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Neuroenhancement

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prevalence of 1%, while 2% of those sampled used such drugs within the last 6 months, 3% within the last 12 months, and 5% of others used the drugs over their lifetimes. Of those students who used such substances during the last 6 months, 39% reported their use once in this period, 24% twice, 12% three times, and 24% more than three times. Consumers of neuroenhancement drugs are more willing to use them again in the future due to positive experiences or a tendency towards addiction.
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methods are being researched and developed. Results indicate details of the stimulation procedures are crucial, with some applications impairing rather than enhancing cognition and questions being raised about whether this approach can deliver any meaningful results for cognitive domains. Stimulation
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In general, people under the age of 25 feel that neuroenhancement agents are acceptable or that the decision to use them is to be made individually. Healthcare officials and parents feel concerned due to safety factors, lack of complete information on these agents, and possible irreversible adverse
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A 2016 German study among 6,454 employees found a rather low life-time prevalence of cognitive enhancement prescription drug use (namely 3%), while the willingness to take such drugs was found in 10% of respondents. A survey of some 5,000 German university students found a relatively low 30-day
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A 2024 study based on a representative sample of more than 20,000 adults in Germany showed that around 70% of those surveyed had taken substances with the aim of improving mental performance within a year, without a medical prescription. The consumption of caffeinated drinks, such as coffee and
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are drop-out rates and subjective rating. The drop-out rates were minimal or non-existent for donepezil, memantine, MPH, and modafinil. In the drug trials, participants reported the following adverse reactions to use of donepezil, memantine, MPH, modafinil or caffeine:
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may be considered a tool for enabling or extending cognition. However, it is not "a simple, uniform technology, either in its composition, or in its use" and, as "an informational resource, currently fails to enhance cognition", partly due to issues that include
222:. Modafinil may impair one's self-monitoring ability; a common trend found in research studies indicated that participants rated their performances on cognitive tests higher than it was, suggesting an "overconfidence" effect. 282:
Common drugs intended for neuroehancement are typically well-tolerated by healthy people. These drugs are already in mainstream use to treat people with different kinds of psychiatric disorders.
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A comparison between the sales of MPH to the number of people for whom it was prescribed revealed a disproportionate ratio, indicating high abuse. MPH may impair cognitive performance.
2542:"Evaluating the drivers of and obstacles to the willingness to use cognitive enhancement drugs: the influence of drug characteristics, social environment, and personal characteristics" 2116: 318:, diuresis. The side effects normally ceased in the course of treatment. Various factors, such as dosage, timing and concurrent behavior, may influence the onset of adverse effects. 2030: 1488:"Effectiveness of bright light exposure, modafinil and armodafinil for improving alertness during working time among nurses on the night shift: A systematic review" 124:
There are many supposed nootropics, most having only small effect sizes in healthy individuals. The most common pharmacological agents in neuroenhancement include
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Sattler S, Wiegel C (2013). "Cognitive test anxiety and cognitive enhancement: the influence of students' worries on their use of performance-enhancing drugs".
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Repantis D, Laisney O, Heuser I (June 2010). "Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: A systematic review".
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energy drinks, was widespread (64% of users), expressly with the aim of improving performance, followed by dietary supplements and home remedies, such as
814:"Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults" 2141:
Marois A, Lafond D (1 November 2022). "Augmenting cognitive work: a review of cognitive enhancement methods and applications for operational domains".
1192:"Pharmacological Neuroenhancement: Current Aspects of Categorization, Epidemiology, Pharmacology, Drug Development, Ethics, and Future Perspectives" 2279: 1103:
Weiergräber M, Ehninger D, Broich K (1 April 2017). "Neuroenhancement and mood enhancement – Physiological and pharmacodynamical background".
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Repantis D, Schlattmann, Peter (2010). "Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review".
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Buckner JD, Morris PE, Abarno CN, Glover NI, Lewis EM (17 April 2021). "Biopsychosocial Model Social Anxiety and Substance Use Revised".
