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Bruce J. Tromberg

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optical transport properties of both normal and malignant tissues, developing optical techniques for use in tissue monitoring, detection of physiological changes, and photodynamic therapy. Tromberg is interested in developing non-invasive methods for in vivo monitoring and imaging using non-linear optical microscopy and diffuse optical spectroscopy. He is a specialist in the interaction of laser radiation with tissue, and has developed diagnostic techniques to analyze the effects of laser energy on tissue. Tromberg has been the principal investigator on a number of major projects relating to
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Program (LAMMP), beginning with its formation in 1997; Professor in the Departments of Biomedical Engineering and Surgery, as of July 2002; Director of the Beckman Laser Institute and Medical Clinic, as of October 2003; and Co-Leader of the Onco-Imaging and Spectroscopy Program of the Chao Family Comprehensive Cancer Center, as of 2004. Tromberg has supervised the research of at least 8 postdoctoral fellows and 17 Ph.D. students. He has published more than 400 publications and holds at least 17 patents.
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the amount of light that is reflected back is measured. The technique can be used to create images of tissue as deep as several centimeters below the skin's surface, detecting signs of metabolic activity such as blood flow, oxygenation, fat content, water content, and fluid build-up. Changes can be viewed in real time, instantaneously, without disturbing the tissue. This allows researchers to better understand and monitor changes in tissue growth and in response to treatment.
228:(OCT). Tromberg is principal investigator of The Laser Microbeam and Medical Program (LAMMP) at the Beckman Laser Institute (BLI), which received funding as a NIH Biomedical Technology Resource Center as part of a multi-year program beginning in 1997. He has chaired NIH workshops on imaging related topics and has been on the advisory council on optical technologies for the US Public Health Service. 180:. He is considered "a pioneer in biophotonics through the continuous development of advanced technologies in diffuse optical spectroscopy and multi-modal imaging." He received the 2015 Michael S. Feld Biophotonics Award "as an advocate for and leader of the Biophotonics Community and for pioneering the development and clinical application of spatially and temporally modulated light imaging." 300:
Tromberg has developed broadband diffuse optical spectroscopic imaging (DOSI), used to measure the magnitude of light scattering and absorption in thick tissues, and is using this method for in vivo functional imaging to detect and monitor cancer. For DOSI, near-infrared light shines onto tissue and
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In broadband diffuse optical spectroscopy (DOS), frequency-domain photon migration (FDPM) and time-independent near-infrared (NIR) spectroscopy are combined to measure absorption and scattering in thick tissue. Observations of the optical properties of absorption and scattering from FDPM are then
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as a Hewitt Foundation postdoctoral fellow at the Beckman Laser Institute from 1988–1989, and joined the faculty of the University of California, Irvine in 1990. He has held a number of positions at Irvine during his career. Ongoing appointments include Director of the Laser Microbeam and Medical
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Tromberg has used non-linear optical microscopy for high resolution functional mapping of physiological processes in living cells and tissues, and ultrafast laser techniques for the multi-dimensional visualization of cell and tissue physiology. Tromberg's research interests include studying the
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SFDI is similar, using near infrared light to detect and measure oxygen saturation, water, and fat content. The information is used to describe tissue at multiple depths, to map an entire area such as a tumor, and to monitor changes.
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Tromberg and others in his laboratory have developed new methods for broadband diffuse optical spectroscopy (DOS) including diffuse optical spectroscopic imaging (DOSI); spatial frequency domain imaging (SFDI); and a type of
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Tromberg was selected as director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) within the National Institutes of Health (NIH) on September 6, 2018, and sworn in on January 7, 2019.
149:. He is the director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) within the National Institutes of Health (NIH). Before joining NIH, he was Professor of Biomedical Engineering at 1367: 639: 231:
Tromberg has been a member of the International Society for Optical Engineering (SPIE) Publications Committee for a number of years. He became a member of the editorial board of SPIE's
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Crouzet, Christian; Wilson, Robert H.; Bazrafkan, Afsheen; Farahabadi, Maryam H.; Lee, Donald; Alcocer, Juan; Tromberg, Bruce J.; Choi, Bernard; Akbari, Yama (20 October 2016).
