:
898:
891:
879:
878:
874:
843:
839:
804:
800:
793:
777:
768:
753:
749:
714:
705:
695:
693:
680:
679:
670:
663:
647:
594:
589:
566:
559:
556:
547:
544:
535:
523:
515:
499:Liquid nitrogen
492:
470:
447:
437:translocation.
339:
299:chondroblastoma
279:
269:Lower leg (24%)
225:
205:
179:medical imaging
88:Medical imaging
20:
17:
12:
11:
5:
2079:
2069:
2068:
2063:
2046:
2045:
2042:
2041:
2039:
2038:
2033:
2028:
2022:
2020:
2016:
2015:
2013:
2012:
2006:
2004:
1998:
1997:
1995:
1994:
1989:
1984:
1974:
1973:
1968:
1963:
1958:
1948:
1947:
1937:
1935:
1929:
1928:
1926:
1925:
1923:I-cell disease
1919:
1917:
1911:
1910:
1908:
1907:
1900:
1899:
1894:
1889:
1883:
1881:
1872:
1868:
1867:
1865:
1864:
1854:
1853:
1843:
1842:
1841:
1840:
1835:
1830:
1818:
1808:
1806:
1802:
1801:
1789:
1788:
1781:
1774:
1766:
1757:
1756:
1753:
1752:
1749:
1748:
1746:
1745:
1744:
1743:
1741:Panner disease
1735:
1734:
1733:
1724:
1722:
1714:
1713:
1711:
1710:
1709:
1708:
1700:
1698:
1688:
1687:
1685:
1684:
1683:
1682:
1677:
1675:Köhler disease
1669:
1668:
1667:
1662:
1652:
1651:
1650:
1641:
1639:
1628:
1622:
1621:
1619:
1618:
1612:
1610:
1601:
1597:
1596:
1593:
1592:
1590:
1589:
1584:
1578:
1576:
1572:
1571:
1569:
1568:
1563:
1557:
1555:
1546:
1540:
1539:
1536:
1535:
1533:
1532:
1527:
1526:
1525:
1523:Melorheostosis
1518:Osteosclerosis
1515:
1514:
1513:
1503:
1502:
1501:
1489:
1484:
1483:
1482:
1477:
1467:
1462:
1460:Pseudarthrosis
1457:
1452:
1447:
1442:
1441:
1440:
1435:
1426:
1424:
1420:
1419:
1417:
1416:
1411:
1406:
1401:
1395:
1393:
1387:
1386:
1384:
1383:
1378:
1373:
1368:
1363:
1362:
1361:
1351:
1345:
1343:
1337:
1336:
1333:
1332:
1330:
1329:
1324:
1319:
1317:Brodie abscess
1314:
1309:
1308:
1307:
1302:
1291:
1289:
1278:
1277:
1275:
1274:
1273:
1272:
1261:
1259:
1245:
1236:
1230:
1229:
1222:
1221:
1214:
1207:
1199:
1190:
1189:
1186:
1185:
1170:
1169:
1167:
1163:
1162:
1159:
1158:
1147:
1136:
1125:
1110:
1094:
1089:
1088:
1086:
1085:Classification
1078:
1077:External links
1075:
1072:
1071:
1068:on 2013-04-15.
1040:J. Clin. Oncol
1026:
1019:
1002:
995:
974:
925:
918:
896:
889:
872:
837:
818:(5): 467–475.
