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Ras that allows anchorage-independent growth of transformed cells. Most recently he has focused on identifying unique weaknesses of cancer cells expressing the activated Ras oncogene using a combination of large-scale functional genomics and pre-clinical models of lung cancer.
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from 2001 to 2005. He is a member of the
European Molecular Biology Organisation (1995) and an honorary Fellow of the Royal College of Physicians (2012). In 2022, he was elected a member of the
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is also a Ras effector, important in regulation of apoptosis. He showed that transformation by Ras requires interaction with multiple effectors, which contribute differentially to
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Julian
Downward: RAS and PI 3-kinase Signaling Networks in Cancer talk, presented at the 2010 Koch Institute Summer Symposium
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has made seminal contributions to our understanding of how cellular signal transduction pathways are subverted in
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One or more of the preceding sentences incorporates text from the royalsociety.org website where:
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Downward, Julian (2003). "Targeting RAS signalling pathways in cancer therapy".
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Proceedings of the
National Academy of Sciences of the United States of America
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http://crick.ac.uk/research/a-z-researchers/researchers-d-h/julian-downward/
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exchange, and to demonstrate that GTP-bound Ras binds to and activates the
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Sir Peter
Aldcroft Downward, KCVO, CB, DSO, DFC. He has three daughters.
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The structure and function of the receptor for epidermal growth factor
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The structure and function of the receptor for epidermal growth factor
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J. Downward; J. de
Gunzburg; R. Riehl; R. A. Weinberg (1988).
333:-loading on Ras, which is commonly mutationally activated in
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Blue Skies & Bench Space: Adventures in Cancer
Research
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Creative
Commons Attribution 4.0 International License
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522:. Archived from the original on 25 September 2015
329:. His work provided the first demonstration that
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540:: CS1 maint: bot: original URL status unknown (
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520:"Royal Society Terms, conditions and policies"
456: ed.). Oxford: A & C Black.
353:pathway. Julian was first to demonstrate that
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902:"Major-General Sir Peter Downward - obituary"
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241:. He is a member of the Editorial Board for
225:is Associate Research Director at the
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396:Fellow of the Academy of Medical Sciences
392:Fellow of the Royal Society (FRS) in 2005
1565:Academics of the Francis Crick Institute
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558:"Professor Julian Downward: Team Leader"
1151:National Institute for Medical Research
355:phosphoinositide 3-kinase (PI 3-kinase)
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701:Downward, David Julian Harry (1986).
630:Castellano, E.; Downward, J. (2011).
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301:Massachusetts Institute of Technology
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707:(PhD thesis). University of London.
737:Cold Spring Harbor Laboratory Press
13:
1545:Alumni of Clare College, Cambridge
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311:Downward's research investigates
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763:. rnaiglobal.org. Archived from
498:"Dr Julian Downward FMedSci FRS"
409:
398:in 2009 and was a member of the
351:mitogen-activated protein kinase
299:for biomedical research at the
285:Epidermal growth factor receptor
1550:People educated at Eton College
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229:and Senior Group Leader at the
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233:. He was formerly head of the
1:
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281:Imperial Cancer Research Fund
1570:Members of Academia Europaea
1540:Fellows of the Royal Society
1377:John Richard Anthony Pearson
562:Institute of Cancer Research
461:UK public library membership
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231:Institute of Cancer Research
170:Other academic advisors
7:
1456:Ernest Marshall Wright
306:
216:David Julian Harry Downward
10:
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1305:Philip Richard Evans
1212:
1156:London Research Institute
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984:University College London
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452:. Vol. 2016 (online
259:and earned a first class
255:Downward was educated at
239:London Research Institute
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979:Medical Research Council
729:Kathleen Weston (2014).
648:10.1177/1947601911408079
479:publications indexed by
443:"DOWNWARD, Prof. Julian"
341:complexes mediating Ras
327:oncogenic transformation
269:Clare College, Cambridge
1427:Daniel St Johnston
1388:Nicholas Proudfoot
1359:Roger Ervin Miller
969:Imperial College London
950:Francis Crick Institute
807:10.1073/pnas.85.16.5774
688:"Editorial board: Cell"
454:Oxford University Press
414:Downward is the son of
390:Downward was elected a
363:cytoskeletal regulation
289:postdoctoral researcher
227:Francis Crick Institute
218:(born 25 October 1960)
83:(1986–1989)
75:Francis Crick Institute
1410:Peter John Sadler
547:
394:. He was also elected
373:, and thereby prevent
339:growth factor receptor
331:Guanosine triphosphate
283:where he investigated
974:King's College London
581:Nature Reviews Cancer
511:
375:programmed cell death
349:, which controls the
1287:Julian Downward
1255:Deborah Charlesworth
568:on 7 September 2015.
508:on 19 November 2015.
1535:British biochemists
1421:David Spiegelhalter
1416:Christopher Snowden
1342:Thomas Masters
912:on 7 February 2016.
882:. Academia Europaea
798:1988PNAS...85.5774D
297:Whitehead Institute
235:Signal transduction
81:Whitehead Institute
1478:Catherine Cesarsky
1433:Lloyd N. Trefethen
1261:John Collinge
1250:Luca Cardelli
1230:Laurence D. Barron
1065:Robin Lovell-Badge
964:Cancer Research UK
636:Genes & Cancer
386:Awards and honours
318:. His work on the
277:Michael Waterfield
275:was supervised by
237:Laboratory at the
164:Michael Waterfield
1522:
1521:
1399:Douglas Ross
1371:Ian Paterson
1365:Michael J. Morgan
1298:Robert Evans
1235:Andrew Blake
1164:
1163:
1125:Jean-Paul Vincent
876:"Julian Downward"
863:"Julian Downward"
792:(16): 5774–5778.
761:"Julian Downward"
746:978-1-621820-77-2
459:(Subscription or
404:Academia Europaea
213:
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121:Scientific career
1577:
1444:Colin Watts
1267:Paul Corkum
1225:Martin T. Barlow
1191:
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1115:Richard Treisman
1080:Vassilis Pachnis
1045:Caroline S. Hill
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908:. Archived from
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767:on 4 March 2016.
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504:. Archived from
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265:Natural Sciences
261:Bachelor of Arts
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201:/julian-downward
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199:/researchers-d-h
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197:/a-z-researchers
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159:Doctoral advisor
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1353:Goverdhan Mehta
1311:Alastair Fitter
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1020:Julian Downward
1010:Doreen Cantrell
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174:Robert Weinberg
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416:Major General
410:Personal life
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361:progression,
360:
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1321:David Gadsby
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1272:John Croxall
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1240:Harry Bryden
1220:James Barber
1095:Geraint Rees
1090:Keith Peters
1085:Anne O'Garra
1060:Harpal Kumar
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998:Senior staff
910:the original
896:
886:14 September
884:. Retrieved
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524:. Retrieved
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257:Eton College
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1555:1960 births
1100:John Skehel
1035:Peter Gruss
865:. f1000.com
371:PKB pathway
1529:Categories
1473:Raoul Bott
1277:Tom Curran
1135:Philip Yea
1075:Paul Nurse
560:. London:
500:. London:
463:required.)
422:References
359:cell cycle
347:RAF kinase
343:nucleotide
263:degree in
56:1960-10-25
1105:Jim Smith
957:Funded by
713:940270478
656:1947-6019
601:1474-175X
449:Who's Who
379:oncogenic
367:apoptosis
295:, at the
251:Education
195:/research
1507:Honorary
1204:elected
1050:Tim Hunt
674:21779497
617:43074411
609:12509763
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