1168:
healthcare options, have been useful in decreasing decisional conflict, improving transfer of diabetes treatment knowledge, and achieving greater risk perception for disease complications, their efficacy in medication adherence has been less substantial. Therefore, the risk perception and decision-making processes surrounding diabetes medication adherence are multi-faceted and complex with socioeconomic implications as well. For example, immigrant health disparities in diabetic outcomes have been associated with a lower risk perception amongst foreign-born adults in the United States compared to their native-born counterparts, which leads to fewer protective lifestyle and treatment changes crucial for combatting diabetes. Additionally, variations in patients' perceptions of time (i.e. taking rigorous, costly medication in the present for abstract beneficial future outcomes can conflict with patients' preferences for immediate versus delayed gratification) may also present severe consequences for adherence as diabetes medication often requires systematic, routine administration.
621:
to be protected against infection, perceived vulnerability, getting COVID-19 and trust in the government. Mobility reduction, compliance with quarantine regulations in
European regions where level of trust in policymakers is high can influence whether one complies with isolation rules. In addition, perceived infectiousness of COVID-19 is a strong predictor of rule compliance such that the more contagious people think COVID-19 is, the less willing social distancing measures are taken, while the sense of duty and fear of the virus contribute to staying at home. People might not leave their homes due to trusting regulations to be effective or placing it in a higher power such that individuals who trust others demonstrate more compliance than those who do not. Compliant individuals see protective measures as effective, while non-compliant people see them as problematic.
429:
Kaiser Family
Foundation survey in 2015, about three quarters (73%) of the public think drug prices are unreasonable and blame pharmaceutical companies for setting prices so high. In the same report, half of the public reported that they are taking prescription drugs and a "quarter (25%) of those currently taking prescription medicine report they or a family member have not filled a prescription in the past 12 months due to cost, and 18 percent report cutting pills in half or skipping doses". In a 2009 comparison to Canada, only 8% of adults reported to have skipped their doses or not filling their prescriptions due to the cost of their prescribed medications.
782:
or vial was accessed, or the medication removed from a blister package. The data can be read via proprietary readers, or NFC enabled devices, such as smartphones or tablets. A 2009 study stated that such devices can help improve adherence. More recently a 2016 scoping review suggested that in comparison to MEMS, median mediction adherence was grossly overestimated by 17% using self-report, by 8% using pill count and by 6% using rating as alternative methods for measuring medication adherence.
174:
1196:, but psychotic disorders can be episodic and antipsychotics are then use prophylactically to reduce the likelihood of relapse rather than treat symptoms and in some cases individuals will have no further episodes despite not using antipsychotics. A 2006 review investigated the effects of compliance therapy for schizophrenia: and found no clear evidence to suggest that compliance therapy was beneficial for people with schizophrenia and related syndromes.
450:
not recall the dose of the medication that they were prescribed and nearly two-thirds did not know what time of day to take them. A 2001 study by Barat et al. evaluated the medical knowledge and factors of adherence in a population of 75-year-olds living at home. They found that 40% of elderly patients do not know the purpose of their regimen and only 20% knew the consequences of non-adherence. Comprehension,
769:
wording that health care professionals take when sharing health advice may have an impact on adherence and health behaviours, however, further research is needed to understand if positive framing (e.g., the chance of surviving is improved if you go for screening) versus negative framing (e.g., the chance of dying is higher if you do not go for screening) is more effective for specific conditions.
269:
medication packaging, providing effective medication reminders, improving patient education, and limiting the number of medications prescribed simultaneously. Studies show a great variation in terms of characteristics and effects of interventions to improve medicine adherence. It is still unclear how adherence can consistently be improved in order to promote clinically important effects.
814:. Some results show that the use of mHealth improves adherence to medication and is cost-effective, though some reviews report mixed results. Studies show that using mHealth to improve adherence to medication is feasible and accepted by patients. Specific mobile applications might also support adherence. mHealth interventions have also been used alongside other
230:, self-directed exercises, or therapy sessions. Both patient and health-care provider affect compliance, and a positive physician-patient relationship is the most important factor in improving compliance. Access to care plays a role in patient adherence, whereby greater wait times to access care contributing to greater absenteeism. The
1204:
A longitudinal study has shown that adherence with treatment about 60%. The predictors of adherence were found to be more of psychological, communication and logistic nature rather than sociodemographic or clinical factors. The following factors were identified as independent predictors of adherence:
1167:
Additionally, it is crucial to understand the decision-making processes that drive diabetics in their choices surrounding risks of not adhering to their medication. While patient decision aids (PtDAs), sets of tools used to help individuals engage with their clinicians in making decisions about their
645:
A wide variety of packaging approaches have been proposed to help patients complete prescribed treatments. These approaches include formats that increase the ease of remembering the dosage regimen as well as different labels for increasing patient understanding of directions. For example, medications
499:
Prescription medical claims records can be used to estimate medication adherence based on fill rate. Patients can be routinely defined as being 'Adherent
Patients' if the amount of medication furnished is at least 80% based on days' supply of medication divided by the number of days patient should be
420:
In 2013 the US National
Community Pharmacists Association sampled for one month 1,020 Americans above age 40 for with an ongoing prescription to take medication for a chronic condition and gave a grade C+ on adherence. In 2009, this contributed to an estimated cost of $ 290 billion annually. In 2012,
400:
Low levels of literacy and numeracy were found to be associated with socio-economic deprivation. Adults in more deprived areas, such as the North East of
England, performed at a lower level than those in less deprived areas such as the South East. Local authority tenants and those in poor health were
268:
and not understanding treatment benefits, the occurrence of undiscussed side effects, poor treatment satisfaction, cost of prescription medicine, and poor communication or lack of trust between a patient and his or her health-care provider. Efforts to improve compliance have been aimed at simplifying
901:
Results of a recent (2016) systematic review found a large proportion of patients struggle to take their oral antineoplastic medications as prescribed. This presents opportunities and challenges for patient education, reviewing and documenting treatment plans, and patient monitoring, especially with
781:
Medication Event
Monitoring Systems (MEMS), as in the form of smart medicine bottle tops, smart pharmacy vials or smart blister packages as used in clinical trials and other applications where exact compliance data are required, work without any patient input, and record the time and date the bottle
611:
For medication in tablet form it is relatively straightforward to calculate the number of days' supply based on a prescription. Some medications are less straightforward though because a prescription of a given number of doses may have a variable number of days' supply because the number of doses to
629:
Once started, patients seldom follow treatment regimens as directed, and seldom complete the course of treatment. In respect of hypertension, 50% of patients completely drop out of care within a year of diagnosis. Persistence with first-line single antihypertensive drugs is extremely low during the
620:
Contextual factors along with intrapersonal circumstances such as mental states affect decisions. They can accurately predict decisions where most contextual information is identified. General compliance with recommendations to follow isolation is influenced beliefs such as taking health precaution
449:
In 1999 Cline et al. identified several gaps in knowledge about medication in elderly patients discharged from hospital. Despite receiving written and verbal information, 27% of older people discharged after heart failure were classed as non-adherent within 30 days. Half the patients surveyed could
285:
As of 2003, US health care professionals more commonly used the term "adherence" to a regimen rather than "compliance", because it has been thought to reflect better the diverse reasons for patients not following treatment directions in part or in full. Additionally, the term adherence includes the
777:
In 2012 it was predicted that as telemedicine technology improves, physicians will have better capabilities to remotely monitor patients in real-time and to communicate recommendations and medication adjustments using personal mobile devices, such as smartphones, rather than waiting until the next
428:
mainly attributed to the government's lack of negotiating lower prices with monopolies in the pharmaceutical industry especially with brand name drugs. In order to manage medication costs, many US patients on long term therapies fail to fill their prescription, skip or reduce doses. According to a
389:
and functional numeracy, described as: "The ability to read, write and speak in
English, and to use mathematics at a level necessary to function at work and in society in general." This made it impossible for them to effectively take medication, read labels, follow drug regimes, and find out more.
305:
As of 2005, the preferred terminology remained a matter of debate. As of 2007, concordance has been used to refer specifically to patient adherence to a treatment regimen which the physician sets up collaboratively with the patient, to differentiate it from adherence to a physician-only prescribed
888:
Asthma non-compliance (28–70% worldwide) increases the risk of severe asthma attacks requiring preventable ER visits and hospitalisations; compliance issues with asthma can be caused by a variety of reasons including: difficult inhaler use, side effects of medications, and cost of the treatment.
490:
Not all patients will fill the prescription at a pharmacy. In a 2010 U.S. study, 20–30% of prescriptions were never filled at the pharmacy. Reasons people do not fill prescriptions include the cost of the medication, A US nationwide survey of 1,010 adults in 2001 found that 22% chose not to fill
491:
prescriptions because of the price, which is similar to the 20–30% overall rate of unfilled prescriptions. Other factors are doubting the need for medication, or preference for self-care measures other than medication. Convenience, side effects and lack of demonstrated benefit are also factors.
301:
initiative. In this context, the patient is informed about their condition and treatment options, involved in the decision as to which course of action to take, and partially responsible for monitoring and reporting back to the team. Informed intentional non-adherence is when the patient, after
1163:
and risk assessment in managing diabetes symptoms and decision making surrounding rigorous medication regiments. Perceived control and self-efficacy not only significantly correlate with each other, but also with diabetes distress psychological symptoms and have been directly related to better
768:
and active listening. Health care providers should work with patients to devise a plan that is meaningful for the patient's needs. A relationship that offers trust, cooperation, and mutual responsibility can greatly improve the connection between provider and patient for a positive impact. The
649:
A not-for-profit organisation called the
Healthcare Compliance Packaging Council of Europe] (HCPC-Europe) was set up between the pharmaceutical industry, the packaging industry with representatives of European patients organisations. The mission of HCPC-Europe is to assist and to educate the
445:
on the care of older people highlighted the importance of taking and effectively managing medicines in this population. However, elderly individuals may face challenges, including multiple medications with frequent dosing, and potentially decreased dexterity or cognitive functioning. Patient
1640:
Health literacy is an important component of adherence to medications,, but given the behavior of allergists as patients, it appears that other factors are more important. Possibly, it is human nature that drives adherence to treatment irrespective of whether the patient is a physician, and
897:
200,000 new cases of cancer are diagnosed each year in the UK. One in three adults in the UK will develop cancer that can be life-threatening, and 120,000 people will be killed by their cancer each year. This accounts for 25% of all deaths in the UK. However while 90% of cancer pain can be
473:
emphasised the influence of ethnic and cultural factors on adherence. They pointed out that groups differ in their attitudes, values and beliefs about health and illness. This view could affect adherence, particularly with preventive treatments and medication for asymptomatic conditions.
