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176:. His original surname was Satō, but he changed it to his mother's maiden name, Shiga, after being brought up by his maternal family. Shiga was raised during Japan's Industrial age and restoration. The changing times put financial troubles on his family. In 1900, Kiyoshi Shiga married Ichiko Shiga and in the following years had eight children. He faced many family hardships. Shiga lost his wife in 1944 to stomach cancer, his eldest son to turbulent seas during a voyage, and another son to tuberculosis.
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strain vaccine, on himself which proved to be ineffective and caused severe complications. Kiyoshi Shiga continued his efforts and created a passive immunization vaccine that was based on horse serum. Test trials for the passive immunization vaccine showed no beneficial results or immunity to the
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as a tribute to
Kiyoshi Shiga. The discovery of the gram-negative bacillus led to the identification of other species of bacteria with similar characteristic. These species of bacteria are classified under the Shigella genus. Species of Shigella are further separated by serogroups that represent
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which was caused by a protozoan microorganism. Paul
Ehrlich is known for his work with dyes and their ability to distinguish and kill certain bacteria and tissues. Ehrlich's previous research, before working with Shiga, lead to the discovery of chemotherapy. Shiga and Ehrlich's research into
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chemotherapy dyes lead them to the discovery of trypan red, a drug that was proven to have an effect on trypanosomiasis. In 1905, after the discovery of trypan red, Shiga returned to Japan with an international reputation and continued his work at
Kitasato's laboratory.
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successors, who was a world famous
Japanese scientist studying the bacteriology and immunology of deadly disease at the time. Shiga's fascination with Kitasato and his work lead him to pursue a career at the Institute for the Study of Infectious Diseases directed by
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to fight the disease. Shiga was a supporter of vaccines, but also an advocate for public health prevention and awareness. He participated in many
Chinese writings about the education and prevention of diseases such as tuberculosis.
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at the
Institute for the Study of Infectious Diseases. While studying many infamous diseases at the time, Kitasato and his colleagues, including Shiga, turned their focus to discovering the microorganism that caused the
374:. In 1924, Shiga delivered a strain of tuberculosis called BCG Tokyo 172 strain from Paris, France to Japan. It was his transportation of the samples that lead scientist to culture and produce a vaccine and
251:, 1st class, on his death in 1957. Along with many of his accomplishments, Shiga had written textbooks on bacteriology and immunology that were widely popular, even after his death in 1957.
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which is produced by the bacteria. He conducted research on other diseases such as tuberculosis and trypanosomiasis, and made many advancements in bacteriology and immunology.
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outbreak in 1897. In 1898, Shiga was able to isolate and identify the microorganism causing the infectious disease by studying patients who had dysentery and following
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147:. He had a well-rounded education and career that led to many scientific discoveries. In 1897, Shiga was credited with the discovery and identification of the
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that is produced by the organism. With this new discovery, Shiga attempted to make a vaccine from the toxin. He tested his first attempt, a heat-killed
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in
Germany from 1901 to 1905. When he returned to Japan, he resumed the study of infectious diseases with Kitasato. Shiga became a professor at
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211:, in 1897, during a severe epidemic in which more than 90,000 cases were reported, with a mortality rate approaching 30%. The bacterium
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After graduating from the Tokyo
Imperial University school of medicine, Kiyoshi Shiga began his career as an assistant to
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736:"Danger in the Air: Tuberculosis Control and BCG Vaccination in the Republic of China, 1930–1949 | Cross-Currents"
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Trofa AF, Ueno-Olsen H, Oiwa R, Yoshikawa M (1999), "Dr. Kiyoshi Shiga: discoverer of the dysentery bacillus",
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infection. These setbacks led Shiga to stop any further trials or production of a Shiga toxin-based vaccine.
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in 1896, after his high school studies. It was at the
University when he was introduced to
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methods, Shiga was able to further deduce that the microorganism causing dysentery was a
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Csuros, Maria. Microbiological
Examination of Water and Wastewater. CRC Press (1999).
