58:
100:
294:
preferred targeting of these alpha-3 collagen chains specifically in the basal membranes of glomerular and alveolar capillaries can be explained by the higher accessible exposure of epitopes, a larger expansion of the alpha-3 collagen units, and because these alpha-3 collagen chains structurally provide higher accessibility for the targeting antibodies. These antibodies bind their reactive
179:
293:
production of anti-GBM antibodies. The major target of these abnormal antibodies is the non-collagen domain of the alpha-3 chain of type 4 collagen, which is mostly found in the basal membranes of glomerular and alveolar capillaries, explaining the obscurely specific symptoms of this condition. This
194:
primarily attack the kidneys and lungs, although, generalized symptoms like malaise, weight loss, fatigue, fever, and chills are also common, as are joint aches and pains. 60â80% of those with the condition experience both lung and kidney involvement; 20â40% have kidney involvement alone, and less
281:). Exposure to dry cleaning chemicals and paraquat herbicide have also been implicated as potential insults. In GPS, anti-GBM antibodies are produced and circulated throughout the bloodstream, damaging the membranes lining the lungs and kidneys as well as targeting their capillaries.
319:
The diagnosis of GPS is often difficult, as numerous other diseases can cause the various manifestations of the condition and the condition itself is rare. The most accurate means of achieving the diagnosis is testing the affected tissues by means of a
403:
demonstrated that in patients requiring renal replacement therapy (including dialysis) the median survival time is 5.93 years. Without treatment, virtually every affected person will die from either advanced kidney failure or lung hemorrhages.
324:, especially the kidney, as it is the best-studied organ for obtaining a sample for the presence of anti-GBM antibodies. On top of the anti-GBM antibodies implicated in the disease, about one in three of those affected also has
1029:
1009:
298:
to the basement membranes and activate the complement cascade, leading to the death of tagged cells. A specific antibody and epitope binding that shows the highest affinity and is pathogenic occurs between
51:
Goodpasture's syndrome, Goodpasture disease, Goodpasture's disease, antiâglomerular basement membrane disease, antiâglomerular basement membrane antibody disease, anti-GBM disease, anti-GBM antibody disease
801:
331:
In addition, if there is substantial suspicion of the disease, serologic testing for ELISA assay is usually done by looking for alpha3 NC1 domain area of collagen IV in order to avoid false positives.
249:. In addition to genetic susceptibility, an initial environmental insult to the pulmonary vasculature is needed to allow the anti-glomerular basement membrane (anti-GBM) antibodies to reach the
328:
in their bloodstream, which often predates the anti-GBM antibodies by about a few months or even years. The later the disease is diagnosed, the worse the outcome is for the affected person.
139:, which has therefore been referred to as Goodpasture's antigen. Goodpasture syndrome may quickly result in permanent lung and kidney damage, often leading to death. It is treated with
667:
1368:
724:
2090:
1847:
395:
With treatment, the five-year survival rate is >80% and fewer than 30% of affected individuals require long-term dialysis. A study performed in
223:. Some other signs and symptoms that could be used to identify Goodpasture syndrome during a physical exam include an increased respiratory rate,
1979:
1361:
2585:
2785:
2724:
1249:
1143:
351:
contains the anti-GBM antibodies that attack the affected person's lungs and kidneys, and is filtered out. The other parts of the blood (the
481:"Recurrence of Goodpasture syndrome without circulating anti-glomerular basement membrane antibodies after kidney transplant, a case report"
2516:
2426:
2250:
2702:
2663:
2580:
2240:
1354:
380:
2641:
949:
Kathuria, P; Sanghera, P; Stevenson, FT; Sharma, S; Lederer, E; Lohr, JW; Talavera, F; Verrelli, M (21 May 2013). Batuman, C (ed.).
883:
Kathuria, P; Sanghera, P; Stevenson, FT; Sharma, S; Lederer, E; Lohr, JW; Talavera, F; Verrelli, M (21 May 2013). Batuman, C (ed.).
774:
Kathuria, P; Sanghera, P; Stevenson, FT; Sharma, S; Lederer, E; Lohr, JW; Talavera, F; Verrelli, M (21 May 2013). Batuman, C (ed.).
639:
Kathuria, P; Sanghera, P; Stevenson, FT; Sharma, S; Lederer, E; Lohr, JW; Talavera, F; Verrelli, M (21 May 2013). Batuman, C (ed.).
2790:
2590:
1930:
1925:
1526:
2326:
1881:
2675:
2632:
2469:
2085:
1703:
2795:
2366:
2210:
2447:
2331:
2310:
1972:
1044:
416:
in that it is more common in males than in females and is also less common in blacks than whites, but more common in the
2557:
1295:
454:
2235:
1920:
1698:
1310:
1274:
1136:
982:
2714:
2509:
1557:
1235:
383:
antibodies so as to prevent further damage to the kidneys and lungs. Other, less toxic immunosuppressants such as
363:) are recycled and intravenously reinfused. Most individuals affected by the disease also need to be treated with
2685:
2431:
1739:
1601:
1305:
1693:
1279:
1965:
732:
1596:
412:
GPS is rare, affecting about 0.5â1.8 per million people per year in Europe and Asia. It is also unusual among
2562:
2288:
1819:
69:
2770:
1876:
1129:
838:
Marques, C., et al. (2020). Review on anti-glomerular basement membrane disease or
Goodpasture's syndrome.