2037: 312:(TPEF) and second-harmonic generation (SHG), taking measurements at different wavelengths and creating a three-dimensional representation of unstained in vivo thick tissue. 1095: 1011: 104: 559: 552: 1256:"Department of Health and Human Services Public Health Service National Institutes of Health National Advisory Council for Biomedical Imaging and Bioengineering" 250:(OSA), and has served as a co-chair at OSA meetings related to biomedical optics. He has been active both as a contributor to and a guest editor of the journals 972: 2181: 1312: 168:, developing biophotonics technologies while working closely with clinicians and patients to explore their possible clinical application in areas such as 1096:"Optical Coherence Tomography Used $ 500M of Federally Funded Research Over The Past Decade: How was it Used, What was Accomplished, and What's to Come?" 2166: 2012: 1987: 492: 719: 386: 331: 1881:
Tromberg, Bruce J.; Shah, Natasha; Lanning, Ryan; Cerussi, Albert; Espinoza, Jennifer; Pham, Tuan; Svaasand, Lars; Butler, John (January 2000).
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analyzed and used to display images of hemoglobin, oxygen, blood volume, water and fat content, and cellular structure of the tissues examined.
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Tromberg, Bruce; Cerussi, Albert; Chung, So-Hyun; Tanamai, Wendy; Durkin, Amanda (2011). "Broadband Diffuse Optical Spectroscopic Imaging".
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Tromberg, B.J.; Coquoz, O.; Fishkin, J.B.; Pham, T.; Anderson, E.R.; Butler, J.; Cahn, M.; Gross, J.D.; Venugopalan, V.; Pham, D. (1997).
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at Irvine. He was a co-leader of the Onco-imaging and Biotechnology Program of the NCI Chao Family Comprehensive Cancer Center at Irvine.
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His publications include peer-reviewed papers, conference papers, book chapters, and patents. Among his most important papers are:
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when it was founded in 1996, and served as its editor-in-chief from 1999 to 2010. He also served as an editor of the journal
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Shah, N.; Cerussi, A.; Eker, C.; Espinoza, J.; Butler, J.; Fishkin, J.; Hornung, R.; Tromberg; Breast Tissue, Human (2001).
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California Breast Cancer Research Program, 07/01/00 – 06/30/03, Non-Invasive Optical Characterization of Breast Physiology
2093: 798:"Cerebral blood flow is decoupled from blood pressure and linked to EEG bursting after resuscitation from cardiac arrest" 1821:"Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence" 1127:"New biophotonics techniques hold promise but need translation, say researchers at NIH-SPIE 'Bench to Bedside' workshop" 60: 1255: 1204: 437:"Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject" 327:"Imaging Cells And Extracellular Matrix In Vivo Using Second-Harmonic Generation And Two-Photon Excited Fluorescence" 983: 900: 309: 293:
combining techniques for second harmonic generation tomography (SHG) and two-photon excited fluorescence (TPEF).
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Cerussi, A. E.; Tanamai, V. W.; Hsiang, D.; Butler, J.; Mehta, R. S.; Tromberg, B. J. (17 October 2011).
1605: 566: 282: 1739: 1497: 640:"Beckman Laser Institute celebrates 30 years of invention: Technologies outdoing Hollywood's imaginings" 488:"Non-Invasive Measurements of Breast Tissue Optical Properties Using Frequency-Domain Photon Migration" 247: 879: 1153:"Special Section Guest Editorial: Optical Diagnostic and Biophotonic Methods from Bench to Bedside" 1936:
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
1769:"Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure" 1620:"Diffuse Optical Technology: A Portable and Simple Method for Noninvasive Tissue Pathophysiology" 1012:"University of California Irvine Receives NIH Grant for A Laser Microbeam Biotechnology Resource" 197: 158: 100: 772:"New research on non-invasive heart and cancer imaging reported in Journal of Biomedical Optics" 2146: 165: 130: 1483: 1431: 1306: 189: 51: 1883:"Non-Invasive In Vivo Characterization of Breast Tumors Using Photon Migration Spectroscopy" 1229: 1943: 1832: 1534: 1405: 1339: 1167: 501: 450: 395: 340: 68: 613: 8: 2126: 1587:
U.S. Army, (BC972457), 9/30/98-10/30/01, Measurements of Breast Tissue Optical Properties
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Jacques, Steven L. (10 May 2013). "Optical properties of biological tissues: a review".
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1987, R&D 100 Award, for dissertation research on antibody-based fiber optic sensors
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Hebden, Jeremy C.; Boas, David A.; George, John S.; Durkin, Anthony J. (1 June 2003).
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Chen, Xiyi; Nadiarynkh, Oleg; Plotnikov, Sergey; Campagnola, Paul J (8 March 2012).