465:
People of different ethnic backgrounds have unique adherence issues through literacy, physiology, culture or poverty. There are few published studies on adherence in medicine taking in ethnic minority communities. Ethnicity and culture influence some health-determining behaviour, such as
630:
first year of treatment. As far as lipid-lowering treatment is concerned, only one third of patients are compliant with at least 90% of their treatment. Intensification of patient care interventions (e.g. electronic reminders, pharmacist-led interventions, healthcare professional
411:
A study of the relationship of literacy to asthma knowledge revealed that 31% of asthma patients with a reading level of a ten-year-old knew they needed to see the doctors, even when they were not having an asthma attack, compared to 90% with a high school graduate reading level.
3454:
Hajdu, Nandor; Schmidt, Kathleen; Acs, Gergely; Röer, Jan P.; Mirisola, Alberto; Giammusso, Isabella; Arriaga, Patrícia; Ribeiro, Rafael; Dubrov, Dmitrii; Grigoryev, Dmitry; Arinze, Nwadiogo C.; Voracek, Martin; Stieger, Stefan; Adamkovic, Matus; Elsherif, Mahmoud (2022-11-28).
658:
The World Health
Organization (WHO) groups barriers to medication adherence into five categories; health care team and system-related factors, social and economic factors, condition-related factors, therapy-related factors, and patient-related factors. Common barriers include:
1139:
Patients with diabetes are at high risk of developing coronary heart disease and usually have related conditions that make their treatment regimens even more complex, such as hypertension, obesity and depression which are also characterised by poor rates of adherence.
1164:
medication adherence outcomes. Various external factors also impact diabetic patients' self-management behaviors including health-related knowledge/beliefs, problem-solving skills, and self-regulatory skills, which all impact perceived control over diabetic symptoms.
3730:
Mazzaglia G, Mantovani LG, Sturkenboom MC, Filippi A, Trifirò G, Cricelli C, et al. (November 2005). "Patterns of persistence with antihypertensive medications in newly diagnosed hypertensive patients in Italy: a retrospective cohort study in primary care".
548:
481:
Recent studies have shown that black patients and those with non-private insurance are more likely to be labeled as non-adherent. The increased risk is observed even in patients with a controlled A1c, and after controlling for other socioeconomic factors.
503:
Two forms of MPR can be calculated, fixed and variable. Calculating either is relatively straightforward, for
Variable MPR (VMPR) it is calculated as the number of days' supply divided by the number of elapsed days including the last prescription.
277:
In medicine, compliance (synonymous with adherence, capacitance) describes the degree to which a patient correctly follows medical advice. Most commonly, it refers to medication or drug compliance, but it can also apply to medical device use,
2540:
286:
ability of the patient to take medications as prescribed by their physician with regards to the correct drug, dose, route, timing, and frequency. It has been noted that compliance may only refer to passively following orders. The term
5078:
1756:(Report). RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I. AHRQ Publication No. 12-E010-EF. Rockville, MD: Agency for Healthcare Research and Quality. Archived from
500:
consuming the medication. This percentage is called the medication possession ratio (MPR). 2013 work has suggested that a medication possession ratio of 90% or above may be a better threshold for deeming consumption as 'Adherent'.
2907:
Beltrán, Sourik, et al. "Associations of race, insurance, and zip code-level income with nonadherence diagnoses in primary and specialty diabetes care." The Journal of the American Board of Family Medicine 34.5 (2021): 891-897.
552:
For the Fixed MPR (FMPR) the calculation is similar but the denominator is the number of days in a year whilst the numerator is constrained to be the number of days' supply within the year that the patient has been prescribed.
477:
Measures of adherence may need to be modified for different ethnic or cultural groups. In some cases, it may be advisable to assess patients from a cultural perspective before making decisions about their individual treatment.
374:' have been known to be major barriers to treatment adherence. There is robust evidence that education and physical health are correlated. Poor educational attainment is a key factor in the cycle of health inequalities.
612:
be taken per day varies, for example with preventative corticosteroid inhalers prescribed for asthma where the number of inhalations to be taken daily may vary between individuals based on the severity of the disease.
607:
2894:
Beltrán, Sourik, Lanair A. Lett, and Peter F. Cronholm. "Nonadherence labeling in primary care: bias by race and insurance type for adults with type 2 diabetes." American journal of preventive medicine 57.5 (2019):
5575:
Karagiannis T, Andreadis P, Manolopoulos A, Malandris K, Avgerinos I, Karagianni A, Tsapas A (May 2019). "Decision aids for people with Type 2 diabetes mellitus: an effectiveness rapid review and meta-analysis".
5210:
Powles T, Eeles R, Ashley S, Easton D, Chang J, Dowsett M, et al. (July 1998). "Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial".
810:(DOT) (recommended by the WHO) for Tuberculosis management. Other mHealth interventions for improving adherence to medication include smartphone applications, voice recognition in interactive phone calls and
637:
The World Health Organization (WHO) estimated in 2003 that only 50% of people complete long-term therapy for chronic illnesses as they were prescribed, which puts patient health at risk. For example, in 2002
1584:"Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence"
2558:
Kennedy J, Morgan S (January 2009). "Cost-related prescription nonadherence in the United States and Canada: a system-level comparison using the 2007 International Health Policy Survey in Seven Countries".
4830:
Chan AH, Reddel HK, Apter A, Eakin M, Riekert K, Foster JM (September 2013). "Adherence monitoring and e-health: how clinicians and researchers can use technology to promote inhaler adherence for asthma".
282:, self-directed exercises, or therapy sessions. Both patient and health-care provider affect compliance, and a positive physician-patient relationship is the most important factor in improving compliance.
226:) describes the degree to which a patient correctly follows medical advice. Most commonly, it refers to medication or drug compliance, but it can also apply to other situations such as medical device use,
4013:"Adherence to Long-Term Therapies - Evidence for Action: Section II - Improving adherence rates: guidance for countries: Chapter V - Towards the solution: 1. Five interacting dimensions affect adherence"
793:
As of 2019, 5.15 billion people, which equates to 67% of the global population, have a mobile device and this number is growing. Mobile phones have been used in healthcare and has fostered its own term,
646:
are sometimes packed with reminder systems for the day and/or time of the week to take the medicine. Some evidence shows that reminder packaging may improve clinical outcomes such as blood pressure.
1582:
Bousquet, Jean; Schünemann, Holger J.; Togias, Akdis; Bachert, Claus; Erhola, Martina; Hellings, Peter W.; et al. (Allergic Rhinitis and Its Impact on Asthma Working Group) (October 15, 2019).
457:
In children with asthma, self-management compliance is critical and co-morbidities have been noted to affect outcomes; in 2013 it has been suggested that electronic monitoring may help adherence.
5721:
Sackett DL, Haynes RB, Gibson ES, Hackett BC, Taylor DW, Roberts RS, Johnson AL (May 1975). "Randomised clinical trial of strategies for improving medication compliance in primary hypertension".
4993:
Smith JP, Herber OR (June 2015). "Ethical issues experienced by mental health nurses in the administration of antipsychotic depot and long-acting intramuscular injections: a qualitative study".
2184:
1403:
798:. They have also played a role in improving adherence to medication. For example, text messaging has been used to remind patients to take medication in patients with chronic conditions such as
1120:
In March 1999, the "Adherence in the International Breast Cancer Intervention Study" evaluating the effect of a daily dose of Tamoxifen for five years in at-risk women aged 35–70 years was
2868:
Prieto LR, Miller DS, Gayowski T, Marino IR (December 1997). "Multicultural issues in organ transplantation: the influence of patients' cultural perspectives on compliance with treatment".
1295:"When Exception to Policy Is Exceptional Policy: How Booking Physical Therapy Appointments Too Far in the Future May Adversely Impact Access to Care, Business Optimization, and Readiness"
5434:
Donnan PT, MacDonald TM, Morris AD (April 2002). "Adherence to prescribed oral hypoglycaemic medication in a population of patients with Type 2 diabetes: a retrospective cohort study".
2541:"Kaiser Family Foundation: Poll Finds Nearly Three Quarters of Americans Say Prescription Drug Costs Are Unreasonable, and Most Blame Drug Makers Rather Than Insurers for the Problem"
3921:
Shrank W, Avorn J, Rolon C, Shekelle P (May 2007). "Effect of content and format of prescription drug labels on readability, understanding, and medication use: a systematic review".
829:
need to be taken less regularly than other forms of medication and a medical professional is involved in the administration of drugs so can increase compliance. Depot's are used for
642:
compliance dropped to between 25 and 40% after two years of treatment, with patients taking statins for what they perceive to be preventative reasons being unusually poor compliers.
3136:"Medication possession ratio: implications of using fixed and variable observation periods in assessing adherence with disease-modifying drugs in patients with multiple sclerosis"
509:
2435:
3774:
Sung JC, Nichol MB, Venturini F, Bailey KL, McCombs JS, Cody M (October 1998). "Factors affecting patient compliance with antihyperlipidemic medications in an HMO population".
806:. Other examples include the use of smartphones for synchronous and asynchronous Video Observed Therapy (VOT) as a replacement for the currently resource intensive standard of
2103:
926:(2002) identified evidence to show that adherence rates in cancer treatment are variable, and sometimes surprisingly poor. The following table is a summary of their findings:
650:
healthcare sector in the improvement of patient compliance through the use of packaging solutions. A variety of packaging solutions have been developed by this collaboration.
2286:
Park DC, Hertzog C, Leventhal H, Morrell RW, Leventhal E, Birchmore D, et al. (February 1999). "Medication adherence in rheumatoid arthritis patients: older is wiser".
2741:"Exploring the impact of elevated depressive symptoms on the ability of a tailored asthma intervention to improve medication adherence among urban adolescents with asthma"
1192:
A 2003 review found that 41–59% of patients prescribed antipsychotics took the medication prescribed to them infrequently or not at all. Sometimes non-adherence is due to
1339:
5619:
Hsueh L, Peña JM, Hirsh AT, de Groot M, Stewart JC (December 2019). "Diabetes Risk Perception Among Immigrant and Racial/Ethnic Minority Adults in the United States".
865:
order, where failure to take medication will result in detention and involuntary administration of treatment. This can also occur if a patient is not deemed to have
2386:
An analysis of over 100 local education authority areas found educational attainment at age 15-16 to be significantly associated with both CHD and infant mortality.
4214:
Atherton H, Sawmynaden P, Sheikh A, Majeed A, Car J (November 2012). "Email for clinical communication between patients/caregivers and healthcare professionals".
5134:
Bender BG, Bender SE (February 2005). "Patient-identified barriers to asthma treatment adherence: responses to interviews, focus groups, and questionnaires".