187:
28:
2502:
1957:
1778:
1581:
1300:
17:
2544:
2611:
2174:
2125:
2034:
1809:
1487:
1201:
136:
2667:
2572:
2484:
2457:
2136:
1839:
1662:
1266:
99:
2775:
2719:
2645:
1753:
1522:
1508:
1254:
1055:
434:
2780:
2023:
1626:
1389:
1168:
950:
240:
140:
1183:
775:
640:
307:, which is residues 17-31 of the alpha 3 subunit of non-collagenous domain of type IV collagen.
2552:
2338:
2105:
2064:
1757:
1211:
1160:
815:
725:"Goodpasture syndrome | Genetic and Rare Diseases Information Center (GARD) â an NCATS Program"
270:
1095:
884:
1335:
278:
167:
420:
of New
Zealand. The peak age ranges for the onset of the disease are 20â30 and 60â70 years.
311:
are also implicated, though it is generally considered a type II hypersensitivity reaction.
2606:
1915:
1910:
1894:
1804:
1734:
1503:
1346:
1191:
1173:
57:
1622:
8:
2266:
1152:
1033:
864:
Borza, D., et al. (2003). Pathogenesis of
Goodpasture syndrome: a molecular perspective.
1937:
554:"The significance of certain pulmonary lesions in relation to the etiology of influenza"
2749:
2744:
2627:
2535:
2388:
2059:
1942:
1824:
1814:
1708:
1634:
1606:
1586:
1423:
1381:
1038:
616:
573:
515:
480:
413:
250:
228:
163:
128:
120:
604:
591:
Salama AD, Levy JB, Lightstone L, Pusey CD (September 2001). "Goodpasture's disease".
2404:
2080:
2075:
1644:
1639:
1439:
1428:
1066:
915:
699:
608:
569:
520:
502:
364:
356:
124:
80:
620:
577:
2494:
2355:
2199:
2101:
2050:
2005:
1688:
1539:
1534:
1475:
1402:
1377:
1196:
600:
565:
510:
492:
368:
148:
1106:
2692:
2680:
2155:
1829:
1799:
1683:
1611:
1465:
1418:
1060:
986:
352:
239:
While the exact cause is unknown, the genetic predisposition to GPS involves the
911:
693:
668:"Goodpasture Syndrome: Diffuse Alveolar Hemorrhage and Pulmonary-Renal Syndrome"
417:
2525:
2452:
1713:
1667:
1460:
340:
152:
144:
132:
1109:
1071:
1018:
497:
2764:
2245:
1997:
1888:
1480:
506:
948:
882:
773:
638:
2706:
1783:
1573:
1455:
1444:
1220:
919:
703:
612:
524:
384:
348:
290:
212:
117:
1987:
979:
479:
Thibaud, V.; Rioux-Leclercq, N.; Vigneau, C.; Morice, S. (December 2019).
277:, high-oxygen environments, and antilymphocyte therapies (especially with
2190:
1470:
1450:
1434:
1090:
400:
262:
253:. Examples of such an insult include: exposure to organic solvents (e.g.
200:
89:
1001:
372:
344:
254:
216:
191:
156:
93:
85:
65:
1121:
215:. Lung symptoms usually antedate kidney symptoms and usually include:
195:
than 10% have lung involvement alone. Kidney symptoms usually include
1101:
851:
Greco, A., et al. (2015). Goodpasture's syndrome: A clinical update.
538:
396:
376:
360:
343:, a procedure in which the affected person's blood is sent through a
196:
73:
553:
1989:
429:
295:
245:
224:
220:
478:
2418:
1993:
1393:
308:
266:
258:
1049:
72:
that was shown to be antiâglomerular basement membrane disease,
1762:
1243:
1229:
1013:
325:
321:
274:
208:
2463:
1729:
1397:
219:, chest pain (in less than 50% of cases overall), cough, and
204:
1376:
2226:
2165:
2146:
2116:
2014:
1022:
178:
162:
The disease was first described by an
American pathologist
347:
and the various components separated based on weight. The
127:
in lungs and kidneys, leading to bleeding from the lungs,
590:
303:
antibodies and the anti-GBM epitope region, designated E
692:
DeVrieze, Bradley; Hurley, John (26 September 2022).
2524:
991:
698:. Treasure Island, FL, US: StatPearls Publishing.
27:"Goodpasture" redirects here. For other uses, see
951:"Goodpasture Syndrome Treatment & Management"
2762:
1848:Transfusion-associated graft-versus-host disease
910:Devrieze, B. W.; Hurley, J. A. (25 March 2020).
