525:. AbbVie offered £46.11 per share (£27.3 billion or $ 46.5 billion in total). On 8 July, the offer was increased to $ 51.5 billion. On 18 July, it was announced that AbbVie would acquire Shire for $ 54.8 billion. On 15 October, news broke suggesting AbbVie was reconsidering their proposed takeover deal due to changes in US "Tax Inversion" law and on 16 October AbbVie's board recommended that shareholders vote against the deal. This news sent Shire's share price down over 27%; however, AbbVie would be subject to a $ 1.6 billion break-up fee, payable to Shire. On 21 October, the merger was called off.
368:
2993:
3513:
459:. Shire changed the name of ViroPharma to Shire Viropharma Inc. upon acquisition and on their final day of trading the company was valued at $ 3.3 billion. At $ 4.2 billion, ViroPharma set a new company record. In 2014 Shire acquired two rare disease drug companies: Fibrotech with its antifibrotic compounds for $ 75 million, and Lumena, a company researching rare gastro-intestinal and hepatic compounds, for $ 260 million.
1052:
36:
470:. On their final day of trading, NPS had a market capitalisation of $ 4.99 billion. The company also acquired, later in the same year, Meritage Pharma for $ 245 million, Foresight Biotherapeutics for $ 300 million and Dyax for $ 6.5 billion. The purchases bolstered Shires gastro-intestinal and rare disease sectors, with Phase-III-ready treatment -
1024:. The Justice Department alleged that Shire had improperly marketed and promoted Adderall XR, Daytrana, Vyvane, Pentasa, and Lialda during various periods between 2004 and 2010. The allegations included claims that Shire had made exaggerated and false statements regarding product safety, promoted medications for non-
454:
manufacturer
Advanced BioHealing. In 2012 the company acquired FerroKin BioSciences for $ 325 million along with FerroKins lead iron chelator - FBS0701. 2013 saw the company complete its highest number of acquisitions with Lotus Tissue Repair, Inc. (lead compound, ABH001), SARcode Bioscience Inc.,
413:
In 2001 the company acquired
Biochem Canada. Shire's next acquisition didn't come until 2005 when it acquired Transkaryotic Therapeutics and two years later – in 2007 – New River Pharmaceuticals Inc, for a then company record of $ 2.6 billion. With the purchase of New River, Shire gained access and
537:
had an approach to acquire Shire. Days later Shire announced they had rejected all three Takeda bids. The first bid valued the business at £41 billion (£28 per Shire shares paid in Takeda shares plus £16 per share in cash), the second £43 billion (£28.75 per Shire shares paid in Takeda shares plus
542:
however they ruled themselves out a day later. A day later Takeda increased their offer with a fourth bid, to £26 per Shire shares paid in Takeda shares plus £21 per share in cash - giving a total value of £44.3 billion ($ 62.1 billion). On 24 April, Takeda submitted an enhanced fifth bid for the
543:
company. On 25 April, Shire said that they will recommend the revised £45.8 billion ($ 64 billion) offer to their shareholders. The enhanced offer included a more generous cash component, with the deal offering £21.76 ($ 30.33) in cash for each Shire ordinary share. The same day,
2240:
2981:
2382:
478:. As well as expanding the company's pipeline with a late-stage treatment candidate for infectious conjunctivitis with lead candidate FST-100 and increasing the company's rare disease catalogue with Dyax's portfolio of plasma
1093:
441:
2010 saw a change in company strategy, with the company seeking to expand through mergers and acquisitions - culminating in the company becoming one of the most acquisitive in the industry. In 2010 the company acquired
2209:
2413:
405:. In 1997 the company acquired Pharmavene for £105 million in order to access Pharmavene's drug delivery methods. Later in the same year Shire acquired Richwood Pharmaceutical Company, forming Shire-Richwood Inc.
2321:
2974:
2822:
2644:
2290:
291:
company focused on serving people with rare diseases and other highly specialized conditions. The company's products were available in more than 100 countries across core therapeutic areas including
2444:
4314:
2959:
2967:
2611:
2533:
2502:
2247:
1937:
2852:
2390:
1305:
1184:
1040:
In August 2017, Shire reached a $ 350 million settlement with the
Department of Justice for violations of the same act, regarding the unlawful promotion of Shire's product Dermagraft.
1639:
1274:
1790:
3351:
3283:
2675:
2030:
2123:
2092:
2061:
1670:
1609:
1336:
1089:
1124:
723:
4304:
1968:
2882:
1446:
2217:
1910:
1384:
3478:
2421:
1003:. James Bowling vacated his position as interim CFO in the aftermath of the collapse of the AbbVie inversion deal. The chair of Shire's board of directors was Susan Kilsby.
1850:
2792:
1999:
2329:
1700:
1579:
3023:
2156:
2989:
1880:
1730:
538:£16.75 per share in cash) and the third £44 billion (£28 per Shire shares paid in Takeda shares plus £17.75 per share in cash). Reuters also reported interest from
4254:
1494:
4284:
4264:
1471:
4274:
3517:
2814:
4249:
2636:
429:
In 2008, in reaction to new taxation measures announced by the UK government in the treatment of royalties on patents, the company moved its tax domicile to
2298:
1028:
approved off-label use, and marketed products on unsubstantiated claims of beneficial side effects, including reductions in criminality, traffic accidents,
4279:
2452:
3551:
3288:
2579:
3336:
2604:
2525:
1422:
4349:
2735:
1239:
4309:
3575:
3560:
350:, Georgia. Shire's headquarters in Lexington, Massachusetts, will be integrated with Takeda's new U.S. headquarters, which is being relocated from
2494:
3293:
1933:
4344:
3313:
2844:
68:
1297:
3493:
3366:
2997:
2702:
1631:
1266:
1177:
1065:
316:
2815:"Shire Pharmaceuticals LLC to Pay $ 56.5 Million to Resolve False Claims Act Allegations Relating to Drug Marketing and Promotion Practices"
2762:
1782:
4319:
4259:
1533:
2667:
2022:
4269:
2115:
2084:
2053:
1662:
1601:
1328:
2912:
878:
In July 2014, Shire licensed the rights to the investigational Hunter syndrome compound, AGT-182, from ArmaGen for up to $ 225 million.
4324:
3303:
1960:
1392:
1116:
2874:
1820:
4334:
4294:
1443:
1902:
909:
850:
752:
490:
and the Phase III DX-2930). In
January 2016, the company made its most significant purchase, with the $ 32 billion acquisition of
4299:
3544:
3410:
2186:
1150:
4359:
4354:
4329:
3298:
1991:
2784:
1842:
1358:
3431:
2146:
1692:
1575:
4289:
3424:
3346:
3278:
1502:
3361:
3008:
2359:
1872:
1760:
1722:
3537:
3371:
3356:
190:
1463:
547:
ruled out making any form of counter-bid. On 8 May 2018, an agreement was finally reached in which Shire was sold to
3488:
3318:
4339:
3942:
3529:
3341:
1029:
2951:
315:/ Endocrine and Hereditary Angioedema; a growing franchise in Oncology; and an emerging, innovative pipeline in
3308:
3887:
3882:
3677:
3273:
3191:
3013:
2575:
548:
534:
281:
234:
137:
3847:
3417:
3221:
2725:
1873:"Baxter's Board of Directors Approves Separation of Baxalta and Declares Special Dividend of Baxalta Stock"
1414:
932:
1243:
881:
The Annual
Revenue figures in the following Table were drawn from the company's 2015 preliminary results.
