1959:) crystallizer, an idea of Richard Chisum Bennett (a Swenson engineer and later President of Swenson) at the end of the 1950s. The DTB crystallizer (see images) has an internal circulator, typically an axial flow mixer â yellow â pushing upwards in a draft tube while outside the crystallizer there is a settling area in an annulus; in it the exhaust solution moves upwards at a very low velocity, so that large crystals settle â and return to the main circulation â while only the fines, below a given grain size are extracted and eventually destroyed by increasing or decreasing temperature, thus creating additional supersaturation. A quasi-perfect control of all parameters is achieved as DTF crystallizers offer superior control over crystal size and characteristics. This crystallizer, and the derivative models (Krystal, CSC, etc.) could be the ultimate solution if not for a major limitation in the evaporative capacity, due to the limited diameter of the vapor head and the relatively low external circulation not allowing large amounts of energy to be supplied to the system.
884:
1921:, control of the contact time of the crystal mass with the supersaturated solution is achieved, together with reasonable velocities at the exchange surfaces. The Oslo, mentioned above, is a refining of the evaporative forced circulation crystallizer, now equipped with a large crystals settling zone to increase the retention time (usually low in the FC) and to roughly separate heavy slurry zones from clear liquid. Evaporative crystallizers tend to yield larger average crystal size and narrows the crystal size distribution curve.
1276:
crystallization is attributable to fluid shear, the other due to collisions between already existing crystals with either a solid surface of the crystallizer or with other crystals themselves. Fluid-shear nucleation occurs when liquid travels across a crystal at a high speed, sweeping away nuclei that would otherwise be incorporated into a crystal, causing the swept-away nuclei to become new crystals. Contact nucleation has been found to be the most effective and common method for nucleation. The benefits include the following:
1116:
not influenced in any way by solids. These solids include the walls of the crystallizer vessel and particles of any foreign substance. The second category, then, is heterogeneous nucleation. This occurs when solid particles of foreign substances cause an increase in the rate of nucleation that would otherwise not be seen without the existence of these foreign particles. Homogeneous nucleation rarely occurs in practice due to the high energy necessary to begin nucleation without a solid surface to catalyze the nucleation.
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1938:
868:. Tank crystallization is an old method still used in some specialized cases. Saturated solutions, in tank crystallization, are allowed to cool in open tanks. After a period of time the mother liquor is drained and the crystals removed. Nucleation and size of crystals are difficult to control. Typically, labor costs are very high.
1949:
it is important to control the retention time and the crystal mass, to obtain the optimum conditions in terms of crystal specific surface and the fastest possible growth. This is achieved by a separation â to put it simply â of the crystals from the liquid mass, in order to manage the two flows in a
1818:
conveyor or some hollow discs, in which a refrigerating fluid is circulated, plunge during rotation on a longitudinal axis. The refrigerating fluid is sometimes also circulated in a jacket around the trough. Crystals precipitate on the cold surfaces of the screw/discs, from which they are removed by
1593:
The appearance and size range of a crystalline product is extremely important in crystallization. If further processing of the crystals is desired, large crystals with uniform size are important for washing, filtering, transportation, and storage, because large crystals are easier to filter out of a
1115:
Primary nucleation is the initial formation of a crystal where there are no other crystals present or where, if there are crystals present in the system, they do not have any influence on the process. This can occur in two conditions. The first is homogeneous nucleation, which is nucleation that is
805:
A typical laboratory technique for crystal formation is to dissolve the solid in a solution in which it is partially soluble, usually at high temperatures to obtain supersaturation. The hot mixture is then filtered to remove any insoluble impurities. The filtrate is allowed to slowly cool. Crystals
628:
start to gather into clusters, on the microscopic scale (elevating solute concentration in a small region), that become stable under the current operating conditions. These stable clusters constitute the nuclei. Therefore, the clusters need to reach a critical size in order to become stable nuclei.
1054:
Regarding crystals, there are no exceptions to this rule. Similarly, when the molten crystal is cooled, the molecules will return to their crystalline form once the temperature falls beyond the turning point. This is because the thermal randomization of the surroundings compensates for the loss of
1751:
Many solutes precipitate in hydrate form at low temperatures: in the previous example this is acceptable, and even useful, but it may be detrimental when, for example, the mass of water of hydration to reach a stable hydrate crystallization form is more than the available water: a single block of
1598:
which contains impurities, and a smaller loss of yield when the crystals are washed to remove the mother liquor. In special cases, for example during drug manufacturing in the pharmaceutical industry, small crystal sizes are often desired to improve drug dissolution rate and bio-availability. The
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of solute touching â or adjacent to â the crystal so that it increases its own dimension in successive layers. The pattern of growth resembles the rings of an onion, as shown in the picture, where each colour indicates the same mass of solute; this mass creates increasingly thin layers due to the
1106:
Nucleation is the initiation of a phase change in a small region, such as the formation of a solid crystal from a liquid solution. It is a consequence of rapid local fluctuations on a molecular scale in a homogeneous phase that is in a state of metastable equilibrium. Total nucleation is the sum
1058:
The nature of a crystallization process is governed by both thermodynamic and kinetic factors, which can make it highly variable and difficult to control. Factors such as impurity level, mixing regime, vessel design, and cooling profile can have a major impact on the size, number, and shape of
680:
state and crystal polymorphs of the same compound exhibit different physical properties, such as dissolution rate, shape (angles between facets and facet growth rates), melting point, etc. For this reason, polymorphism is of major importance in industrial manufacture of crystalline products.