4747:"Do mobile device apps designed to support medication adherence demonstrate efficacy? A systematic review of randomised controlled trials, with meta-analysis"
5807:
Olfson M, Marcus SC, Wilk J, West JC (February 2006). "Awareness of illness and nonadherence to antipsychotic medications among persons with schizophrenia".
5379:
4711:
1096:
Medication event monitoring system - a medication dispenser containing a microchip that records when the container is opened and from Partridge et al (2002)
377:
Educational qualifications help to determine an individual's position in the labour market, their level of income and therefore their access to resources.
4100:
3969:
Mahtani KR, Heneghan CJ, Glasziou PP, Perera R (September 2011). "Reminder packaging for improving adherence to self-administered long-term medications".
201:
1748:
Viswanathan M, Golin CE, Jones CD, Ashok M, Blalock S, Wines RC, Coker-Schwimmer EJ, Grodensky CA, Rosen DL, Yuen A, Sista P, Lohr KN (September 2012).
5764:
Dolder CR, Lacro JP, Leckband S, Jeste DV (August 2003). "Interventions to improve antipsychotic medication adherence: review of recent literature".
474:
Additionally, some cultures fatalistically attribute their good or poor health to their god(s), and attach less importance to self-care than others.
2338:
2192:
1411:
4159:"A scoping review of studies comparing the medication event monitoring system (MEMS) with alternative methods for measuring medication adherence"
1535:"Impact of adverse drug events and treatment satisfaction on patient adherence with antihypertensive medication - a study in ambulatory patients"
408:
areas found educational attainment at 15–16 years of age to be strongly associated with coronary heart disease and subsequent infant mortality.
5063:
3457:"Contextual factors predicting compliance behavior during the COVID-19 pandemic: A machine learning analysis on survey data from 16 countries"
2833:
Meyerowitz BE, Richardson J, Hudson S, Leedham B (January 1998). "Ethnicity and cancer outcomes: behavioral and psychosocial considerations".
1144:
Diabetes non-compliance is 98% in US and the principal cause of complications related to diabetes including nerve damage and kidney failure.
558:
3628:
Kleitman, Sabina; Fullerton, Dayna J.; Zhang, Lisa M.; Blanchard, Matthew D.; Lee, Jihyun; Stankov, Lazar; Thompson, Valerie (2021-07-29).
3091:
Watanabe JH, Bounthavong M, Chen T (March 2013). "Revisiting the medication possession ratio threshold for adherence in lipid management".
2502:
Kesselheim AS, Avorn J, Sarpatwari A (2016). "The High Cost of Prescription Drugs in the United States: Origins and Prospects for Reform".
4122:
Santschi V, Chiolero A, Burnier M (November 2009). "Electronic monitors of drug adherence: tools to make rational therapeutic decisions".
3571:"Moral Disengagement and Generalized Social Trust as Mediators and Moderators of Rule-Respecting Behaviors During the COVID-19 Outbreak"
2398:
Williams MV, Baker DW, Honig EG, Lee TM, Nowlan A (October 1998). "Inadequate literacy is a barrier to asthma knowledge and self-care".
1749:
785:
The effectiveness of two-way email communication between health care professionals and their patients has not been adequately assessed.
3999:
323:
2432:
1177:
Hypertension non-compliance (93% in US, 70% in UK) is the main cause of uncontrolled hypertension-associated heart attack and stroke.
4068:
Akl EA, Oxman AD, Herrin J, Vist GE, Terrenato I, Sperati F, et al. (December 2011). "Framing of health information messages".
4012:
2371:
2111:
634:
of patients) improves patient adherence rates to lipid-lowering medicines, as well as total cholesterol and LDL-cholesterol levels.
2071:
1346:
194:
1184:
As a result of poor compliance, 75% of patients with a diagnosis of hypertension do not achieve optimum blood-pressure control.
807:
441:
medicines are prescribed for people over retirement age, despite representing only about 20% of the UK population. The recent
5039:
3864:
1277:
17:
1371:
1750:
Medication Adherence Interventions: Comparative Effectiveness. Closing the Quality Gap: Revisiting the State of the Science
866:
764:
Health care providers play a great role in improving adherence issues. Providers can improve patient interactions through
4315:
Anglada-Martinez H, Riu-Viladoms G, Martin-Conde M, Rovira-Illamola M, Sotoca-Momblona JM, Codina-Jane C (January 2015).
885:
study estimates that only 50% of patients with chronic diseases in developed countries follow treatment recommendations.
5256:"Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study"
5079:"An international comparison of legal frameworks for supported and substitute decision-making in mental health services"
6000:
187:
84:
4944:"Aripiprazole once-monthly as maintenance treatment for bipolar I disorder: a 52-week, multicenter, open-label study"
4556:"The role of mHealth for improving medication adherence in patients with cardiovascular disease: a systematic review"
438:
2451:
Thinking Outside the Pillbox: A System-wide Approach to Improving Patient Adherence for Chronic Disease." NEHI. 2009
5528:"Psychosocial factors in medication adherence and diabetes self-management: Implications for research and practice"
3569:
Alessandri, Guido; Filosa, Lorenzo; Tisak, Marie S.; Crocetti, Elisabetta; Crea, Giuseppe; Avanzi, Lorenzo (2020).
2790:
Courtenay WH, McCreary DR, Merighi JR (May 2002). "Gender and ethnic differences in health beliefs and behaviors".
2215:"Standardised assessment of patients' capacity to manage medications: a systematic review of published instruments"
1484:"Standardised assessment of patients' capacity to manage medications: a systematic review of published instruments"
397:, found more than one-third of people with poor or very poor health had literary skills of Entry Level 3 or below.
311:
290:
is often used to imply a collaborative approach to decision-making and treatment between a patient and clinician.
244:
Worldwide, non-compliance is a major obstacle to the effective delivery of health care. 2003 estimates from the
6020:
4662:"Impact of mHealth chronic disease management on treatment adherence and patient outcomes: a systematic review"
4415:"International Standards for Tuberculosis Care (ISTC) and Patients' Charter: New Advances in Tuberculosis Care"
4108:
4610:"Impact of eHealth on medication adherence among patients with asthma: A systematic review and meta-analysis"
3630:"To comply or not comply? A latent profile analysis of behaviours and attitudes during the COVID-19 pandemic"
2107:
543:{\displaystyle VMPR={\dfrac {\text{All days' supply}}{\text{Elapsed days (inclusive of last prescription)}}}}
315:
6030:
6015:
5991:
4454:
Ngwatu BK, Nsengiyumva NP, Oxlade O, Mappin-Kasirer B, Nguyen NL, Jaramillo E, et al. (January 2018).
4041:
Stefanacci RG, Guerin S (January 2013). "Why medication adherence matters to patients, payers, providers".
3851:
1439:
Ngoh LN (2009). "Health literacy: a barrier to pharmacist-patient communication and medication adherence".
1264:
393:
In 2003, 20% of adults in the UK had a long-standing illness or disability and a national study for the UK
4157:
El Alili, Mohamed; Vrijens, Bernard; Demonceau, Jenny; Evers, Silvia M.; Hiligsmann, Mickael (July 2016).
1656:
Nieuwlaat R, Wilczynski N, Navarro T, Hobson N, Jeffery R, Keepanasseril A, et al. (November 2014).
264:. Major barriers to compliance are thought to include the complexity of modern medication regimens, poor
79:
72:
35:
4505:"Expert Involvement and Adherence to Medical Evidence in Medical Mobile Phone Apps: A Systematic Review"
2357:
1908:
385:
In 1999 one fifth of UK adults, nearly seven million people, had problems with basic skills, especially
5254:
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, et al. (September 1998).
4866:
Hansen LB, Saseen JJ (February 2004). "New contraceptive options: patient adherence and satisfaction".
1533:
Berhe DF, Taxis K, Haaijer-Ruskamp FM, Mulugeta A, Mengistu YT, Burgerhof JG, Mol PG (September 2017).
1034:
442:
421:
increase in patient medication cost share was found to be associated with low adherence to medication.
177:
132:
104:
45:
354:
An estimated half of those for whom treatment regimens are prescribed do not follow them as directed.
5995:
2358:"The skills for life survey. A national needs and impact survey of literacy, numeracy and ICT skills"
983:
765:
405:
307:
245:
1147:
Among patients with Type 2 Diabetes, adherence was found in less than one third of those prescribed
4250:
319:
2739:
Guglani L, Havstad SL, Ownby DR, Saltzgaber J, Johnson DA, Johnson CC, Joseph CL (November 2013).
454:, living arrangement, multiple doctors, and use of compliance aids was correlated with adherence.
5942:"Multilevel factors predict medication adherence in rheumatoid arthritis: a 6-month cohort study"
5842:
Murray RM, Quattrone D, Natesan S, van Os J, Nordentoft M, Howes O, et al. (November 2016).
830:
298:
241:, which is the process by which a patient and clinician make decisions together about treatment.
31:
1293:
Baker SE, Silvernail J, Scoville C, Kushner S, Mabry L, Konitzer L, et al. (January 2020).
5844:"Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?"
898:
effectively treated, only 40% of patients adhere to their medicines due to poor understanding.
858:
4276:"Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease: A Meta-analysis"
2643:"Non-compliance and knowledge of prescribed medication in elderly patients with heart failure"
5373:
3882:"Adherence with statin therapy in elderly patients with and without acute coronary syndromes"
2995:"Factors associated with first-fill adherence rates for diabetic medications: a cohort study"
1757:
1233:
862:
854:
386:
306:
treatment regimen. Despite the ongoing debate, adherence has been the preferred term for the
3522:
DeFranza, David; Lindow, Mike; Harrison, Kevin; Mishra, Arul; Mishra, Himanshu (July 2021).
3042:
Shah NR, Hirsch AG, Zacker C, Wood GC, Schoenthaler A, Ogedegbe G, Stewart WF (April 2009).
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1810:
Greer JA, Amoyal N, Nisotel L, Fishbein JN, MacDonald J, Stagl J, et al. (March 2016).
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In 1975, only about 50% took at least 80% of their prescribed anti-hypertensive medications.
4274:
Thakkar J, Kurup R, Laba TL, Santo K, Thiagalingam A, Rodgers A, et al. (March 2016).
3641:
3468:
3239:
1003:
394:
252:
follow treatment recommendations with particularly low rates of adherence to therapies for
5479:"Distress and type 2 diabetes-treatment adherence: A mediating role for perceived control"
5395:"Depression and diabetes: impact of depressive symptoms on adherence, function, and costs"
4895:"The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal"
4554:
Gandapur Y, Kianoush S, Kelli HM, Misra S, Urrea B, Blaha MJ, et al. (October 2016).
4456:"The impact of digital health technologies on tuberculosis treatment: a systematic review"
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to involve a patient in the treatment process to improve compliance, and refers to a 2003
8:
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Lustman PJ, Griffith LS, Clouse RE (January 1997). "Depression in Adults with Diabetes".
