273:
optical transport properties of both normal and malignant tissues, developing optical techniques for use in tissue monitoring, detection of physiological changes, and photodynamic therapy. Tromberg is interested in developing non-invasive methods for in vivo monitoring and imaging using non-linear optical microscopy and diffuse optical spectroscopy. He is a specialist in the interaction of laser radiation with tissue, and has developed diagnostic techniques to analyze the effects of laser energy on tissue. Tromberg has been the principal investigator on a number of major projects relating to
217:
Program (LAMMP), beginning with its formation in 1997; Professor in the
Departments of Biomedical Engineering and Surgery, as of July 2002; Director of the Beckman Laser Institute and Medical Clinic, as of October 2003; and Co-Leader of the Onco-Imaging and Spectroscopy Program of the Chao Family Comprehensive Cancer Center, as of 2004. Tromberg has supervised the research of at least 8 postdoctoral fellows and 17 Ph.D. students. He has published more than 400 publications and holds at least 17 patents.
301:
the amount of light that is reflected back is measured. The technique can be used to create images of tissue as deep as several centimeters below the skin's surface, detecting signs of metabolic activity such as blood flow, oxygenation, fat content, water content, and fluid build-up. Changes can be viewed in real time, instantaneously, without disturbing the tissue. This allows researchers to better understand and monitor changes in tissue growth and in response to treatment.
228:(OCT). Tromberg is principal investigator of The Laser Microbeam and Medical Program (LAMMP) at the Beckman Laser Institute (BLI), which received funding as a NIH Biomedical Technology Resource Center as part of a multi-year program beginning in 1997. He has chaired NIH workshops on imaging related topics and has been on the advisory council on optical technologies for the US Public Health Service.
180:. He is considered "a pioneer in biophotonics through the continuous development of advanced technologies in diffuse optical spectroscopy and multi-modal imaging." He received the 2015 Michael S. Feld Biophotonics Award "as an advocate for and leader of the Biophotonics Community and for pioneering the development and clinical application of spatially and temporally modulated light imaging."
300:
Tromberg has developed broadband diffuse optical spectroscopic imaging (DOSI), used to measure the magnitude of light scattering and absorption in thick tissues, and is using this method for in vivo functional imaging to detect and monitor cancer. For DOSI, near-infrared light shines onto tissue and
296:
In broadband diffuse optical spectroscopy (DOS), frequency-domain photon migration (FDPM) and time-independent near-infrared (NIR) spectroscopy are combined to measure absorption and scattering in thick tissue. Observations of the optical properties of absorption and scattering from FDPM are then
216:
as a Hewitt
Foundation postdoctoral fellow at the Beckman Laser Institute from 1988–1989, and joined the faculty of the University of California, Irvine in 1990. He has held a number of positions at Irvine during his career. Ongoing appointments include Director of the Laser Microbeam and Medical
272:
Tromberg has used non-linear optical microscopy for high resolution functional mapping of physiological processes in living cells and tissues, and ultrafast laser techniques for the multi-dimensional visualization of cell and tissue physiology. Tromberg's research interests include studying the
1152:
304:
SFDI is similar, using near infrared light to detect and measure oxygen saturation, water, and fat content. The information is used to describe tissue at multiple depths, to map an entire area such as a tumor, and to monitor changes.
288:
Tromberg and others in his laboratory have developed new methods for broadband diffuse optical spectroscopy (DOS) including diffuse optical spectroscopic imaging (DOSI); spatial frequency domain imaging (SFDI); and a type of
263:
Tromberg was selected as director of the
National Institute of Biomedical Imaging and Bioengineering (NIBIB) within the National Institutes of Health (NIH) on September 6, 2018, and sworn in on January 7, 2019.
149:. He is the director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) within the National Institutes of Health (NIH). Before joining NIH, he was Professor of Biomedical Engineering at
1367:
639:
231:
Tromberg has been a member of the
International Society for Optical Engineering (SPIE) Publications Committee for a number of years. He became a member of the editorial board of SPIE's
31:
845:
796:
Crouzet, Christian; Wilson, Robert H.; Bazrafkan, Afsheen; Farahabadi, Maryam H.; Lee, Donald; Alcocer, Juan; Tromberg, Bruce J.; Choi, Bernard; Akbari, Yama (20 October 2016).