592:
591:
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587:
1440:
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Secondary nucleation is the formation of nuclei attributable to the influence of the existing microscopic crystals in the magma. More simply put, secondary nucleation is when crystal growth is initiated with contact of other existing crystals or "seeds". The first type of known secondary
593:
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1869:
Another option is to obtain, at an approximately constant temperature, the precipitation of the crystals by increasing the solute concentration above the solubility threshold. To obtain this, the solute/solvent mass ratio is increased using the technique of
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conditions, may then take place at a concentration higher than the theoretical solubility level. The difference between the actual value of the solute concentration at the crystallization limit and the theoretical (static) solubility threshold is called
652:
is the subsequent size increase of the nuclei that succeed in achieving the critical cluster size. Crystal growth is a dynamic process occurring in equilibrium where solute molecules or atoms precipitate out of solution, and dissolve back into solution.
521:, which is the increase in the size of particles and leads to a crystal state. An important feature of this step is that loose particles form layers at the crystal's surface and lodge themselves into open inconsistencies such as pores, cracks, etc.
1740:), the precipitation of a mass of sulfate occurs corresponding to the change in solubility from 29% (equilibrium value at 30 °C) to approximately 4.5% (at 0 °C) â actually a larger crystal mass is precipitated, since sulfate entrains
645:â note that "crystal structure" is a special term that refers to the relative arrangement of the atoms or molecules, not the macroscopic properties of the crystal (size and shape), although those are a result of the internal crystal structure.
910:, when heated by an external source, will become liquid. This occurs at a sharply defined temperature (different for each type of crystal). As it liquifies, the complicated architecture of the crystal collapses. Melting occurs because the
1005:
813:
For biological molecules in which the solvent channels continue to be present to retain the three dimensional structure intact, microbatch crystallization under oil and vapor diffusion methods have been the common methods.
1954:
to be able to extract (and possibly recycle separately) the (almost) clear liquid, while managing the mass flow around the crystallizer to obtain a precise slurry density elsewhere. A typical example is the DTB
1399:
1802:
for internal circulation, where temperature decrease is obtained by heat exchange with an intermediate fluid circulating in a jacket. These simple machines are used in batch processes, as in processing of
1210:
1049:
1861:
in the last crystallization stage downstream of vacuum pans, prior to centrifugation. The massecuite enters the crystallizers at the top, and cooling water is pumped through pipes in counterflow.
248:
589:
1736:, it is clear that sulfate solubility quickly decreases below 32.5 °C. Assuming a saturated solution at 30 °C, by cooling it to 0 °C (note that this is possible thanks to the
1067:
As mentioned above, a crystal is formed following a well-defined pattern, or structure, dictated by forces acting at the molecular level. As a consequence, during its formation process the
1599:
theoretical crystal size distribution can be estimated as a function of operating conditions with a fairly complicated mathematical process called population balance theory (using
544:, are often difficult to crystallize. The ease with which molecules will crystallize strongly depends on the intensity of either atomic forces (in the case of mineral substances),
3552:
1930:
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Crystal formation can be achieved by various methods, such as: cooling, evaporation, addition of a second solvent to reduce the solubility of the solute (technique known as
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solution than small crystals. Also, larger crystals have a smaller surface area to volume ratio, leading to a higher purity. This higher purity is due to less retention of
1781:
solubility, a term to indicate that solubility increases with temperature decrease (an example occurs with sodium sulfate where solubility is reversed above 32.5 °C).
1519:
The first value is a consequence of the physical characteristics of the solution, while the others define a difference between a well- and poorly designed crystallizer.
802:
The formation of a supersaturated solution does not guarantee crystal formation, and often a seed crystal or scratching the glass is required to form nucleation sites.
676:, it is kinetically stable and requires some input of energy to initiate a transformation to the equilibrium phase. Each polymorph is in fact a different thermodynamic
2552:
899:. Whereas most processes that yield more orderly results are achieved by applying heat, crystals usually form at lower temperatures – especially by
932:
2362:
Jancic, S. J.; Grootscholten, P.A.M.: âIndustrial
Crystallizationâ, Textbook, Delft University Press and Reidel Publishing Company, Delft, The Netherlands, 1984.
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2303:
1055:
entropy that results from the reordering of molecules within the system. Such liquids that crystallize on cooling are the exception rather than the rule.
903:. However, due to the release of the heat of fusion during crystallization, the entropy of the universe increases, thus this principle remains unaltered.
2359:
Glynn P.D. and
Reardon E.J. (1990) "Solid-solution aqueous-solution equilibria: thermodynamic theory and representation". Amer. J. Sci. 290, 164â201.
2080:
Lin, Yibin (2008). "An
Extensive Study of Protein Phase Diagram Modification:Increasing Macromolecular Crystallizability by Temperature Screening".
784:
Crystal formation can be divided into two types, where the first type of crystals are composed of a cation and anion, also known as a salt, such as
2664:
2418:
1814:
crystallizer is a model, specifically conceived by
Swenson Co. around 1920, having a semicylindric horizontal hollow trough in which a hollow
891:
magnification series for a snow crystal. The crystals are captured, stored, and sputter-coated with platinum at cryo-temperatures for imaging.
1759:
Maximum supersaturation will take place in the coldest points. These may be the heat exchanger tubes which are sensitive to scaling, and
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1299:
681:
Additionally, crystal phases can sometimes be interconverted by varying factors such as temperature, such as in the transformation of
430:
1507:
Flow pattern, again as an index of the probability of a molecule of solute to come into contact with an existing crystal (higher in
3057:
3024:
2107:
Chayen, Blow (1992). "Microbatch crystallization under oil â a new technique allowing many small-volume crystallization trials".
1471:
expressed in kg/(m*h), and is a constant specific to the process. Growth rate is influenced by several physical factors, such as
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1994:
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359:
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and are prone to scaling. Batch processes normally provide a relatively variable quality of the product along with the batch.
184:
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units, whose production accounts for more than 50% of the total world production of crystals. The most common type is the
1458:
Once the first small crystal, the nucleus, forms it acts as a convergence point (if unstable due to supersaturation) for
657:
is one of the driving forces of crystallization, as the solubility of a species is an equilibrium process quantified by K
389:
661:. Depending upon the conditions, either nucleation or growth may be predominant over the other, dictating crystal size.