4020:
818:
interventions such as wearable wireless pill sensors, smart pillboxes and smart inhalers
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4712:"Apps to help patients take medication on time need to be evaluated in a consistent way"
3645:
3472:
3243:
2971:
2078:
5971:
5917:
5892:
5873:
5789:
5777:
5746:
5703:
5654:
5601:
5552:
5527:
5503:
5478:
5459:
5326:
5236:
5116:
5057:
4970:
4943:
4919:
4894:
4771:
4746:
4727:
4688:
4661:
4639:
4580:
4555:
4531:
4504:
4480:
4455:
4390:
4365:
4346:
4314:
4191:
4158:
3946:
3827:
3802:
3756:
3744:
3672:
3629:
3605:
3570:
3499:
3456:
3439:
3406:
3382:
3325:
3292:
3268:
3228:"Predictors of COVID-19 voluntary compliance behaviors: An international investigation"
3227:
3202:
3162:
3135:
3116:
3068:
3043:
3019:
2994:
2947:
2922:
2815:
2767:
2740:
2716:
2691:
2672:
2479:
2462:
2321:
2299:
2241:
2214:
2161:
2134:
2047:
2022:
1998:
1989:
1973:
1954:
1885:
1860:
1836:
1811:
1730:
1682:
1657:
1631:
1559:
1534:
1510:
1483:
1464:
5734:
5313:
5296:
5224:
4718:(Plain English summary). National Institute for Health and Care Research. 2020-06-02.
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2642:
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2069:
1769:
1767:
6025:
5975:
5963:
5922:
5865:
5824:
5781:
5738:
5695:
5658:
5646:
5593:
5557:
5508:
5451:
5447:
5416:
5361:
5318:
5277:
5228:
5192:
5151:
5108:
5045:
5035:
5010:
4975:
4942:
Calabrese JR, Jin N, Johnson B, Such P, Baker RA, Madera J, et al. (June 2018).
4924:
4875:
4848:
4776:
4731:
4693:
4631:
4585:
4536:
4485:
4436:
4395:
4338:
4297:
4231:
4196:
4178:
4139:
4081:
4050:
3982:
3938:
3903:
3860:
3832:
3783:
3748:
3712:
3708:
3677:
3659:
3610:
3592:
3551:
3543:
3504:
3486:
3426:
3387:
3369:
3330:
3312:
3273:
3255:
3206:
3167:
3120:
3108:
3073:
3024:
2952:
2877:
2850:
2807:
2772:
2721:
2707:
2664:
2576:
2519:
2484:
2415:
2313:
2246:
2166:
2052:
2038:
2003:
1946:
1890:
1841:
1722:
1687:
1635:
1623:
1615:
1564:
1515:
1456:
1374:. National Institute for Health and Clinical Excellence. 3 March 2008. Archived from
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1958:
1827:
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1468:
1372:"Medicines concordance (involving patients in decisions about prescribed medicines)"
327:
5953:
5912:
5908:
5904:
5877:
5855:
5816:
5793:
5773:
5730:
5707:
5685:
5636:
5628:
5585:
5547:
5539:
5498:
5490:
5443:
5406:
5353:
5308:
5267:
5220:
5182:
5143:
5120:
5098:
5090:
5002:
4965:
4955:
4914:
4906:
4840:
4810:
4766:
4758:
4719:
4683:
4673:
4621:
4575:
4567:
4526:
4516:
4475:
4467:
4426:
4385:
4377:
4350:
4328:
4287:
4227:
4223:
4186:
4170:
4131:
4077:
4073:
3978:
3974:
3930:
3893:
3822:
3818:
3814:
3740:
3704:
3667:
3649:
3600:
3582:
3535:
3494:
3476:
3434:
3418:
3377:
3361:
3320:
3304:
3263:
3247:
3194:
3157:
3147:
3100:
3063:
3055:
3014:
3006:
2942:
2934:
2842:
2799:
2762:
2752:
2711:
2703:
2654:
2641:
Cline CM, Björck-Linné AK, Israelsson BY, Willenheimer RB, Erhardt LR (June 1999).
2607:
2568:
2511:
2474:
2407:
2303:
2295:
2236:
2226:
2156:
2146:
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2042:
2034:
1993:
1985:
1938:
1880:
1872:
1831:
1823:
1787:
1764:
1714:
1677:
1673:
1669:
1605:
1595:
1575:
1554:
1546:
1505:
1495:
1448:
1306:
870:
842:
425:
231:
94:
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Harper, Craig A.; Satchell, Liam P.; Fido, Dean; Latzman, Robert D. (2021-10-01).
3308:
1340:"Out-of-pocket costs may be a substantial barrier to prescription drug compliance"
5411:
5394:
4431:
4414:
4135:
3654:
3481:
3104:
2439:
1375:
1228:
1193:
826:
371:
370:
Cost and poor understanding of the directions for the treatment, referred to as '
265:
158:
122:
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466:
participation in screening programmes and attendance at follow-up appointments.
30:
This article is about following medical advice. For the physiological term, see
5094:
4844:
4626:
4609:
4317:"Does mHealth increase adherence to medication? Results of a systematic review"
3365:
2909:
2896:
2846:
1600:
1583:
1148:
294:
127:
67:
5860:
5843:
5272:
5255:
5147:
4960:
3422:
3251:
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Shah NR, Hirsch AG, Zacker C, Taylor S, Wood GC, Stewart WF (February 2009).
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3350:"Functional Fear Predicts Public Health Compliance in the COVID-19 Pandemic"
3198:
2692:"Drug therapy in the elderly: what doctors believe and patients actually do"
2515:
1311:
1294:
343:
5967:
5926:
5869:
5828:
5785:
5699:
5650:
5597:
5561:
5512:
5455:
5420:
5365:
5322:
5196:
5155:
5112:
5014:
4979:
4928:
4879:
4852:
4780:
4697:
4660:
Hamine S, Gerth-Guyette E, Faulx D, Green BB, Ginsburg AS (February 2015).
4635:
4589:
4540:
4489:
4399:
4342:
4301:
4235:
4200:
4143:
4085:
4054:
3986:
3942:
3907:
3898:
3881:
3836:
3787:
3752:
3681:
3614:
3555:
3508:
3407:"To Follow or Not to Follow: Social Norms and Civic Duty during a Pandemic"
3391:
3334:
3277:
3171:
3112:
3077:
3028:
2956:
2811:
2776:
2757:
2725:
2668:
2580:
2523:
2488:
2250:
2231:
2170:
2101:
2056:
2007:
1950:
1894:
1845:
1726:
1691:
1627:
1568:
1519:
1500:
1460:
1320:
1159:
Other aspects that drive medicine adherence rates is the idea of perceived
811:
803:
451:
261:
113:
5281:
5232:
5031:
Coercion in community mental health care : international perspectives
5029:
4503:
Subhi Y, Bube SH, Rolskov Bojsen S, Skou Thomsen AS, Konge L (July 2015).
4381:
2881:
2854:
2419:
2317:
2308:
437:
The elderly often have multiple health conditions, and around half of all
248:
indicated that only about 50% of patients with chronic diseases living in
5574:
5357:
4521:
3716:
3059:
1942:
1909:"Therapeutics Initiative | [132] Rethinking Medication Adherence"
1641:
behavioral science is an important need to be considered in medical care.
1610:
950:
302:
understanding the risks and benefits, chooses not to take the treatment.
137:
5742:
5672:
Brown MT, Bussell J, Dutta S, Davis K, Strong S, Mathew S (April 2016).
4723:
3226:
Clark, Cory; Davila, Andrés; Regis, Maxime; Kraus, Sascha (2020-01-01).
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Jeminiwa R, Hohmann L, Qian J, Garza K, Hansen R, Fox BI (March 2019).
4333:
4316:
3539:
3187:"Extending the Choice Architecture Toolbox: The Choice Context Mapping"
3152:
2640:
2612:
2595:
2151:
909:
The poor quality of information available to them about their treatment
815:
5641:
5589:
5006:
4678:
4174:
3934:
1718:
1550:
1116:
29% in the National Surgical Adjuvant Breast and Bowel Project of 1998
1105:
as a preventative agent have shown dropout rates of around one-third:
905:
The reasons for non-adherence have been given by patients as follows:
602:{\displaystyle FMPR={\dfrac {{\text{All days' supply}}\leq 365}{365}}}
5543:
4893:
Brissos S, Veguilla MR, Taylor D, Balanzá-Martinez V (October 2014).
4892:
4453:
3523:
3293:"Trust and compliance to public health policies in times of COVID-19"
1152:
1102:
279:
227:
153:
89:
4366:"The new Stop TB Strategy and the Global Plan to Stop TB, 2006-2015"
3729:
1972:
Bell JS, Airaksinen MS, Lyles A, Chen TF, Aslani P (November 2007).
912:
A lack of knowledge as to how to raise concerns whilst on medication
4502:
3044:"Predictors of first-fill adherence for patients with hypertension"
1812:"A Systematic Review of Adherence to Oral Antineoplastic Therapies"
979:
257:
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Eaddy MT, Cook CL, O'Day K, Burch SP, Cantrell CR (January 2012).
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Osterberg L, Blaschke T (August 2005). "Adherence to medication".
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3803:"Interventions to improve adherence to lipid-lowering medication"
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European Heart Journal - Quality of Care & Clinical Outcomes
3404:
1655:
3627:
2355:
2070:
US NIH Office of Behavior and Social Sciences Research (2008).
1581:
857:
to ensure compliance. This can occur if an individual has been
799:
639:
253:
4213:
3186:
1292:
5939:
5890:
5525:
5076:
4659:
4156:
3968:
3568:
3133:
2738:
989:
362:
Negative side effects of a medicine can influence adherence.
5891:
McIntosh AM, Conlon L, Lawrie SM, Stanfield AC (July 2006).
5841:
4251:"1 Billion More Phones Than People In The World! BankMyCell"
3800:
3521:
1974:"Concordance is not synonymous with compliance or adherence"
5526:
Gonzalez JS, Tanenbaum ML, Commissariat PV (October 2016).
4833:
The Journal of Allergy and Clinical Immunology. In Practice
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educationengland.org, 14 pages (1999)retrieved 28. 12. 2017
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Tackling health inequalities (Report). HM Government. 2002.
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Jin J, Sklar GE, Min Sen Oh V, Chuen Li S (February 2008).
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Technology report on NFC enabled smart medication packages
5720:
5476:
4799:"A Review of Medication Adherence Monitoring Technologies"
4553:
3524:"Religion and reactance to COVID-19 mitigation guidelines"
2867:
2132:
1809:
1747:
424:
The United States is among the countries with the highest
3849:
3773:
3347:
2501:
1262:
882:
5763:
4607:
3920:
2789:
1155:. Patients taking both drugs achieve only 13% adherence.