820:NORD (National Organization for Rare Disorders)
909:
691:
551:
2725:Eosinophilic granulomatosis with polyangiitis
2510:
1973:
1362:
1250:Eosinophilic granulomatosis with polyangiitis
1137:
641:"Goodpasture Syndrome Clinical Presentation"
2251:Transient bullous dermolysis of the newborn
665:
339:The major mainstay of treatment for GPS is
141:medications that suppress the immune system
2517:
2503:
2241:Recessive dystrophic epidermolysis bullosa
1980:
1966:
1369:
1355:
1144:
1130:
182:Diagram of a monomeric (one-unit) antibody
170:in 1919 and was later named in his honor.
98:
56:
514:
496:
114:antiâglomerular basement membrane disease
980:GBM antibodies: immunofluorescence image
177:
2591:Membranoproliferative/mesangiocapillary
1882:Allergic bronchopulmonary aspergillosis
1151:
944:
942:
940:
938:
936:
878:
876:
874:
769:
326:cytoplasmic antineutrophilic antibodies
137:the alpha-3 subunit of type IV collagen
14:
2763:
2086:Spondyloepiphyseal dysplasia congenita
767:
765:
763:
761:
759:
757:
755:
753:
751:
749:
634:
632:
630:
2498:
2367:Ullrich congenital muscular dystrophy
2211:Ullrich congenital muscular dystrophy
1961:
1704:Post-streptococcal glomerulonephritis
1350:
1125:
205:unexplained swelling of limbs or face
173:
2786:Systemic connective tissue disorders
2448:Congenital stromal corneal dystrophy
933:
871:
840:The Journal of Internal Medicine, 41
2332:Otospondylomegaepiphyseal dysplasia
2311:Schmid metaphyseal chondrodysplasia
746:
627:
387:may be used to maintain remission.
269:inhalation, metal dust inhalation,
24:
1296:Acute hemorrhagic edema of infancy
379:, to prevent the formation of new
284:
25:
2807:
2327:WeissenbacherâZweymĂŒller syndrome
2236:Epidermolysis bullosa dystrophica
2091:Spondyloepimetaphyseal dysplasia,
1921:Autoimmune polyendocrine syndrome
1311:Cutaneous small-vessel vasculitis
1275:Cutaneous small-vessel vasculitis
973:
659:
209:high amounts of urea in the blood
2715:Granulomatosis with polyangiitis
2526:Disease of the kidney glomerules
2427:Junctional epidermolysis bullosa
1558:Hemolytic disease of the newborn
1236:Granulomatosis with polyangiitis
570:10.1097/00000441-191911000-00012
2791:Syndromes affecting the kidneys
2432:Laryngoonychocutaneous syndrome
1740:Subacute bacterial endocarditis
1602:Immune thrombocytopenic purpura
1306:Bullous small vessel vasculitis
903:
858:
845:
832:
808:
794:
407:
257:) or hydrocarbons, exposure to
123:in which antibodies attack the
717:
685:
584:
545:
531:
472:
447:
13:
1:
2289:Multiple epiphyseal dysplasia
1820:Postorgasmic illness syndrome
885:"Goodpasture Syndrome Workup"
666:Schwarz, MI (November 2013).
605:10.1016/S0140-6736(01)06077-9
440:
70:crescentic glomerulonephritis
2796:Syndromes affecting the lung
1877:Hypersensitivity pneumonitis
390:
334:
314:
188:glomerular basement membrane
159:are removed from the blood.
29:Goodpasture (disambiguation)
7:
2586:Endocapillary proliferative
1943:Systemic autoimmune disease
1779:Allergic contact dermatitis
1699:Hypersensitivity vasculitis
1582:Autoimmune hemolytic anemia
1301:Cryoglobulinemic vasculitis
423:
243:(HLA) system, specifically
10:
2812:
1449:common allergies include:
1202:Thromboangiitis obliterans
866:Seminars in Nephrology, 23
289:GPS is caused by abnormal
261:smoke, infection (such as
135:. It is thought to attack
110:Goodpasture syndrome (GPS)
26:
2737:
2701:
2668:Type III hypersensitivity
2662:
2640:
2624:
2599:
2571:
2543:
2532:
2480:
2440:
2417:
2397:
2381:
2348:
2319:
2303:
2281:
2259:
2225:
2189:
2164:
2145:
2115:
2049:
2013:
2004:
1903:
1869:
1860:
1838:
1792:
1771:
1752:
1722:
1676:
1661:
1620:
1572:
1565:
1551:
1521:
1496:
1411:
1388:
1323:
1288:
1267:Type III hypersensitivity
1265:
1219:
1210:
1182:
1159:
1081:
995:
729:rarediseases.info.nih.gov
672:Merck Manual Professional
498:10.1186/s12882-018-1197-6
79:
64:
55:
47:
42:
2720:Microscopic polyangiitis
2646:Type II hypersensitivity
1694:HenochâSchönlein purpura
1509:Eosinophilic esophagitis
1255:Microscopic polyangiitis
853:Autoimmunity Reviews, 14
435:Pulmonary-renal syndrome
234:
2581:Mesangial proliferative
2024:Osteogenesis imperfecta
1810:Hashimoto's thyroiditis
1597:GuillainâBarrĂ© syndrome
552:Goodpasture EW (1919).