2657:
2411:
896:
874:: MSMPR is used for much larger scale inorganic crystallization. MSMPR can crystalize solutions in a continuous manner.
163:
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scrapers and settle on the bottom of the trough. The screw, if provided, pushes the slurry towards a discharge port.
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Retention time, as an index of the probability of a molecule of solute to come into contact with an existing crystal;
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crystals in a steel form well above 1000 °C. An example of this crystallization process is the production of
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Many compounds have the ability to crystallize with some having different crystal structures, a phenomenon called
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Total crystal surface in unit fluid mass, as an index of the capability of the solute to fix onto the crystal;
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that form are then filtered and washed with a solvent in which they are not soluble, but is miscible with the
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Low kinetic order and rate-proportional to supersaturation, allowing easy control without unstable operation.
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molecules crystallize easily, and the resulting crystals are generally of good quality, i.e. without visible
423:
339:
298:
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So, whenever the conditions are favorable, crystal formation results from simply cooling the solution. Here
152:
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Geankoplis, C.J. (2003) "Transport
Processes and Separation Process Principles". 4th Ed. Prentice-Hall Inc.
2004:
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Low necessary energy at which crystals strike avoids the breaking of existing crystals into new crystals.
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increasing surface area of the growing crystal. The supersaturated solute mass the original nucleus may
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2428:
1874:. This process is insensitive to change in temperature (as long as hydration state remains unchanged).
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This division is not really clear-cut, since hybrid systems exist, where cooling is performed through
838:
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or drown-out), solvent layering, sublimation, changing the cation or anion, as well as other methods.
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Supersaturation value, as an index of the quantity of solute available for the growth of the crystal;
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85:
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All considerations on control of crystallization parameters are the same as for the cooling models.
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The quantitative fundamentals have already been isolated and are being incorporated into practice.
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2019:
2014:
1999:
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810:. The process is then repeated to increase the purity in a technique known as recrystallization.
533:
130:
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The following model, although somewhat simplified, is often used to model secondary nucleation:
1075:
reaches a certain critical value, before changing status. Solid formation, impossible below the
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3183:
3163:
3010:
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1914:
1668:. This is not a different process, rather a special application of one (or both) of the above.
637:, etc.). It is at the stage of nucleation that the atoms or molecules arrange in a defined and
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1969:
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1000:{\displaystyle T(S_{\text{liquid}}-S_{\text{solid}})>H_{\text{liquid}}-H_{\text{solid}},}
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A common practice is to cool the solutions by flash evaporation: when a liquid at a given T
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is an empirical exponent that can be as large as 10, but generally ranges between 3 and 4.
8:
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2009:
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crystal. The video covers an area of 2.0 by 1.5 mm and was captured over 7.2 min.
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Primary nucleation (both homogeneous and heterogeneous) has been modeled as follows:
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Process by which a solid with a highly organized atomic or molecular structure forms
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and equilibrium concentration (as mass percent of solute in saturated solution) in
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2144:"Crystallization of soluble proteins in vapor diffusion for x-ray crystallography"
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Most industrial crystallizers are of the evaporative type, such as the very large
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of a solute from the liquid solution to a pure solid crystalline phase occurs. In
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918:) gain in the system by spatial randomization of the molecules has overcome the
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according to the temperature difference and a quantity of solvent, whose total
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1453:
785:
713:
616:
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Crystallization is also a chemical solidâliquid separation technique, in which
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313:
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1857:
In the sugar industry, vertical cooling crystallizers are used to exhaust the
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3354:
3309:
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2509:
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1979:
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Occurs at low supersaturation, where growth rate is optimal for good quality.
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807:
788:. The second type of crystals are composed of uncharged species, for example
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which are driven by thermodynamic properties as well as chemical properties.
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water, and this has the side effect of increasing the final concentration.
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900:
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510:
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throughout the tank, including the exchange surfaces; by controlling pump
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1989:
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of a solution. Too high a viscosity may give hydraulic problems, and the
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solubility that is, the solubility threshold increases with temperature.
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796:
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There are many examples of natural process that involve crystallization.
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537:
499:
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354:
3067:
2184:"MSMPR Crystallizer | Practical Solubility Science | Prof Steven Abbott"
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486:. Attributes of the resulting crystal depend largely on factors such as
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is an empirical exponent that can range up to 1.5, but is generally 1,
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1854:. In simple words, the liquid is cooled by evaporating a part of it.
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1717:
1459:
766:
720:
705:
638:
571:, although the result is not amorphous or disordered, but a crystal.
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So one may identify two main families of crystallization processes:
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is an empirical exponent that can range up to 5, but is generally 2.
119:
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1951:
1858:
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1657:, thus obtaining at the same time a concentration of the solution.
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is the step where the solute molecules or atoms dispersed in the
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3002:
1945:
Whichever the form of the crystallizer, to achieve an effective
1394:{\displaystyle B={\dfrac {dN}{dt}}=k_{1}M_{T}^{j}(c-c^{*})^{b},}
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effect of two categories of nucleation â primary and secondary.
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3103:
2742:
1910:
686:
447:
3553:
List of largest biomedical companies by market capitalization
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2937:
1815:
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The simplest cooling crystallizers are tanks provided with a
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A decrease in temperature usually implies an increase of the
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There are limitations in the use of cooling crystallization:
1222:
is the number of nuclei formed per unit volume per unit time,
772:
725:
677:
3127:
1902:
1843:
1752:
hydrate solute will be formed â this occurs in the case of
708:
are a very well-known example, where subtle differences in
451:
2426:
1929:
1728:. In the diagram, where equilibrium temperature is on the
1622:
Some of the important factors influencing solubility are:
629:
Such critical size is dictated by many different factors (
608:
The crystallization process consists of two major events,
3117:
3113:
2332:
1950:
different way. The practical way is to perform a gravity
1515:, but the reverse applies to the probability of contact).