5940:
Balsa A, García de Yébenes MJ, Carmona L (March 2022).
5477:
Gonzalez JS, Shreck E, Psaros C, Safren SA (May 2015).
5209:
5168:
4941:
4121:
3134:
Kozma CM, Dickson M, Phillips AL, Meletiche DM (2013).
3090:
2920:
2689:
2606:(1) (12th ed.). London: Department of Health: 38.
2460:
1971:
5671:
5618:
5392:
5171:"Adherence to therapy with oral antineoplastic agents"
5027:
4744:
2992:
2433:
New Report Card on Medication Use Gives Americans a C+
2356:
Williams J, Clemens S, Oleinikova K, Tarvin K (2003).
5433:
5393:
Ciechanowski PS, Katon WJ, Russo JE (November 2000).
5343:
5169:
Partridge AH, Avorn J, Wang PS, Winer EP (May 2002).
4796:
4273:
4101:"Patient compliance: technology tools for physicians"
3853:
Adherence to long-term therapies: evidence for action
3225:
2397:
1266:
Adherence to long-term therapies: evidence for action
578:
561:
529:
512:
5806:
4829:
3879:
3354:
International Journal of Mental Health and Addiction
3041:
27:
Descriptor of patient compliance with medical advice
3453:
3291:Bargain, Olivier; Aminjonov, Ulugbek (2020-12-01).
1780:
Egyptian Journal of Chest Diseases and Tuberculosis
1215:
having received information on treatment adaptation
902:the increase in patient cancer treatments at home.
4745:Armitage LC, Kassavou A, Sutton S (January 2020).
4067:
1658:"Interventions for enhancing medication adherence"
601:
542:
5378:: CS1 maint: DOI inactive as of September 2024 (
4000:Healthcare Compliance Packaging Council of Europe
2102:Office of Behavior and Social Sciences Research.
1928:
6007:
4040:
3290:
3185:Hajdu, Nandor; Szaszi, Barnabas; Aczel, Balazs.
2972:"Many patients may not fill their prescriptions"
2690:Barat I, Andreasen F, Damsgaard EM (June 2001).
876:
759:
5136:Immunology and Allergy Clinics of North America
2212:
1773:
1481:
1441:Journal of the American Pharmacists Association
654:World Health Organization Barriers to Adherence
446:knowledge is a concern that has been observed.
5674:"Medication Adherence: Truth and Consequences"
4995:International Journal of Mental Health Nursing
4797:Aldeer M, Javanmard M, Martin RP (June 2018).
2630:. London: UK Office of Health Economics. 2000.
2360:. London: Department for Education and Skills.
2263:
494:
5294:
2596:"National Service Framework for Older People"
2557:
2535:
2533:
535:Elapsed days (inclusive of last prescription)
195:
5678:The American Journal of the Medical Sciences
5133:
4865:
4034:
3184:
2910:https://doi.org/10.3122/jabfm.2021.05.200639
2897:https://doi.org/10.1016/j.amepre.2019.06.005
1858:
754:
5897:The Cochrane Database of Systematic Reviews
5083:International Journal of Law and Psychiatry
4992:
4859:
4216:The Cochrane Database of Systematic Reviews
4070:The Cochrane Database of Systematic Reviews
3971:The Cochrane Database of Systematic Reviews
3807:The Cochrane Database of Systematic Reviews
1662:The Cochrane Database of Systematic Reviews
1258:
1256:
1254:
1252:
1250:
1248:
971:Taking less than 90% of prescribed medicine
918:Issues about remembering to take medication
5297:"Drop-outs in tamoxifen prevention trials"
5062:: CS1 maint: location missing publisher (
4948:International Journal of Bipolar Disorders
4899:Therapeutic Advances in Psychopharmacology
4363:
4321:International Journal of Clinical Practice
2530:
2288:Journal of the American Geriatrics Society
1588:Journal of Allergy and Clinical Immunology
1475:
485:
401:particularly likely to lack basic skills.
324:United States National Library of Medicine
293:The term concordance has been used in the
202:
188:
5957:
5916:
5859:
5689:
5640:
5551:
5502:
5410:
5312:
5271:
5186:
5102:
5028:Molodynski A, Rugkåsa J, Burns T (2016).
4969:
4959:
4918:
4814:
4770:
4687:
4677:
4625:
4579:
4530:
4520:
4479:
4430:
4389:
4370:Bulletin of the World Health Organization
4332:
4291:
4190:
3897:
3880:Jackevicius CA, Mamdani M, Tu JV (2002).
3826:
3671:
3653:
3604:
3586:
3498:
3480:
3438:
3381:
3324:
3267:
3161:
3151:
3067:
3018:
2946:
2766:
2756:
2715:
2658:
2634:
2611:
2478:
2307:
2240:
2230:
2160:
2150:
2139:Therapeutics and Clinical Risk Management
2046:
1997:
1884:
1835:
1791:
1681:
1609:
1599:
1558:
1509:
1499:
1310:
342:are distinguished under the MeSH tree of
5884:
5260:Journal of the National Cancer Institute
5175:Journal of the National Cancer Institute
4412:
4163:British Journal of Clinical Pharmacology
4098:
2969:
2745:Allergy, Asthma, and Clinical Immunology
2696:British Journal of Clinical Pharmacology
2027:British Journal of Clinical Pharmacology
1978:British Journal of Clinical Pharmacology
1539:British Journal of Clinical Pharmacology
1334:
1332:
1330:
1245:
2020:
1199:
1113:Tamoxifen Chemoprevention Study of 1998
14:
6008:
5893:"Compliance therapy for schizophrenia"
5766:Journal of Clinical Psychopharmacology
4792:
4790:
4655:
4653:
4603:
4601:
4599:
4248:
2593:
2351:
2349:
2347:
1704:
1434:
1432:
1430:
1428:
821:
3964:
3962:
3960:
3859:. Geneva: World Health Organisation.
3694:
3411:Canadian Journal of Political Science
2213:Elliott RA, Marriott JL (July 2009).
1805:
1803:
1651:
1649:
1482:Elliott RA, Marriott JL (July 2009).
1398:
1396:
1394:
1392:
1327:
1272:. Geneva: World Health Organisation.
1218:clinician perception of patient trust
955:Serum levels below expected threshold
713:Availability of Effective Treatments
681:Inadequate Access to Health Services
615:
326:defines various terms with the words
5346:Seminars in Clinical Neuropsychiatry
4666:Journal of Medical Internet Research
3776:The American Journal of Managed Care
3093:Current Medical Research and Opinion
2999:Journal of General Internal Medicine
2986:
2927:Journal of General Internal Medicine
2023:"Compliance, concordance, adherence"
1859:Marinker M, Shaw J (February 2003).
1774:Nizar R, Elham AJ, Hasan AA (2013).
1438:
1345:. Harris Interactive. Archived from
624:
349:
4787:
4650:
4596:
2344:
1931:The New England Journal of Medicine
1852:
1425:
1012:More than one missed dose per month
673:Poor Patient-provider Relationship
24:
5778:10.1097/01.jcp.0000085413.08426.41
5295:Cuzick J, Edwards R (March 1999).
3957:
3850:World Health Organization (2003).
3745:10.1097/01.hjh.0000186832.41125.8a
2300:10.1111/j.1532-5415.1999.tb04575.x
1990:10.1111/j.1365-2125.2007.02971_1.x
1800:
1646:
1389:
1263:World Health Organization (2003).
1082:Level of drug metabolites in blood
1068:Level of drug metabolites in blood
745:Inadequate Knowledge of Treatment
365:
344:Treatment Adherence and Compliance
25:
6042:
5985:
5848:The British Journal of Psychiatry
4130:(11): 2294–5, author reply 2295.
2647:European Journal of Heart Failure
1187:
1054:Level of drug metabolite in urine
415:
5992:Adherence to long-term therapies
5946:Annals of the Rheumatic Diseases
5933:
5835:
5800:
5757:
5714:
5665:
5612:
5568:
5519:
5470:
5448:10.1046/j.1464-5491.2002.00689.x
5427:
5386:
5337:
5288:
5247:
5203:
5162:
4460:The European Respiratory Journal
3140:Patient Preference and Adherence
3048:American Journal of Hypertension
2708:10.1046/j.0306-5251.2001.01401.x
2039:10.1111/j.1365-2125.2007.02893.x
1984:(5): 710–1, author reply 711–3.
1209:the type of treatment prescribed
788:
721:Immediacy of Beneficial Effects
318:Adherence Research Network. The
312:American Pharmacists Association
237:Compliance can be confused with
173:
172:
5959:10.1136/annrheumdis-2021-221163
5127:
5070:
5021:
4986:
4935:
4886:
4823:
4738:
4704:
4547:
4496:
4447:
4406:
4357:
4308:
4293:10.1001/jamainternmed.2015.7667
4267:
4242:
4207:
4150:
4115:
4092:
4061:
4005:
3993:
3914:
3873:
3843:
3794:
3767:
3723:
3688:
3621:
3562:
3515:
3447:
3398:
3341:
3284:
3219:
3178:
3127:
3084:
3035:
2963:
2914:
2901:
2888:
2861:
2826:
2783:
2732:
2683:
2628:Compendium of Health Statistics
2620:
2587:
2573:10.1016/j.clinthera.2009.01.006
2551:
2495:
2454:
2445:
2426:
2391:
2364:
2332:
2279:
2268:
2257:
2206:
2177:
2126:
2095:
2063:
2014:
1965:
1922:
1901:
1828:10.1634/theoncologist.2015-0405
1741:
1698:
1171:
915:Concerns about unwanted effects
404:A 2002 analysis of over 100 UK
357:
232:cost of prescription medication
5909:10.1002/14651858.CD003442.pub2
4228:10.1002/14651858.CD007978.pub2
4078:10.1002/14651858.CD006777.pub2
3979:10.1002/14651858.CD005025.pub3
3819:10.1002/14651858.CD004371.pub4
2191:. October 2004. Archived from
1674:10.1002/14651858.CD000011.pub4
1526:
1410:. October 2004. Archived from
1364:
1286:
869:to consent to treatment in an
272:
13:
1:
5735:10.1016/S0140-6736(75)92192-3
5399:Archives of Internal Medicine
5314:10.1016/S0140-6736(05)75043-1
5225:10.1016/S0140-6736(98)85012-5
4043:Managed Care (Langhorne, Pa.)