719:
The Annual
Revenue figures in the following table were drawn from the company's 2015 preliminary results.
4101:
3696:
304:
3992:
3789:
3726:
3446:
3403:
2151:
1017:
4017:
3779:
3659:
3135:
1217:
3438:
1000:
475:
462:
In 2015, NPS Pharmaceuticals was acquired for $ 5.2 billion, bringing along its rare disease drugs
372:
343:
331:
308:
2698:
4364:
3857:
3716:
3231:
2758:
2671:
1525:
996:
988:
502:
the previous year), creating the largest global biotech company focused solely on rare diseases.
3972:
3912:
3483:
3206:
3075:
1070:
347:
20:
2561:
2480:
2275:
1561:
3927:
3665:
3468:
3463:
3095:
2904:
826:
451:
423:
391:
1813:"Dyax Corp. Announces Early Termination of Hart-Scott-Rodino Waiting Period - Business Wire"
4111:
4072:
4057:
4037:
3867:
3140:
1812:
510:
499:
2905:"U.S. says Shire subsidiaries to pay $ 350 million to settle false claims act allegations"
450:
company focusing on gastrointestinal products for $ 565 million, a year later it acquired
8:
4167:
3706:
3388:
3176:
3038:
936:
386:, Dennis Stephens, Peter Moriarty, Geoff Hall and Dr Jim Murray. Under the management of
351:
85:
984:
3917:
3804:
2549:
2468:
2263:
811:
773:
495:
2178:
1146:
4067:
3977:
3892:
3822:
3769:
3653:
3641:
1549:
312:
4161:
3987:
3741:
3125:
1057:
1021:
991:
through 8 January 2019 with Takeda's acquisition of Shire. Ginger
Gregory as chief
769:
3559:
2113:
2082:
4177:
3937:
3932:
3852:
3794:
3711:
3671:
3624:
3564:
3160:
3110:
2637:"GEN - News Highlights:ArmaGen Licenses AGT-182 Rights to Shire for Up to $ 225M"
1450:
992:
941:
865:
544:
383:
367:
74:
1117:"Takeda closes $ 62B purchase of Shire, creating largest Mass. biotech employer"
551:
in a $ 62 billion deal. Takeda's acquisition of Shire closed on 8 January 2019.
268:
with an operational base in the United States, its brands and products included
4203:
4151:
4127:
4022:
3982:
3947:
3613:
3498:
3120:
3043:
2992:
2875:"Pharmaceutical company agrees to 'landmark' settlement in Tampa federal court"
2351:
1752:
265:
229:
2051:
1090:"Takeda completes buyout of Shire to become top 10 global pharmaceutical firm"
4243:
4227:
4217:
4197:
4117:
4077:
4032:
3957:
3952:
3759:
3186:
3080:
3065:
2114:
Albertina
Torsoli, Manuel Baigorri & Matthew Campbell (16 October 2014).
2083:
Albertina
Torsoli, Manuel Baigorri & Matthew Campbell (16 October 2014).
956:
376:
288:
151:
147:
54:
1934:"Shire sells oncology unit for £1.7bn as Takeda boss prepares potential bid"
4207:
4147:
4137:
4097:
3902:
3842:
3832:
3784:
3736:
3584:
3201:
3181:
3155:
1989:
1958:
807:
402:
395:
300:
4183:
4027:
3922:
3862:
3628:
3588:
3115:
3053:
2052:
Albertina
Torsoli, Kristen Hallam & Oliver Staley (15 October 2014).
901:
387:
323:
277:
3226:
2414:"Shire bid marks Takeda's latest - and biggest - push for global status"
4157:
3967:
3897:
3799:
3764:
3395:
3236:
924:
920:
648:
483:
479:
471:
456:
296:
292:
205:
46:
2383:"Shire willing to back $ 64 billion Takeda bid, market signals doubts"
2322:"Shire willing to back $ 64 billion Takeda bid, market signals doubts"
2241:"Exclusive - Allergan in talks to acquire Shire, competing against..."
1016:
In September 2014, Shire reached a $ 56.5 million settlement with the
4223:
3997:
3473:
3130:
3085:
3058:
2845:"Adderall Maker to Pay $ 56.5 Million to Resolve False Claims Charge"
566:
264:-registered specialty biopharmaceutical company. Originating in the
4107:
3877:
3872:
3721:
3701:
3196:
3100:
3070:
2023:"AbbVie Is Biggest to Quit U.S. Address in $ 55 Billion Shire Deal"
1959:
David Welch, Matthew Campbell & Simeon Bennett (21 June 2014).
948:
539:
487:
447:
3284:
European Directorate for the Quality of Medicines & HealthCare
2179:"Statement re Proposal from Takeda Pharmaceutical Company Limited"
1990:
Caroline Chen, Drew Armstrong & Simeon Bennett (8 July 2014).
4213:
4173:
4121:
4047:
4042:
3907:
3774:
3607:
3601:
3352:
European Federation of Pharmaceutical Industries and Associations
3246:
3216:
3150:
3090:
2730:
2210:"Shire rejects $ 63 billion Takeda bid as Allergan drops pursuit"
818:
798:
781:
744:
722:
700:
491:
467:
443:
415:
335:
269:
4315:
Multinational companies headquartered in the Republic of Ireland
4187:
4131:
3962:
3837:
3827:
3647:
3251:
3211:
3145:
2998:
Pharmaceutical and biotechnology industry in the United Kingdom
794:
760:
604:
522:
506:
463:
430:
419:
327:
273:
261:
211:
196:
181:
60:
2785:"Shire Pays $ 56.5M to Settle False-Claims Whistleblower Suit"
3731:
3479:
European and Developing Countries Clinical Trials Partnership
3105:
3048:
2723:
505:
In April 2018, Shire agreed to sell its oncology business to
35:
1663:"Shire Buys ViroPharma for $ 4.2 Billion to Add Orphan Drug"
1660:
1632:"Shire Buys ViroPharma for $ 4.2 Billion to Add Orphan Drug"
394:
in 1996. Shire's initial products were calcium supplements (
4141:
2020:
1961:"AbbVie Said to Consider New Bid After Shire Rejects Offer"
382:
Shire was founded in 1986 in the UK by five entrepreneurs:
2495:"Takeda Clinches $ 62 Billion Deal to Buy Drugmaker Shire"
2116:"Shire Shares Extend Drop After AbbVie Backtracks on Deal"
4193:
4052:
2085:"AbbVie Board Recommends Holders Vote Against Shire Deal"
2054:"AbbVie Reconsidering Shire Sends Inversion Targets Down"
1723:"GEN - News Highlights:Shire Acquires Lumena for $ 260M+"
1693:"Fibrotech acquired by Shire for US$ 75M plus milestones"
1209:
1025:
339:
170:
164:
2724:
Schaps, Karolin & Hirschler, Ben (20 October 2014).