483:
1937:
775:
crystallization (nearly all types of honey crystallize).
505:
Crystallization occurs in two major steps. The first is
1826:
temperature is transferred in a chamber at a pressure P
1205:{\displaystyle B={\dfrac {dN}{dt}}=k_{n}(c-c^{*})^{n},}
1044:{\displaystyle G_{\text{liquid}}<G_{\text{solid}}.}
509:, the appearance of a crystalline phase from either a
1794:
Vertical cooling crystallizer in a beet sugar factory
1774:
thus created may affect the crystallization dynamics.
1310:
1302:
1136:
1128:
1014:
935:
926:) loss due to breaking the crystal packing forces:
895:The crystallization process appears to violate the
858:
144:. Unsourced material may be challenged and removed.
1393:
1204:
1043:
999:
2558:Ultravioletâvisible spectroscopy of stereoisomers
1685:, dissolved in most solvents, show the so-called
1606:
3597:
1092:and is a fundamental factor in crystallization.
1660:A crystallization process often referred to in
872:Mixed-Suspension, Mixed-Product-Removal (MSMPR)
1864:
741:Natural (mineral) crystal formation (see also
3018:
2658:
2412:
2222:
2220:
1830:such that the liquid saturation temperature T
859:main industrial processes for crystallization
424:
1880:
1561:. Unsourced material may be challenged and
60:Learn how and when to remove these messages
3025:
3011:
2665:
2651:
2419:
2405:
2217:
1671:
1494:The main values to control are therefore:
1249:is the solute concentration at saturation,
1243:is the instantaneous solute concentration,
567:. Crystallization is therefore related to
431:
417:
2159:
2141:
1850:of vaporization equals the difference in
1777:It is not applicable to compounds having
1581:Learn how and when to remove this message
222:Learn how and when to remove this message
204:Learn how and when to remove this message
3058:Competitions and prizes in biotechnology
2672:
2206:
2204:
1936:
1928:
1789:
1785:
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1610:
1438:
1228:is the number of nuclei per unit volume,
882:
719:
700:
584:
548:(organic and biochemical substances) or
2306:from the original on September 25, 2016
2228:Unit Operations of Chemical Engineering
1763:may be greatly reduced or discontinued;
1270:
466:. Some ways by which crystals form are
3598:
2296:"Draft Tube Baffle (DTB) Crystallizer"
2251:from the original on November 27, 2016
2106:
1995:Fractional crystallization (chemistry)
1071:is in an environment where the solute
3006:
2646:
2400:
2201:
1110:
878:
672:, meaning that although it is not in
517:solvent. The second step is known as
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2271:"Submerge Circulating Crystallizers"
1975:Chiral resolution by crystallization
1559:adding citations to reliable sources
1526:
1522:
821:
817:
142:adding citations to reliable sources
113:
66:
25:
2367:Crystallization Technology Handbook
2079:
1924:
1260:) is also known as supersaturation,
494:, cooling rate, and in the case of
390:Shaping processes in crystal growth
13:
2342:Arkenbout-de Vroome, Tine (1995).
2322:
2275:Thermal Kinetics Engineering, PLLC
897:second principle of thermodynamics
14:
3632:
3032:
2553:NMR spectroscopy of stereoisomers
2380:
41:This article has multiple issues.
3577:
3566:
3565:
3066:
2846:
2591:Diastereomeric recrystallization
2337:Illinois Institute of Technology
2329:"Small Molecule Crystallization"
1531:
825:
246:
118:
71:
30:
21:Crystallization (disambiguation)
3543:Index of biotechnology articles
2344:Melt Crystallization Technology
712:conditions result in different
581:Crystallization § Dynamics
360:Fractional crystallization
129:needs additional citations for
49:or discuss these issues on the
3548:List of biotechnology articles
2288:
2263:
2233:
2176:
2135:
2100:
2073:
2035:Recrystallization (metallurgy)
1676:
1607:Main crystallization processes
1379:
1359:
1190:
1170:
965:
939:
563:, crystallization occurs in a
1:
3392:Genetically modified organism
3159:Biotechnology industrial park
2066:
2030:Recrystallization (chemistry)
1467:in a time unit is called the
1095:
906:The molecules within a pure,
580:
2586:Chiral column chromatography
2129:10.1016/0022-0248(92)90241-A
2005:Laser heated pedestal growth
1601:population balance equations
696:
668:. Certain polymorphs may be
458:are highly organized into a
380:Laser-heated pedestal growth
7:
3382:Environmental biotechnology
2226:McCabe & Smith (2000).
2142:Benvenuti, Mangani (2007).
2082:Crystal Growth & Design
1962:
1865:Evaporative crystallization
1696:Solubility of the system Na
1649:Evaporative crystallization
1632:Solvent mixture composition
1062:
370:Hydrothermal synthesis
335:BridgmanâStockbarger method
84:to comply with Knowledge's
10:
3637:
2883:Electrostatic precipitator
2548:Chiral derivatizing agents
2429:enantioselective synthesis
2392:Industrial Crystallization
2212:Industrial Crystallization
1842:, the liquid will release
1666:fractional crystallization
1451:
1423:is the suspension density,
1099:
779:
762:process examples include:
737:process examples include:
578:
574:
552:(biochemical substances).
18:
3561:
3535:
3442:
3322:
3252:
3201:
3192:
3151:
3096:
3075:
3064:
3053:Timeline of biotechnology
3040:
2984:
2956:
2923:Rotary vacuum-drum filter
2855:
2844:
2680:
2599:
2566:
2535:
2487:
2435:
2214:. Plenum Press, New York.
2109:Journal of Crystal Growth
1881:Evaporative crystallizers
1738:freezing-point depression
1447:
674:thermodynamic equilibrium
412:
340:Van Arkelâde Boer process
326:
321:
285:
280:
259:
254:
245:
238:
3409:Microbial biodegradation
3088:Industrial biotechnology
3048:History of biotechnology
2966:Aqueous two-phase system
2788:Liquidâliquid extraction
2474:Supramolecular chirality
2230:. McGraw-Hill, New York.