459:www.hopkinsmedicine.org
241:human leukocyte antigen
34:Rare autoimmune disease
2339:Type XI collagenopathy
2175:EhlersâDanlos syndrome
2126:EhlersâDanlos syndrome
2106:Type II collagenopathy
2035:EhlersâDanlos syndrome
1911:Autoimmune adrenalitis
912:"Goodpasture Syndrome"
816:"Goodpasture Syndrome"
802:"Goodpasture Syndrome"
776:"Goodpasture Syndrome"
695:"Goodpasture Syndrome"
455:"Goodpasture Syndrome"
183:
2686:diffuse proliferative
2458:UrbachâWiethe disease
2295:(types 2, 3, & 6)
2137:SackâBarabas syndrome
2041:(types 1, 2, & 7)
279:monoclonal antibodies
181:
168:Vanderbilt University
2654:Goodpasture syndrome
1916:Autoimmune hepatitis
1895:Transplant rejection
1805:Giant cell arteritis
1735:Rheumatoid arthritis
1592:Goodpasture syndrome
1504:Autoimmune urticaria
1331:Goodpasture syndrome
1192:Polyarteritis nodosa
1174:Giant cell arteritis
1169:Takayasu's arteritis
251:alveolar capillaries
231:, and hypertension.
201:protein in the urine
43:Goodpasture syndrome
2771:Autoimmune diseases
1382:autoimmune diseases
1153:Systemic vasculitis
804:. 19 November 2019.
414:autoimmune diseases
221:shortness of breath
213:high blood pressure
2750:glomerulonephrosis
2745:glomerulonephritis
2676:Post-streptococcal
2389:Bullous pemphigoid
2060:Hypochondrogenesis
1825:Reactive arthritis
1815:Multiple sclerosis
1709:Reactive arthritis
1607:Pemphigus vulgaris
1587:Bullous pemphigoid
1488:Penicillin allergy
1424:Allergic urticaria
1336:Sneddon's syndrome
1082:External resources
985:2007-03-22 at the
955:Medscape Reference
889:Medscape Reference
780:Medscape Reference
645:Medscape Reference
461:. 19 November 2019
367:drugs, especially
229:hepatosplenomegaly
197:blood in the urine
184:
174:Signs and symptoms
164:Ernest Goodpasture
129:glomerulonephritis
121:autoimmune disease
2758:
2757:
2733:
2732:
2620:
2619:
2545:Non-proliferative
2492:
2491:
2413:
2412:
2405:Knobloch syndrome
2181:(types 1 & 2)
2132:(types 3 & 4)
2081:Marshall syndrome
2076:Stickler syndrome
1955:
1954:
1951:
1950:
1856:
1855:
1748:
1747:
1657:
1656:
1653:
1652:
1645:Pernicious anemia
1640:Myasthenia gravis
1517:
1516:
1440:Atopic dermatitis
1429:Allergic rhinitis
1344:
1343:
1319:
1318:
1119:
1118:
599:(9285): 917â920.
430:HLA-DR § DR2
365:immunosuppressant
357:white blood cells
217:coughing up blood
125:basement membrane
107:
106:
37:Medical condition
16:(Redirected from
2803:
2638:
2637:
2541:
2540:
2519:
2512:
2505:
2496:
2495:
2485:fibrous proteins
2470:DFNA8/12, DFNB21
2374:
2371:
2363:
2360:
2356:Bethlem myopathy
2336:
2296:
2293:
2274:
2271:
2267:Fuchs' dystrophy
2218:
2215:
2207:
2204:
2200:Bethlem myopathy
2182:
2179:
2133:
2130:
2102:Kniest dysplasia
2097:
2096:(Strudwick type)
2094:
2071:
2068:
2042:
2039:
2031:
2028:
2011:
2010:
2006:Collagen disease
1982:
1975:
1968:
1959:
1958:
1938:Sjögren syndrome
1867:
1866:
1769:
1768:
1674:
1673:
1570:
1569:
1549:
1548:
1409:
1408:
1378:Hypersensitivity
1371:
1364:
1357:
1348:
1347:
1217:
1216:
1197:Kawasaki disease
1146:
1139:
1132:
1123:
1122:
993:
992:
967:
966:
964:
962:
946:
931:
930:
928:
926:
907:
901:
900:
898:
896:
880:
869:
862:
856:
849:
843:
836:
830:
829:
827:
826:
812:
806:
805:
798:
792:
791:
789:
787:
771:
744:
743:
741:
740:
731:. Archived from
721:
715:
714:
712:
710:
689:
683:
682:
680:
678:
663:
657:
656:
654:
652:
636:
625:
624:
588:
582:
581:
549:
543:
542:
535:
529:
528:
518:
500:
476:
470:
469:
467:
466:
451:
369:cyclophosphamide
149:cyclophosphamide
112:, also known as
103:
102:
60:
40:
39:
21:
2811:
2810:
2806:
2805:
2804:
2802:
2801:
2800:
2776:Kidney diseases
2761:
2760:
2759:
2754:
2729:
2697:
2658:
2631:
2626:
2616:
2595:
2567:
2558:Focal segmental
2534:
2528:
2523:
2493:
2488:
2476:
2436:
2409:
2393:
2377:
2372:
2369:
2361:
2358:
2344:
2334:
2315:
2299:
2294:
2291:
2277:
2272:
2269:
2255:
2221:
2216:
2213:
2205:
2202:
2185:
2180:
2177:
2160:
2156:Alport syndrome
2141:
2131:
2128:
2111:
2095:
2092:
2069:
2066:
2065:Achondrogenesis
2045:
2040:
2037:
2029:
2026:
2000:
1986:
1956:
1947:
1899:
1862:
1852:
1834:
1830:Type 1 diabetes
1800:Coeliac disease
1788:
1760:
1744:
1718:
1684:Arthus reaction
1665:
1649:
1635:Graves' disease
1616:
1612:Rheumatic fever
1561:
1529:
1513:
1492:
1419:Allergic asthma
1400:
1384:
1375:
1345:
1340:
1315:
1284:
1261:
1206:
1178:
1155:
1150:
1120:
1115:
1114:
1077:
1076:
1004:
987:Wayback Machine
976:
971:
970:
960:
958:
947:
934:
924:
922:
908:
904:
894:
892:
881:
872:
863:
859:
850:
846:
837:
833:
824:
822:
814:
813:
809:
800:
799:
795:
785:
783:
772:
747:
738:
736:
723:
722:
718:
708:
706:
690:
686:
676:
674:
664:
660:
650:
648:
637:
628:
589:
585:
550:
546:
537:
536:
532:
477:
473:
464:
462:
453:
452:
448:
443:
426:
410:
393:
353:red blood cells
337:
317:
306:
302:
287:
285:Pathophysiology
237:
176:
155:, in which the
145:corticosteroids
97:
38:
35:
32:
23:
22:
15:
12:
11:
5:
2809:
2799:
2798:
2793:
2788:
2783:
2781:Rare syndromes
2778:
2773:
2756:
2755:
2753:
2752:
2747:
2741:
2739:
2735:
2734:
2731:
2730:
2728:
2727:
2722:
2717:
2711:
2709:
2699:
2698:
2696:
2695:
2690:
2689:
2688:
2678:
2672:
2670:
2660:
2659:
2657:
2656:
2650:
2648:
2635:
2622:
2621:
2618:
2617:
2615:
2614:
2609:
2603:
2601:
2597:
2596:
2594:
2593:
2588:
2583:
2577:
2575:
2569:
2568:
2566:
2565:
2560:
2555:
2553:Minimal change
2549:
2547:
2538:
2530:
2529:
2522:
2521:
2514:
2507:
2499:
2490:
2489:
2481:
2478:
2477:
2475:
2474:
2473:
2472:
2460:
2455:
2453:Raine syndrome
2450:
2444:
2442:
2438:
2437:
2435:
2434:
2429:
2423:
2421:
2415:
2414:
2411:
2410:
2408:
2407:
2401:
2399:
2395:
2394:
2392:
2391:
2385:
2383:
2379:
2378:
2376:
2375:
2364:
2352:
2350:
2346:
2345:
2343:
2342:
2329:
2323:
2321:
2317:
2316:
2314:
2313:
2307:
2305:
2301:
2300:
2298:
2297:
2285:
2283:
2279:
2278:
2276:
2275:
2263:
2261:
2257:
2256:
2254:
2253:
2248:
2243:
2238:
2232:
2230:
2223:
2222:
2220:
2219:
2208:
2196:
2194:
2187:
2186:
2184:
2183:
2171:
2169:
2162:
2161:
2159:
2158:
2152:
2150:
2143:
2142:
2140:
2139:
2134:
2122:
2120:
2113:
2112:
2110:
2109:
2099:
2088:
2083:
2078:
2073:
2062:
2056:
2054:
2047:
2046:
2044:
2043:
2032:
2020:
2018:
2008:
2002:
2001:
1998:scleroproteins
1985:
1984:
1977:
1970:
1962:
1953:
1952:
1949:
1948:
1946:
1945:
1940:
1935:
1934:
1933:
1928:
1918:
1913:
1907:
1905:
1901:
1900:
1898:
1897:
1892:
1886:
1885:
1884:
1873:
1871:
1864:
1858:
1857:
1854:
1853:
1851:
1850:
1844:
1842:
1836:
1835:
1833:
1832:
1827:
1822:
1817:
