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may underestimate the real risk from the product as a whole. Several concepts are available for predicting the effect of a mixture on the basis of known toxicities and concentrations of the single components. Approaches for mixture toxicity assessments for regulatory purposes typically advocate assumptions of additive effects;. This means that each substance in the mixture is assumed to contribute to a mixture effect in direct proportion to its concentration and potency. In a strict sense, the assumption is thereby that all substances act by the same mode or mechanism of action. Compared to other available assumptions, this concentration addition model (or dose addition model) can be used with commonly available (eco)toxicity data and effect data together with estimates of e.g. LC50, EC50, PNEC, AEL. Furthermore, assumptions of additive effects from any given mixture are generally considered as a more precautionary approach compared to other available predictive concepts.
485:
its physical chemical properties, partition to sewage sludge, which in turn can be used for soil amendments thereby releasing the substance into the soil compartment. Alternatively, the substance can remain in the water phase in the STP and subsequently end up in the water compartment such as surface water etc. Risk assessment for the environment focuses on protecting the environmental compartments (air, water and soil) by performing hazard assessments on key species, which represent the food chain within the specific compartment. Of special concern is a well functioning STP, which is elemental in many removal processes. The large variety in biocidal applications leads to complicated exposure scenarios that need to reflect the intended use and possible degradation pathways, in order to perform an accurate risk assessment for the environment. Further areas of concern are endocrine disruption, PBT-properties, secondary poisoning, and mixture toxicity.
505:
order to define the conditions of use and to ensure that the product fulfils its intended uses, efficacy assessments are carried out as an essential part of the risk assessment. Within the efficacy assessment the target organisms, the effective concentrations, including any thresholds or dependence of the effects on concentrations, the likely concentrations of the active substance used in the products, the mode of action, and the possible occurrence of resistance, cross resistance or tolerance is evaluated. A product cannot be authorized if the desired effect cannot be reached at a dose without posing unacceptable risks to human health or the environment. Appropriate management strategies needs to be taken to avoid the buildup of (cross)resistance. Last but not least, other fundamental elements are the instructions of use, the risk management measures and the
430:
2013. Several
Technical Notes for Guidance (TNsG) have been developed to facilitate the implementation of the BPR and to assure a common understanding of its obligations. According to the EU legislation, biocidal products need authorisation to be placed or to remain on the market. Competent Authorities of the EU member states are responsible for assessing and approving the active substances contained in the biocides. The BPR follows some of the principles set previously under the REACH Regulation (Registration, Evaluation, Authorisation and Restrictions of Chemicals) and the coordination of the risk assessment process for both REACH and BPR are mandated to the European Chemicals Agency (ECHA), which assures the harmonization and integration of risk characterization methodologies between the two regulations.
497:
initial worse case exposure assessment and for subsequent refinements. ESDs are developed in close collaboration with the OECD Task Force on
Biocides and the OECD Exposure Assessment Task Force and are publicly available from websites managed by the Joint Research Centre and OECD (see below). Once ESDs become available they are introduced in the European Union System for the Evaluation of Substances (EUSES), an IT tool supporting the implementation of the risk assessment principles set in the Technical Guidance Document for the Risk Assessment of Biocides (TGD). EUSES enables government authorities, research institutes and chemical companies to carry out rapid and efficient assessments of the general risks posed by substances to man and the environment.
481:
potential exposure of non-users of biocidal products (i.e. the general public) may occur indirectly via the environment, for example through drinking water, the food chain, as well as through atmospheric and residential exposure. Particular attention should be paid to the exposure of vulnerable sub-populations, such as the elderly, pregnant women, and children. Also pets and other domestic animals can be exposed indirectly following the application of biocidal products. Furthermore, exposure to biocides may vary in terms of route (inhalation, dermal contact, and ingestion) and pathway (food, drinking water, residential, occupational) of exposure, level, frequency and duration.
501:
participated in the Review
Programme of active substances) or when a change appears in the manufacturing location and/or manufacturing process of a reference active substance, then a technical equivalence between these different sources needs to be established with regard to the chemical composition and hazard profile. This is to check if the level of hazard posed to health and environment by the active substance from the secondary source is comparable to the initial assessed active substance.
42:(EPA) uses a slightly different definition for biocides as "a diverse group of poisonous substances including preservatives, insecticides, disinfectants, and pesticides used for the control of organisms that are harmful to human or animal health or that cause damage to natural or manufactured products". When compared, the two definitions roughly imply the same, although the US EPA definition includes plant protection products and some veterinary medicines.