1661:
Trista Kelley & Makiko Kitamura (11 November 2013).
1526:"Shire to buy U.S. biotech firm for up to $ 325 million"
1385:"Shire buys New River Pharmaceuticals for $ 2.6 billion"
1359:"Shire to Buy Transkaryotic Therapies for $ 1.6 Billion"
2938:
2668:"Shire's New CEO Adds Sales Staff, Damps Takeover Talk"
1602:"Shire to Buy Eye-Drug Maker SARcode for $ 160 Million"
1329:"Canadians give go-ahead for Shire takeover of BioChem"
418:. A year later the company acquired the German company
257:
245:
4305:
Companies formerly listed on the London Stock Exchange
2526:"Japan's Takeda agrees $ 62 billion takeover of Shire"
1147:"Contact us | Takeda Pharmaceuticals U.S.A., Inc"
521:
On 20 June 2014, Shire rejected a takeover attempt by
1783:"Shire Acquires Foresight Biotherapeutics for $ 300M"
1298:"Investment Column: Shire focuses on buying Richwood"
1753:"UK drug firm Shire to buy US rival in $ 5.2bn deal"
1047:
3289:
Medicines and Healthcare products Regulatory Agency
2021:Simeon Bennett & Caroline Chen (19 July 2014).
1267:"Shire buys US drugs delivery firm for pounds 105m"
322:The original corporate headquarters was located in
3337:Association of the British Pharmaceutical Industry
2726:"Shire CFO to leave drugmaker as AbbVie drops bid"
2291:"Japan's Takeda sweetens $ 62 billion Shire offer"
1035:
326:, Hampshire, England. Main offices are located in
2144:
1992:"AbbVie Raises Offer for Shire to $ 51.5 Billion"
1523:
342:. In addition, Shire owns manufacturing sites in
4241:
3576:List of companies based in the Philadelphia area
3489:List of world's largest pharmaceutical companies
1242:. Sunday Times. 27 November 2011. Archived from
422:, for $ 521 million. Jerini focused on treating
4255:Pharmaceutical companies disestablished in 2019
3294:National Collaborating Centre for Mental Health
2821:. Office of Public Affairs. 24 September 2014.
2665:
1295:
1264:
4285:Biotechnology companies disestablished in 2019
4265:Pharmaceutical companies of the United Kingdom
2599:
2597:
2445:"GSK rules out entering Shire takeover battle"
1011:
4275:Biotechnology companies of the United Kingdom
3545:
3494:Pharmaceutical Services Negotiating Committee
3367:Royal Pharmaceutical Society of Great Britain
2975:
2523:
1903:"Shire, Baxalta Tie the Knot in $ 32B Merger"
1492:
1464:"Shire forges $ 565M buyout deal for Movetis"
1066:Pharmaceutical industry in the United Kingdom
839:Fabry Disease (α-galactosidase A deficiency)
4250:Pharmaceutical companies established in 1986
2789:Genetic Engineering & Biotechnology News
1326:
4280:Biotechnology companies established in 1986
2756:
2696:
2594:
2207:
873:
401:) for patients seeking to treat or prevent
3552:
3538:
3304:Pharmaceutical Society of Northern Ireland
2982:
2968:
516:
34:
2442:
2238:
1495:"Shire swoops to buy Advanced BioHealing"
1172:
1170:
1168:
1114:
4350:British companies disestablished in 2019
1843:"Shire to Acquire Dyax for Up to $ 6.5B"
910:Attention deficit hyperactivity disorder
851:Attention deficit hyperactivity disorder
753:Attention deficit hyperactivity disorder
721:
366:
4310:Companies formerly listed on the Nasdaq
3411:British National Formulary for Children
2948:Historical business data for Shire plc:
2819:The United States Department of Justice
2147:"AbbVie, Shire Call Off $ 51.7B Merger"
979:
4242:
3299:Pharmaceutical Price Regulation Scheme
2411:
2380:
2319:
2288:
1165:
554:
4345:British companies established in 1986
3533:
3432:Monthly Index of Medical Specialities
2963:
2915:from the original on 27 November 2021
2855:from the original on 27 November 2021
2825:from the original on 27 November 2021
2795:from the original on 27 November 2021
2145:Philippidis, Alex (21 October 2014).
1931:
1763:from the original on 17 February 2016
1339:from the original on 28 February 2016
1153:from the original on 25 February 2021
1127:from the original on 28 February 2022
1115:DeAngelis, Allison (7 January 2019).
1096:from the original on 26 February 2021
3425:Journal of Pharmacy and Pharmacology
3347:European Federation of Biotechnology
2885:from the original on 14 January 2017
2582:from the original on 11 January 2019
2576:"Takeda completes Shire acquisition"
2443:Editorial, Reuters (25 April 2018).
2239:Editorial, Reuters (19 April 2018).
2159:from the original on 24 October 2014
2095:from the original on 12 January 2015
2064:from the original on 11 January 2015
2033:from the original on 12 January 2015
1971:from the original on 12 January 2015
1673:from the original on 11 January 2015
1576:"Shire Acquires Lotus Tissue Repair"
1415:"Shire to buy Jerini in $ 521M deal"
1265:Grimond, Magnus (26 February 1997).
4320:Irish companies established in 1986
4260:Pharmaceutical companies of Ireland
3009:Manufacturing in the United Kingdom
2208:Roumeliotis, Greg (20 April 2018).
2126:from the original on 9 January 2015
2002:from the original on 8 January 2015
1524:Reuters Editorial (15 March 2012).
1220:from the original on 8 October 2019
13:
4270:Biotechnology companies of Ireland
3372:Worshipful Society of Apothecaries
3357:Faculty of Pharmaceutical Medicine
2765:from the original on 25 March 2016
2362:from the original on 28 April 2018
2352:"Shire backs Takeda's £46bn offer"
2189:from the original on 20 April 2018
1940:from the original on 16 April 2018
1913:from the original on 20 March 2016
1853:from the original on 19 March 2016
1642:from the original on 19 March 2016
1582:from the original on 13 April 2016
1190:from the original on 17 March 2018
528:
14:
4376:
4325:2019 disestablishments in Ireland
2930:
2738:from the original on 4 April 2016
2705:from the original on 15 June 2015
2699:"Leadership: Executive Committee"
2678:from the original on 3 April 2016
2647:from the original on 27 July 2014
2617:from the original on 6 April 2016
1823:from the original on 4 March 2016
1793:from the original on 6 April 2016
1703:from the original on 17 July 2014
1612:from the original on 7 April 2016
1536:from the original on 8 March 2016
1474:from the original on 4 March 2016
1425:from the original on 6 April 2016
1308:from the original on 5 March 2016
1296:Grimond, Magnus (4 August 1997).
1277:from the original on 4 March 2016
806:Short Bowel Syndrome (SBS) &
4335:2019 disestablishments in Jersey
4295:Companies based in Dublin (city)
3688:Other notable Philadelphia-based
3512:
3511:
3362:Pharmacists' Defence Association
3319:Veterinary Medicines Directorate
2991:
2759:"Leadership: Board of Directors"
2666:Bennett, Simeon (10 June 2013).