1724:, a crystalline form of
641:manner that defines the
446:is the process by which
365:Fractional freezing
97:may contain suggestions.
82:may need to be rewritten
3606:Liquid-solid separation
3083:Colors of biotechnology
2863:API oilâwater separator
2733:Dissolved air flotation
2020:Pumpable ice technology
2015:Protein crystallization
2000:Igneous differentiation
1901:). A pumping device (a
1672:Cooling crystallization
1646:Cooling crystallization
1079:threshold at the given
345:Czochralski method
3477:Biomedical engineering
3184:Pharmaceutical company
3164:Biotechnology products
2828:Solid-phase extraction
2210:Tavare, N. S. (1995).
2188:www.stevenabbott.co.uk
2161:10.1038/nprot.2007.198
1942:
1934:
1795:
1709:
1619:
1444:
1395:
1206:
1045:
1001:
892:
728:
717:
605:
322:Methods and technology
3616:Laboratory techniques
2948:Vacuum ceramic filter
2943:Sublimation apparatus
2748:Electrochromatography
2708:Cross-flow filtration
2612:Chiral pool synthesis
2526:Diastereomeric excess
2387:Batch Crystallization
2245:www.reciprocalnet.org
2060:X-ray crystallography
1970:Abnormal grain growth
1957:Draft Tube and Baffle
1940:
1932:
1793:
1786:Cooling crystallizers
1695:
1614:
1442:
1396:
1207:
1046:
1002:
886:
735:Geological time scale
723:
704:
596:
550:intramolecular forces
546:intermolecular forces
3502:Chemical engineering
3365:Reproductive cloning
3229:Hybridoma technology
3179:Human Genome Project
2898:Fractionating column
2693:Acidâbase extraction
2674:Separation processes
2622:Asymmetric catalysis
2607:Asymmetric induction
2365:Mersmann, A. (2001)
1909:) keeps the crystal
1716:is a relative term:
1662:chemical engineering
1555:improve this section
1300:
1271:Secondary nucleation
1126:
1012:
933:
561:chemical engineering
138:improve this article
19:For other uses, see
3387:Genetic engineering
3370:Therapeutic cloning
3350:Bionic architecture
3330:Animal cell culture
3097:Biological concepts
2718:Cyclonic separation
2520:Enantiomeric excess
2121:1992JCrGr.122..176C
1615:Crystallization of
1483:, relative crystal
1414:is a rate constant,
1358:
1237:is a rate constant,
1059:crystals produced.
314:Single crystal
294:Crystal growth
3443:Interdisciplinary
3397:Molecular genetics
3143:Selective breeding
2778:Gravity separation
2617:Chiral auxiliaries
2581:Kinetic resolution
2479:Inherent chirality
2464:-symmetric ligands
2300:Swenson Technology
2010:Micro-pulling-down
1943:
1935:
1895:forced circulation
1796:
1710:
1683:chemical compounds
1620:
1445:
1391:
1344:
1329:
1202:
1155:
1111:Primary nucleation
1041:
997:
893:
879:Thermodynamic view
866:Tank crystallizers
857:Equipment for the
837:. You can help by
755:, rings formation;
729:
718:
606:
536:. However, larger
385:Micro-pulling-down
3621:Phase transitions
3593:
3592:
3522:Nanobiotechnology
3517:Molecular biology
3318:
3317:
3169:Biotechnology law
3000:
2999:
2918:Rapid sand filter
2813:Recrystallization
2793:Electroextraction
2753:Electrofiltration
2640:
2639:
2576:Recrystallization
2568:Chiral resolution
2241:"Crystallization"
2094:10.1021/cg800698p
1985:Crystal structure
1905:or an axial flow
1591:
1590:
1583:
1523:Size distribution
1487:in the solution,
1328:
1154:
1035:
1022:
991:
978:
962:
949:
855:
854:
818:Typical equipment
643:crystal structure
594:
478:, or more rarely
441:
440:
375:Kyropoulos method
304:Seed crystal
299:Recrystallization
268:Crystal structure
232:
231:
224:
214:
213:
206:
188:
153:"Crystallization"
112:
111:
86:quality standards
64:
3628:
3581:
3580:
3569:
3568:
3419:Pharmacogenomics
3199:
3198:
3193:Basic techniques
3174:Green Revolution
3152:General concepts
3070:
3027:
3020:
3013:
3004:
3003:
2850:
2667:
2660:
2653:
2644:
2643:
2543:Optical rotation
2488:Chiral molecules
2453:Planar chirality
2421:
2414:
2407:
2398:
2397:
2316:
2315:
2313:
2311:
2292:
2286:
2285:
2283:
2281:
2267:
2261:
2260:
2258:
2256:
2237:
2231:
2224:
2215:
2208:
2199:
2198:
2196:
2194:
2180:
2174:
2173:
2163:
2154:(7): 1633â1651.
2148:Nature Protocols
2139:
2133:
2132:
2115:(1â4): 176â180.
2104:
2098:
2097:
2077:
1941:Schematic of DTB
1933:DTB Crystallizer
1925:DTB crystallizer
1897:(FC) model (see
1754:calcium chloride
1586:
1579:
1575:
1572:
1566:
1535:
1527:
1491:, and so forth.