192:
products. For example, disinfectants contains products to be used for human hygiene (PT 1) and veterinary hygiene (PT 3), preservatives contains wood preservatives (PT 8), for pest control contains rodenticides (PT 14) and repellents and attractants (PT 19), while other biocidal products contains antifouling products (PT 21). It should noted that one active substance can be used in several product types, such as for example
473:
non-target species, such as predatory birds, due to their long half-life after ingestion by target species (i.e. rats and mice) and high toxicity to non-target species. Pyrethroids used as insecticides have been shown to cause unwanted effects in the environment, due to their unspecific toxic action, also causing toxic effects in non-target aquatic organisms.
493:
knowledge of the modes of action of substances as well as circumstances under which such effects may occur (e.g. mixture composition, exposure concentrations, species and endpoints) often hamper predictive approaches. Indications that synergistic effects might occur in a product will warrant either a more precautionary approach, or product testing.chemical
477:
risk assessment of biocidal products is carried out before they can be placed on the market. A central element in the risk assessment of the biocidal products are the utilization instructions that defines the dosage, application method and number of applications and thus the exposure of humans and the environment to the biocidal substance.
92:. Biocidal substances and products are also employed as anti-fouling agents or disinfectants under other circumstances: chlorine, for example, is used as a short-life biocide in industrial water treatment but as a disinfectant in swimming pools. Many biocides are synthetic, but there are naturally occurring biocides classified as
513:
spread more easily, since rodents can be a vector for diseases. It is difficult to imagine hospitals, food industry premises without using disinfectants or using untreated wood for telephone poles. Another example of benefit is the fuel saving of antifouling substances applied to ships to prevent the buildup of
500:
Once a biocidal active substance is allowed onto the list of approved active substances, its specifications become a reference source of that active substance (so called 'reference active substance'). Thus, when an alternative source of that active substance appears (e.g. from a company that have not
488:
Biocidal products are often composed of mixtures of one or more active substances together with co-formulants such as stabilisers, preservatives and colouring agents. Since these substances may act together to produce a combination effect, an assessment of the risk from each of these substances alone
484:
The environment can be exposed directly due to the outdoor use of biocides or as the result of indoor use followed by release to the sewage system after e.g. wet cleaning of a room in which a biocide is used. Upon this release a biocidal substance can pass a sewage treatment plant (STP) and, based on
480:
Humans may be exposed to biocidal products in different ways in both occupational and domestic settings. Many biocidal products are intended for industrial sectors or professional uses only, whereas other biocidal products are commonly available for private use by non-professional users. In addition,
191:
In Europe biocidal products are divided into different product types (PT), based on their intended use. These product types, 22 in total under the
Biocidal Products Regulation (EU) 528/2012 (BPR), are grouped into four main groups, namely disinfectants, preservatives, pest control, and other biocidal
429:
The EU regulatory framework for biocides has for years been defined by the
Directive 98/8/EC, also known as the Biocidal Products Directive (BPD). The BPD was revoked by the Biocidal Products Regulation 528/2012 (BPR), which entered into force on 17 July 2012 with the application date of 1 September
52:
When discussing biocides a distinction should be made between the biocidal active substance and the biocidal product. The biocidal active substances are mostly chemical compounds, but can also be microorganisms (e.g. bacteria). Biocidal products contain one or more biocidal active substances and may
496:
As indicated above, the risk assessment of biocides in EU hinges for a large part by the development of specific emission scenario documents (ESDs) for each product type, which is essential for assessing its exposure of man and the environment. Such ESDs provide detailed scenarios to be used for an
476:
In light of potential adverse effects, and to ensure a harmonised risk assessment and management, the EU regulatory framework for biocides has been established with the objective of ensuring a high level of protection of human and animal health and the environment. To this aim, it is required that
472:
Due to their intrinsic properties and patterns of use, biocides, such as rodenticides or insecticides, can cause adverse effects in humans, animals and the environment and should therefore be used with the utmost care. For example, the anticoagulants used for rodent control have caused toxicity in
512:
While biocides can have severe effects on human health and/or the environment, their benefits should not be overlooked. To provide some examples, without the above-mentioned rodenticides, crops and food stocks might be seriously affected by rodent activity, or diseases like
Leptospirosis might be
492:
The potential occurrence of synergistic effects presents a special case, and may occur for example when one substance increases the toxicity of another, e.g. if substance A inhibits the detoxification of substance B. Currently, predictive approaches cannot account for this phenomenon. Gaps in our
504:
It goes without saying that biocidal products must be used in an appropriate and controlled way. The amount utilized of an active substance should be minimized to that necessary to reach the desired effects thereby reducing the load on the environment and the linked potential adverse effects. In
49:" are regularly interchanged, and often confused with "plant protection products". To clarify this, pesticides include both biocides and plant protection products, where the former refers to substances for non-food and feed purposes and the latter refers to substances for food and feed purposes.