244: 2464:"Prevalence of Legal, Prescription, and Illegal Drugs Aiming at Cognitive Enhancement across Sociodemographic Groups in Germany" 1780:"The ethics of AI-assisted warfighter enhancement research and experimentation: Historical perspectives and ethical challenges" 2491:"Associations Between the Big Five Personality Traits and the Non-Medical Use of Prescription Drugs for Cognitive Enhancement" 2604: 2254: 1911: 1654:"Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine" 1410: 1383: 71:
Non-pharmacological measures of cognitive enhancement may include behavioral methods (activities, techniques, and changes),
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Enhancers are multidimensional and can be clustered into biochemical, physical, and behavioral enhancement strategies.
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for cognitive enhancement (lifetime prevalence of 6%), corresponding to around 2.5 million users in Germany.
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Studies are too preliminary to determine whether there are any cognitive-enhancing effects of agents such as
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is a wakefulness-promoting drug used to decrease fatigue, increase vigilance, and reduce daytime sleepiness.
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improves alertness, attention, long-term memory, and daily performance in people with sleep disorders.
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Dresler M, Sandberg A, Bublitz C, Ohla K, Trenado C, Mroczko-Wąsowicz A, et al. (20 March 2019).
1259: 615:"Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review" 392:
technologies may affect general memory enhancement, extending perception and learning-assistance. The
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Daubner J, Arshaad MI, Henseler C, Hescheler J, Ehninger D, Broich K, et al. (13 January 2021).
513:(2011), which may to some degree probe and explore opportunities and threats of using such products. 196: 2463: 2687: 2241:. Science, Technology and Innovation Studies. Springer International Publishing. pp. 243–259. 2234: 192: 45:. Agents or methods of neuroenhancement are intended to affect cognitive, social, psychological, 1141:
Marazziti D, Avella MT, Ivaldi T, Palermo S, Massa L, Della Vecchia A, et al. (June 2021).
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Tennison MN, Moreno JD (2017). "Neuroenhancement and Therapy in National Defense Contexts".
214:, repeated use of modafinil helped individuals maintain higher levels of wakefulness than a 2363: 1271: 1049: 398: 247:(ADHD). MPH is abused by a segment of the general population, especially college students. 8: 2667: 466: 38: 2367: 1275: 1053: 75:, which has been used with the intent to improve cognitive and affective functions, and 2672: 2646: 2568: 2541: 2517: 2490: 2439: 2386: 2351: 2318: 2260: 2166: 2007: 1974: 1951: 1871: 1838: 1814: 1779: 1755: 1722: 1698: 1653: 1629: 1594: 1525: 1463: 1430: 1346: 1295: 1226: 1191: 1167: 1142: 1080: 1037: 1013: 980: 949: 922: 921:
Jangwan NS, Ashraf GM, Ram V, Singh V, Alghamdi BS, Abuzenadah AM, et al. (2022).
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increase incentives to develop potential therapies for various brain diseases, such as
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Glisson JK (14 March 2011). "Dietary Supplements: Safety Issues and Quality Control".
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Antal A, Luber B, Brem AK, Bikson M, Brunoni AR, Cohen Kadosh R, et al. (2022).
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Neuroenhancement products are mentioned in entertainment productions, such as
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Upper photo of modafinil tablets acquired via the Internet; below photo is a
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Pharmacological neuroenhancement agents may include compounds thought to be
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Sattler S, van Veen F, Hasselhorn F, El Tabei L, Fuhr U, Mehlkop G (2024).
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Moreno J, Gross ML, Becker J, Hereth B, Shortland ND, Evans NG (2022).
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effects; such concerns may reduce the willingness to take such agents.
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Neuroenhancement products or methods are used with the intent to:
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Schneider F, Horowitz A, Lesch KP, Dandekar T (21 January 2020).