2578:. Pharma Times. 8 January 2019.
1733:from the original on 2 June 2014
1050:
999:, and Philip Vickers as head of
580:Richwood Pharmaceutical Company
390:, Shire was first listed on the
362:
330:, Ireland, the United States in
3943:Susquehanna International Group
3342:Chemical Industries Association
2897:
2867:
2837:
2807:
2777:
2750:
2717:
2690:
2659:
2629:
2568:
2536:from the original on 8 May 2018
2517:
2505:from the original on 8 May 2018
2487:
2436:
2405:
2374:
2344:
2313:
2282:
2232:
2201:
2171:
2138:
2107:
2076:
2045:
2014:
1983:
1952:
1932:Javed, Ayesha (16 April 2018).
1925:
1895:
1883:from the original on 6 May 2017
1865:
1835:
1805:
1775:
1745:
1715:
1685:
1654:
1638:. Bloomberg. 11 November 2013.
1624:
1594:
1568:
1517:
1486:
1456:
1437:
1407:
1377:
1351:
1240:"Shire is one of the big stars"
1036:Illegal promotion of Dermagraft
1030:sexually transmitted infections
1006:
436:
408:
95:Shire Pharmaceuticals Group Plc
4300:Companies based in Basingstoke
3561:Philadelphia-area corporations
3309:General Pharmaceutical Council
1444:Shire moves to Ireland for tax
1320:
1289:
1258:
1232:
1202:
1139:
1108:
1082:
1020:for alleged violations of the
598:New River Pharmaceuticals Inc
482:inhibitors against hereditary
16:British pharmaceutical company
1:
4360:Takeda Pharmaceutical Company
4355:2019 mergers and acquisitions
4330:1986 establishments in Jersey
4087:Notable Delaware Valley-based
4007:Notable Delaware Valley-based
3888:Crozer Keystone Health System
3883:Christiana Care Health System
3314:Scottish Medicines Consortium
3274:Commission on Human Medicines
3192:Cambridge Antibody Technology
3014:Economy of the United Kingdom
2757:Shire Staff (22 March 2016).
2697:Shire Staff (22 March 2016).
2412:Nussey, Sam (25 April 2018).
2381:Martin, Ben (25 April 2018).
2320:Martin, Ben (25 April 2018).
2289:Nussey, Sam (20 April 2018).
1493:Grogan, Kevin (18 May 2011).
1076:
789:Swelling attacks in children
535:Takeda Pharmaceutical Company
533:In April 2018, reported that
282:Takeda Pharmaceutical Company
235:Takeda Pharmaceutical Company
3418:British Pharmaceutical Codex
1879:. Baxter International Inc.
1608:. Bloomberg. 25 March 2013.
1327:Dunne, Helen (10 May 2001).
995:officer, Jeffrey Poulton as
184:15,160.6 million (2017)
7:
4290:Defunct companies of Jersey
4102:Cerberus Capital Management
3993:W. L. Gore & Associates
3790:Morgan, Lewis & Bockius
1043:
1012:False Claims Act violations
883:
714:
592:Transkaryotic Therapeutics
305:Lysosomal Storage Disorders
214:4,271.5 million (2017)
199:2,455.2 million (2017)
10:
4381:
3780:Drinker Biddle & Reath
3751:Notable Philadelphia-based
3727:Philadelphia Media Network
3447:The Pharmaceutical Journal
3404:British National Formulary
2605:"Preliminary Results 2015"
2152:Gen. Eng. Biotechnol. News
1453:Irish Examiner, April 2008
1178:"Preliminary Results 2017"
1018:U.S. Department of Justice
726:A container of Adderall XR
688:Foresight Biotherapeutics
486:(led by the approved drug
357:
120:; 5 years ago
18:
4086:
4018:Aberdeen Asset Management
4006:
3813:
3753:professional partnerships
3750:
3687:
3660:Universal Health Services
3623:
3583:
3572:
3507:
3456:
3380:
3327:
3264:
3169:
3031:
3022:
3004:
630:Lotus Tissue Repair, Inc
241:
228:
218:
203:
188:
177:
157:
143:
132:
114:
99:
91:
81:
67:
52:
42:
33:
4089:division headquarters of
2849:Corporate Crime Reporter
874:Licences & Royalties
652:(Founded 1994, Acq 2013)
570:(Founded 1986, Acq 2019)
476:eosinophilic esophagitis
280:. Shire was acquired by
4170:(Johnson & Johnson)
3858:Brandywine Realty Trust
3816:Valley-based businesses
3717:Independence Blue Cross
3634:(rank in the 2017 list)
3594:(rank in the 2017 list)
3232:Reliant Pharmaceuticals
2672:Bloomberg Business News
2149:. GEN News Highlights.
1578:. GEN. 8 January 2013.
1210:"Shire Company Profile"
1121:Boston Business Journal
989:chief executive officer
642:SARcode Bioscience Inc
517:Aborted AbbVie takeover
509:pharmaceutical company
474:- for the treatment of
4340:Life sciences industry
3973:Vishay Intertechnology
3913:Liberty Property Trust
3814:Other notable Delaware
3484:European Pharmacopoeia
3207:The Distillers Company
3076:Dechra Pharmaceuticals
1071:Takeda Pharmaceuticals
727:
560:Shire Plc Acquisitions
379:
354:, to the Boston area.
21:Shire (disambiguation)
4112:Johnson & Johnson
4063:Shire Pharmaceuticals
3469:British Pharmacopoeia
3464:British Approved Name
3096:Hikma Pharmaceuticals
2879:The Business Journals
2851:. 25 September 2014.
2791:. 25 September 2014.
1032:, and divorce rates.
827:Hereditary angioedema
725:
624:FerroKin BioSciences
452:regenerative medicine
424:hereditary angioedema
392:London Stock Exchange
370:
346:, Massachusetts, and
334:, Massachusetts, and
4073:Teva Pharmaceuticals
4058:Siemens Healthineers
4038:Delaware Investments
3868:Carpenter Technology
3707:Day & Zimmermann
3279:Department of Health
3177:Allen & Hanburys
3141:Silence Therapeutics
987:, was the company's
980:Corporate leadership
676:NPS Pharmaceuticals
656:Lev Pharmaceuticals
618:Advanced BioHealing
455:with the last being
19:For other uses, see
4168:McNeil Laboratories
3330:professional bodies
3039:AAH Pharmaceuticals
2911:. 11 January 2017.
2524:Reuters Editorial.
1909:. 11 January 2016.
1877:investor.baxter.com
1849:. 2 November 2015.
1819:. 2 December 2015.
1759:. 11 January 2015.
1449:26 May 2013 at the
937:Chronic hepatitis B
925:Zeffix (Lamivudine)
555:Acquisition history
352:Deerfield, Illinois
338:, Illinois, and in
287:Shire was a global
284:on 8 January 2019.