246:
Because biocides are intended to kill living organisms, many biocidal products pose significant risk to human health and welfare. Great care is required when handling biocides and appropriate protective clothing and equipment should be used. The use of biocides can also have significant adverse
68:, which exhibit their biocidal activity only under certain specific conditions such as in closed systems. In such cases, the biocidal product is the combination of the active substance and the device that ensures the intended biocidal activity, i.e. suffocation of rodents by CO
230:, sometimes referred to as "trichlor". These compounds are stable while solids and may be used in powdered, granular, or tablet form. When added in small amounts to pool water or industrial water systems, the chlorine atoms hydrolyze from the rest of the molecule forming
72:
in a closed system trap. Another example of biocidal products available to consumers are products impregnated with biocides (also called treated articles), such as clothes and wristbands impregnated with insecticides, socks impregnated with antibacterial substances etc.
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255:, have been shown to have severe and long-lasting impacts on marine eco-systems and such materials are now banned in many countries for commercial and recreational vessels (though sometimes still used for
438:
457:
966:
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Christensen FM, Eisenreich EJ, Rasmussen K, Riego-Sintes J, Sokull-Kluettgen B, Van de
Plassche EJ (2011). "European Experience in Chemicals Management: Integrating Science into Policy".
460:, which includes plant protection products (see websites below). In Europe, the plant protection products are placed on the market under another regulatory framework, managed by the
812:
Schug, Angela R.; Bartel, Alexander; Scholtzek, Anissa D.; Meurer, Marita; Brombach, Julian; Hensel, Vivian; Fanning, Séamus; Schwarz, Stefan; Feßler, Andrea T. (1 September 2020).
666:"REGULATION (EU) No 528/2012 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 22 May 2012 concerning the making available on the market and use of biocidal products"
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REGULATION (EU) No 528/2012 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 22 May 2012 concerning the making available on the market and use of biocidal products
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https://web.archive.org/web/20160305110234/http://ec.europa.eu/health/scientific_committees/consultations/public_consultations/scher_consultation_06_en.htm
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275:
The classification of biocides in the BPR is broken down into 22 product types (i.e. application categories), with several comprising multiple subgroups:
724:
Backhaus, Thomas; Altenburger, Rolf; Faust, Michael; Frein, Daniel; Frische, Tobias; Johansson, Per; Kehrer, Anja; Porsbring, Tobias (28 February 2013).
218:. It is often impractical to store and use poisonous chlorine gas for water treatment, so alternative methods of adding chlorine are used. These include
64:
Although most of the biocidal active substances have a relative high toxicity, there are also examples of active substances with low toxicity, such as CO
61:, colour, odour, etc. of the final product. Biocidal products are available on the market for use by professional and/or non-professional consumers.
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Disposal of used or unwanted biocides must be undertaken carefully to avoid serious and potentially long-lasting damage to the environment.
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programme on testing methods. Exchange of information requires the use of the OECD harmonised templates implemented in IUCLID – the
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203:) to protect them against biological infestation and growth. For example, certain types of quaternary ammonium compounds (
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intended to destroy, deter, render harmless, or exert a controlling effect on any harmful organism. The US
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D'Aquino M, Teves SA (December 1994), "Lemon juice as a natural biocide for disinfecting drinking water",
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or industrial water systems to act as an algicide, protecting the water from infestation and growth of
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234:(HOCl) which acts as a general biocide killing germs, micro-organisms, algae, and so on. Halogenated
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Communication from the
Commission to the Council: The combination effects of chemicals. 2012/ENV/017
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Product-type 2: Private area and public health area disinfectants and other biocidal products
196:, which is approved for use as a wood preservative (PT 8) as well as an insecticide (PT 18).
