330:”); methods for the synthesis of aromatic and dihydroaromatic compounds based on cycloadditions of highly unsaturated conjugated molecules such as conjugated 1,3-enynes; and formal cycloadditions based on propargylic ene reaction/Diels-Alder cycloaddition cascades. Natural products synthesized in his laboratory at MIT include the neurotoxic alkaloids anatoxin a and quinolizidine 217A, the immunosuppressant agent mycophenolic acid the antitumor agent ascochlorin and a number of diterpene quinones derived from the Chinese traditional medicine
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carbanion-accelerated vinylcyclopropane rearrangements; the application of organosilanes (e.g., allenylsilanes, propargylsilanes, and allylsilanes) in a general annulation strategy for the synthesis of five-membered carbocycles and heterocycles (the "Danheiser
Annulation"); benzannulation strategies based on pericyclic transformations of vinylketenes (“
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Danheiser has a longstanding interest in laboratory safety and at MIT he has served as the chair of several committees including the MIT Chemistry
Department EHS Committee which was recognized in 1991 as the first recipient of the American Chemical Society Division of Chemical Safety national award
325:
Danheiser's research has focused on the development of new strategies for the synthesis of complex molecules and their application in the total synthesis of natural products. Synthetic methods invented in his laboratory include highly stereoselective cyclopentene annulations based on oxyanion and
364:
At MIT, Danheiser's educational contributions have been recognized with a MacVicar
Faculty Fellowship, the School of Science Prize for Excellence in Undergraduate Teaching, the MIT Graduate Student Council Teaching Award, and the School of Science Prize for Graduate Education.
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and a member of the board of directors of the
Organic Syntheses corporation since 2004. Organic Syntheses has the unusual feature that all data and experiments reported in articles must be confirmed in the laboratory of a member of the editorial board prior to publication.
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for "best university safety program". Danheiser also served on the
National Research Council Committee on Prudent Practices for the Handling, Storage and Disposal of Chemicals in Laboratories, chairing the Subcommittee on Assessing Chemical Hazards.
305:, Danheiser developed a method for the regiospecific alkylation of beta-diketone enol ethers (the "Stork-Danheiser Alkylation"). and employed it in a total synthesis of the spiro sesquiterpene beta-vetivone. Danheiser received his Ph.D. at
516:
Danheiser, R. L.; Bronson, J. J.; Okano, K. (1985). "The
Carbanion-Accelerated Vinylcyclopropane Rearrangement. Application in a General, Stereocontrolled Annulation Approach to Cyclopentene Derivatives".
1243:
449:
Corey, E. J.; Danheiser, R. L.; Chandrasekaran, S.; Siret, P.; Keck, G. E.; Gras, J.-L. (1978). "Stereospecific Total
Synthesis of Gibberellic Acid. A Key Tricyclic Intermediate".
476:
Corey, E. J.; Danheiser, R. L.; Chandrasekaran, S.; Keck, G. E.; Gopalan, B.; Larsen, S. D.; Siret, P.; Gras, J.-L. (1978). "Stereospecific Total
Synthesis of Gibberellic Acid".
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and chair of the MIT faculty. His research involves the invention of new methods for the synthesis of complex organic compounds. Danheiser is known for the
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882:
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Stork, G.; Danheiser, R. L.; Ganem, B. (1973). "Spiroannelation of Enol Ethers of Cyclic 1,3-Diketones. A Simple
Stereospecific Synthesis of -Vetivone".
702:
Danheiser, R. L.; Gould, A. E.; Fernandez de la
Pradilla, R.; Helgason, A. L. (1994). "Intramolecular Cycloaddition Reactions of Conjugated Enynes".
1268:
395:
Stork, G.; Danheiser, R. L. (1973). "The Regiospecific Alkylation of Cyclic b Diketone Enol Ethers. A General Synthesis of 2-Alkylcyclohexenones".
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731:"Cyano Diels-Alder and Cyano Ene Reactions. Applications in a Formal [2 + 2 +2] Cycloaddition Strategy for the Synthesis of Pyridines"
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Danheiser was awarded the Cope Scholar Award of the American Chemical Society in 1995. He is a Fellow of the American Chemical Society.
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Danheiser has a particular interest in reproducibility in scientific research. He has been the editor-in-chief of the journal
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807:"Total Synthesis Quinolizidine Alkaloid (-)-217A. Application of Iminoacetonitrile Cycloadditions in Organic Synthesis"
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Danheiser, R. L.; Gee, S. K. (1984). "A Regiocontrolled Annulation Approach to Highly Substituted Aromatic Compounds".
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Danheiser, R. L.; Morin, J. M.; Salaski, E. J. (1985). "An Efficient Total Synthesis of Anatoxin a".
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1198:"School of Science announces winners of Teaching Prizes for Graduate and Undergraduate Education"
546:"TMS-Cyclopentene Annulation: A Regiocontrolled Approach to the Synthesis of Five-Membered Rings"
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Danheiser, R. L.; Gee, S. K.; Perez, J. J. (1986). "The Total Synthesis of Mycophenolic Acid".
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883:"Total Synthesis of (-)-Ascochlorin via a Cyclobutenone-Based Benzannulation Strategy"
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It may require cleanup to comply with Knowledge's content policies, particularly
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A C Cope Professor of Chemistry." Chemistry Directory. MIT, Web. 23 Nov. 2014.
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Dudley, G. B.; Takaki, K. S.; Cha, D. D.; Danheiser, R. L. (2000).
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may have been created or edited in return for undisclosed payments
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1147:"MIT Names 3 MacVicar Fellows, Recognizing Outstanding Teaching"
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Danheiser was born in New York and received his B.A. in 1972 at
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chemist and is the Arthur C. Cope Professor of Chemistry at the
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Massachusetts Institute of Technology School of Science faculty
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1088:"SafetyStratus College and University Health and Safety Award"
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Strategic Applications of Named Reactions in Organic Synthesis
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Strategic Applications of Named Reactions in Organic Synthesis
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in 1978. His doctoral research (under the direction of
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A major contributor to this article appears to have a
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Fellows of the American Academy of Arts and Sciences
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67:)
61:(
56:)
52:(
48:.
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