3923:The Annals of Pharmacotherapy
3697:Social Science & Medicine
3309:10.1016/j.jpubeco.2020.104316
2660:10.1016/S1388-9842(99)00014-8
2442:Pharmacy Times. JUNE 25, 2013
2108:National Institutes of Health
1861:"Not to be taken as directed"
1707:The Annals of Pharmacotherapy
1239:
1009:Self-report and parent report
877:Health and disease management
772:
760:Role of health care providers
316:National Institutes of Health
5412:10.1001/archinte.160.21.3278
4432:10.3126/hprospect.v10i0.5651
4136:10.1097/hjh.0b013e328332a501
3709:10.1016/0037-7856(77)90044-0
3655:10.1371/journal.pone.0255268
3482:10.1371/journal.pone.0276970
3105:10.1185/03007995.2013.766164
2792:Journal of Health Psychology
2104:"Adherence Research Network"
1594:(1). Elsevier BV: 70–80.e3.
1020:Lymphoma, other malignancies
988:Level of drug metabolite in
684:Health Care Team and System
676:Health Care Team and System
460:
426:prices of prescription drugs
7:
5691:10.1016/j.amjms.2016.01.010
4763:10.1136/bmjopen-2019-032045
4472:10.1183/13993003.01596-2017
3297:Journal of Public Economics
2804:10.1177/1359105302007003216
1793:10.1016/j.ejcdt.2013.07.010
1447:(5): e132-46, quiz e147-9.
1222:
1134:
1101:In 1998, trials evaluating
946:Haematological malignancies
938:Definition of non-Adherence
848:
737:Stigma Surrounding Disease
495:Medication Possession Ratio
380:
80:Doctor-patient relationship
10:
6047:
5095:10.1016/j.ijlp.2015.08.029
4845:10.1016/j.jaip.2013.06.015
4627:10.1016/j.rmed.2019.02.011
4364:Raviglione MC (May 2007).
3366:10.1007/s11469-020-00281-5
2847:10.1037/0033-2909.123.1.47
1601:10.1016/j.jaci.2019.06.049
1035:acute lymphocytic leukemia
853:Sometimes drugs are given
705:Level of Symptom Severity
443:National Service Framework
105:Social model of disability
29:
5996:World Health Organization
5861:10.1192/bjp.bp.116.182683
5532:The American Psychologist
5148:10.1016/j.iac.2004.09.005
4961:10.1186/s40345-018-0122-z
4868:American Family Physician
4803:Applied System Innovation
4413:Bhandari R (2018-07-22).
3423:10.1017/S0008423920000554
3252:10.1016/j.glt.2020.06.003
3011:10.1007/s11606-008-0870-z
2939:10.1007/s11606-010-1253-9
2594:Jolley D (January 2003).
2189:APA Highlights Newsletter
2021:Aronson JK (April 2007).
1408:APA Highlights Newsletter
1085:Level lower than expected
1071:Level lower than expected
1057:Level lower than expected
1043:Level lower than expected
994:Level lower than expected
892:
837:medication used to treat
808:Directly Observed Therapy
766:motivational interviewing
755:Improving adherence rates
406:local education authority
308:World Health Organization
246:World Health Organization
234:also plays a major role.
5821:10.1176/appi.ps.57.2.205
5633:10.1177/0145721719873640
4911:10.1177/2045125314540297
4509:JMIR mHealth and uHealth
3588:10.3389/fpsyg.2020.02102
2870:Clinical Transplantation
2545:Kaiser Family Foundation
2412:10.1378/chest.114.4.1008
1877:10.1136/bmj.326.7385.348
1453:10.1331/JAPhA.2009.07075
935:Measure of non-Adherence
320:Medical Subject Headings
5360:(inactive 2024-09-12).
5273:10.1093/jnci/90.18.1371
4249:Turner A (2018-07-10).
4124:Journal of Hypertension
3733:Journal of Hypertension
3575:Frontiers in Psychology
2516:10.1001/jama.2016.11237
1754:Evidence Report No. 208
861:or are subjected to an
859:involuntarily committed
831:oral contraceptive pill
486:Prescription fill rates
32:Compliance (physiology)
4572:10.1093/ehjqcco/qcw018
4280:JAMA Internal Medicine
3899:10.1001/jama.288.4.462
2835:Psychological Bulletin
2758:10.1186/1710-1492-9-45
2232:10.1186/1471-2318-9-27
1501:10.1186/1471-2318-9-27
1212:agreement on treatment
984:non Hodgkin's lymphoma
941:Rate of Non-Adherence
603:
544:
432:
85:Shared decision making
34:. For other uses, see
6021:Clinical pharmacology
5621:The Diabetes Educator
5188:10.1093/jnci/94.9.652
4382:10.2471/blt.06.038513
3528:American Psychologist
3199:10.31234/osf.io/cbrwt
2561:Clinical Therapeutics
1312:10.1093/milmed/usz287
1234:Patient participation
949:Serum levels of drug
863:outpatient commitment
689:High Medication Cost
604:
545:
18:Compliance (medicine)
5994:, a report from the
5809:Psychiatric Services
5358:10.1053/SCNP00200015
4614:Respiratory Medicine
4522:10.2196/mhealth.4169
3060:10.1038/ajh.2008.367
2600:Psychiatric Bulletin
2339:Moser Report Summary
1943:10.1056/NEJMra050100
1305:(Suppl 1): 565–570.
1200:Rheumatoid arthritis
1130:74% after four years
700:Social and Economic
692:Social and Economic
559:
510:
395:Department of Health
340:Medication Adherence
6031:Health care quality
6016:Medical terminology
5729:(7918): 1205–1207.
4874:(4): 811–2, 815–6.
4724:10.3310/alert_40365
4105:Physicians Practice
4099:Torrieri M (2012).
4002:www.hcpc-europe.org
3646:2021PLoSO..1655268K
3473:2022PLoSO..1776970H
3244:2020GloT....2...76C
1127:83% after two years
1033:Hodgkin's disease,
822:Forms of medication
387:functional literacy
250:developed countries
5495:10.1037/hea0000131
4816:10.3390/asi1020014
4334:10.1111/ijcp.12582
3703:(11–13): 619–624.
3540:10.1037/amp0000717
3232:Global Transitions
3153:10.2147/PPA.S40736
2613:10.1192/pb.27.1.38
2438:2017-12-28 at the
2152:10.2147/tcrm.s1458
1352:on January 3, 2010
1124:90% after one year
1040:Biological markers
616:Contextual factors
599:
597:
540:
538:
336:Patient Compliance
216:patient compliance
5590:10.1111/dme.13939
5578:Diabetic Medicine
5483:Health Psychology
5436:Diabetic Medicine
5405:(21): 3278–3285.
5266:(18): 1371–1388.
5041:978-0-19-103431-2
5007:10.1111/inm.12105
4679:10.2196/jmir.3951
4175:10.1111/bcp.12942
3935:10.1345/aph.1H582
3866:978-92-4-154599-0
3782:(10): 1421–1430.
3739:(11): 2093–2100.
2970:Norton M (2010).
1871:(7385): 348–349.
1719:10.1345/aph.1D207
1551:10.1111/bcp.13312
1299:Military Medicine
1279:978-92-4-154599-0
1092:
1091:
1004:Hodgkin's disease
752:
751:
697:Cultural Beliefs
625:Course completion
596:
584:
537:
536:
533:
350:Adherence factors
212:
211:
54:Medical sociology
16:(Redirected from
6038:
5980:
5979:
5961:
5937:
5931:
5930:
5920:
5888:
5882:
5881:
5863:
5839:
5833:
5832:
5804:
5798:
5797:
5761:
5755:
5754:
5718:
5712:
5711:
5693:
5669:
5663:
5662:
5644:
5616:
5610:
5609:
5572:
5566:
5565:
5555:
5544:10.1037/a0040388
5523:
5517:
5516:
5506:
5474:
5468:
5467:
5431:
5425:
5424:
5414:
5390:
5384:
5383:
5377:
5369:
5341:
5335:
5334:
5316:
5292:
5286:
5285:
5275:
5251:
5245:
5244:
5219:(9122): 98–101.
5207:
5201:
5200:
5190:
5166:
5160:
5159:
5131:
5125:
5124:
5106:
5074:
5068:
5067:
5061:
5053:
5025:
5019:
5018:
4990:
4984:
4983:
4973:
4963:
4939:
4933:
4932:
4922:
4890:
4884:
4883:
4863:
4857:
4856:
4827:
4821:
4820:
4818:
4794:
4785:
4784:
4774:
4742:
4736:
4735:
4708:
4702:
4701:
4691:
4681:
4657:
4648:
4647:
4629:
4605:
4594:
4593:
4583:
4551:
4545:
4544:
4534:
4524:
4500:
4494:
4493:
4483:
4451:
4445:
4444:
4434:
4410:
4404:
4403:
4393:
4361:
4355:
4354:
4336:
4312:
4306:
4305:
4295:
4271:
4265:
4264:
4262:
4261:
4246:
4240:
4239:
4211:
4205:
4204:
4194:
4154:
4148:
4147:
4119:
4113:
4112:
4107:. Archived from
4096:
4090:
4089:
4072:(12): CD006777.
4065:
4059:
4058:
4038:
4032:
4031:
4029:
4028:
4023:on March 7, 2012
4019:. Archived from
4009:
4003:
3997:
3991:
3990:
3966:
3955:
3954:
3918:
3912:
3911:
3901:
3877:
3871:
3870:
3858:
3847:
3841:
3840:
3830:
3798:
3792:
3791:
3771:
3765:
3764:
3727:
3721:
3720:
3692:
3686:
3685:
3675:
3657:
3625:
3619:
3618:
3608:
3590:
3566:
3560:
3559:
3519:
3513:
3512:
3502:
3484:
3467:(11): e0276970.
3451:
3445:
3444:
3442:
3402:
3396:
3395:
3385:
3360:(5): 1875–1888.
3345:
3339:
3338:
3328:
3288:
3282:
3281:
3271:
3223:
3217:
3216:
3214:
3213:
3182:
3176:
3175:
3165:
3155:
3131:
3125:
3124:
3088:
3082:
3081:
3071:
3039:
3033:
3032:
3022:
2990:
2984:
2983:
2981:
2979:
2974:. Reuters Health
2967:
2961:
2960:
2950:
2918:
2912:
2905:
2899:
2892:
2886:
2885:
2865:
2859:
2858:
2830:
2824:
2823:
2787:
2781:
2780:
2770:
2760:
2736:
2730:
2729:
2719:
2687:
2681:
2680:
2662:
2638:
2632:
2631:
2624:
2618:
2617:
2615:
2591:
2585:
2584:
2555:
2549:
2548:
2537:
2528:
2527:
2499:
2493:
2492:
2482:
2458:
2452:
2449:
2443:
2430:
2424:
2423:
2406:(4): 1008–1015.
