126:"Biological Resource Centres are an essential part of the infrastructure underpinning biotechnology. They consist of service providers and repositories of the living cells, genomes of organisms, and information relating to heredity and the functions of biological systems. BRCs contain collections of culturable organisms (e.g.
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is a facility that collects, catalogs, and stores samples of biological material for laboratory research. Biorepositories collect and manage specimens from animals, plants, and other living organisms. Biorepositories store many different types of specimens, including samples of
82:(iii) Storage and inventory are where all samples are held prior to being requested via a distribution request. The inventory system is composed of sample holding boxes and the boxes are stored in freezers of various types depending on the sample storage requirements.
79:(ii) Processing of specimens is standardized to minimize variation due to handling. Processing may prepare the specimen for long-term storage. For example, DNA samples are processed into a salt buffer (aqueous solution) of proper pH to stabilize the DNA for storage.
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The purpose of a biorepository is to maintain biological specimens, and associated information, for future use in research. The biorepository maintains the quality of specimens in its collection and ensures that they are accessible for scientific research.
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Genetic
Testing Reference Material Program (GeT-RM) maintains DNA samples for use in molecular genetic testing. These samples are from diseases such as Huntington Disease, Cystic Fibrosis, Fragile X Syndrome, Alpha-Thalassemia, and Muenke
76:("LIMS"), which tracks information about all of the specimens in the biorepository. Typical information linked to a specimen would be the specimen's origin and when it arrived at the biorepository.
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The
National Institute on Aging (NIA) Aging Cell Repository facilitates research into the mechanisms of aging by providing cell lines collected from subjects of different ages.
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SOPs provide a standardized framework of how to conduct operations within a biorepository. They ensure seamless and reliable processes be implemented throughout operations.
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The
National Institute of General Medical Sciences (NIGMS) Human Genetic Cell Repository is collection of well-characterized human cells for use in biomedical research.
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The four main operations of a biorepository are; (i) collection (ii) processing, (iii) storage or inventory, and (iv) distribution of biological specimens.
52:. If the samples are from people, they may be stored with medical information along with written consent to use the samples in laboratory studies.
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Smith, D; Ryan, MJ (January 2008). "The impact of OECD best practice on the validation of cryopreservation techniques for microorganisms".
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72:(i) Collection or accession occurs when a specimen arrives at the biorepository. Information about the specimen is entered into the
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SOPs reduce variability within the samples and storage processes by providing standardized guidelines for proper storage and care.
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Biorepository is a collection of over 4.5 million biological samples preserved in formalin and embedded in paraffin wax.
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Human Cell and Data
Repository maintains a collection of cell lines to advance the study of neurological disorders.
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85:(iv) Distribution is the process of retrieving one or more samples from the biorepository inventory system.
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play a crucial role in the biorepository industry. There are a number of reasons why they are important:
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Biospecimen samples should closely resemble biospecimens in their natural state. SOPs help ensure that.
422:"A Resource for Stem Cells including iPSCs and Fibroblasts | The NINDS Human Cell and Data Repository"
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Siwek, Martina (October 2015). "An
Overview of Biorepositories—Past, Present, and Future".
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ProMedDx BioServices cGMP Biostorage & Biorepository - Biorepository
Consulting Design
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National
Institute of Allergies and Infectious Diseases HIV/AIDS Specimen Repository
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has issued best practice guidelines for biorepositories, which are referred to as
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Society for Biological and Environmental Repositories ("ISBER")
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345:"The Importance of Standard Operating Procedures (SOPS) in Biobanking"
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and structural information relevant to these collections and related
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320:"Genomic Medicine: Biobanking Standard Operating Procedures (SOPs)"
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Clinical
Specimens Database and Specimen Collections Repository
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National
Institute of Neurological Disorders and Stroke (NINDS)
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Global Directory of Biobanks, Tissue Banks and Biorepositories
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OECD Best Practice Guidelines for Biological Resource Centres
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604:, A worldwide listing of active biobanks and biorepositories
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Place in which biological materials are stored and preserved
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Cell&Co Biorepository - The first French Eco-Biobank
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Human Reference Genome makes available DNA samples from
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186:Examples of Biorepositories in the United States
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123:. They are defined by the OECD as follows:
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74:laboratory information management system
526:"About the Intermountain Biorepository"
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502:"NIGMS Human Genetic Cell Repository"
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94:Standard Operating Procedures (SOPs)
602:Specimen Central biorepository list
142:), replicable parts of these (e.g.
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295:"NCI Dictionaries - biorepository"
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111:Biological Resource Centres
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464:10.7205/MILMED-D-15-00119
299:National Cancer Institute
225:J. Craig Venter Institute
218:Intermountain Healthcare
265:Genetic fingerprinting
191:Cell Line Repositories
654:Biological specimens
409:OECD BRC Guidelines
255:Biological database
211:Sample Repositories
613:Biorepository LIMS
506:www.nigms.nih.gov
452:Military Medicine
426:nindsgenetics.org
324:Inside Biobanking
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580:. 2019-11-05
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578:www.cdc.gov
140:human cells
648:Categories
584:2021-10-20
559:2021-10-20
535:2021-10-20
511:2021-10-20
487:2021-10-20
431:2021-10-20
354:2017-10-16
330:2017-10-16
305:2021-09-23
281:References
65:Operations
260:Gene bank
239:Syndrome.
172:molecular
160:organisms
382:18392291
275:Genotype
270:Genomics
244:See also
148:plasmids
50:proteins
550:"HuRef"
250:Biobank
168:tissues
152:viruses
144:genomes
56:Purpose
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136:animal
48:, and
34:tissue
478:"NIA"
164:cells
156:cDNAs
132:plant
38:cells
30:urine
26:blood
378:PMID
234:The
223:The
216:The
196:The
166:and
138:and
117:OECD
115:The
460:doi
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182:."
46:RNA
42:DNA
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