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terminal fiber into the synapse. This characteristic is true for fibers without neural input signals, such as pacemaker neurons, as mentioned previously, and cortical pyramidal neurons that have highly-irregular firing pattern. Noise generally hinders neural performance, but recent studies show, in dynamical non-linear neural networks, this statement does not always hold true. Non-linear neural networks are a network of complex neurons that have many connections with one another such as the neuronal systems found within our brains. Comparatively, linear networks are an experimental view of analyzing a neural system by placing neurons in series with each other.
177:: Generally, action potentials are transferred down a neuron, which then are converted to either electrical or chemical signals between neurons. Chemical synapses are not deterministic, which means that every action potential produced does not result in the release of neurotransmitters. Rather, the release of vesicles containing neurotransmitters are probabilistic in nature. The number of vesicles released by a single synapse is random in response to a specific input signal and is further influenced by the firing history of the pre- and post-synaptic neurons. This means that neurotransmitters can be released in the absence of an input signal.
20:
161:: Membrane embedded ATPase ion pumps produce fluctuating potentials by transporting ions against their concentration gradient. The multistep process in which ions are transported across their gradient requires ATP. The steps involved in active transport have a net forward direction, but small stochastic steps still exist in the conformational process that move backwards. These backward steps contribute to neuronal noise present in all dynamic neuronal circuits.
237:
auditory external noise to a stimuli, and measure how it affects reaction time or the subject's performance. If performance is more inconsistent than without the noise, the subject is said to have "internal noise." As in the case of "internal noise," it is not clear on what theoretical grounds researchers distinguish "external noise" from "external signal" in terms of the perceptual response of the viewer, which is a response to the stimulus as a whole.
204:: Noise that arises from the number of connections and non-uniformity that a neuron has with other neurons within a neuronal network. There is a stronger presence of sub-threshold noise when the interconnectivity is strengthened, or the number of connection to other neurons is increased. The opposite remains true, too. If the interconnectivity of the neurons is decreased so then is the level of sub-threshold noise.
167:: The number of ions that migrate through an open ion channel are discrete and random. In synapses, the number of calcium ions that enter the postsynaptic side after a spike is on the order of 250 ions, potentially making potentiation processes noisy. This noise is also associated with thermal fluctuations affecting the protein channels, as previously mentioned. This is not to be confused with
87:) confers to neurons more sensitivity to a broader range of inputs, it can equalize the efficacy of synaptic inputs located at different positions on the neuron, and it can also enable finer temporal discrimination. There are many theories of why noise is apparent in the neuronal networks, but many neurologists are unclear of why they exist.
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Initially, noise in complex computer circuit or neural circuits is thought to slow down and negatively affect the processing power. However, current research suggests that neuronal noise is beneficial to non-linear or complex neural networks up until optimal value. A theory by
Anderson and colleagues
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exist inside and outside of the neuron and are subject to many bodily conditions. One major source of noise arises from ions or molecules in response to the third law of thermodynamics. This law states that the entropy of a system approaches a constant value as the temperature approaches zero. Since
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More generally, two types of impacts of neuronal noise can be distinguished: it will either add variability to the neural response, or enable noise-induced dynamical phenomena which cannot be observed in a noise-free system. For instance, channel noise has been shown to induce oscillations in the
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assumes "neural noise" and speculates that external noise should multiplicatively increase the amount of internal noise in the central nervous system. It is not clear how "neural noise" is theoretically distinguished from "neural signal." Proponents of this paradigm believe that adding visual or
38:. These fluctuations are not associated with encoding a response to internal or external stimuli and can be from one to two orders of magnitude. Most noise commonly occurs below a voltage-threshold that is needed for an action potential to occur, but sometimes it can be present in the form of an
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Neuronal activity at the microscopic level has a stochastic character, with atomic collisions and agitation, that may be termed "noise." While it isn't clear on what theoretical basis neuronal responses involved in perceptual processes can be segregated into a "neuronal noise" versus a "signal"
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in the membrane undergo spontaneous changes in conformation between different states and can open (or close) due to thermal fluctuations. The transmembrane embedded protein channels are made up of small subunits that undergo conformational changes and are affected by thermal fluctuations. When
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and those who especially support the theory of distributed processing, propose that large neuronal populations effectively decrease noise by averaging out the noise in individual neurons. Some investigators have shown in experiments and in models that neuronal noise is a possible mechanism to
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Single neurons demonstrate different responses to specific neuronal input signals. This is commonly referred to as neural response variability. If a specific input signal is initiated in the dendrites of a neuron, then a hypervariability exists in the number of vesicles released from the axon
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are another major source of neural noise. More than often, there is random exocytosis of vesicles containing neurotransmitters, which eventually bind to the postsynaptic membrane, leading to a spontaneous action potential by graded potentials in the postsynaptic neuron. It is considered the
108:. Ions are constantly being leaked across the membrane in efforts to equalize the ionic gradient produced by ATPase channels embedded in the membrane. These leaky channels permit the movement of ions across the membrane leading to small fluctuations, or noise, in the membrane potential.