1812:
1807:
1802:
1796:
1794:
1790:
1789:
1787:
1786:
1781:
1775:
1773:
1766:
1750:
1749:
1746:
1745:
1743:
1742:
1737:
1732:
1726:
1724:
1720:
1719:
1717:
1716:
1714:Serum sickness
1711:
1706:
1701:
1696:
1691:
1686:
1680:
1678:
1671:
1668:Immune complex
1659:
1658:
1655:
1654:
1651:
1650:
1648:
1647:
1642:
1637:
1631:
1629:
1618:
1617:
1615:
1614:
1609:
1604:
1599:
1594:
1589:
1584:
1578:
1576:
1567:
1563:
1562:
1560:
1555:
1553:
1546:
1545:
1544:
1543:
1542:
1537:
1519:
1518:
1515:
1514:
1512:
1511:
1506:
1500:
1498:
1494:
1493:
1491:
1490:
1485:
1484:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1442:
1437:
1432:
1426:
1421:
1415:
1413:
1406:
1386:
1385:
1374:
1373:
1366:
1359:
1351:
1342:
1341:
1339:
1338:
1333:
1327:
1325:
1321:
1320:
1317:
1316:
1314:
1313:
1308:
1303:
1298:
1292:
1290:
1286:
1285:
1283:
1282:
1280:IgA vasculitis
1277:
1271:
1269:
1263:
1262:
1260:
1259:
1258:
1257:
1252:
1240:
1239:
1238:
1225:
1223:
1214:
1208:
1207:
1205:
1204:
1199:
1194:
1188:
1186:
1180:
1179:
1177:
1176:
1171:
1165:
1163:
1157:
1156:
1149:
1148:
1141:
1134:
1126:
1117:
1116:
1113:
1112:
1098:
1086:
1085:
1083:
1079:
1078:
1075:
1074:
1063:
1052:
1041:
1026:
1005:
1000:
999:
997:
996:Classification
990:
989:
975:
974:External links
972:
969:
968:
932:
902:
870:
868:(6), 522-531.
857:
855:(3), 246-253.
844:
831:
807:
793:
745:
716:
684:
658:
626:
583:
564:(6): 863â870.
544:
530:
485:BMC Nephrology
471:
445:
444:
442:
439:
438:
437:
432:
425:
422:
409:
406:
392:
389:
341:plasmapheresis
336:
333:
316:
313:
304:
300:
286:
283:
236:
233:
175:
172:
153:plasmapheresis
133:kidney failure
105:
104:
83:
77:
76:
62:
61:
53:
52:
49:
45:
44:
36:
33:
9:
6:
4:
3:
2:
2808:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2772:
2769:
2768:
2766:
2751:
2748:
2746:
2743:
2742:
2740:
2736:
2726:
2723:
2721:
2718:
2716:
2713:
2712:
2710:
2708:
2704:
2700:
2694:
2691:
2687:
2684:
2683:
2682:
2679:
2677:
2674:
2673:
2671:
2669:
2665:
2661:
2655:
2652:
2651:
2649:
2647:
2643:
2639:
2636:
2634:
2629:
2623:
2613:
2610:
2608:
2605:
2604:
2602:
2598:
2592:
2589:
2587:
2584:
2582:
2579:
2578:
2576:
2574:
2573:Proliferative
2570:
2564:
2561:
2559:
2556:
2554:
2551:
2550:
2548:
2546:
2542:
2539:
2537:
2531:
2527:
2520:
2515:
2513:
2508:
2506:
2501:
2500:
2497:
2487:
2486:
2479:
2471:
2468:
2467:
2466:
2465:
2461:
2459:
2456:
2454:
2451:
2449:
2446:
2445:
2443:
2439:
2433:
2430:
2428:
2425:
2424:
2422:
2420:
2416:
2406:
2403:
2402:
2400:
2396:
2390:
2387:
2386:
2384:
2380:
2368:
2365:
2357:
2354:
2353:
2351:
2347:
2340:
2333:
2330:
2328:
2325:
2324:
2322:
2318:
2312:
2309:
2308:
2306:
2302:
2290:
2287:
2286:
2284:
2280:
2268:
2265:
2264:
2262:
2258:
2252:
2249:
2247:
2246:Bart syndrome
2244:
2242:
2239:
2237:
2234:
2233:
2231:
2228:
2224:
2212:
2209:
2201:
2198:
2197:
2195:
2192:
2188:
2176:
2173:
2172:
2170:
2167:
2163:
2157:
2154:
2153:
2151:
2148:
2144:
2138:
2135:
2127:
2124:
2123:
2121:
2118:
2114:
2107:
2103:
2100:
2098:
2089:
2087:
2084:
2082:
2079:
2077:
2074:
2072:
2063:
2061:
2058:
2057:
2055:
2052:
2048:
2036:
2033:
2025:
2022:
2021:
2019:
2016:
2012:
2009:
2007:
2003:
1999:
1995:
1991:
1983:
1978:
1976:
1971:
1969:
1964:
1963:
1960:
1944:
1941:
1939:
