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Cardiac resynchronization therapy

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131: 1954: 25: 425: 278:(ICD), to quickly terminate an abnormally fast, life-threatening heart rhythm. CRT and CRT-D have become increasingly important therapeutic options for patients with moderate and severe heart failure. CRT with pacemaker only is often termed "CRT-P" to help distinguish it from CRT with defibrillator (CRT-D). 441:
CRT requires the placement of an electrical device for biventricular pacing, along with placement of (at least) two pacing leads, to facilitate stable left ventricular and right ventricular pacing. For all elements, the first stage of the process is local anaesthetic followed by incision to allow for
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Left ventricular lead placement is the most complicated and potentially hazardous element of the operation, due to the significant variability of coronary venous structure. Alterations in heart structure, fatty deposits, valves and natural variations all cause additional complications in the process
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Zhou, Weihua; Hou, Xiaofeng; Piccinelli, Marina; Tang, Xiangyang; Tang, Lijun; Cao, Kejiang; Garcia, Ernest V.; Zou, Jiangang; Chen, Ji (December 2014). "3D fusion of LV venous anatomy on fluoroscopy venograms with epicardial surface on SPECT myocardial perfusion images for guiding CRT LV lead
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Several research papers have proposed software platforms for planning and guiding the implantation of CRT devices. This research proposes using pre-operative images to characterize tissue and left ventricle activation to identify potential target regions for deploying the CRT leads.
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The device is inserted in a subcutaneous pocket created by the surgeon, the choice of left or right side of the chest wall is determined mainly by the patient's preference or location of preexisting device. The device, similar to that of a traditional
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Auricchio, Angelo; Gasparini, Maurizio; Linde, Cecilia; Dobreanu, Dan; Cano, Óscar; Sterlinski, Maciej; Bogale, Nigussie; Stellbrink, Christoph; Refaat, Marwan M.; Blomström-Lundqvist, Carina; Lober, Christiane (September 2019).
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Sinitca, Aleksandr; Chmelevsky, Mikhail; Arduino, Chiara; Zubarev, Stepan; Shirshin, Aleksandr; Dokuchaev, Arsenii; Budanova, Margarita; Khamzin, Svyatoslav; Bazhutina, Anastasia; Rud, Sergei; Rainer, Werner (2023-11-26).
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Once the phlebogram has been obtained, the multi-delivery catheter is used to guide in the lead, from the chosen vein of entry, into the right atrium, through the coronary sinus and into the relevant cardiac vein.
458:, through to the right ventricle. The guide wire is then used to assist in the placement of the electrode lead, which travels through the venous system into the right ventricle where the electrode is embedded. 1077: 302:, contributing to poor left ventricular coordination and reduced systolic function, thereby reduced ejection fraction (<35%). This reduction in ejection fraction is considered heart failure. 840:"Effective cardiac resynchronization therapy for an adolescent patient with dilated cardiomyopathy seven years after mitral valve replacement and septal anterior ventricular exclusion" 660:
Choi, Anthony J.; Thomas, Sunu S.; Singh, Jagmeet P. (2016). "Cardiac Resynchronization Therapy and Implantable Cardioverter Defibrillator Therapy in Advanced Heart Failure".
313:(NICE) guidelines state that CRT-D device placement is inappropriate for class IV heart failure, but placement of CRT-P devices may be appropriate in certain circumstances. 431:
of cardiac resynchronization therapy with defibrillator (CRT-D) in an individual with dilated cardiomyopathy after mitral valve replacement (MVR). The leads are:
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of cannulation. However, this risk can be reduced using AI-based preoperative visualization of LV venous anatomy using computer tomography (CT) imaging.
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NICE Guidelines for Treatment Options with ICD or CRT for Heart Failure Patients with Left Ventricular Dysfunction with an LVEF of 35% or less
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Brambatti, M.; Guerra, F.; Matassini, M. V.; Cipolletta, L.; Barbarossa, A.; Urbinati, A.; Marchesini, M.; Capucci, A. (5 February 2013).