220:Number of employees
30:
4011:foreign businesses
4009:US headquarters of
3928:Rita's Italian Ice
3918:Penn Entertainment
3805:White and Williams
3381:Books and journals
2560:has generic name (
2479:has generic name (
2274:has generic name (
1560:has generic name (
1092:. 8 January 2019.
812:hypoparathyroidism
774:ulcerative colitis
728:
380:
163:Flemming Ornskov (
28:
4237:
4236:
3823:Actua Corporation
3678:Burlington Stores
3654:Lincoln Financial
3642:AmerisourceBergen
3527:
3526:
3267:regulatory bodies
3260:
3259:
3062:
2358:. 25 April 2018.
1936:. The Telegraph.
1789:. 3 August 2015.
1470:. 3 August 2010.
977:
976:
871:
870:
810:in patients with
797:/Revestive &
705:
697:
691:
685:
679:
673:
667:
659:
653:
645:
639:
633:
627:
621:
615:
609:
601:
595:
589:
583:
577:
571:
513:for £1.7billion.
375:, Massachusetts,
313:Internal Medicine
251:
250:
169:Thomas Dittrich (
4372:
4162:Sherwin-Williams
3988:Wilmington Trust
3742:Urban Outfitters
3635:
3595:
3554:
3547:
3540:
3531:
3530:
3515:
3514:
3126:Oxford Biomedica
3056:
3029:
3028:
2996:
2995:
2984:
2977:
2970:
2961:
2960:
2942:
2941:
2939:Official website
2925:
2924:
2922:
2920:
2901:
2895:
2894:
2892:
2890:
2871:
2865:
2864:
2862:
2860:
2841:
2835:
2834:
2832:
2830:
2811:
2805:
2804:
2802:
2800:
2781:
2775:
2774:
2772:
2770:
2754:
2748:
2747:
2745:
2743:
2721:
2715:
2714:
2712:
2710:
2694:
2688:
2687:
2685:
2683:
2663:
2657:
2656:
2654:
2652:
2643:. 23 July 2014.
2633:
2627:
2626:
2624:
2622:
2616:
2609:
2601:
2592:
2591:
2589:
2587:
2572:
2566:
2565:
2559:
2555:
2553:
2545:
2543:
2541:
2521:
2515:
2514:
2512:
2510:
2491:
2485:
2484:
2478:
2474:
2472:
2464:
2462:
2460:
2455:on 25 April 2018
2451:. Archived from
2440:
2434:
2433:
2431:
2429:
2424:on 25 April 2018
2420:. Archived from
2409:
2403:
2402:
2400:
2398:
2393:on 25 April 2018
2389:. Archived from
2378:
2372:
2371:
2369:
2367:
2348:
2342:
2341:
2339:
2337:
2332:on 24 April 2018
2328:. Archived from
2317:
2311:
2310:
2308:
2306:
2301:on 20 April 2018
2297:. Archived from
2286:
2280:
2279:
2273:
2269:
2267:
2259:
2257:
2255:
2250:on 19 April 2018
2246:. Archived from
2236:
2230:
2229:
2227:
2225:
2220:on 19 April 2018
2216:. Archived from
2205:
2199:
2198:
2196:
2194:
2175:
2169:
2168:
2166:
2164:
2142:
2136:
2135:
2133:
2131:
2111:
2105:
2104:
2102:
2100:
2080:
2074:
2073:
2071:
2069:
2049:
2043:
2042:
2040:
2038:
2018:
2012:
2011:
2009:
2007:
1987:
1981:
1980:
1978:
1976:
1956:
1950:
1949:
1947:
1945:
1929:
1923:
1922:
1920:
1918:
1899:
1893:
1892:
1890:
1888:
1869:
1863:
1862:
1860:
1858:
1839:
1833:
1832:
1830:
1828:
1817:businesswire.com
1809:
1803:
1802:
1800:
1798:
1779:
1773:
1772:
1770:
1768:
1749:
1743:
1742:
1740:
1738:
1719:
1713:
1712:
1710:
1708:
1689:
1683:
1682:
1680:
1678:
1658:
1652:
1651:
1649:
1647:
1628:
1622:
1621:
1619:
1617:
1598:
1592:
1591:
1589:
1587:
1572:
1566:
1565:
1559:
1555:
1553:
1545:
1543:
1541:
1521:
1515:
1514:
1512:
1510:
1501:. Archived from
1490:
1484:
1483:
1481:
1479:
1460:
1454:
1441:
1435:
1434:
1432:
1430:
1411:
1405:
1404:
1402:
1400:
1395:on 10 March 2016
1391:. Archived from
1381:
1375:
1374:
1372:
1370:
1355:
1349:
1348:
1346:
1344:
1324:
1318:
1317:
1315:
1313:
1293:
1287:
1286:
1284:
1282:
1262:
1256:
1255:
1253:
1251:
1236:
1230:
1229:
1227:
1225:
1206:
1200:
1199:
1197:
1195:
1189:
1182:
1174:
1163:
1162:
1160:
1158:
1143:
1137:
1136:
1134:
1132:
1112:
1106:
1105:
1103:
1101:
1086:
1060:
1058:Companies portal
1055:
1054:
1053:
1022:False Claims Act
985:Flemming Ørnskov
921:3TC (Lamivudine)
884:
770:Gastrointestinal
730:
729:
703:
695:
689:
683:
682:Meritage Pharma
677:
671:
665:
657:
651:
643:
637:
631:
625:
619:
613:
607:
599:
593:
587:
581:
575:
569:
494:(which had been
340:Zug, Switzerland
309:Gastrointestinal
191:Operating income
128:
126:
121:
110:
108:
77:
38:
31:
27:
4380:
4379:
4375:
4374:
4373:
4371:
4370:
4369:
4240:
4239:
4238:
4233:
4204:Rohm & Haas
4178:Hewlett-Packard
4091:US corporations
4090:
4088:
4082:
4010:
4008:
4002:
3933:SEI Investments
3853:Bentley Systems
3815:
3809:
3795:Pepper Hamilton
3752:
3746:
3712:FMC Corporation
3689:
3683:
3633:
3631:
3625:Delaware Valley
3619:
3593:
3591:
3579:
3568:
3565:Delaware Valley
3563:(including the
3558:
3528:
3523:
3503:
3452:
3376:
3329:
3323:
3266:
3256:
3165:
3161:ViiV Healthcare
3111:MacFarlan Smith
3018:
3000:
2990:
2988:
2956:
2937:
2936:
2933:
2928:
2918:
2916:
2903:
2902:
2898:
2888:
2886:
2873:
2872:
2868:
2858:
2856:
2843:
2842:
2838:
2828:
2826:
2813:
2812:
2808:
2798:
2796:
2783:
2782:
2778:
2768:
2766:
2755:
2751:
2741:
2739:
2722:
2718:
2708:
2706:
2695:
2691:
2681:
2679:
2664:
2660:
2650:
2648:
2635:
2634:
2630:
2620:
2618:
2614:
2607:
2603:
2602:
2595:
2585:
2583:
2574:
2573:
2569:
2557:
2556:
2547:
2546:
2539:
2537:
2522:
2518:
2508:
2506:
2493:
2492:
2488:
2476:
2475:
2466:
2465:
2458:
2456:
2441:
2437:
2427:
2425:
2410:
2406:
2396:
2394:
2379:
2375:
2365:
2363:
2350:
2349:
2345:
2335:
2333:
2318:
2314:
2304:
2302:
2287:
2283:
2271:
2270:
2261:
2260:
2253:
2251:
2237:
2233:
2223:
2221:
2206:
2202:
2192:
2190:
2177:
2176:
2172:
2162:
2160:
2143:
2139:
2129:
2127:
2112:
2108:
2098:
2096:
2081:
2077:
2067:
2065:
2050:
2046:
2036:
2034:
2019:
2015:
2005:
2003:
1988:
1984:
1974:
1972:
1957:
1953:
1943:
1941:
1930:
1926:
1916:
1914:
1901:
1900:
1896:
1886:
1884:
1871:
1870:
1866:
1856:
1854:
1841:
1840:
1836:
1826:
1824:
1811:
1810:
1806:
1796:
1794:
1781:
1780:
1776:
1766:
1764:
1751:
1750:
1746:
1736:
1734:
1729:. 12 May 2014.