1400:
1398:
1397:
1392:
1387:
1386:
1377:
1376:
1357:
1352:
1343:
1342:
1330:
1327:
1319:
1311:
1211:
1209:
1208:
1203:
1198:
1197:
1188:
1187:
1169:
1168:
1156:
1153:
1145:
1137:
1050:
1048:
1047:
1042:
1037:
1036:
1033:
1024:
1023:
1020:
1006:
1004:
1003:
998:
993:
992:
989:
980:
979:
976:
964:
963:
960:
951:
950:
947:
887:Low-temperature
850:
847:
829:
822:
760:Human time scale
691:titanium dioxide
595:
540:particles, like
524:The majority of
498:, time of fluid
482:directly from a
450:form, where the
433:
426:
419:
309:Protocrystalline
250:
236:
235:
227:
220:
209:
202:
198:
195:
189:
187:
146:
122:
114:
107:
104:
98:
75:
67:
56:
34:
33:
26:
3636:
3635:
3631:
3630:
3629:
3627:
3626:
3625:
3611:Crystallography
3596:
3595:
3594:
3589:
3557:
3531:
3472:Biopharmacology
3444:
3438:
3314:
3285:Electrophoresis
3280:Kidney dialysis
3270:Crystallization
3248:
3194:
3188:
3147:
3092:
3071:
3062:
3036:
3031:
3001:
2996:
2980:
2958:
2952:
2913:Protein skimmer
2851:
2842:
2838:Ultrafiltration
2818:Reverse osmosis
2798:Microfiltration
2773:Froth flotation
2713:Crystallization
2676:
2671:
2641:
2636:
2627:Organocatalysis
2595:
2562:
2531:
2515:Racemic mixture
2483:
2469:Axial chirality
2463:
2436:Chirality types
2431:
2425:
2383:
2325:
2323:Further reading
2320:
2319:
2309:
2307:
2294:
2293:
2289:
2279:
2277:
2269:
2268:
2264:
2254:
2252:
2239:
2238:
2234:
2225:
2218:
2209:
2202:
2192:
2190:
2182:
2181:
2177:
2140:
2136:
2105:
2101:
2078:
2074:
2069:
2064:
1965:
1947:process control
1927:
1913:in homogeneous
1887:sodium chloride
1883:
1867:
1841:
1838:is lower than T
1837:
1833:
1829:
1825:
1805:pharmaceuticals
1788:
1707:
1703:
1699:
1679:
1674:
1609:
1587:
1576:
1570:
1567:
1552:
1536:
1525:
1489:Reynolds number
1473:surface tension
1456:
1450:
1421:
1413:
1382:
1378:
1372:
1368:
1353:
1348:
1338:
1334:
1320:
1312:
1309:
1301:
1298:
1297:
1273:
1235:
1193:
1189:
1183:
1179:
1164:
1160:
1146:
1138:
1135:
1127:
1124:
1123:
1113:
1104:
1098:
1090:supersaturation
1065:
1032:
1028:
1019:
1015:
1013:
1010:
1009:
988:
984:
975:
971:
959:
955:
946:
942:
934:
931:
930:
908:perfect crystal
881:
851:
845:
842:
835:needs expansion
820:
782:
699:
660:
655:Supersaturation
635:supersaturation
600:of growth of a
585:
583:
577:
496:liquid crystals
444:Crystallization
437:
400:Verneuil method
289:Crystallization
240:Crystallization
228:
217:
216:
215:
210:
199:
193:
190:
147:
145:
135:
123:
108:
102:
99:
89:
76:
35:
31:
24:
17:
12:
11:
5:
3634:
3624:
3623:
3618:
3613:
3608:
3591:
3590:
3588:
3587:
3575:
3562:
3559:
3558:
3556:
3555:
3550:
3545:
3539:
3537:
3533:
3532:
3530:
3529:
3524:
3519:
3514:
3509:
3504:
3499:
3494:
3489:
3484:
3479:
3474:
3469:
3464:
3462:Bioengineering
3459:
3457:Bioelectronics
3454:
3448:
3446:
3440:
3439:
3437:
3436:
3434:Tissue culture
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3400:
3399:
3394:
3384:
3379:
3374:
3373:
3372:
3367:
3357:
3352:
3347:
3342:
3340:Bioinformatics
3337:
3335:Biofabrication
3332:
3326:
3324:
3320:
3319:
3316:
3315:
3313:
3312:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3275:Chromatography
3272:
3267:
3262:
3260:Centrifugation
3256:
3254:
3253:Chemical field
3250:
3249:
3247:
3246:
3241:
3236:
3231:
3226:
3224:Flow cytometry
3221:
3216:
3211:
3205:
3203:
3196:
3190:
3189:
3187:
3186:
3181:
3176:
3171:
3166:
3161:
3155:
3153:
3149:
3148:
3146:
3145:
3140:
3135:
3130:
3125:
3120:
3111:
3106:
3100:
3098:
3094:
3093:
3091:
3090:
3085:
3079:
3077:
3073:
3072:
3065:
3063:
3061:
3060:
3055:
3050:
3044:
3042:
3038:
3037:
3030:
3029:
3022:
3015:
3007:
2998:
2997:
2995:
2994:
2992:Unit operation
2988:
2986:
2982:
2981:
2979:
2978:
2973:
2968:
2962:
2960:
2954:
2953:
2951:
2950:
2945:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2905:
2900:
2895:
2890:
2885:
2880:
2875:
2870:
2865:
2859:
2857:
2853:
2852:
2845:
2843:
2841:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2720:
2715:
2710:
2705:
2703:Chromatography
2700:
2695:
2690:
2684:
2682:
2678:
2677:
2670:
2669:
2662:
2655:
2647:
2638:
2637:
2635:
2634:
2629:
2624:
2619:
2614:
2609:
2603:
2601:
2597:
2596:
2594:
2593:
2588:
2583:
2578:
2572:
2570:
2564:
2563:
2561:
2560:
2555:
2550:
2545:
2539:
2537:
2533:
2532:
2530:
2529:
2523:
2517:
2512:
2507:
2502:
2497:
2491:
2489:
2485:
2484:
2482:
2481:
2476:
2471:
2466:
2461:
2455:
2450:
2445:
2439:
2437:
2433:
2432:
2424:
2423:
2416:
2409:
2401:
2395:
2394:
2389:
2382:
2381:External links
2379:
2378:
2377:
2363:
2360:
2357:
2354:
2340:
2324:
2321:
2318:
2317:
2287:
2262:
2232:
2216:
2200:
2175:
2134:
2099:
2071:
2070:
2068:
2065:
2063:
2062:
2057:
2052:
2047:
2045:Single crystal
2042:
2037:
2032:
2027:
2022:
2017:
2012:
2007:
2002:
1997:
1992:
1987:
1982:
1977:
1972:
1966:
1964:
1961:
1926:
1923:
1882:
1879:
1866:
1863:
1839:
1835:
1831:
1827:
1823:
1812:Swenson-Walker
1787:
1784:
1783:
1782:
1775:
1764:
1757:
1726:sodium sulfate
1722:Glauber's salt
1705:
1701:
1697:
1678:
1675:
1673:
1670:
1651:
1650:
1647:
1640:
1639:
1638:Ionic strength
1636:
1633:
1630:
1627:
1617:sodium acetate
1608:
1605:
1589:
1588:
1539:
1537:
1530:
1524:
1521:
1517:
1516:
1513:turbulent flow
1505:
1502:
1499:
1454:Crystal growth
1452:Main article:
1449:
1446:
1443:Crystal growth
1437:
1436:
1430:
1424:
1419:
1415:
1411:
1402:
1401:
1390:
1385:
1381:
1375:
1371:
1367:
1364:
1361:
1356:
1351:
1347:
1341:
1337:
1333:
1326:
1323:
1318:
1315:
1308:
1305:
1291:
1290:
1287:
1284:
1281:
1272:
1269:
1268:
1267:
1261:
1250:
1244:
1238:
1233:
1229:
1223:
1213:
1212:
1201:
1196:
1192:
1186:
1182:
1178:
1175:
1172:
1167:
1163:
1159:
1152:
1149:
1144:
1141:
1134:
1131:
1112:
1109:
1100:Main article:
1097:
1094:
1064:
1061:
1052:
1051:
1040:
1031:
1027:
1018:
1007:
996:
987:
983:
974:
970:
967:
958:
954:
945:
941:
938:
880:
877:
876:
875:
869:
853:
852:
832:
830:
819:
816:
786:sodium acetate
781:
778:
777:
776:
770:
757:
756:
746:
710:crystal growth
698:
695:
658:
650:crystal growth
617:crystal growth
576:
573:
519:crystal growth
515:supersaturated
439:
438:
436:
435:
428:
421:
413:
410:
409:
408:
407:
402:
397:
395:Skull crucible
392:
387:
382:
377:
372:
367:
362:
357:
352:
347:
342:
337:
332:
324:
323:
319:
318:
317:
316:
311:
306:
301:
296:
291:
283:
282:
278:
277:
276:
275:
270:
265:
257:
256:
252:
251:
243:
242:
230:
229:
212:
211:
126:
124:
117:
110:
109:
79:
77:
70:
65:
39:
38:
36:
29:
15:
9:
6:
4:
3:
2:
3633:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3603:
3601:
3586:
3585:
3576:
3574:
3573:
3564:
3563:
3560:
3554:
3551:
3549:
3546:
3544:
3541:
3540:
3538:
3534:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3449:
3447:
3441:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3398:
3395:
3393:
3390:
3389:
3388:
3385:
3383:
3380:
3378:
3375:
3371:
3368:
3366:
3363:
3362:
3361:
3358:
3356:
3355:Cell immunity
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3327:
3325:
3321:
3311:
3310:Sedimentation
3308:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3257:
3255:
3251:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3219:Cultured meat
3217:
3215:
3212:
3210:
3207:
3206:
3204:
3202:Biology field
3200:
3197:
3191:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3156:
3154:
3150:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3115:
3112:
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3043:
3039:
3035:
3034:Biotechnology
3028:
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2990:
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2961:
2955:
2949:
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2941:
2939:
2936:
2934:
2933:Spinning cone
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2908:Mixer-settler
2906:
2904:
2901:
2899:
2896:
2894:
2891:
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2879:
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2839:
2836:
2834:
2831:
2829:
2826:
2824:
2823:Sedimentation
2821:
2819:
2816:
2814:
2811:
2809:
2808:Precipitation
2806:
2804:
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2794:
2791:
2789:
2786:
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2781:
2779:
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2510:Meso compound
2508:
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2375:0-8247-0528-9
2372:
2369:CRC; 2nd ed.
2368:
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2353:
2352:1-56676-181-6
2349:
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2110:
2103:
2095:
2091:
2087:
2083:
2076:
2072:
2061:
2058:
2056:
2055:Vitrification
2053:
2051:
2048:
2046:
2043:
2041:
2038:
2036:
2033:
2031:
2028:
2026:
2023:
2021:
2018:
2016:
2013:
2011:
2008:
2006:
2003:
2001:
1998:
1996:
1993:
1991:
1988:
1986:
1983:
1981:
1980:Crystal habit
1978:
1976:
1973:
1971:
1968:
1967:
1960:
1958:
1953:
1948:
1939:
1931:
1922:
1920:
1916:
1912:
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1900:
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1761:heat exchange
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1626:Concentration
1625:
1624:
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1597:
1596:mother liquor
1585:
1582:
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1556:
1550:
1549:
1545:
1540:This section
1538:
1534:
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1500:
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1475:of solution,
1474:
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1122:
1121:
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1103:
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1073:concentration
1070:
1060:
1056:
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1029:
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1016:
1008:
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956:
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860:
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840:
836:
833:This section
831:
828:
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809:
808:mother liquor
803:
800:
798:
793:
791:
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771:
768:
765:
764:
763:
761:
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750:
747:
744:
740:
739:
738:
736:
732:
727:
724:Crystallized
722:
715:
711:
707:
703:
694:
692:
688:
684:
679:
675:
671:
667:
662:
656:
651:
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644:
640:
636:
632:
627:
623:
619:
618:
613:
612:
603:
599:
582:
572:
570:
569:precipitation
566:
562:
558:
557:mass transfer
553:
551:
547:
543:
539:
535:
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527:
522:
520:
516:
512:
508:
503:
501:
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493:
489:
485:
481:
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469:
468:precipitating
465:
461:
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429:
427:
422:
420:
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205:
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183:
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176:
172:
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158:
155: â
154:
150:
149:Find sources:
143:
139:
133:
132:
127:This article
125:
121:
116:
115:
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83:
80:This article
78:
74:
69:
68:
63:
61:
54:
53:
48:
47:
42:
37:
28:
27:
22:
3582:
3570:
3507:Microbiology
3492:Biochemicals
3404:Gene therapy
3345:Biosynthesis
3323:Applications
3269:
3244:Spectroscopy
3214:Cell culture
3123:Fermentation
2893:Filter press
2878:Depth filter
2768:Flocculation
2738:Distillation
2712:
2632:Biocatalysis
2505:Diastereomer
2495:Stereoisomer
2458:
2448:Stereocenter
2427:Concepts in
2366:
2343:
2310:November 15,
2308:. Retrieved
2299:
2290:
2278:. Retrieved
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2265:
2253:. Retrieved
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2088:(12): 4277.