2395:
2389:
2388:
2383:
2381:
2376:
2368:
2362:
2361:
2353:
2342:
2336:
2330:
2329:
2311:
2283:
2277:
2276:
2272:
2266:
2265:
2261:
2255:
2254:
2244:
2234:
2210:
2204:
2203:
2201:
2200:
2181:
2175:
2174:
2164:
2154:
2130:
2124:
2123:
2121:
2119:
2110:. Archived from
2099:
2093:
2092:
2090:
2089:
2083:
2077:. Archived from
2076:
2067:
2061:
2060:
2050:
2018:
2012:
2011:
2001:
1969:
1963:
1962:
1926:
1920:
1919:
1917:
1915:
1905:
1899:
1898:
1888:
1856:
1850:
1849:
1839:
1807:
1798:
1797:
1795:
1771:
1762:
1761:
1745:
1739:
1738:
1702:
1696:
1695:
1685:
1668:(11): CD000011.
1653:
1644:
1643:
1613:
1603:
1579:
1573:
1572:
1562:
1545:(9): 2107–2117.
1530:
1524:
1523:
1513:
1503:
1479:
1473:
1472:
1436:
1423:
1422:
1420:
1419:
1400:
1387:
1386:
1384:
1383:
1368:
1362:
1361:
1359:
1357:
1351:
1344:
1336:
1325:
1324:
1314:
1290:
1284:
1283:
1271:
1260:
929:
928:
843:bipolar disorder
827:Depot injections
662:
661:
633:
608:
606:
605:
600:
598:
592:
585:
583:All days' supply
582:
579:
549:
547:
546:
541:
539:
534:
532:All days' supply
531:
530:
204:
197:
190:
176:
175:
95:Labelling theory
41:
40:
21:
6046:
6045:
6041:
6040:
6039:
6037:
6036:
6035:
6006:
6005:
5988:
5983:
5938:
5934:
5903:(3): CD003442.
5889:
5885:
5840:
5836:
5805:
5801:
5762:
5758:
5719:
5715:
5670:
5666:
5617:
5613:
5573:
5569:
5524:
5520:
5475:
5471:
5432:
5428:
5391:
5387:
5371:
5370:
5342:
5338:
5293:
5289:
5252:
5248:
5208:
5204:
5167:
5163:
5132:
5128:
5075:
5071:
5055:
5054:
5042:
5026:
5022:
4991:
4987:
4940:
4936:
4891:
4887:
4864:
4860:
4828:
4824:
4795:
4788:
4743:
4739:
4710:
4709:
4705:
4658:
4651:
4606:
4597:
4552:
4548:
4501:
4497:
4452:
4448:
4419:Health Prospect
4411:
4407:
4362:
4358:
4313:
4309:
4272:
4268:
4259:
4257:
4247:
4243:
4212:
4208:
4155:
4151:
4120:
4116:
4097:
4093:
4066:
4062:
4039:
4035:
4026:
4024:
4011:
4010:
4006:
3998:
3994:
3973:(9): CD005025.
3967:
3958:
3919:
3915:
3878:
3874:
3867:
3856:
3848:
3844:
3813:(3): CD004371.
3799:
3795:
3772:
3768:
3728:
3724:
3693:
3689:
3640:(7): e0255268.
3626:
3622:
3567:
3563:
3520:
3516:
3452:
3448:
3403:
3399:
3346:
3342:
3289:
3285:
3224:
3220:
3211:
3209:
3183:
3179:
3132:
3128:
3089:
3085:
3040:
3036:
2991:
2987:
2977:
2975:
2968:
2964:
2919:
2915:
2906:
2902:
2893:
2889:
2866:
2862:
2831:
2827:
2788:
2784:
2737:
2733:
2688:
2684:
2639:
2635:
2626:
2625:
2621:
2592:
2588:
2556:
2552:
2547:. 16 June 2015.
2539:
2538:
2531:
2500:
2496:
2459:
2455:
2450:
2446:
2440:Wayback Machine
2431:
2427:
2396:
2392:
2379:
2377:
2374:
2370:
2369:
2365:
2354:
2345:
2337:
2333:
2284:
2280:
2274:
2273:
2269:
2262:
2258:
2211:
2207:
2198:
2196:
2183:
2182:
2178:
2131:
2127:
2117:
2115:
2100:
2096:
2087:
2085:
2081:
2074:
2068:
2064:
2019:
2015:
1970:
1966:
1927:
1923:
1913:
1911:
1907:
1906:
1902:
1857:
1853:
1808:
1801:
1772:
1765:
1746:
1742:
1703:
1699:
1654:
1647:
1580:
1576:
1531:
1527:
1480:
1476:
1437:
1426:
1417:
1415:
1402:
1401:
1390:
1381:
1379:
1370:
1369:
1365:
1355:
1353:
1349:
1342:
1338:
1337:
1328:
1291:
1287:
1280:
1269:
1261:
1246:
1242:
1229:Drug withdrawal
1225:
1202:
1194:lack of insight
1190:
1174:
1137:
1006:, non Hodgkin's
895:
879:
867:mental capacity
851:
824:
791:
775:
762:
757:
656:
631:
627:
618:
581:
580:
577:
560:
557:
556:
528:
511:
508:
507:
497:
488:
463:
435:
418:
383:
372:health literacy
368:
366:Health literacy
360:
352:
314:, and the U.S.
275:
266:health literacy
208:
159:Social medicine
123:Talcott Parsons
39:
28:
23:
22:
15:
12:
11:
5:
6044:
6034:
6033:
6028:
6023:
6018:
6004:
6003:
5998:
5987:
5986:External links
5984:
5982:
5981:
5952:(3): 327–334.
5932:
5883:
5854:(5): 361–365.
5834:
5815:(2): 205–211.
5799:
5772:(4): 389–399.
5756:
5713:
5684:(4): 387–399.
5664:
5627:(6): 642–651.
5611:
5584:(5): 557–568.
5567:
5538:(7): 539–551.
5518:
5489:(5): 505–513.
5469:
5442:(4): 279–284.
5426:
5385:
5336:
5287:
5246:
5202:
5181:(9): 652–661.
5161:
5142:(1): 107–130.
5126:
5069:
5040:
5020:
5001:(3): 222–230.
4985:
4934:
4905:(5): 198–219.
4885:
4858:
4839:(5): 446–454.
4822:
4786:
4757:(1): e032045.
4737:
4703:
4649:
4595:
4566:(4): 237–244.
4546:
4495:
4466:(1): 1701596.
4446:
4405:
4356:
4307:
4286:(3): 340–349.
4266:
4241:
4206:
4169:(1): 268–279.
4149:
4114:
4111:on 2012-10-06.
4091:
4060:
4033:
4004:
3992:
3956:
3929:(5): 783–801.
3913:
3892:(4): 462–467.
3872:
3865:
3842:
3793:
3766:
3722:
3687:
3620:
3561:
3534:(5): 744–754.
3514:
3446:
3417:(2): 273–278.
3397:
3340:
3283:
3218:
3177:
3126:
3099:(3): 175–180.
3083:
3054:(4): 392–396.
3034:
3005:(2): 233–237.
2985:
2962:
2933:(4): 284–290.
2913:
2900:
2887:
2876:(6): 529–535.
2860:
2825:
2798:(3): 219–231.
2782:
2731:
2702:(6): 615–622.
2682:
2653:(2): 145–149.
2633:
2619:
2586:
2567:(1): 213–219.
2550:
2529:
2510:(8): 858–871.
2494:
2453:
2444:
2425:
2390:
2363:
2343:
2331:
2309:2027.42/111192
2294:(2): 172–183.
2278:
2267:
2256:
2219:BMC Geriatrics
2205:
2176:
2145:(1): 269–286.
2125:
2094:
2062:
2033:(4): 383–384.
2013:
1964:
1937:(5): 487–497.
1921:
1900:
1851:
1822:(3): 354–376.
1816:The Oncologist
1799:
1786:(3): 371–376.
1763:
1760:on 2017-01-06.
1740:
1713:(1): 161–162.
1697:
1645:
1574:
1525:
1488:BMC Geriatrics
1474:
1424:
1388:
1363:
1326:
1285:
1278:
1243:
1241:
1238:
1237:
1236:
1231:
1224:
1221:
1220:
1219:
1216:
1213:
1210:
1201:
1198:
1189:
1188:Mental illness
1186:
1182:
1181:
1178:
1173:
1170:
1157:
1156:
1149:sulphonylureas
1145:
1136:
1133:
1132:
1131:
1128:
1125:
1118:
1117:
1114:
1099:
1098:
1090:
1089:
1086:
1083:
1080:
1076:
1075:
1072:
1069:
1066:
1062:
1061:
1058:
1055:
1052:
1048:
1047:
1044:
1041:
1038:
1030:
1029:
1027:
1024:
1023:Serum bioassay
1021:
1017:
1016:
1013:
1010:
1007:
999:
998:
995:
992:
986:
976:
975:
972:
969:
966:
960:
959:
956:
953:
947:
943:
942:
939:
936:
933:
932:Type of Cancer
920:
919:
916:
913:
910:
894:
891:
878:
875:
850:
847:
823:
820:
790:
787:
778:office visit.
774:
771:
761:
758:
756:
753:
750:
749:
746:
742:
741:
738:
734:
733:
730:
726:
725:
722:
718:
717:
714:
710:
709:
706:
702:
701:
698:
694:
693:
690:
686:
685:
682:
678:
677:
674:
670:
669:
666:
655:
652:
626:
623:
617:
614:
595:
591:
588:
576:
573:
570:
567:
564:
527:
524:
521:
518:
515:
496:
493:
487:
484:
462:
459:
434:
431:
417:
416:Treatment cost
414:
382:
379:
367:
364:
359:
356:
351:
348:
295:United Kingdom
274:
271:
210:
209:
207:
206:
199:
192:
184:
181:
180:
169:
168:
167:
166:
161:
156:
148:
147:
146:Related topics
143:
142:
141:
140:
135:
130:
128:Eliot Freidson
125:
117:
116:
110:
109:
108:
107:
102:
97:
92:
87:
82:
77:
76:
75:
68:Medicalization
62:
61:
57:
56:
50:
49:
26:
9:
6:
4:
3:
2:
6043:
6032:
6029:
6027:
6024:
6022:
6019:
6017:
6014:
6013:
6011:
6002:
5999:
5997:
5993:
5990:
5989:
5977:
5973:
5969:
5965:
5960:
5955:
5951:
5947:
5943:
5936:
5928:
5924:
5919:
5914:
5910:
5906:
5902:
5898:
5894:
5887:
5879:
5875:
5871:
5867:
5862:
5857:
5853:
5849:
5845:
5838:
5830:
5826:
5822:
5818:
5814:
5810:
5803:
5795:
5791:
5787:
5783:
5779:
5775:
5771:
5767:
5760:
5752:
5748:
5744:
5740:
5736:
5732:
5728:
5724:
5717:
5709:
5705:
5701:
5697:
5692:
5687:
5683:
5679:
5675:
5668:
5660:
5656:
5652:
5648:
5643:
5638:
5634:
5630:
5626:
5622:
5615:
5607:
5603:
5599:
5595:
5591:
5587:
5583:
5579:
5571:
5563:
5559:
5554:
5549:
5545:
5541:
5537:
5533:
5529:
5522:
5514:
5510:
5505:
5500:
5496:
5492:
5488:
5484:
5480:
5473:
5465:
5461:
5457:
5453:
5449:
5445:
5441:
5437:
5430:
5422:
5418:
5413:
5408:
5404:
5400:
5396:
5389:
5381:
5375:
5367:
5363:
5359:
5355:
5351:
5347:
5340:
5332:
5328:
5324:
5320:
5315:
5310:
5307:(9156): 930.
