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are designed to have specific native configurations in which multiple nucleic acid strands are assembled into a single complex. In some cases native state of biological DNA performs their functions without being controlled by any other regulatory units.
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native state proteins can be manufactured is important, as attempts to create proteins from scratch have resulted in molten globules and not true native state products. Therefore, an understanding of the native state is crucial in
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have more than one native state, and they operate or undergo regulation by transitioning between these states. However, "native state" is used almost exclusively in the singular, typically to distinguish properly
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Folded and unfolded proteins are often easily distinguished by virtue of their water solubilities, as many proteins become insoluble on denaturation. Proteins in the native state will have defined
194:. It is a protein's tertiary, folded structure that makes it capable of performing its biological function. In fact, shape changes in proteins are the primary cause of several
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may touch or lie very close to one another within a stably folded protein. In a molten globule, on the other hand, their time-averaged distances are liable to be greater.
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state, in which these weak interactions are disrupted, leading to the loss of these forms of structure and retaining only the biomolecule's primary structure.
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often form complex native configurations approaching the complexity of folded proteins. Additionally, artificial nucleic acid structures used in
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and/or assembled form, which is operative and functional. The native state of a biomolecule may possess all four levels of
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Hoang, Trinh X.; Marsella, Luca; Trovato, Antonio; Seno, Flavio; Banavar, Jayanth R.; Maritan, Amos (2006-05-02).
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or unfolded ones. In other contexts, the folded shape of a protein is most often referred to as its native "
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While all protein molecules begin as simple unbranched chains of
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The native state of a protein can be distinguished from a
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and, to a lesser extent, other interactions such as
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288:Nucleic acids attain their native state through
344:Proceedings of the National Academy of Sciences
249:, which can be detected spectroscopically, by
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123:Learn how and when to remove this message
16:Proper form of a protein or nucleic acid
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26:For native states in metallurgy, see
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356:10.1073/pnas.0601824103
157:biomolecular structure
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278:protein engineering
247:secondary structure
318:DNA nanotechnology
251:circular dichroism
242:" or "structure."
188:tertiary structure
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350:(18): 6883–6888.
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113:April 2024
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312:such as
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