1936:
1932:
1929:
1927:
1924:
1923:
1922:
1919:
1917:
1914:
1912:
1909:
1908:
1906:
1902:
1896:
1893:
1890:
1889:Latex allergy
1887:
1883:
1880:
1879:
1878:
1875:
1874:
1872:
1868:
1865:
1859:
1849:
1846:
1845:
1843:
1841:
1837:
1831:
1828:
1826:
1823:
1821:
1818:
1816:
1813:
1811:
1808:
1806:
1803:
1801:
1798:
1797:
1795:
1791:
1785:
1782:
1780:
1777:
1776:
1774:
1770:
1767:
1764:
1759:
1758:cell-mediated
1755:
1751:
1741:
1738:
1736:
1733:
1731:
1728:
1727:
1725:
1721:
1715:
1712:
1710:
1707:
1705:
1702:
1700:
1697:
1695:
1692:
1690:
1689:Farmer's lung
1687:
1685:
1682:
1681:
1679:
1675:
1672:
1669:
1664:
1660:
1646:
1643:
1641:
1638:
1636:
1633:
1632:
1630:
1628:
1624:
1619:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1579:
1577:
1575:
1571:
1568:
1564:
1559:
1556:
1554:
1550:
1547:
1541:
1538:
1536:
1533:
1532:
1531:
1530:
1528:
1524:
1520:
1510:
1507:
1505:
1502:
1501:
1499:
1495:
1489:
1486:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1448:
1447:
1446:
1443:
1441:
1438:
1436:
1433:
1430:
1427:
1425:
1422:
1420:
1417:
1416:
1414:
1410:
1407:
1404:
1399:
1395:
1391:
1387:
1383:
1379:
1372:
1367:
1365:
1360:
1358:
1353:
1352:
1349:
1337:
1334:
1332:
1329:
1328:
1326:
1322:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1293:
1291:
1287:
1281:
1278:
1276:
1273:
1272:
1270:
1268:
1264:
1256:
1253:
1251:
1248:
1247:
1246:
1245:
1241:
1237:
1234:
1233:
1232:
1231:
1227:
1226:
1224:
1222:
1218:
1215:
1213:
1209:
1203:
1200:
1198:
1195:
1193:
1190:
1189:
1187:
1185:
1184:Medium vessel
1181:
1175:
1172:
1170:
1167:
1166:
1164:
1162:
1158:
1154:
1147:
1142:
1140:
1135:
1133:
1128:
1127:
1124:
1111:
1108:
1104:
1103:
1099:
1097:
1093:
1092:
1088:
1087:
1084:
1080:
1073:
1069:
1068:
1064:
1062:
1058:
1057:
1053:
1051:
1047:
1046:
1042:
1040:
1036:
1035:
1031:
1027:
1024:
1020:
1016:
1015:
1011:
1007:
1006:
1003:
998:
994:
988:
984:
981:
978:
977:
956:
952:
945:
943:
941:
939:
937:
921:
917:
913:
906:
890:
886:
879:
877:
875:
867:
861:
854:
848:
841:
835:
821:
817:
811:
803:
797:
781:
777:
770:
768:
766:
764:
762:
760:
758:
756:
754:
752:
750:
735:on 2020-11-23
734:
730:
726:
720:
705:
701:
697:
696:
688:
673:
669:
662:
646:
642:
635:
633:
631:
622:
618:
614:
610:
606:
602:
598:
594:
587:
579:
575:
571:
567:
563:
559:
555:
548:
540:
539:"COL4A3 gene"
534:
526:
522:
517:
512:
508:
504:
499:
494:
490:
486:
482:
475:
460:
456:
450:
446:
436:
433:
431:
428:
427:
421:
419:
415:
405:
402:
398:
388:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
332:
329:
327:
323:
312:
310:
297:
292:
282:
280:
276:
272:
268:
264:
260:
256:
252:
248:
247:
242:
232:
230:
226:
222:
218:
214:
210:
206:
202:
198:
193:
189:
180:
171:
169:
165:
160:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
119:
115:
111:
101:
95:
91:
87:
84:
82:
78:
75:
71:
67:
63:
59:
54:
50:
46:
41:
30:
19:
2707:Pauci-immune
2703:Type III RPG
2653:
2600:By condition
2482:
2462:
2030:(types IâIV)
1988:Diseases of
1784:Mantoux test
1591:
1445:Food allergy
1330:
1242:
1228:
1221:Pauci-immune
1212:Small vessel
1161:Large vessel
1100:
1089:
1065:
1054:
1043:
1028:
1008:
959:. Retrieved
954:
923:. Retrieved
905:
893:. Retrieved
888:
865:
860:
852:
847:
842:(1), 14-20.