5306:
5302:
5298:
5291:
5283:
5279:
5274:
5269:
5265:
5261:
5257:
5250:
5242:
5238:
5234:
5230:
5226:
5222:
5218:
5214:
5206:
5198:
5194:
5189:
5184:
5180:
5176:
5172:
5165:
5157:
5153:
5149:
5145:
5141:
5137:
5130:
5122:
5118:
5114:
5110:
5105:
5100:
5096:
5092:
5088:
5084:
5080:
5073:
5065:
5059:
5051:
5047:
5043:
5037:
5033:
5032:
5024:
5016:
5012:
5008:
5004:
5000:
4996:
4989:
4981:
4977:
4972:
4967:
4962:
4957:
4953:
4949:
4945:
4938:
4930:
4926:
4921:
4916:
4912:
4908:
4904:
4900:
4896:
4889:
4881:
4877:
4873:
4869:
4862:
4854:
4850:
4846:
4842:
4838:
4834:
4826:
4817:
4812:
4808:
4804:
4800:
4793:
4791:
4782:
4778:
4773:
4768:
4764:
4760:
4756:
4752:
4748:
4741:
4733:
4729:
4725:
4721:
4717:
4716:NIHR Evidence
4713:
4707:
4699:
4695:
4690:
4685:
4680:
4675:
4671:
4667:
4663:
4656:
4654:
4645:
4641:
4637:
4633:
4628:
4623:
4619:
4615:
4611:
4604:
4602:
4600:
4591:
4587:
4582:
4577:
4573:
4569:
4565:
4561:
4557:
4550:
4542:
4538:
4533:
4528:
4523:
4518:
4514:
4510:
4506:
4499:
4491:
4487:
4482:
4477:
4473:
4469:
4465:
4461:
4457:
4450:
4442:
4438:
4433:
4428:
4424:
4420:
4416:
4409:
4401:
4397:
4392:
4387:
4383:
4379:
4375:
4371:
4367:
4360:
4352:
4348:
4344:
4340:
4335:
4330:
4326:
4322:
4318:
4311:
4303:
4299:
4294:
4289:
4285:
4281:
4277:
4270:
4256:
4252:
4245:
4237:
4233:
4229:
4225:
4221:
4217:
4210:
4202:
4198:
4193:
4188:
4184:
4180:
4176:
4172:
4168:
4164:
4160:
4153:
4145:
4141:
4137:
4133:
4129:
4125:
4118:
4110:
4106:
4102:
4095:
4087:
4083:
4079:
4075:
4071:
4064:
4056:
4052:
4048:
4044:
4037:
4022:
4018:
4014:
4008:
4001:
3996:
3988:
3984:
3980:
3976:
3972:
3965:
3963:
3961:
3952:
3948:
3944:
3940:
3936:
3932:
3928:
3924:
3917:
3909:
3905:
3900:
3895:
3891:
3887:
3883:
3876:
3868:
3862:
3855:
3854:
3846:
3838:
3834:
3829:
3824:
3820:
3816:
3812:
3808:
3804:
3797:
3789:
3785:
3781:
3777:
3770:
3762:
3758:
3754:
3750:
3746:
3742:
3738:
3734:
3726:
3718:
3714:
3710:
3706:
3702:
3698:
3691:
3683:
3679:
3674:
3669:
3665:
3661:
3656:
3651:
3647:
3643:
3639:
3635:
3631:
3624:
3616:
3612:
3607:
3602:
3598:
3594:
3589:
3584:
3580:
3576:
3572:
3565:
3557:
3553:
3549:
3545:
3541:
3537:
3533:
3529:
3525:
3518:
3510:
3506:
3501:
3496:
3492:
3488:
3483:
3478:
3474:
3470:
3466:
3462:
3458:
3450:
3441:
3436:
3432:
3428:
3424:
3420:
3416:
3412:
3408:
3401:
3393:
3389:
3384:
3379:
3375:
3371:
3367:
3363:
3359:
3355:
3351:
3344:
3336:
3332:
3327:
3322:
3318:
3314:
3310:
3306:
3302:
3298:
3294:
3287:
3279:
3275:
3270:
3265:
3261:
3257:
3253:
3249:
3245:
3241:
3237:
3233:
3229:
3222:
3208:
3204:
3200:
3196:
3192:
3188:
3181:
3173:
3169:
3164:
3159:
3154:
3149:
3145:
3141:
3137:
3130:
3122:
3118:
3114:
3110:
3106:
3102:
3098:
3094:
3087:
3079:
3075:
3070:
3065:
3061:
3057:
3053:
3049:
3045:
3038:
3030:
3026:
3021:
3016:
3012:
3008:
3004:
3000:
2996:
2989:
2973:
2966:
2958:
2954:
2949:
2944:
2940:
2936:
2932:
2928:
2924:
2917:
2911:
2904:
2898:
2891:
2883:
2879:
2875:
2871:
2864:
2856:
2852:
2848:
2844:
2840:
2836:
2829:
2821:
2817:
2813:
2809:
2805:
2801:
2797:
2793:
2786:
2778:
2774:
2769:
2764:
2759:
2754:
2750:
2746:
2742:
2735:
2727:
2723:
2718:
2713:
2709:
2705:
2701:
2697:
2693:
2686:
2678:
2674:
2670:
2666:
2661:
2656:
2652:
2648:
2644:
2637:
2629:
2623:
2614:
2609:
2605:
2601:
2597:
2590:
2582:
2578:
2574:
2570:
2566:
2562:
2554:
2546:
2542:
2536:
2534:
2525:
2521:
2517:
2513:
2509:
2505:
2498:
2490:
2486:
2481:
2476:
2472:
2468:
2464:
2457:
2448:
2441:
2437:
2434:
2429:
2421:
2417:
2413:
2409:
2405:
2401:
2394:
2387:
2373:
2367:
2359:
2352:
2350:
2348:
2340:
2335:
2327:
2323:
2319:
2315:
2310:
2305:
2301:
2297:
2293:
2289:
2282:
2271:
2260:
2252:
2248:
2243:
2238:
2233:
2228:
2224:
2220:
2216:
2209:
2195:on 2011-06-15
2194:
2190:
2186:
2180:
2172:
2168:
2163:
2158:
2153:
2148:
2144:
2140:
2136:
2129:
2114:on 2010-05-02
2113:
2109:
2105:
2098:
2084:on 2010-05-28
2080:
2073:
2066:
2058:
2054:
2049:
2044:
2040:
2036:
2032:
2028:
2024:
2017:
2009:
2005:
2000:
1995:
1991:
1987:
1983:
1979:
1975:
1968:
1960:
1956:
1952:
1948:
1944:
1940:
1936:
1932:
1925:
1910:
1904:
1896:
1892:
1887:
1882:
1878:
1874:
1870:
1866:
1862:
1855:
1847:
1843:
1838:
1833:
1829:
1825:
1821:
1817:
1813:
1806:
1804:
1794:
1789:
1785:
1781:
1777:
1770:
1768:
1759:
1755:
1751:
1744:
1736:
1732:
1728:
1724:
1720:
1716:
1712:
1708:
1701:
1693:
1689:
1684:
1679:
1675:
1671:
1667:
1663:
1659:
1652:
1650:
1642:
1637:
1633:
1629:
1625:
1621:
1617:
1612:
1611:10400.17/3723
1607:
1602:
1597:
1593:
1589:
1585:
1578:
1570:
1566:
1561:
1556:
1552:
1548:
1544:
1540:
1536:
1529:
1521:
1517:
1512:
1507:
1502:
1497:
1493:
1489:
1485:
1478:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1435:
1433:
1431:
1429:
1414:on 2011-06-15
1413:
1409:
1405:
1399:
1397:
1395:
1393:
1378:on 2007-04-27
1377:
1373:
1367:
1348:
1341:
1335:
1333:
1331:
1322:
1318:
1313:
1308:
1304:
1300:
1296:
1289:
1281:
1275:
1268:
1267:
1259:
1257:
1255:
1253:
1251:
1249:
1244:
1235:
1232:
1230:
1227:
1226:
1217:
1214:
1211:
1208:
1207:
1206:
1197:
1195:
1185:
1179:
1176:
1175:
1169:
1165:
1162:
1161:self-efficacy
1154:
1150:
1146:
1143:
1142:
1141:
1129:
1126:
1123:
1122:
1121:
1115:
1112:
1111:Royal Marsden
1108:
1107:
1106:
1104:
1097:
1094:
1093:
1087:
1084:
1081:
1078:
1077:
1073:
1070:
1067:
1064:
1063:
1059:
1056:
1053:
1050:
1049:
1045:
1042:
1039:
1036:
1032:
1031:
1028:
1026:Not described
1025:
1022:
1019:
1018:
1014:
1011:
1008:
1005:
1001:
1000:
996:
993:
991:
987:
985:
981:
978:
977:
973:
970:
967:
965:
964:Breast cancer
962:
961:
957:
954:
952:
948:
945:
944:
940:
937:
934:
931:
930:
927:
925:
917:
914:
911:
908:
907:
906:
903:
899:
890:
886:
884:
874:
872:
868:
864:
860:
856:
855:involuntarily
846:
844:
840:
839:schizophrenia
836:
835:antipsychotic
832:
828:
819:
817:
813:
809:
805:
801:
797:
789:Mobile phones
786:
783:
779:
770:
767:
747:
744:
743:
739:
736:
735:
731:
729:Side Effects
728:
727:
723:
720:
719:
715:
712:
711:
707:
704:
703:
699:
696:
695:
691:
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968:Self-report
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1418:2018-10-02
1382:2011-12-31
1240:References
1002:Leukemia,
922:Partridge
816:telehealth
773:Technology
716:Condition
708:Condition
332:compliance
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288:adherence
280:self care
228:self care
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90:Sick role
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