531:). A 2013 study showed that CRT improved the left ventricular ejection fraction (LVEF) by an average of 10.6% 12 months after placement. 68: 1902: 1228: 1324: 467: 466:
This is generally performed subsequent to RV lead placement, with the RV lead providing a backup in case of accidental damage to the
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Mountney, P.; Behar, J. M.; Toth, D.; Panayiotou, M.; Reiml, S.; Jolly, M. P.; Karim, R.; Zhang, L.; Brost, A. (November 2017).
1722: 1312: 275: 57: 1597: 607:"Cardiac Resynchronization Therapy Technique: Approach Considerations, Placement of Pacing Leads, Programming of Device" 1976: 1847: 1523: 1428: 644: 108: 1186: 979:"Cardiac resynchronization therapy improves ejection fraction and cardiac remodelling regardless of patients' age" 1735: 1542: 783:"Indications of Cardiac Resynchronization in Non-Left Bundle Branch Block: Clinical Review of Available Evidence" 707:"Implantable cardioverter defibrillators and cardiac resynchronisation therapy for arrhythmias and heart failure" 838:
Mima, Takahiro; Baba, Shiro; Yokoo, Noritaka; Kaichi, Shinji; Doi, Takahiro; Doi, Hiraku; Heike, Toshio (2010).
478:. The catheter is subsequently maneuvered to the opening of the coronary sinus in the right atrium. From here a 1835: 1532: 82: 46: 1857: 900:"A Machine Learning-Based Approach for Automatic Coronary Sinus Vein Segmentation and Anatomy Reconstruction" 424: 1981: 1842: 1830: 1711: 1358: 508: 290:(LBBB) of the heart, a cardiac abnormality leading to delayed left ventricular contraction. LBBB causes a 1957: 1179: 734:"Indications for Cardiac Resynchronization Therapy: A Comparison of the Major International Guidelines" 1789: 1679: 1482: 1433: 1223: 1868: 1852: 1319: 1302: 287: 154: 174: 1864: 1806: 1706: 1671: 1517: 35: 1910: 520: 606: 1941: 1745: 1666: 1915: 1472: 1285: 1280: 1171: 544: 487: 899: 8: 1794: 1772: 1458: 1297: 1270: 299: 263:. Right ventricular access is direct, while left ventricular access is conferred via the 1777: 1690: 1686: 1632: 1627: 1568: 1489: 1397: 1346: 1260: 1113: 1058: 874: 839: 815: 782: 474:. As with the RV lead, a guide wire is first inserted, allowing for the insertion of a 511:, is generally no larger than a pocket watch and has inserts for the electrode leads. 1820: 1766: 1696: 1604: 1592: 1453: 1443: 1438: 1341: 1292: 1203: 1157: 1149: 1105: 1097: 1062: 1050: 1008: 1000: 959: 951: 879: 861: 820: 802: 763: 755: 685: 677: 640: 442:
approach from the appropriate vein. From here, the leads and device can be inserted.
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is made, and a guide wire inserted into the vein, where it is guided, with use of
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Bleeding and pocket haematoma, each of which with an incidence of less than 1%
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Several studies have also shown that CRT can decrease mortality, reverse
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Henin, M; Ragy, H; Mannion, J; David, S; Refila, B; Boles, U (2020).
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Inability to cannulate coronary sinus (approximately 5% of patients)
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Dissection or perforation of coronary sinus which can in turn cause
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by coordinating the function of the left and right ventricles via a
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is injected, allowing the surgical team to obtain a coronary sinus
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The insertion of electrodes into the ventricles is done under
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to direct the placement of the lead into the most suitable
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Leyva, Francisco; Nisam, Seah; Auricchio, Angelo (2014).
225:, a small device inserted into the anterior chest wall. 305:
Heart failure patients are generally considered if in
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Normand, C; Linde, C; Singh, J; Dickstein, K (2018).
