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Holgate and his research group demonstrated the causal link between exacerbations in the autumn and winter months and respiratory virus infections. This led to the subsequent discovery that epithelial cells from those with moderate-severe asthma were deficient in their ability to generate an innate
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and Genome
Therapeutics Corporation in Waltham, Mass, USA to identify the first novel asthma susceptibility gene of ADAM33 that encodes a metalloprotease linked to airway hyperresponsiveness and remodelling. This originated from the theory that in severe asthma, the airways behaved like a chronic
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In 1980, Holgate began work at the
University of Southampton researching the causes of human asthma and its treatment. After establishing the role that mast cells and other effector cells play in triggering the acute allergic inflammatory response in asthma, he examined the mechanisms of asthma
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to explore the potential therapeutic benefits of inhaled interferon beta in attenuating virus-induced exacerbations of asthma and COPD. Synairgen completed a Phase II placebo-controlled trial to treat COVID-19.
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Holgate, Stephen; Agusti, Alvar; Strieter, Robert M.; Anderson, Gary P.; Fogel, Robert; Bel, Elisabeth; Martin, Thomas R.; Reiss, Theodore F. (2015). "Drug development for airway diseases: looking forward".
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While a
Clinical Lecturer at the University of Southampton, he researched the link between asthma death and over-use of beta-adrenergic bronchodilator inhalers. In 1978, Holgate received a
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wound with impaired epithelial repair and underlying tissue remodelling involving the deposition of new matrix, mucous metaplasia and proliferation of smooth muscle.
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Holgate was educated at The King's School in
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In 1980, Holgate completed a two year post doctoral fellowship with K. Frank Austen at the Robert
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It may require cleanup to comply with
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Beta-Adrenergic
Resistance - The development and Mechanisms in normal man
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interferon beta response when infected by human rhinoviruses.
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from the article and its talk page, especially if potentially
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398:(born 2 May 1947) is a British physician who specializes in
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Fellows of the Royal
College of Physicians of Edinburgh
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A major contributor to this article appears to have a
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University
Hospital Southampton NHS Foundation Trust
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may be too technical for most readers to understand
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878:"Professor Stephen Holgate CBE - AAIR Charity"
1087:Commanders of the Order of the British Empire
729:used this patented information to create the
1102:Fellows of the Royal College of Pathologists
748:Commander of the Order of the British Empire
557:(MD) degree from the University of London.
62:Learn how and when to remove these messages
1122:Presidents of the British Thoracic Society
1092:Fellows of the Royal College of Physicians
1082:Academics of the University of Southampton
1049:(Supplement). 10 October 2020. p. B2.
754:in 2020 for services to medical research.
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850:(MD thesis). University of London.
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803:. University of Southampton
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162:neutral point of view
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1112:1947 births
1041:"No. 63135"
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1061:Categories
1014:. London.
887:22 October
856:1006020949
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807:22 October
781:22 October
758:References
644:newspapers
494:newspapers
336:Occupation
328:Lancashire
317:2 May 1947
313:1947-05-02
225:April 2023
150:improve it
48:improve it
1020:0261-3077
950:1474-1776
912:20 August
735:Synairgen
596:citations
446:citations
422:Education
339:Physician
330:, England
96:talk page
54:talk page
958:26000726
776:Kfip.org
752:knighted
733:company
724:Wikidata
622:libelous
472:libelous
352:Children
1025:25 July
989:25 July
966:8539798
658:scholar
508:scholar
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889:2017
852:OCLC
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783:2017
716:and
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