359:. It does this via a filtration barrier. The renal corpuscle filtration barrier is composed of: the fenestrated endothelium of glomerular capillaries, the fused basal lamina of endothelial cells and podocytes, and the filtration slits of the podocytes. This barrier permits passage of water, ions, and small molecules from the bloodstream into Bowman's space (the space between the visceral and parietal layers). Large and/or negatively charged proteins are prevented from passing into Bowman's space, thus retaining these proteins in the circulation. The basal lamina is composed of 3 layers: lamina rara externa, lamina densa, and lamina rara interna. The lamina rara externa is adjacent to the podocyte processes. The lamina densa is the central layer consisting of type IV collagen and laminin. This layer acts as a selective macromolecular filter, preventing the passage of large protein molecules into Bowman's space. The lamina rara interna is adjacent to endothelial cells. This layer contains
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Diagram of the circulation related to a single glomerulus, associated tubule, and collecting system The renal corpuscle in the cortex (outer layer) of the kidney. At the top, the renal corpuscle containing the glomerulus. The filtered blood exits into the renal tubule as
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The renal corpuscle acts to filter blood. Fluid from blood in the glomerulus is collected in the Bowman's capsule to form "glomerular filtrate", which is then further processed along the nephron to form
163:, at right. At left, blood flows from the afferent arteriole (red), enters into the renal corpuscle and is filtered in the glomerulus; blood flows out of the efferent arteriole (blue).
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The Bowman's capsule has an outer parietal layer composed of simple squamous epithelium. The visceral layer, composed of modified simple squamous epithelium, is lined by
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enter and leave the glomerulus in the Bowman's capsule. The tubular pole is at the other end opposite to the vascular pole. At the tubular pole, the
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are modified smooth muscle cells that lie between the capillaries. They regulate blood flow by their contractile activity and secrete
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The renal corpuscle is composed of two structures, the glomerulus and the Bowman's capsule. The glomerulus is a small tuft of
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that contributes to the electrostatic barrier of the glomerular filter.
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545:"Image 9: Normal glomerulus with tubular and vascular poles"
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Image showing the main components of the renal corpusle.
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Blood-filtering component of the nephron of the kidney
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375:A renal corpuscle is also known as a
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262:- and a glomerular capsule known as
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363:, a negatively charged
321:podocyte foot processes
312:or filtration barrier.
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908:Collecting duct system
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218:Anatomical terminology
968:Juxtaglomerular cells
573:. Lange. p. 397.
396:Malpighian corpuscle
377:Malpighian corpuscle
298:extracellular matrix
250:. It consists of a
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1131:Lacunae of Morgagni
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1021:Circulation
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552:. Retrieved
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332:tubular pole
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258:composed of
254:- a tuft of
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110:October 2017
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52:Please help
47:verification
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940:Major calyx
935:Minor calyx
728:Circulation
381:named after
286:capillaries
256:capillaries
188:Identifiers
886:Descending
828:Glomerulus
794:interlobar
784:Vasa recta
774:Renal vein
749:interlobar
468:2021-04-15
445:References
421:Glomerulus
274:See also:
252:glomerulus
80:newspapers
1111:prostatic
1080:External
973:Mesangium
853:Mesangium
744:segmental
735:Arteries
510:cite book
502:192027371
392:biologist
388:physician
317:podocytes
306:cytokines
290:fenestrae
270:Structure
1158:Category
1096:Internal
1037:(female)
843:Podocyte
799:efferent
764:afferent
686:pyramids
427:is pink.
423:is red;
350:Function
346:arises.
174:Location
161:filtrate
1063:Urethra
1053:Trigone
1014:Bladder
996:Ureters
811:Nephron
789:arcuate
754:arcuate
718:Nephron
681:Medulla
664:Capsule
644:Kidneys
549:UKidney
398:in the
246:of the
244:nephron
180:of the
178:Nephron
169:Details
94:scholar
1121:spongy
1089:female
770:Veins
674:column
669:Cortex
659:Fascia
652:Layers
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400:spleen
371:Eponym
330:and a
304:, and
248:kidney
182:kidney
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698:Sinus
357:urine
222:[
211:15625
194:Latin
101:JSTOR
87:books
1084:male
703:Lobe
556:2024
516:link
498:OCLC
488:ISBN
390:and
338:and
278:and
238:(or
73:news
319:,
206:FMA
56:by
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