927: 837: 445: 437:- Left ventricular lead through the coronary sinus. 49:. Unsourced material may be challenged and removed. 461: 711:National Institute for Health and Care Excellence 311:National Institute for Health and Care Excellence 274:) also incorporate the additional function of an 1968: 566:, all of which have an incidence of less than 1% 930:"20 Years of Cardiac Resynchronization Therapy" 659: 213:of the heart, as well as on occasion the right 970: 353:ICD only if high risk of sudden cardiac death 309:(NYHA) class II or III heart failure. Current 1187: 989:(5). Oxford University Press (OUP): 704–710. 934:Journal of the American College of Cardiology 653: 255:, although access may be conferred from the 831: 701: 699: 1229:Cardiology diagnostic tests and procedures 1194: 1180: 129: 1325:Transcatheter pulmonary valve replacement 1044: 994: 945: 921: 873: 855: 814: 774: 749: 109:Learn how and when to remove this message 1368:shunt from heart chamber to blood vessel 696: 423: 228:CRT is indicated in patients with a low 1468:shunt from blood vessel to blood vessel 639:. USA: Elsevier Saunders. p. 379. 634: 1969: 400:≥150 milliseconds with or without LBBB 276:implantable cardioverter-defibrillator 1598:Valve-sparing aortic root replacement 1337:enlargement of existing septal defect 1175: 433:- Atrial lead at the right appendage 1332:production of septal defect in heart 1082:IEEE Transactions on Medical Imaging 630: 628: 626: 601: 599: 597: 595: 593: 591: 589: 435:- Right ventricular lead at the apex 47:adding citations to reliable sources 18: 907:2023 Computing in Cardiology (CinC) 501: 58:"Cardiac resynchronization therapy" 13: 1429:transposition of the great vessels 1354:creation of septal defect in heart 14: 1993: 1729:Cardiac resynchronization therapy 844:Journal of Cardiothoracic Surgery 623: 586: 362:120–149 milliseconds without LBBB 195:Cardiac resynchronisation therapy 124:Cardiac resynchronization therapy 1953: 1952: 1033:JACC: Clinical Electrophysiology 534: 446:Right ventricular lead placement 23: 1736:Left atrial appendage occlusion 1124: 1069: 1019: 462:Left ventricular lead placement 232:(typically <35%) indicating 34:needs additional citations for 940:(10). Elsevier BV: 1047–1058. 890: 725: 381:120–149 milliseconds with LBBB 286:The key indication for CRT is 281: 1: 1858:Radionuclide ventriculography 579: 570: 1843:Myocardial perfusion imaging 1134:JACC: Cardiovascular Imaging 468:electric fibers of the heart 7: 1046:10.1016/j.jacep.2019.06.003 947:10.1016/j.jacc.2014.06.1178 539:Key complications include: 521:left ventricular remodeling 514: 16:Treatment for heart failure 10: 1998: 1450:for univentricular defect 1146:10.1016/j.jcmg.2014.09.002 751:10.1016/j.jchf.2018.01.022 307:New York Heart Association 1977:Cardiac electrophysiology 1950: 1929: 1901: 1790:Implantable loop recorder 1758: 1613: 1509: 1434:Arterial switch operation 1249: 1242: 1224:Interventional cardiology 1214: 674:10.1016/j.hfc.2016.03.010 419: 352: 323: 181: 167: 153: 137: 128: 123: 1869:Coronary catheterization 1359:Blalock–Hanlon procedure 1320:Mitral valve replacement 1303:Aortic valve replacement 1094:10.1109/TMI.2017.2720158 917:– via IEEE Xplore. 