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The Exercise Effect on Mental Health: Neurobiological Mechanisms
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Repantis D, Bovy L, Ohla K, Kühn S, Dresler M (February 2021).
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methods include electrical stimulation, magnetic stimulation,
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Wood S, Sage JR, Shuman T, Anagnostaras SG (January 2014).
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Becker M, Repantis D, Dresler M, Kühn S (October 2022).
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Cognitive Enhancement: Social and Public Policy Issues
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Smart PR (22 November 2013). "The Web-Extended Mind".
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or other neurological therapies may affect cognition.
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Around 4% stated that they had taken 408: 1398: 1105:Medizinische Monatsschrift für Pharmazeuten 277: 30:or non-pharmacological methods intended to 1264:Annals of the New York Academy of Sciences 608: 606: 604: 602: 600: 598: 2567: 2557: 2516: 2506: 2450: 2402: 2385: 2375: 2201: 2006: 1870: 1813: 1795: 1754: 1697: 1679: 1669: 1628: 1610: 1511: 1462: 1225: 1207: 1166: 1079: 1061: 1012: 948: 938: 847: 829: 785: 736: 718: 677: 2277: 807: 805: 491:possibly encourage societal productivity 245:attention-deficit hyperactivity disorder 2232: 2183: 2080: 1975:"The Internet as Cognitive Enhancement" 1898:. 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Palgrave Macmillan UK. 2307:10.1007/s11019-013-9481-5 1904:10.1002/9781118700143.ch8 1896:Philosophical Engineering 1855:10.1007/s13347-016-0250-2 1797:10.3389/fdata.2022.978734 1739:10.1038/s41398-020-0697-x 1681:21.11116/0000-0007-453B-A 1435:ACS Chemical Neuroscience 1038:"Brain–machine interface" 997:10.1016/j.cnp.2022.05.002 679:10.1007/s41465-018-0108-x 409:Quality and social issues 253: 197:shift work sleep disorder 2508:10.3389/fpsyg.2015.01971 2416:Substance Use and Misuse 1727:Translational Psychiatry 1560:Pharmacological Research 1376:10.4324/9781315708652-12 1147:Clinical Neuropsychiatry 888:Pharmacological Research 278:Possible adverse effects 169:psychological resilience 77:brain-machine interfaces 2495:Frontiers in Psychology 2190:WIREs Cognitive Science 1612:10.3390/brainsci9110291 1063:10.1073/pnas.1319310110 766:Pharmacological Reviews 720:10.3390/brainsci9080178 193:obstructive sleep apnea 136:in general and various 563:Deep brain stimulation 243:that is used to treat 187:Approved for treating 66:neurological disorders 2559:10.1186/1747-597X-9-8 1784:Frontiers in Big Data 1036:Nair P (2013-11-12). 778:10.1124/pr.112.007054 558:Cosmetic pharmacology 553:Cognitive development 24:cognitive enhancement 1370:. pp. 150–165. 1209:10.1155/2021/8823383 399:information overload 150:('mood enhancement') 2368:2013PLoSO...868821S 2061:Scientific American 1276:2016NYASA1369..195B 1054:2013PNAS..11018343N 818:Human Brain Mapping 496:Alzheimer's disease 471:dietary supplements 461:Quality standards, 452:mail order pharmacy 322:Non-pharmacological 166:cognitive endurance 138:dementia treatments 2233:Saritas O (2019). 1658:Psychopharmacology 1284:10.1111/nyas.13040 532:prescription drugs 503:In popular culture 384:Software and media 348:. 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Index

pharmacological
improve
cognitive
affective
mental illness
mood
nootropics
modafinil
caffeine
neurological disorders
non-invasive brain stimulation
brain-machine interfaces

adding to it
modafinil
methylphenidate
Stimulants
dementia treatments
mood
motivation
creativity
Modafinil
narcolepsy
obstructive sleep apnea
shift work sleep disorder
modafinil
Modafinil
sleep deprivation
placebo
executive function

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