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The large number of synthetic organic chemicals currently in production presents a major challenge for timely collection of detailed environmental data on each compound. The concept of structure biodegradability relationships (SBR) has been applied to explain variability in persistence among organic
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There can be no reasonable doubt that a relation exists between the physiological action of a substance and its chemical composition ... we are not aware that any approach has been made to the statement of a law connecting the physiological action of a substance with its chemical
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of several chemical classes, with resulting general themes, such as halogens generally conferring persistence under aerobic conditions. Subsequently, more quantitative approaches have been developed using principles of QSAR and often accounting for the role of
146:(1868). "V.—On the Connection between Chemical Constitution and Physiological Action. Part. I.—On the Physiological Action of the Salts of the Ammonium Bases, derived from Strychnia, Brucia, Thebaia, Codeia, Morphia, and Nicotia".
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chemicals in the environment. Early attempts generally consisted of examining the degradation of a homologous series of structurally related compounds under identical conditions with a complex "universal"
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The analysis of SAR enables the determination of the chemical group responsible for evoking a target biological effect in the organism. This allows modification of the effect or the
184:(1869). "XX.—On the Connection between Chemical Constitution and Physiological Action. Part II.—On the Physiological Action of the Ammonium Bases derived from Atropia and Conia".
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Mani, S.V.; Connell, D.W.; Braddock, R.D. (1991). "Structure activity relationships for the prediction of biodegradability of environmental pollutants".
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82:, typically derived from numerous sources. This approach revealed that the nature and positions of substituents affected the apparent
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Alexander, Martin; Lustigman, Bonnie K. (1966). "Effect of chemical structure on microbial degradation of substituted benzenes".
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This method was refined to build mathematical relationships between the chemical structure and the biological activity, known as
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to insert new chemical groups into the biomedical compound and test the modifications for their biological effects.
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Sims, Gerald K.; Sommers, Lee E. (1986). "Biodegradation of pyridine derivatives in soil suspensions".
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69:(QSAR). A related term is structure affinity relationship (SAFIR).
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182:Fraser, Thomas Richard
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37:Alexander Crum Brown
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