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2075:
2040:Seed crystal
2025:Quasicrystal
1956:
1944:
1894:
1884:
1876:
1868:
1856:
1821:
1811:
1809:
1797:
1778:
1772:laminar flow
1746:
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1680:
1659:
1652:
1641:
1621:
1592:
1577:
1568:
1553:Please help
1541:
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894:
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839:adding to it
834:
812:
804:
801:
794:
783:
758:
733:
730:
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666:polymorphism
663:
649:
647:
621:
615:
609:
607:
565:crystallizer
554:
523:
513:liquid or a
504:
443:
442:
405:Zone melting
288:
255:Fundamentals
239:
233:
218:
200:
194:October 2021
191:
181:
174:
167:
160:
148:
136:Please help
131:verification
128:
103:October 2021
100:
91:You can help
81:
57:
50:
44:
43:Please help
40:
3497:Biorobotics
3487:Biomimetics
3482:Biomedicine
2868:Belt filter
2833:Sublimation
2723:Decantation
2050:Symplectite
1990:Crystallite
1872:evaporation
1848:latent heat
1677:Application
1655:evaporation
1629:Temperature
1511:, lower in
1481:temperature
1469:growth rate
1081:temperature
797:antisolvent
767:Snow flakes
631:temperature
602:citric acid
538:biochemical
511:supercooled
500:evaporation
488:temperature
462:known as a
355:Flux method
3600:Categories
3452:Bioeconomy
3424:Stem cells
3377:Embryology
3300:Filtration
3290:Extraction
3209:Bioreactor
2957:Multiphase
2888:Evaporator
2873:Centrifuge
2763:Filtration
2758:Extraction
2698:Adsorption
2688:Absorption
2500:Enantiomer
2280:January 3,
2255:January 3,
2067:References
1915:suspension
1899:evaporator
1102:Nucleation
1096:Nucleation
1077:solubility
846:March 2023
769:formation;
753:stalagmite
749:Stalactite
714:geometries
706:Snowflakes
689:phases of
670:metastable
622:Nucleation
611:nucleation
598:Time-lapse
579:See also:
507:nucleation
480:deposition
273:Nucleation
164:newspapers
46:improve it
3295:Fed Batch
3195:and tools
2971:Azeotrope
2681:Processes
2600:Reactions
2443:Chirality
1768:viscosity
1742:hydration
1718:austenite
1571:July 2017
1542:does not
1460:molecules
1374:∗
1366:−
1185:∗
1177:−
982:−
953:−
697:In nature
460:structure
456:molecules
95:talk page
52:talk page
3572:Category
3527:Virology
3429:Telomere
3076:Branches
2985:Concepts
2976:Eutectic
2928:Scrubber
2903:Leachate
2783:Leaching
2728:Dialysis
2536:Analysis
2304:Archived
2249:Archived
2170:17641629
1963:See also
1952:settling
1859:molasses
1852:enthalpy
1635:Polarity
1485:velocity
1477:pressure
1085:pressure
1063:Dynamics
920:enthalpy
743:gemstone
639:periodic
542:proteins
526:minerals
492:pressure
476:freezing
472:solution
281:Concepts
3584:Commons
3467:Biology
3360:Cloning
3138:Protein
3133:Plasmid
3041:History
2959:systems
2856:Devices
2803:Osmosis
2339:website
2193:May 25,
2117:Bibcode
1891:sucrose
1779:reverse
1714:cooling
1664:is the
1563:removed
1548:sources
1465:capture
1069:crystal
912:entropy
790:menthol
780:Methods
683:anatase
626:solvent
575:Process
534:defects
530:organic
470:from a
464:crystal
350:Epitaxy
263:Crystal
178:scholar
3512:Mining
3445:fields
3104:Allele
2743:Drying
2373:
2350:
2168:
1911:slurry
1734:y-axis
1730:x-axis
1687:direct
1448:Growth
1404:where
1215:where
1021:liquid
977:liquid
948:liquid
687:rutile
490:, air
448:solids
330:Boules
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173:
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3536:Lists
3414:Omics
2938:Still
2335:) at
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1800:mixer
1681:Most
1034:solid
990:solid
961:solid
773:Honey
726:honey
678:solid
452:atoms
185:JSTOR
171:books
3265:CSTR
3234:HPLC
3128:Gene
3109:Cell
2528:(de)
2522:(ee)
2371:ISBN
2348:ISBN
2346:CRC
2312:2023
2282:2017
2257:2017
2195:2024
2166:PMID
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1889:and
1844:heat
1834:at P
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1546:any
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614:and
528:and
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3239:NMR
3118:RNA
3114:DNA
2333:PDF
2156:doi
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