839:
834:
823:. Retrieved
819:
810:
796:
784:. Retrieved
779:
737:. Retrieved
733:the original
728:
719:
707:. Retrieved
694:
687:
675:. Retrieved
671:
661:
649:. Retrieved
644:
596:
592:
586:
561:
558:Am J Med Sci
557:
547:
533:
488:
484:
474:
463:. Retrieved
458:
449:
418:MÄori people
411:
408:Epidemiology
394:
385:azathioprine
338:
330:
318:
288:
244:
238:
227:, crackles,
185:
161:
113:
109:
108:
2664:Type II RPG
2612:Amyloidosis
1435:Anaphylaxis
1431:(Hay fever)
1091:MedlinePlus
925:20 December
401:New Zealand
291:plasma cell
263:influenza A
151:, and with
90:pulmonology
48:Other names
18:Goodpasture
2765:Categories
2642:Type I RPG
2563:Membranous
1996:and other
1904:Autoimmune
1793:Autoimmune
1723:Autoimmune
1566:Autoimmune
1497:Autoimmune
1067:DiseasesDB
825:2020-11-29
739:2020-12-01
709:20 January
465:2020-12-05
441:References
373:prednisone
345:centrifuge
271:bacteremia
255:chloroform
192:antibodies
157:antibodies
94:immunology
86:Nephrology
66:Micrograph
2628:nephritic
2625:Primarily
2536:nephrotic
2533:Primarily
2483:see also
1574:Cytotoxic
1289:Ungrouped
1102:eMedicine
507:1471-2369
397:Australia
391:Prognosis
377:rituximab
361:platelets
335:Treatment
315:Diagnosis
186:The antiâ
81:Specialty
74:PAS stain
2607:Diabetic
2373:(type 2)
2362:(type 2)
2273:(type 1)
2217:(type 1)
2206:(type 1)
2070:(type 2)
1990:collagen
1863:multiple
1861:Unknown/
1663:Type III
1627:receptor
1476:Tree nut
1025:M31.010)
983:Archived
961:14 March
920:29083697
914:. NCBI.
895:14 March
786:14 March
704:29083697
677:14 March
651:14 March
621:40175400
613:11567730
578:71773779
525:30621605
491:(1): 6.
424:See also
381:anti-GBM
296:epitopes
246:HLA-DR15
225:cyanosis
143:such as
116:, is a
2738:General
2419:Laminin
1994:laminin
1870:Foreign
1772:Foreign
1763:T cells
1754:Type IV
1677:Foreign
1552:Foreign
1523:Type II
1466:Seafood
1412:Foreign
1394:allergy
1110:ped/888
1107:med/923
1061:D019867
957:. WebMD
891:. WebMD
782:. WebMD
647:. WebMD
516:6323659
309:T cells
267:cocaine
259:tobacco
2398:COL18:
2382:COL17:
2370:
2359:
2349:COL12:
2335:
2320:COL11:
2304:COL10:
2292:
2270:
2214:
2203:
2178:
2129:
2093:
2067:
2038:
2027:
1891:(I+IV)
1623:Type V
1461:Peanut
1390:Type I
1244:p-ANCA
1230:c-ANCA
1096:000142
1050:233450
1039:446.21
918:
702:
619:
611:
593:Lancet
576:
523:
513:
505:
375:, and
359:, and
349:plasma
322:biopsy
275:sepsis
211:, and
190:(GBM)
131:, and
96:
2681:Lupus
2464:TECTA
2441:Other
2282:COL9:
2260:COL8:
1730:Lupus
1481:Wheat
1398:atopy
1324:Other
1019:M31.0
617:S2CID
574:S2CID
235:Cause
68:of a
2227:COL7
2191:COL6
2166:COL5
2147:COL4
2117:COL3
2051:COL2
2015:COL1
1931:APS2
1926:APS1
1840:GVHD
1527:ADCC
1456:Milk
1380:and
1072:5363
1056:MeSH
1045:OMIM
1034:9-CM
1023:ILDS
963:2014
927:2020
916:PMID
897:2014
788:2014
711:2023
700:PMID
679:2014
653:2014
609:PMID
521:PMID
503:ISSN
399:and
147:and
118:rare
2693:IgA
2633:RPG
1540:IgM
1535:IgG
1471:Soy
1451:Egg
1403:IgE
1030:ICD
1010:ICD
601:doi
597:358
566:doi
562:158
511:PMC
493:doi
265:),
166:of
2767::
1992:,
1625:"/
1105::
1094::
1070::
1059::
1048::
1037::
1017::
1014:10
953:.
935:^
887:.
873:^
818:.
778:.
748:^
727:.
670:.
643:.
629:^
615:.
607:.
595:.
572:.
560:.
556:.
519:.
509:.
501:.
489:20
487:.
483:.
457:.
371:,
355:,
299:GP
273:,
207:,
203:,
199:,
92:,
88:,
2705:/
2666:/
2644:/
2630:,
2518:e
2511:t
2504:v
2341:)
2337:(
2229::
2193::
2168::
2149::
2119::
2108:)
2104:(
2053::
2017::
1981:e
1974:t
1967:v
1765:)
1761:(
1756:/
1670:)
1666:(
1621:"
1525:/
1405:)
1401:(
1396:/
1392:/
1370:e
1363:t
1356:v
1145:e
1138:t
1131:v
1032:-
1021:(
1012:-
1002:D
965:.
929:.
899:.
828:.
790:.
742:.
713:.
681:.
655:.
623:.
603::
580:.
568::
541:.
527:.
495::
468:.
305:A
301:A
31:.
20:)
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