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still exists for the mechanism in which noise affects neural signal conduction. Instead, research has focused more on the sources of the noise present in dynamic neural networks. Several sources of response variability exist for neurons and neural networks:
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the body maintains temperatures above 0K, the molecules are subjected to increased kinetic energy, or motion. The stochastic, or random, movements give rise to receptor noise produced by the constant bombardment of ions, as described by
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temperature drops below 33 °C, the rate at which the channel becomes active or inactive decreases. In contrast when the temperature is increased above 33 °C, the rate at which the channel becomes active or inactive increases.
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due to intrinsic currents). Simple networks of neurons can also exhibit chaotic dynamics. Even if the chaos is deterministic, it can amplify noise from the other sources to macroscopic levels due to sensitive dependence on initial
183:: The large number of incoming spikes add a fluctuating amount of charge to the cell, which depends on the structure of the incoming spike trains and affects the cell's excitability.
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Another theory suggests that stochastic noise in a non-linear network shows a positive relationship between the interconnectivity and noise-like activity. Thus based on this theory,
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occurs due to the thermal motions of ions and other charge carriers, producing voltage fluctuations proportional to temperature. This source of noise is attributed to the
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supports that neural noise is beneficial. Their theory suggests that noise produced in the visual cortex helps linearize or smooth the threshold of action potentials.
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component, and how such a proposed dichotomy could be corroborated empirically, a number of computational models incorporating a "noise" term have been constructed.
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was crucial to determine shot noise because the use of intercellular recording was not able to show the movement or detection of the few ions escaping at a time.
144:, stating that kinetic energy of molecules increases with a raise in temperature. Thermal noise is the weakest source of noise and can be considered negligible.
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can be used to test the noise present in large neuronal networks. This measure of voltage can be used to determine the interconnectivity by the level of noise.
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in the blood allows for either vasoconstriction or vasodilation, which can encroach, or expand, into nearby neural networks producing noise.
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can be used to measure the brain since the signal-to-noise ratio is poor, so noise produced by the brain can be detected
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Local recording has contributed much to discovering many of the new sources of ion channel noise.
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210:: Noise can be produced on a larger scale due to fluctuations in CO
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312:"Subthreshold voltage noise of rat neocortical pyramidal neurones"
42:; for example, stochastic oscillations in pacemaker neurons in
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refers to the random intrinsic electrical fluctuations within
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Mysterious 'Neural Noise' Primes Brain for Peak
Performance
891:"Spontaneous subthreshold activity at motor nerve endings"
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214:, which lead to variations in blood flow. The level of CO
772:"Bayesian inference with probabilistic population codes"
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largest-amplitude noise source in the cerebral cortex.
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can occur in single cells (due to periodic inputs or
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Eckert animal physiology: mechanisms and adaptations
1021:"Current noise generated by electrogenic ion pumps"
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464:Destexhe, A. (2012).
273:Patch clamp technique
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298:References
169:shot noise
54:Background
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126:black box
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281:See also
195:bursting
112:Synapses
1199:Bibcode
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669:Bibcode
661:Science
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