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1999, Cornelius Hopper Innovation Award, California Breast Cancer Research Symposium
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In multiphoton microscopy, Tromberg has developed a noninvasive technique combining
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Fishkin, J. B.; Coquoz, O.; Anderson, E. R.; Brenner, M.; Tromberg, B. J. (1997).
1205:"Biophotonic technologies on fast path from bench to bedside, NIH workshop hears" 1045: 1635: 441: 436: 252: 142: 86: 2101: 1180: 2171: 2140: 720:"Beckman's portable laser breast scanner detects cancer and guides treatment" 274: 173: 169: 1393: 220:
As of 2011, Tromberg was one of the ten top researchers to be funded by the
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the U.S. Army, the California Breast Cancer Research Program, and the
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Goode, Barbara; Overton, Gail; Wallace, John; Holton, Conard (2013).
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in 1979, and a M.S.(1983) and Ph.D.(1988) in Chemistry, working with
382:"Noninvasive functional optical spectroscopy of human breast tissue" 30: 2013:"The Optical Society Bestows Fifteen Prestigious Awards for 2015" 1766: 177: 795: 243:. He served on the SPIE Board of Directors from 2003 to 2006. 846:"NIBIB-funded team develops a new way to image fat metabolism" 551:
2007, Fellow, International Society for Optical Engineering (
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https://www.nibib.nih.gov/about-nibib/staff/bruce-j-tromberg
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National Institute of Biomedical Imaging and Bioengineering
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2016, Fellow Member of the Optical Society of America (OSA)
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National Institute of Biomedical Imaging and Bioengineering
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American Institute for Medical and Biological Engineering
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Zoumi, A.; Yeh, A.; Tromberg, B. J. (12 August 2002).
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4/1/99-4/31/03, Laser Microbeam Biotechnology Resource
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2000, Avon Foundation Breast Cancer Research Scholar
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2000, Coherent Biophotonics Young Investigator Award
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Tromberg, curriculum vitae 11/11/08" 868: 610:Beckman Laser Institute and Medical Clinic 310:two photon excited fluorescence microscopy 159:Beckman Laser Institute and Medical Clinic 29: 1963: 1906: 1854: 1844: 1792: 1737: 1722: 1643: 1424: 1351: 1319: 1276: 1179: 1001: 821: 633: 631: 521: 417: 407: 362: 352: 145:and a leading researcher in the field of 2167:University of California, Irvine faculty 1814: 1812: 1672:"Broadband Diffuse Optical Spectroscopy" 1463:Institute of Electro-Optical Engineering 1034: 967: 965: 963: 961: 959: 957: 955: 953: 951: 878:Spitzer, Anna Lynn (December 21, 2015). 1923: 1876: 1874: 1762: 1760: 1738:Dougherty, Elizabeth (April 24, 2017). 1524: 1518: 1461:"IPC2011 General Program Information". 1449: 1063: 895: 893: 877: 637: 600: 598: 151:The Henry Samueli School of Engineering 2139: 2086: 1490: 1385: 1202: 1196: 1124: 925: 923: 921: 789: 769: 628: 2056: 1809: 1740:"Wearable Windows into Breast Tumors" 1617: 1611: 948: 662: 660: 2177:National Institutes of Health people 1871: 1757: 1689: 1669: 1325: 1151:Gandjbakhche, Amir (6 August 2012). 1043: 1018:. September 14, 2011. Archived from 901:"Michael S. Feld Biophotonics Award" 890: 838: 763: 737: 717: 595: 539: 2005: 1118: 1088: 918: 711: 277:, which have been supported by the 13: 2094:"Lasers in Medicine & Biology" 718:Cruz, Sherri (November 29, 2013). 657: 61:University of Tennessee, Knoxville 14: 2193: 2120: 1203:Nelson, Amy (16 September 2011). 1100:Optical Coherence Tomography News 1075:UCI Samueli School of Engineering 1016:Optical Coherence Tomography News 884:UCI Samueli School of Engineering 638:Wolfson, Wendy (March 29, 2017). 