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throughout his career and grew an interest in chemotherapy and immunology. After the
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593:(4th ed.), Galveston (TX): University of Texas Medical Branch at Galveston,
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201:. While working for the Institute, Shiga became famous for the discovery of
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Kiyoshi Shiga also played a role in the development of the BCG vaccine for
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in Europe on discovering chemotherapy methods for a blood diseases called
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542:"The rediscovery of Shiga toxin and its role in clinical disease"
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Hale, Thomas L.; Keusch, Gerald T. (1996), Baron, Samuel (ed.),
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Shiga K (1898), "Ueber den Erreger der Dysenterie in Japan",
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in 1920. From 1929 to 1931, Shiga was the president of
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bacillus. Kiyoshi Shiga initially called the bacteria
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Kleinman. Pediatric Gastrointestinal Disease (2008).
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335:Shiga had done research on other topics aside from
546:Japanese Journal of Medical Science & Biology
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302:dysenteriae, but the name was later changed to
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156:microorganism which causes dysentery, and the
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184:Kiyoshi Shiga attended the Medical School of
838:Members of the Government-General of Chōsen
833:Academic staff of Keijō Imperial University
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628:"Shiga Kiyoshi | Japanese bacteriologist"
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318:bacteria, Shiga was able to discover the
215:was thus named after him, as well as the
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652:"Shiga Kiyoshi -- Britannica Academic"
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828:Recipients of the Order of Culture
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241:Japanese Governor-General of Korea
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471:Zentralbl Bakteriol Mikrobiol Hyg
314:. Through further studies of the
247:in 1944. He was also awarded the
488:Felsenfeld, Oscar (1957-07-19).
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243:. Shiga was a recipient of the
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16:Japanese physician (1871–1957)
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683:A History of Modern Chemistry
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818:People of Meiji-period Japan
506:10.1126/science.126.3264.113
435:Clinical Infectious Diseases
249:Order of the Sacred Treasure
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740:cross-currents.berkeley.edu
656:academic-eb-com.eres.qnl.qa
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269:Dark field microscopy of a
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823:University of Tokyo alumni
490:"K. Shiga, Bacteriologist"
233:Keijō Imperial University
186:Tokyo Imperial University
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95:Tokyo Imperial University
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798:Japanese microbiologists
793:Japanese bacteriologists
680:Hirota, Noboru (2016).
632:Encyclopedia Britannica
540:Keusch, G. T. (1998).
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35:Kiyoshi Shiga in 1924
591:Medical Microbiology
356:Shigella dysenteriae
279:Kitasato Shibasaburō
271:Shigella dysenteriae
223:, Shiga worked with
204:Shigella dysenteriae
199:Kitasato Shibasaburō
190:Kitasato Shibasaburō
548:. 51 Suppl: S5–22.
803:People from Sendai
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168:Shiga was born in
104:Medical Researcher
693:978-1-920901-14-1
600:978-0-9631172-1-2
288:Koch's Postulates
174:Miyagi Prefecture
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757:Bibliography
743:. Retrieved
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719:. Retrieved
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659:. Retrieved
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635:. Retrieved
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612:, retrieved
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372:tuberculosis
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344:tuberculosis
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72:(1957-01-25)
45:Kiyoshi Satō
813:1957 deaths
808:1871 births
340:dysenteriae
320:Shiga toxin
307:dysenteriae
260:dysenteriae
217:Shiga toxin
158:Shiga toxin
153:dysenteriae
83:Nationality
787:Categories
745:2021-03-21
721:2021-03-21
661:2021-03-19
637:2021-03-08
614:2021-03-08
587:"Shigella"
383:References
376:tuberculin
342:including
310:different
101:Occupation
51:1871-02-07
564:0021-5112
514:0036-8075
312:serotypes
284:dysentery
209:dysentery
192:, one of
141:physician
609:21413292
572:10211432
522:13442654
457:10524979
352:beriberi
337:Shigella
331:Research
304:Shigella
300:Bacillus
290:. Using
273:culture.
257:Shigella
221:Shigella
213:Shigella
150:Shigella
114:Shigella
86:Japanese
494:Science
348:leprosy
61:, Japan
776:
766:
711:"タイトル"
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350:, and
180:Career
170:Sendai
774:ISBN
764:ISBN
715:サイト名
688:ISBN
605:PMID
595:ISBN
568:PMID
560:ISSN
518:PMID
510:ISSN
453:PMID
143:and
128:志賀 潔
67:Died
41:Born
550:doi
502:doi
498:126
443:doi
235:in
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