2037:
312:(TPEF) and second-harmonic generation (SHG), taking measurements at different wavelengths and creating a three-dimensional representation of unstained in vivo thick tissue.
1095:
1011:
104:
559:
552:
1256:"Department of Health and Human Services Public Health Service National Institutes of Health National Advisory Council for Biomedical Imaging and Bioengineering"
250:(OSA), and has served as a co-chair at OSA meetings related to biomedical optics. He has been active both as a contributor to and a guest editor of the journals
972:
2181:
1312:
168:, developing biophotonics technologies while working closely with clinicians and patients to explore their possible clinical application in areas such as
1096:"Optical Coherence Tomography Used $ 500M of Federally Funded Research Over The Past Decade: How was it Used, What was Accomplished, and What's to Come?"
2166:
2012:
1987:
492:
719:
386:
331:
1881:
Tromberg, Bruce J.; Shah, Natasha; Lanning, Ryan; Cerussi, Albert; Espinoza, Jennifer; Pham, Tuan; Svaasand, Lars; Butler, John (January 2000).
297:
analyzed and used to display images of hemoglobin, oxygen, blood volume, water and fat content, and cellular structure of the tissues examined.
2176:
746:"PHOTONICS WEST PREVIEW: Bigger than ever, SPIE Photonics West 2014 offers technologies, products, and new opportunities across the spectrum"
745:
1696:
Tromberg, Bruce; Cerussi, Albert; Chung, So-Hyun; Tanamai, Wendy; Durkin, Amanda (2011). "Broadband
Diffuse Optical Spectroscopic Imaging".
486:
Tromberg, B.J.; Coquoz, O.; Fishkin, J.B.; Pham, T.; Anderson, E.R.; Butler, J.; Cahn, M.; Gross, J.D.; Venugopalan, V.; Pham, D. (1997).
161:
at Irvine. He was a co-leader of the Onco-imaging and
Biotechnology Program of the NCI Chao Family Comprehensive Cancer Center at Irvine.
1608:, 2/1/00-2/1/02, Fiber Optics Confocal Module for Biomedical Application (SBIR - Intelligent Optical Systems), and similar earlier grants
853:
320:
His publications include peer-reviewed papers, conference papers, book chapters, and patents. Among his most important papers are:
605:
1286:
2161:
150:
1103:
1019:
2151:
1932:"Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy"
1713:
237:
when it was founded in 1996, and served as its editor-in-chief from 1999 to 2010. He also served as an editor of the journal
380:
Shah, N.; Cerussi, A.; Eker, C.; Espinoza, J.; Butler, J.; Fishkin, J.; Hornung, R.; Tromberg; Breast Tissue, Human (2001).
2156:
692:
1596:
California Breast Cancer
Research Program, 07/01/00 – 06/30/03, Non-Invasive Optical Characterization of Breast Physiology
2093:
798:"Cerebral blood flow is decoupled from blood pressure and linked to EEG bursting after resuscitation from cardiac arrest"
1821:"Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence"
1127:"New biophotonics techniques hold promise but need translation, say researchers at NIH-SPIE 'Bench to Bedside' workshop"
60:
1255:
1204:
437:"Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject"
327:"Imaging Cells And Extracellular Matrix In Vivo Using Second-Harmonic Generation And Two-Photon Excited Fluorescence"
983:
900:
309:
293:
combining techniques for second harmonic generation tomography (SHG) and two-photon excited fluorescence (TPEF).
154:
96:
2063:
771:
157:. He was the principal investigator of the Laser Microbeam and Medical Program (LAMMP), and the Director of the
1575:
278:
239:
221:
201:
1126:
233:
225:
1930:
Cerussi, A. E.; Tanamai, V. W.; Hsiang, D.; Butler, J.; Mehta, R. S.; Tromberg, B. J. (17 October 2011).