1721:
1720:
1716:
1706:
1704:
1691:
1690:
1686:
1676:
1674:
1659:
1655:
1645:
1643:
1630:
1629:
1625:
1615:
1613:
1600:
1599:
1595:
1585:
1583:
1574:
1573:
1569:
1557:
1556:
1547:
1546:
1539:
1537:
1522:
1518:
1508:
1506:
1505:on 7 March 2016
1499:pharmatimes.com
1491:
1487:
1477:
1475:
1462:
1461:
1457:
1451:Wayback Machine
1442:
1438:
1428:
1426:
1421:. 3 July 2008.
1413:
1412:
1408:
1398:
1396:
1389:pharmatimes.com
1383:
1382:
1378:
1368:
1366:
1365:. 29 April 2005
1357:
1356:
1352:
1342:
1340:
1333:Telegraph.co.uk
1325:
1321:
1311:
1309:
1302:The Independent
1294:
1290:
1280:
1278:
1271:The Independent
1263:
1259:
1249:
1247:
1246:on 6 April 2016
1238:
1237:
1233:
1223:
1221:
1208:
1207:
1203:
1193:
1191:
1187:
1180:
1176:
1175:
1166:
1156:
1154:
1145:
1144:
1140:
1130:
1128:
1113:
1109:
1099:
1097:
1088:
1087:
1083:
1079:
1056:
1051:
1049:
1046:
1038:
1014:
1009:
993:human resources
982:
942:GlaxoSmithKline
915:Impax and Teva
890:Annual revenue
876:
866:Gaucher disease
736:Annual revenue
717:
712:
711:
710:
586:Biochem Canada
561:
557:
545:GlaxoSmithKline
531:
529:Takeda takeover
519:
439:
411:
399:
384:Harry Stratford
365:
360:
221:
208:
193:
168:
160:
124:
122:
119:
106:
104:
86:Pharmaceuticals
73:
57:
24:
17:
12:
11:
5:
4378:
4368:
4367:
4365:Tax inversions
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4272:
4267:
4262:
4257:
4252:
4235:
4234:
4232:
4231:
4221:
4211:
4201:
4191:
4181:
4171:
4165:
4155:
4145:
4135:
4128:Delmarva Power
4125:
4115:
4105:
4094:
4092:
4084:
4083:
4081:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4048:Keystone Foods
4045:
4040:
4035:
4030:
4025:
4023:AgustaWestland
4020:
4014:
4012:
4004:
4003:
4001:
4000:
3995:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
3895:
3893:David's Bridal
3890:
3885:
3880:
3875:
3870:
3865:
3860:
3855:
3850:
3845:
3840:
3835:
3830:
3825:
3819:
3817:
3811:
3810:
3808:
3807:
3802:
3797:
3792:
3787:
3782:
3777:
3772:
3770:Cozen O'Connor
3767:
3762:
3756:
3754:
3748:
3747:
3745:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3704:
3699:
3693:
3691:
3685:
3684:
3682:
3681:
3675:
3669:
3663:
3657:
3651:
3645:
3638:
3636:
3621:
3620:
3618:
3617:
3614:Crown Holdings
3611:
3605:
3598:
3596:
3581:
3580:
3573:
3570:
3569:
3557:
3556:
3549:
3542:
3534:
3525:
3524:
3522:
3521:
3508:
3505:
3504:
3502:
3501:
3499:Wellcome Trust
3496:
3491:
3486:
3481:
3476:
3471:
3466:
3460:
3458:
3454:
3453:
3451:
3450:
3443:
3435:
3428:
3421:
3414:
3407:
3400:
3392:
3384:
3382:
3378:
3377:
3375:
3374:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3333:
3331:
3325:
3324:
3322:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3270:
3268:
3265:Government and
3262:
3261:
3258:
3257:
3255:
3254:
3249:
3244:
3239:
3234:
3229:
3224:
3219:
3217:Glaxo Wellcome
3214:
3209:
3204:
3199:
3194:
3189:
3184:
3179:
3173:
3171:
3167:
3166:
3164:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3121:Norbrook Group
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3051:
3046:
3044:Alliance Boots
3041:
3035:
3033:
3026:
3020:
3019:
3017:
3016:
3011:
3005:
3002:
3001:
2987:
2986:
2979:
2972:
2964:
2958:
2957:
2955:
2954:
2949:
2945:
2943:
2932:
2931:External links
2929:
2927:
2926:
2896:
2866:
2836:
2806:
2776:
2749:
2716:
2689:
2658:
2628:
2593:
2567:
2516:
2486:
2435:
2404:
2373:
2343:
2312:
2281:
2231:
2200:
2170:
2137:
2106:
2075:
2044:
2013:
1982:
1951:
1924:
1894:
1864:
1834:
1804:
1774:
1744:
1714:
1684:
1653:
1623:
1593:
1567:
1516:
1485:
1455:
1436:
1406:
1376:
1350:
1319:
1288:
1257:
1231:
1201:
1164:
1138:
1107:
1080:
1078:
1075:
1074:
1073:
1068:
1062:
1061:
1045:
1042:
1037:
1034:
1013:
1010:
1008:
1005:
981:
978:
975:
974:
972:
970:
967:
963:
962:
961:Bayer Yakuhin
959:
954:
951:
945:
944:
939:
930:
927:
917:
916:
913:
907:
904:
898:
897:
894:
891:
888:
875:
872:
869:
868:
862:
859:
855:
854:
848:
845:
841:
840:
837:
834:
830:
829:
824:
821:
815:
814:
804:
801:
791:
790:
787:
784:
778:
777:
767:
764:
757:
756:
750:
747:
741:
740:
737:
734:
716:
713:
709:
708:
707:
706:
698:
692:
686:
680:
674:
668:
662:
661:
660:
646:
640:
634:
628:
622:
616:
610:
602:
596:
590:
584:
578:
563:
562:
559:
558:
556:
553:
530:
527:
518:
515:
438:
435:
410:
407:
397:
364:
361:
359:
356:
266:United Kingdom
249:
248:
243:
239:
238:
232:
226:
225:
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15:
9:
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3:
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4228:Flowers Foods
4225:
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4209:
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4199:
4198:Liberty Media
4195:
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4118:Colonial Penn
4116:
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3958:Triumph Group
3956:
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3953:Toll Brothers
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3760:Ballard Spahr
3758:
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3666:Campbell Soup
3664:
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3632:corporations
3630:
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3210:
3208:
3205:
3203:
3200:
3198:
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3193:
3190:
3188:
3187:Beecham Group
3185:
3183:
3180:
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3175:
3174:
3172:
3168:
3162:
3159:
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3119:
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3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3081:GE HealthCare
3079:
3077:
3074:
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3069:
3067:
3064:
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3055:
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3047:
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2700:
2693:
2677:
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2606:
2600:
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2499:Bloomberg.com
2496:
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2184:
2183:www.shire.com
2180:
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2110:
2094:
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2079:
2063:
2059:
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2028:
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2017:
2001:
1997:
1993:
1986:
1970:
1966:
1962:
1955:
1939:
1935:
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1698:
1697:FierceBiotech
1694:
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1672:
1668:
1667:Bloomberg.com
1664:
1657:
1641:
1637:
1636:Bloomberg.com
1633:
1627:
1611:
1607:
1606:Bloomberg.com
1603:
1597:
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1558:|author=
1551:
1535:
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1500:
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1469:
1468:FierceBiotech
1465:
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1424:
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1419:FierceBiotech
1416:
1410:
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1004:
1002:
998:
994:
990:
986:
973:
971:
968:
965:
964:
960:
958:
957:Renal disease
955:
952:
950:
947:
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938:
934:
931:
928:
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702:
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693:
687:
681:
675:
669:
663:
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650:
647:
641:
636:Premacure AB
635:
629:
623:
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611:
606:
603:
597:
591:
585:
579:
573:
572:
568:
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414:ownership of
406:
404:
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393:
389:
385:
378:
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369:
363:Early history
355:
353:
349:
348:Social Circle
345:
341:
337:
333:
329:
325:
320:
318:
314:
310:
306:
302:
298:
294:
290:
289:biotechnology
285:
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267:
263:
259:
255:
247:
246:www.shire.com
244:
240:
236:
233:
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224:23,044 (2018)
223:
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187:
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172:
166:
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156:
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152:United States
149:
148:Massachusetts
146:
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139:
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117:
113:
102:
98:
94:
90:
87:
84:
80:
76:
72:
70:
66:
62:
59:
56:
51:
48:
45:
41:
37:
32:
26:
22:
4224:Tasty Baking
4208:Dow Chemical
4138:GSI Commerce
4062:
3903:EPAM Systems
3843:Aqua America
3833:AlliedBarton
3785:Duane Morris
3737:Radian Group
3585:Philadelphia
3574:
3516:
3445:
3439:Side Effects
3437:
3430:
3423:
3416:
3409:
3402:
3394:
3387:
3328:Industry and
3241:
3202:Chiroscience
2917:. Retrieved
2908:
2899:
2887:. Retrieved
2878:
2869:
2857:. Retrieved
2848:
2839:
2827:. Retrieved
2818:
2809:
2797:. Retrieved
2788:
2779:
2767:. Retrieved
2752:
2740:. Retrieved
2729:
2719:
2707:. Retrieved
2692:
2680:. Retrieved
2661:
2649:. Retrieved
2640:
2631:
2619:. Retrieved
2584:. Retrieved
2570:
2538:. Retrieved
2529:
2519:
2507:. Retrieved
2498:
2489:
2477:|first=
2457:. Retrieved
2453:the original
2448:
2438:
2426:. Retrieved
2422:the original
2417:
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2395:. Retrieved
2391:the original
2386:
2376:
2364:. Retrieved
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2330:the original
2325:
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2303:. Retrieved
2299:the original
2294:
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2248:the original
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2218:the original
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2191:. Retrieved
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2161:. Retrieved
2150:
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2128:. Retrieved
2119:
2109:
2097:. Retrieved
2088:
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2066:. Retrieved
2057:
2047:
2035:. Retrieved
2026:
2016:
2004:. Retrieved
1995:
1985:
1973:. Retrieved
1964:
1954:
1942:. Retrieved
1927:
1915:. Retrieved
1906:
1897:
1885:. Retrieved
1876:
1867:
1855:. Retrieved
1846:
1837:
1825:. Retrieved
1816:
1807:
1795:. Retrieved
1786:
1777:
1765:. Retrieved
1756:
1747:
1735:. Retrieved
1726:
1717:
1707:23 September
1705:. Retrieved
1699:. May 2014.
1696:
1687:
1675:. Retrieved
1666:
1656:
1644:. Retrieved
1635:
1626:
1614:. Retrieved
1605:
1596:
1584:. Retrieved
1570:
1538:. Retrieved
1529:
1519:
1507:. Retrieved
1503:the original
1498:
1488:
1476:. Retrieved
1467:
1458:
1439:
1427:. Retrieved
1418:
1409:
1397:. Retrieved
1393:the original
1388:
1379:
1367:. Retrieved
1362:
1353:
1341:. Retrieved
1332:
1322:
1310:. Retrieved
1301:
1291:
1279:. Retrieved
1270:
1260:
1248:. Retrieved
1244:the original
1234:
1222:. Retrieved
1213:
1204:
1192:. Retrieved
1155:. Retrieved
1141:
1129:. Retrieved
1120:
1110:
1098:. Retrieved
1084:
1039:
1015:
1007:Legal issues
983:
880:
877:
844:Adderall XR
808:hypocalcemia
718:
532:
520:
504:
461:
440:
437:2010 onwards
428:
412:
409:2000 to 2009
403:osteoporosis
381:
371:Location in
321:
301:Neuroscience
286:
253:
252:
144:Headquarters
136:Acquired by
75:JE00B2QKY057
43:Company type
25:
4028:AstraZeneca
3923:Penn Mutual
3629:Fortune 500
3589:Fortune 500
3116:Mundipharma
3054:AstraZeneca
2952:SEC filings
2919:27 November
2889:27 November
2859:27 November
2829:27 November
2799:27 November
2709:13 February
1157:24 February
1131:24 February
1100:22 February
902:Adderall XR
893:Indication
739:Indication
574:Pharmavene
433:, Ireland.