798:
791:
766:
747:
703:
668:
661:
591:
590:
588:
585:
584:
583:
578:
573:
565:
562:
561:
560:
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531:
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491:
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409:
406:
401:
397:
396:
390:
386:
385:
382:
373:
372:
365:
338:
335:
327:chondrosarcoma
278:
275:
274:
273:
270:
267:
264:
261:
258:
255:
252:
224:
221:
204:
201:
144:
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126:
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118:
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108:
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85:
79:
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67:
61:
60:
55:
49:
48:
44:
43:
35:
34:
31:
27:
26:
18:
15:
9:
6:
4:
3:
2:
2078:
2067:
2064:
2062:
2059:
2058:
2056:
2037:
2034:
2032:
2029:
2027:
2024:
2023:
2021:
2017:
2011:
2008:
2007:
2005:
2003:
1999:
1993:
1990:
1988:
1985:
1983:
1979:
1976:
1975:
1972:
1969:
1967:
1964:
1962:
1959:
1957:
1953:
1950:
1949:
1946:
1942:
1939:
1938:
1936:
1934:
1930:
1924:
1921:
1920:
1918:
1916:
1912:
1906:
1903:chaperonins:
1902:
1901:
1898:
1895:
1893:
1890:
1888:
1885:
1884:
1882:
1880:
1876:
1873:
1869:
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1859:
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1834:
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1826:
1825:
1824:
1823:
1819:
1817:
1813:
1810:
1809:
1807:
1803:
1799:
1795:
1792:Disorders of
1787:
1782:
1780:
1775:
1773:
1768:
1767:
1764:
1742:
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1736:
1732:
1729:
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1645:
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1632:
1629:
1627:
1623:
1617:
1614:
1613:
1611:
1609:
1605:
1602:
1598:
1588:
1585:
1583:
1580:
1579:
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2061:Osteopathies
1986:
1966:3-M syndrome
1820:
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1506:Hyperostosis
1498:
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1371:Osteomalacia
1354:Osteoporosis
1349:Bone density
1312:Sesamoiditis
1282:
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1243:Inflammation
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1066:the original
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694:. Retrieved
690:the original
686:patient.info
685:
651:
524:
521:Epidemiology
516:
493:
471:
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432:
428:
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384:Description
374:
369:fibroblastic
355:
323:osteosarcoma
295:hemodynamics
292:
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280:
226:
217:quadriplegia
210:
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1805:Translation
1794:translation
1480:Polyostotic
1322:Periostitis
1270:Brown tumor
728:: 325–335.
266:Femur (13%)
254:Spine (16%)
58:Orthopedics
30:Other names
2055:Categories
1553:Chondritis
1475:Monostotic
1429:Ischaemia
1399:Osteolysis
1366:Osteopenia
1305:Involucrum
1300:Sequestrum
996:9241545550
761:StatPearls
587:References
393:Osteolysis
346:Micrograph
237:flat bones
229:metaphyses
215:may cause
160:bone tumor
1933:Ubiquitin
1493:bone cyst
1341:Metabolic
1284:infection
1254:endocrine
1175:eMedicine
1156:203468000
1151:SNOMED CT
824:1509-3492
734:1090-3941
527:pediatric
513:Prognosis
495:Curettage
490:Treatment
462:Bone scan
445:Diagnosis
337:Pathology
319:malignant
272:Foot (3%)
139:Frequency
130:Prognosis
121:Treatment
104:bone scan
53:Specialty
1812:Ribosome
1600:Combined
1359:Juvenile
1180:radio/26
1062:16170183
969:20418905
939:Oncogene
867:22118925
832:19920289
742:31476792
696:24 April
564:See also
233:vertebra
168:aneurysm
65:Symptoms
1145:D017824
960:2892027
454:CT scan
362:Osteoid
213:lesions
211:Spinal
183:CT scan
155:) is a
124:Surgery
92:CT scan
77:Unknown
1737:elbow
1727:wrist
1409:Ainhum
1134:606179
1123:733.22
1060:
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503:phenol
329:, and
288:et al.
284:et al.
277:Causes
170:nor a
164:spaces
74:Causes
2019:Other
2010:OFC10
1858:snRNP
1694:spine
1671:foot
1655:tibia
1626:Child
1575:Other
1544:Joint
1423:Other
1108:M85.5
572:(SBC)
450:X-ray
429:TRE17
381:Stage
313:, or
305:, an
245:tibia
241:femur
223:Sites
187:X-ray
96:X-ray
2002:SUMO
1822:FMR1
1796:and
1719:arm:
1644:hip
1636:leg:
1234:Bone
1140:MeSH
1129:OMIM
1118:9-CM
1058:PMID
1015:ISBN
991:ISBN
965:PMID
914:ISBN
885:ISBN
863:PMID
828:PMID
820:ISSN
787:ISBN
738:PMID
730:ISSN
698:2021
657:ISBN
452:and
434:USP6
309:, a
301:, a
243:and
185:and
172:cyst
1114:ICD
1099:ICD
1048:doi
955:PMC
947:doi
855:doi
458:MRI
231:of
191:MRI
153:ABC
100:MRI
2057::
1980::
1954::
1952:E3
1943::
1941:E1
1860::
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1103:10
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151:(
106:.
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