1605:
566:
282:
1739:
1497:
640:"Beckman Laser Institute celebrates 30 years of invention: Technologies outdoing Hollywood's imaginings"
488:"Non-Invasive Measurements of Breast Tissue Optical Properties Using Frequency-Domain Photon Migration"
247:
879:
1153:"Special Section Guest Editorial: Optical Diagnostic and Biophotonic Methods from Bench to Bedside"
1936:
Philosophical
Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
1769:"Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure"
1620:"Diffuse Optical Technology: A Portable and Simple Method for Noninvasive Tissue Pathophysiology"
1012:"University of California Irvine Receives NIH Grant for A Laser Microbeam Biotechnology Resource"
197:
158:
100:
772:"New research on non-invasive heart and cancer imaging reported in Journal of Biomedical Optics"
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165:
130:
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1431:
1306:
189:
51:
1883:"Non-Invasive In Vivo Characterization of Breast Tumors Using Photon Migration Spectroscopy"
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1339:
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68:
613:
8:
2126:
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U.S. Army, (BC972457), 9/30/98-10/30/01, Measurements of Breast Tissue
Optical Properties
930:
55:
1947:
1836:
1538:
1525:
Jacques, Steven L. (10 May 2013). "Optical properties of biological tissues: a review".
1409:
1343:
1171:
693:"New Photonics West Translational Research program advances technologies for healthcare"
584:
1987, R&D 100 Award, for dissertation research on antibody-based fiber optic sensors
505:
454:
399:
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1964:
1931:
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797:
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Hebden, Jeremy C.; Boas, David A.; George, John S.; Durkin, Anthony J. (1 June 2003).
363:
326:
1969:
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381:
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64:
1767:
Chen, Xiyi; Nadiarynkh, Oleg; Plotnikov, Sergey; Campagnola, Paul J (8 March 2012).
1562:
581:
1999, Cornelius Hopper
Innovation Award, California Breast Cancer Research Symposium
478:
308:
In multiphoton microscopy, Tromberg has developed a noninvasive technique combining
1959:
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1902:
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Fishkin, J. B.; Coquoz, O.; Anderson, E. R.; Brenner, M.; Tromberg, B. J. (1997).
1205:"Biophotonic technologies on fast path from bench to bedside, NIH workshop hears"
1045:
1635:
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252:
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86:
2101:
1180:
2171:
2140:
720:"Beckman's portable laser breast scanner detects cancer and guides treatment"
274:
173:
169:
1393:
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As of 2011, Tromberg was one of the ten top researchers to be funded by the
1973:
1955:
1916:
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1802:
1784:
1653:
1554:
1189:
831:
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193:
146:
116:
1988:"77 Members of the Optical Society are Elected as Newest Class of Fellows"
531:
1417:
813:
462:
2071:
281:
the U.S. Army, the California Breast Cancer Research Program, and the
1705:
1352:
1327:
744:
Goode, Barbara; Overton, Gail; Wallace, John; Holton, Conard (2013).
192:
in 1979, and a M.S.(1983) and Ph.D.(1988) in Chemistry, working with
382:"Noninvasive functional optical spectroscopy of human breast tissue"
30:
2013:"The Optical Society Bestows Fifteen Prestigious Awards for 2015"
1766:
177:
795:
243:. He served on the SPIE Board of Directors from 2003 to 2006.
846:"NIBIB-funded team develops a new way to image fat metabolism"
551:
2007, Fellow, International Society for Optical Engineering (
1230:"SPIE/NIH Workshop 2015: Biophotonics from Bench to Bedside"
434:
131:
https://www.nibib.nih.gov/about-nibib/staff/bruce-j-tromberg
1695:
1293:(185). 1999. Archived from the original on 7 September 2006
1287:"Appointment to Editor of the Journal of Biomedical Optics"
850:
National Institute of Biomedical Imaging and Bioengineering
545:
2016, Fellow Member of the Optical Society of America (OSA)
105:
National Institute of Biomedical Imaging and Bioengineering
1929:
1880:
2131:
743:
560:
American Institute for Medical and Biological Engineering
485:
379:
1819:
Zoumi, A.; Yeh, A.; Tromberg, B. J. (12 August 2002).