396:Calcichew-D
388:Rolf Stahel
324:Basingstoke
317:Ophthalmics
278:Adderall XR
92:Predecessor
63:: SHPG
4244:Categories
4158:MAB Paints
3968:ViroPharma
3898:DuckDuckGo
3800:Saul Ewing
3765:Blank Rome
3690:businesses
3396:Bad Pharma
3227:Phytopharm
3136:Proximagen
2586:24 January
2163:22 October
1887:15 January
1077:References
763:/Mezavant
704:(Acq 2016)
696:(Acq 2015)
690:(Acq 2015)
684:(Acq 2015)
678:(Acq 2015)
672:(Acq 2014)
666:(Acq 2014)
664:Fibrotech
658:(Acq 2008)
649:ViroPharma
644:(Acq 2013)
638:(Acq 2013)
632:(Acq 2013)
626:(Acq 2012)
620:(Acq 2011)
614:(Acq 2012)
608:(Acq 2008)
600:(Acq 2007)
594:(Acq 2005)
588:(Acq 2001)
582:(Acq 1997)
576:(Acq 1997)
484:angioedema
480:kallikrein
472:Budesonide
457:ViroPharma
297:Immunology
293:Hematology
206:Net income
159:Key people
47:Subsidiary
3998:WSFS Bank
3697:Amoroso's
3474:DrugScope
3389:Bandolier
3131:Pfizer UK
3059:MedImmune
3024:Companies
2761:. Shire.
2701:. Shire.
2610:. Shire.
2550:cite news
2469:cite news
2264:cite news
2120:Bloomberg
2089:Bloomberg
2058:Bloomberg
2027:Bloomberg
1996:Bloomberg
1965:Bloomberg
1224:8 October
1183:. Shire.
896:Licensee
833:Replagal
749:$ 1,722M
567:Shire Plc
373:Lexington
344:Lexington
332:Cambridge
260:-founded
254:Shire plc
55:Traded as
29:Shire plc
4148:Hercules
4108:Centocor
3948:Vanguard
3878:Chemours
3873:Cephalon
3863:Boscov's
3848:Asplundh
3722:Pep Boys
3702:Chemtura
3518:category
3197:Celltech
3182:Amersham
3156:Vernalis
3101:Indivior
3071:Cyclacel
2913:Archived
2883:Archived
2853:Archived
2823:Archived
2793:Archived
2769:22 March
2763:Archived
2742:22 March
2736:Archived
2703:Archived
2682:22 March
2676:Archived
2645:Archived
2621:26 March
2612:Archived
2580:Archived
2534:Archived
2503:Archived
2459:25 April
2428:25 April
2397:25 April
2360:Archived
2356:BBC News
2336:24 April
2305:20 April
2254:19 April
2224:19 April
2193:19 April
2187:Archived
2157:Archived
2130:11 March
2124:Archived
2099:11 March
2093:Archived
2068:11 March
2062:Archived
2037:11 March
2031:Archived
2006:11 March
2000:Archived
1975:11 March
1969:Archived
1944:16 April
1938:Archived
1917:22 March
1911:Archived
1881:Archived
1857:22 March
1851:Archived
1827:22 March
1821:Archived
1797:22 March
1791:Archived
1767:22 March
1761:Archived
1757:BBC News
1731:Archived
1701:Archived
1677:22 March
1671:Archived
1646:26 March
1640:Archived
1616:26 March
1610:Archived
1586:26 March
1580:Archived
1550:cite web
1540:22 March
1534:Archived
1509:22 March
1478:22 March
1472:Archived
1447:Archived
1429:22 March
1423:Archived
1399:22 March
1369:17 April
1363:FDA News
1343:22 March
1337:Archived
1312:22 March
1306:Archived
1281:22 March
1275:Archived
1250:26 March
1218:Archived
1214:craft.co
1194:17 March
1185:Archived
1151:Archived
1125:Archived
1094:Archived
1044:See also
969:$ 26.4M
953:$ 53.3M
949:Fosrenol
929:$ 91.6M
906:$ 70.3M
715:Products
612:Movetis
540:Allergan
496:spun-off
488:Kalbitor
82:Industry
4214:SunGard
4174:Neoware
4152:Ashland
4122:Conseco
4078:TD Bank
3908:EnerSys
3775:Dechert
3627:-based
3608:Aramark
3602:Comcast
3587:-based
3247:Unipath
3170:Defunct
3151:Vectura
3032:Current
2909:Reuters
2731:Reuters
2651:24 July
2449:Reuters
2418:Reuters
2387:Reuters
2366:22 June
2326:Reuters
2295:Reuters
2244:Reuters
2214:Reuters
1530:Reuters
1001:R&D
912:(ADHD)
864:Type 1
861:$ 342M
853:(ADHD)
847:$ 362M
836:$ 441M
823:$ 445M
819:Firazyr
803:$ 166M
799:Natpara
786:$ 618M
782:Cinryze
766:$ 684M
755:(ADHD)
745:Vyvanse
701:Baxalta
670:Lumena
511:Servier
492:Baxalta
468:Natpara
448:Belgian
444:Movetis
416:Vyvanse
358:History
336:Chicago
270:Vyvanse
242:Website
178:Revenue
123: (
115:Defunct
105: (
100:Founded
4188:Exelon
4132:Exelon
4068:Subaru
3963:Unisys
3838:Ametek
3828:Airgas
3648:DuPont
3442:(2008)
3399:(2012)
3252:Zeneca
3237:Renovo
3212:Fisons
3146:TBS GB
1737:2 June
966:Other
858:Vpriv
795:Gattex
761:Lialda
605:Jerini
549:Takeda
523:AbbVie
507:French
500:Baxter
464:Gattex
431:Dublin
420:Jerini
328:Dublin
276:, and
274:Lialda
262:Jersey
256:was a
237:(2019)
230:Parent
138:Takeda
61:Nasdaq
4033:Chubb
3732:PREIT
3680:(463)
3674:(457)
3668:(339)
3662:(276)
3656:(207)
3650:(113)
3616:(333)
3610:(192)
3457:Other
3242:Shire
3106:IXICO
3086:Genus
3049:Astex
2615:(PDF)
2608:(PDF)
2540:8 May
2509:8 May
1188:(PDF)
1181:(PDF)
887:Name
733:Name
694:Dyax
498:from
4184:PECO
4142:eBay
4098:Acme
3983:Wawa
3644:(11)
3604:(31)
2921:2021
2891:2021
2861:2021
2831:2021
2801:2021
2771:2016
2744:2016
2711:2015
2684:2016
2653:2014
2623:2016
2588:2019
2562:help
2542:2018
2511:2018
2481:help
2461:2018
2430:2018
2399:2018
2368:2018
2338:2018
2307:2018
2276:help
2256:2018
2226:2018
2195:2018
2165:2014
2132:2017
2101:2017
2070:2017
2039:2017
2008:2017
1977:2017
1946:2018
1919:2016
1889:2017
1859:2016
1829:2016
1799:2016
1769:2016
1739:2014
1709:2014
1679:2016
1648:2016
1618:2016
1588:2016
1562:help
1542:2016
1511:2016
1480:2016
1431:2016
1401:2016
1371:2022
1345:2016
1314:2016
1283:2016
1252:2016
1226:2019
1196:2018
1159:2021
1133:2021
1102:2021
935:and
923:and
466:and
446:, a
133:Fate
125:2019
118:2019
107:1986
103:1986
69:ISIN
4218:FIS
4194:QVC
4053:SAP
4043:GSK
3978:VWR
3938:SLM
3672:UGI
3222:ICI
3091:GSK
3066:BTG
2641:GEN
2530:U.S
1907:GEN
1847:GEN
1787:GEN
1727:GEN
1026:FDA
997:CFO
933:HIV
171:CFO
165:CEO
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