288:left bundle branch block 1865:Cardiac catheterization 1807:Electrophysiology study 1707:Radiofrequency ablation 1672:Alcohol septal ablation 996:10.1093/europace/eus376 476:multi-delivery catheter 456:real time X-ray imaging 1911:Impedance cardiography 1533:Coronary artery bypass 915:10.22489/CinC.2023.220 857:10.1186/1749-8090-5-47 637:Goldman-Cecil Medicine 611:emedicine.medscape.com 556:Myocardial perforation 438: 209:in the left and right 205:) is the insertion of 1942:Transcutaneous pacing 1746:Heart transplantation 1667:Ventricular reduction 1483:Blalock–Taussig shunt 662:Heart Failure Clinics 635:Goldman, Lee (2012). 427: 294:prolongation of ≥120 1916:Ballistocardiography 1473:systemic circulation 545:pericardial effusion 349:<120 milliseconds 270:CRT defibrillators ( 240:duration to >120 43:improve this article 1982:Implants (medicine) 1795:Cardiac stress test 1773:Electrocardiography 1712:Pacemaker insertion 1459:Kawashima procedure 1423:compound procedures 1298:Aortic valve repair 1271:Mitral valve repair 787:Cardiology Research 738:JACC: Heart Failure 318: 1848:Cardiovascular MRI 1778:Vectorcardiography 1633:Pericardial window 1628:Pericardiocentesis 1569:Drug-eluting stent 1398:Rastelli procedure 1347:Balloon septostomy 439: 316: 1964: 1963: 1821:Angiocardiography 1767:Electrophysiology 1754: 1753: 1697:Catheter ablation 1680:Conduction system 1605:LeCompte maneuver 1593:Bentall procedure 1454:Norwood procedure 1444:Senning procedure 1439:Mustard procedure 1342:Atrial septostomy 1293:Valve replacement 1140:(12): 1239–1248. 1088:(11): 2366–2375. 429:Chest radiographs 417: 416: 300:electrocardiogram 230:ejection fraction 192: 191: 119: 118: 111: 93: 1989: 1956: 1955: 1921:Cardiotocography 1889: 1853:Ventriculography 1826:Echocardiography 1817: 1769: 1685:Maze procedure ( 1682: 1648: 1624: 1577: 1576:Obstacle removal 1564:Bare-metal stent 1560: 1520: 1477:pulmonary artery 1469: 1424: 1409:pulmonary artery 1382:Fontan procedure 1377:pulmonary artery 1369: 1333: 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356:Not indicated 354: 351: 345: 344: 341: 338: 335: 332: 326: 325: 322: 283: 280: 265:coronary sinus 261:cephalic veins 190: 189: 182: 179: 178: 171: 165: 164: 157: 151: 150: 141: 135: 134: 126: 125: 117: 116: 31: 29: 22: 15: 9: 6: 4: 3: 2: 1994: 1983: 1980: 1978: 1975: 1974: 1972: 1959: 1949: 1943: 1940: 1938: 1937:Cardioversion 1935: 1934: 1932: 1928: 1922: 1919: 1917: 1914: 1912: 1909: 1908: 1906: 1904: 1900: 1894: 1891: 1888: 1884: 1883: 1880: 1877: 1875: 1872: 1870: 1866: 1863: 1859: 1856: 1855: 1854: 1851: 1849: 1846: 1844: 1841: 1837: 1834: 1832: 1829: 1828: 1827: 1824: 1822: 1819: 1816: 1812: 1811: 1808: 1805: 1801: 1798: 1797: 1796: 1793: 1791: 1788: 1786: 1783: 1779: 1776: 1775: 1774: 1771: 1768: 1764: 1763: 1761: 1757: 1747: 1744: 1742: 1739: 1737: 1734: 1733: 1730: 1727: 1724: 1721: 1718: 1715: 1713: 1710: 1708: 1705: 1703: 1700: 1698: 1695: 1692: 1688: 1684: 1681: 1677: 1676: 1673: 1670: 1668: 1665: 1663: 1660: 1658: 1657:Dor procedure 1655: 1653: 1650: 1647: 1643: 1642: 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ICD-9-CM
00.51
00.54
MeSH
D058409
eMedicine
1839506-devices
edit on Wikidata
electrodes
ventricles
atrium
heart failure
pacemaker
ejection fraction
heart failure
QRS
ms
local anesthetic

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