1578:
4/1/99-4/31/03, Laser Microbeam Biotechnology Resource
1391:
578:
2000, Avon Foundation Breast Cancer Research Scholar
575:
2000, Coherent Biophotonics Young Investigator Award
493:Philosophical Transactions of the Royal Society B
2138:
1818:
1311:: CS1 maint: bot: original URL status unknown (
324:
1825:Proceedings of the National Academy of Sciences
387:Proceedings of the National Academy of Sciences
332:Proceedings of the National Academy of Sciences
1665:
1663:
548:2015, Michael S. Feld Biophotonics Award, OSA
873:
871:
188:Tromberg received a B.A., in Chemistry from
2030:
1733:
1731:
1729:
1727:
1725:
1281:
1279:
1150:
1144:
1006:
1004:
685:
572:2001, OE Magazine Technology Innovator Award
2182:Members of the National Academy of Medicine
1660:
1394:"Topics in biomedical optics: introduction"
1039:
1037:
325:Zoumi, A.; Yeh, A.; Tromberg, B.J. (2002).
204:as a predoctoral fellow from 1986 to 1988.
153:and of Surgery at the School of Medicine,
1456:
1454:
1452:
1046:"A Laser Microbeam Biotechnology Resource"
973:"B.J. Tromberg, curriculum vitae 11/11/08"
868:
610:Beckman Laser Institute and Medical Clinic
310:two photon excited fluorescence microscopy
159:Beckman Laser Institute and Medical Clinic
29:
1963:
1906:
1854:
1844:
1792:
1737:
1722:
1643:
1424:
1351:
1319:
1276:
1179:
1001:
821:
633:
631:
521:
417:
407:
362:
352:
145:and a leading researcher in the field of
2167:University of California, Irvine faculty
1814:
1812:
1672:"Broadband Diffuse Optical Spectroscopy"
1463:Institute of Electro-Optical Engineering
1034:
967:
965:
963:
961:
959:
957:
955:
953:
951:
878:Spitzer, Anna Lynn (December 21, 2015).
1923:
1876:
1874:
1762:
1760:
1738:Dougherty, Elizabeth (April 24, 2017).
1524:
1518:
1461:"IPC2011 General Program Information".
1449:
1063:
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893:
877:
637:
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151:The Henry Samueli School of Engineering
2139:
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925:
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769:
628:
2056:
1809:
1740:"Wearable Windows into Breast Tumors"
1617:
1611:
948:
662:
660:
2177:National Institutes of Health people
1871:
1757:
1689:
1669:
1325:
1151:Gandjbakhche, Amir (6 August 2012).
1043:
1018:. September 14, 2011. Archived from
901:"Michael S. Feld Biophotonics Award"
890:
838:
763:
737:
717:
595:
539:
2005:
1118:
1088:
918:
711:
277:, which have been supported by the
13:
2094:"Lasers in Medicine & Biology"
718:Cruz, Sherri (November 29, 2013).
657:
61:University of Tennessee, Knoxville
14:
2193:
2120:
1203:Nelson, Amy (16 September 2011).
1100:Optical Coherence Tomography News
1075:UCI Samueli School of Engineering
1016:Optical Coherence Tomography News
884:UCI Samueli School of Engineering
638:Wolfson, Wendy (March 29, 2017).
606:"BLI Profiles: Bruce J. Tromberg"
569:on Lasers in Biology and Medicine
2064:"AIMBE Honors Bruce J. Tromberg"
672:University of California, Irvine
164:Tromberg is actively engaged in
155:University of California, Irvine
97:University of California, Irvine
1980:
1618:Chung, So Hyun (January 2012).
1599:
1590:
1581:
1569:
1527:Physics in Medicine and Biology
1360:
1248:
1222:
1102:. July 16, 2011. Archived from
315:
2162:21st-century American chemists
1328:"From the New Editor-in-Chief"
1125:Nelson, Amy (6 October 2009).
852:. July 7, 2016. Archived from
258:Lasers in Medicine and Surgery
1:
2038:"56 New SPIE Fellows Elected"
1698:Handbook of Biomedical Optics
1576:National Institutes of Health
1368:"SPIE Thanks Journal Editors"
1263:National Institutes of Health
880:"Tromberg Elected OSA Fellow"
588:
279:National Institutes of Health
222:National Institutes of Health
202:Oak Ridge National Laboratory
2152:Vanderbilt University alumni
1332:Journal of Biomedical Optics
1160:Journal of Biomedical Optics
770:Nelson, Amy (31 July 2012).