606:"BLI Profiles: Bruce J. Tromberg" 569:on Lasers in Biology and Medicine 2064:"AIMBE Honors Bruce J. Tromberg" 672:University of California, Irvine 164:Tromberg is actively engaged in 155:University of California, Irvine 97:University of California, Irvine 1980: 1618:Chung, So Hyun (January 2012). 1599: 1590: 1581: 1569: 1527:Physics in Medicine and Biology 1360: 1248: 1222: 1102:. July 16, 2011. Archived from 315: 2162:21st-century American chemists 1328:"From the New Editor-in-Chief" 1125:Nelson, Amy (6 October 2009). 852:. July 7, 2016. Archived from 258:Lasers in Medicine and Surgery 1: 2038:"56 New SPIE Fellows Elected" 1698:Handbook of Biomedical Optics 1576:National Institutes of Health 1368:"SPIE Thanks Journal Editors" 1263:National Institutes of Health 880:"Tromberg Elected OSA Fellow" 588: 279:National Institutes of Health 222:National Institutes of Health 202:Oak Ridge National Laboratory 2152:Vanderbilt University alumni 1332:Journal of Biomedical Optics 1160:Journal of Biomedical Optics 770:Nelson, Amy (31 July 2012). 246:Tromberg is a fellow of the 234:Journal of Biomedical Optics 226:optical coherence tomography 183: 7: 2157:American optical physicists 2098:Gordon Research Conferences 1606:National Science Foundation 1547:10.1088/0031-9155/58/11/R37 283:National Science Foundation 267: 10: 2198: 1636:10.1016/j.cpet.2011.12.008 567:Gordon Research Conference 248:Optical Society of America 2127:UC Irvine faculty profile 1372:SPIE Professional January 1181:10.1117/1.JBO.17.8.081401 802:Biomedical Optics Express 207: 126: 122: 110: 92: 82: 75: 47: 37: 28: 21: 1326:Wang, Lihong V. (2010). 2132:Beckman Laser Institute 2068:Beckman Laser Institute 1505:Beckman Laser Institute 980:Beckman Laser Institute 198:University of Tennessee 101:Beckman Laser Institute 1956:10.1098/rsta.2011.0279 1899:10.1038/sj.neo.7900082 1846:10.1073/pnas.172368799 1785:10.1038/nprot.2012.009 1338:(1): 010101–010101–1. 724:Oregon County Register 644:UCI Applied Innovation 514:10.1098/rstb.1997.0047 409:10.1073/pnas.071511098 354:10.1073/pnas.172368799 224:(NIH) in the field of 166:translational research 1498:"Biographical Sketch" 565:2004, U.S. Co-Chair, 212:Tromberg worked with 190:Vanderbilt University 52:Vanderbilt University 2104:on 22 September 2015 2074:on 11 September 2015 1700:. pp. 181–194. 1418:10.1364/AO.42.002869 814:10.1364/BOE.7.004660 616:on 13 September 2017 558:2006, Fellow of the 463:10.1364/ao.36.000010 42:Bruce Jason Tromberg 2017:The Optical Society 1948:2011RSPTA.369.4512C 1942:(1955): 4512–4530. 1837:2002PNAS...9911014Z 1831:(17): 11014–11019. 1670:Tromberg, Bruce J. 1539:2013PMB....58R..37J 1410:2003ApOpt..42.2869H 1344:2010JBO....15a0101W 1172:2012JBO....17h1401G 1044:Tromberg, Bruce J. 931:"Bruce J. Tromberg" 905:The Optical Society 506:1997RSPTB.352..661T 455:1997ApOpt..36...10F 400:2001PNAS...98.4420S 345:2002PNAS...9911014Z 339:(17): 11014–11019. 240:Optical Engineering 1022:on 27 January 2018 989:on 28 October 2017 291:optical tomography 2042:SPIE Professional 1715:978-1-4200-9036-9 1706:10.1201/b10951-12 1478:Missing or empty 1432:"Advisory Boards" 1353:10.1117/1.3276692 808:(11): 4660–4673. 750:Laser Focus World 699:. 20 January 2014 540:Awards and honors 500:(1354): 661–668. 139:Bruce J. Tromberg 136: 135: 77:Scientific career 2189: 2114: 2113: 2111: 2109: 2100:. Archived from 2090: 2084: 2083: 2081: 2079: 2070:. 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Index


Vanderbilt University
BS
University of Tennessee, Knoxville
MS
PhD
Photochemistry
University of California, Irvine
Beckman Laser Institute
National Institute of Biomedical Imaging and Bioengineering
Doctoral advisor
Tuan Vo-Dinh
https://www.nibib.nih.gov/about-nibib/staff/bruce-j-tromberg
photochemist
biophotonics
The Henry Samueli School of Engineering
University of California, Irvine
Beckman Laser Institute and Medical Clinic
translational research
breast cancer
heart disease
obesity
Vanderbilt University
Tuan Vo-Dinh
University of Tennessee
Oak Ridge National Laboratory
Michael W. Berns
National Institutes of Health
optical coherence tomography
Journal of Biomedical Optics

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