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effects on the natural environment. Anti-fouling paints, especially those utilising organic
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contain other non-active co-formulants that ensure the effectiveness as well as the desired
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SCHER, SCCS, SCENIHR. (2012) Opinion on the
Toxicity and Assessment of Chemical Mixtures
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and subsequent fouling organisms on the hulls which increase the drag during navigation.
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The biocides legislation puts emphasis on making the
Regulation compatible with the
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For the class of organic molecules containing a disaccharide functional group, see
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solutions, which gradually release chlorine into the water, and compounds like
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Organisation for Economic Co-operation and Development (OECD) Biocides website
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Product-type 9: Fibre, leather, rubber and polymerised materials preservatives
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Directory of Microbicides for the Protection of Materials and Processes
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Chemical substance or microorganism used against a harmful organism
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226:(dihydrate or anhydrous), sometimes referred to as "dichlor", and
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Wittmer IK, Scheidegger R, Bader HP, Singer H, Stamm C (2011).
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European Chemicals Agency Biocides Product Regulation website
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567:"AFSCA – Production végétale: Produits phytopharmaceutiques"
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International Unified Chemical Information Data System
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Product-type 3: Veterinary hygiene biocidal products
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Biocides can be added to other materials (typically
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335:Product-type 13: Metalworking-fluid preservatives
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452:Many biocides in the US are regulated under the
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285:Product-type 1: Human hygiene biocidal products
297:Product-type 5: Drinking water disinfectants
30:is defined in the European legislation as a
280:Disinfectants and general biocidal products
96:, derived from, e.g., bacteria and plants.
437:(WTO) rules and requirements and with the
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788:"Guidance on biocides legislation – ECHA"
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670:Official Journal of the European Union
323:Product-type 10: Masonry preservatives
888:Inventory of Biocides used in Denmark
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238:compounds are also used as biocides.
939:Environmental Science and Technology
874:. Springer Netherland, Berlin 2006,
458:Federal Food, Drugs and Cosmetic Act
308:Product-type 6: In-can preservatives
995:EFSA European Food Safety Authority
985:US EPA Office of Pesticide Programs
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619:"Shark Skin Inspires Ship Coating"
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617:Leahy, Stephen (10 March 2005).
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75:
63:
51:
44:
27:
25:
651:20 December
425:Legislation
418:taxidermist
407:Antifouling
393:vertebrates
178:. See also
168:antifungals
156:antibiotics
82:agriculture
1036:Pesticides
1015:Categories
865:Literature
824:: 108791.
553:References
386:Repellents
380:arthropods
376:acaricides
366:Piscicides
331:Slimicides
259:vessels).
180:spermicide
164:antivirals
152:germicides
141:slimicides
133:piscicides
113:herbicides
109:fungicides
47:pesticides
854:221258755
838:0378-1135
752:2190-4707
576:27 August
527:Fungicide
414:Embalming
236:hydantoin
129:miticides
121:algicides
105:pesticide
59:viscosity
1021:Biocides
979:Biocides
959:20958022
930:21183204
846:32827921
797:13 April
772:13 April
693:13 April
628:22 April
547:Virucide
521:See also
464:(EFSA).
409:products
354:Avicides
90:industry
86:forestry
78:medicine
908:Bibcode
605:7858646
515:biofilm
201:liquids
28:biocide
21:Bioside
1007:(gone)
957:
928:
878:
852:
844:
836:
750:
603:
420:fluids
174:, and
139:, and
88:, and
850:S2CID
736:(1).
623:Wired
257:naval
216:algae
212:water
205:quats
955:PMID
926:PMID
876:ISBN
842:PMID
834:ISSN
799:2018
774:2018
748:ISSN
695:2018
653:2012
630:2020
601:PMID
578:2022
443:OECD
416:and
209:pool
187:Uses
981:by
947:doi
916:doi
904:409
826:doi
822:248
738:doi
253:TBT
249:tin
146:An
34:or
1017::
953:.
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924:.
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902:.
898:.
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820:.
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790:.
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166:,
162:,
158:,
154:,
135:,
131:,
127:,
123:,
119:,
115:,
111:,
103:A
84:,
80:,
57:,
55:pH
26:A
961:.
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918::
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882:.
856:.
828::
801:.
776:.
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740::
697:.
632:.
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182:.
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70:2
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23:.
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