246:Tromberg is a fellow of the
234:Journal of Biomedical Optics
226:optical coherence tomography
183:
7:
2157:American optical physicists
2098:Gordon Research Conferences
1606:National Science Foundation
1547:10.1088/0031-9155/58/11/R37
283:National Science Foundation
267:
10:
2198:
1636:10.1016/j.cpet.2011.12.008
567:Gordon Research Conference
248:Optical Society of America
2127:UC Irvine faculty profile
1372:SPIE Professional January
1181:10.1117/1.JBO.17.8.081401
802:Biomedical Optics Express
207:
126:
122:
110:
92:
82:
75:
47:
37:
28:
21:
1326:Wang, Lihong V. (2010).
2132:Beckman Laser Institute
2068:Beckman Laser Institute
1505:Beckman Laser Institute
980:Beckman Laser Institute
198:University of Tennessee
101:Beckman Laser Institute
1956:10.1098/rsta.2011.0279
1899:10.1038/sj.neo.7900082
1846:10.1073/pnas.172368799
1785:10.1038/nprot.2012.009
1338:(1): 010101–010101–1.
724:Oregon County Register
644:UCI Applied Innovation
514:10.1098/rstb.1997.0047
409:10.1073/pnas.071511098
354:10.1073/pnas.172368799
224:(NIH) in the field of
166:translational research
1498:"Biographical Sketch"
565:2004, U.S. Co-Chair,
212:Tromberg worked with
190:Vanderbilt University
52:Vanderbilt University
2104:on 22 September 2015
2074:on 11 September 2015
1700:. pp. 181–194.
1418:10.1364/AO.42.002869
814:10.1364/BOE.7.004660
616:on 13 September 2017
558:2006, Fellow of the
463:10.1364/ao.36.000010
42:Bruce Jason Tromberg
2017:The Optical Society
1948:2011RSPTA.369.4512C
1942:(1955): 4512–4530.
1837:2002PNAS...9911014Z
1831:(17): 11014–11019.
1670:Tromberg, Bruce J.
1539:2013PMB....58R..37J
1410:2003ApOpt..42.2869H
1344:2010JBO....15a0101W
1172:2012JBO....17h1401G
1044:Tromberg, Bruce J.
931:"Bruce J. Tromberg"
905:The Optical Society
506:1997RSPTB.352..661T
455:1997ApOpt..36...10F
400:2001PNAS...98.4420S
345:2002PNAS...9911014Z
339:(17): 11014–11019.
240:Optical Engineering
1022:on 27 January 2018
989:on 28 October 2017
291:optical tomography
2042:SPIE Professional
1715:978-1-4200-9036-9
1706:10.1201/b10951-12
1478:Missing or empty
1432:"Advisory Boards"
1353:10.1117/1.3276692
808:(11): 4660–4673.
750:Laser Focus World
699:. 20 January 2014
540:Awards and honors
500:(1354): 661–668.
139:Bruce J. Tromberg
136:
135:
77:Scientific career
2189:
2114:
2113:
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2109:
2100:. Archived from
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2084:
2083:
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2070:. Archived from
2060:
2054:
2053:
2051:
2049:
2034:
2028:
2027:
2025:
2023:
2009:
2003:
2002:
2000:
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1992:23 November 2015
1984:
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1816:
1807:
1806:
1796:
1773:Nature Protocols
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1116:
1115:
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1111:
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1083:
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1071:"Bruce Tromberg"
1067:
1061:
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1058:
1056:
1041:
1032:
1031:
1029:
1027:
1008:
999:
998:
996:
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988:
982:. Archived from
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941:
927:
916:
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689:
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678:
668:"Bruce Tromberg"
664:
655:
654:
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635:
626:
625:
623:
621:
612:. Archived from
602:
535:
525:
482:
431:
421:
411:
394:(8): 4420–4425.
376:
366:
356:
285:, among others.
214:Michael W. Berns
200:. He worked at
112:Doctoral advisor
33:
19:
18:
16:American chemist
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2019:
2011:
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1574:
1570:
1533:(11): R37–R61.
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