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dichotomous ever/never measure that lumped together predominantly heterosexual, bisexual and homosexual individuals, including those who only experimented once with a same-sex partner, possibly resulting in misleading associations to personality traits. Hamer said that the findings of the 2019 study do not reveal any biological pathways for sexual orientation, but stated he hoped it would be the first of many to come.
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287:, providing statistically significant evidence for linkage to the sexual orientation phenotype. This finding was replicated in two other studies in the United States whereas a study in Canada found contrary results; meta-analysis of all data available at that time suggested that Xq28 has a significant but not exclusive effect. Subsequently, a genomewide scan by Hamerʻs group revealed additional regions on
358:" approach to HIV/AIDS prevention. By genetically engineering normal vaginal bacteria to produce a potent anti-HIV peptide, significant protection against viral infection was provided in a durable and obtainable fashion for up to one month. The methodology was shown to be applicable to both rectal and vaginal use and is in the initial stages of preclinical testing.
312:
Hamer's findings provoked extensive public reaction, often based on misunderstanding of the science, which led to his interest in explaining the data to a wide audience through a book written in collaboration with a journalist. Social science surveys have shown that research on the origins of
490:
formed Qwaves with the mission of producing "insightful and provocative films that emanate from the voices of those on the outside and compel us to question and to act." Their short films won multiple awards including winner of the PBS Independent Lens Shorts
Festival and Seeds of Tolerance Award.
353:
Hamer's lab developed several biotechnological strategies to treat and reduce the transmission of HIV/AIDS. As a means to reduce the latent pools of virus responsible for viral persistence, they discovered novel chemical agent to induce integrated virus, and molecularly-engineered immunotoxins to
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linkage by two-point and multipoint LOD score mapping. Significant linkage was also detected in the pericentromeric region of chromosome 8, overlapping with one of the regions detected in the Hamer lab's previous genomewide study. The authors concluded that "our findings, taken in context with
308:
of 493,001 individuals concluded that hundreds or thousands of genetic variants underlie same-sex sexual behavior in both sexes, but in contrast to linkage studies they found no excess of signal on Xq28 or the rest of the X chromosome. This study was questioned on account of its reliance on a
592:. The animated film was followed by a children's book published by Kokila, a PBS feature documentary, a multimedia exhibition at the Bishop Museum, permanent display at the Hawai'i Convention center, and inclusion in new interpretative signage at the Kapaemahu monument in Waikiki.
1154:
Sanders, A. R.; Martin, E. R.; Beecham, G. W.; Guo, S; Dawood, K; Rieger, G; Badner, J. A.; Gershon, E. S.; Krishnappa, R. S.; Kolundzija, A. B.; Duan, J; Gejman, P. V.; Bailey, J. M. (2015). "Genome-wide scan demonstrates significant linkage for male sexual orientation".
253:
gene system. They elucidated the mechanism of induction of yeast metallothionein by copper ions, one of the first eukaryotic gene regulatory systems to be understood at the molecular level and a useful method for regulating therapeutic protein production.
294:
Hamer's results were robustly replicated in 2012 in a large, comprehensive multi-center genetic linkage study of male sexual orientation conducted by several independent groups of researchers. Analysis of 409 pairs of gay brothers with over 300,000
507:
for achievement in documentary. The Out in the
Silence Youth Activism Award was initiated in 2011 to highlight the contributions of young people to achieving respect, inclusion and equality for lesbian, gay, bisexual and transgender people.
1198:
Ganna, Andrea; Verweij, Karin J. H.; Nivard, Michel G.; Maier, Robert; Wedow, Robbee; Busch, Alexander S.; Abdellaoui, Abdel; Guo, Shengru; Sathirapongsasuti, J. Fah; 23andMe
Research Team; Lichtenstein, Paul (August 30, 2019).
171:. He is known for his research on the role of genetics in sexual orientation and for a series of popular books and films that have changed scientific and public understandings and perceptions of human sexuality and gender.
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Genome-wide linkage scan of male sexual orientation. A. R. Sanders, K. Dawood, G. Rieger, J. A. Badner, E. S. Gershon, R. S. Krishnappa, A. B. Kolundzija, S. Guo, G. W. Beecham, E. R. Martin, J.M. Bailey8, Abstract
1270:
Hamer, Dean; Mustanski, Brian; Sell, Randall; Sanders, Stephanie A.; Garcia, Justin R. (March 26, 2021). "Comment on "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior"".
499:, the first feature film from Qwaves, documented the controversy that was ignited by Hamer and Wilson's wedding announcement in Wilson's conservative small hometown in Pennsylvania The film was supported by the
274:
in 1993, reported that the maternal but not paternal male relatives of gay men had increased rates of same-sex orientation, suggesting the possibility of sex-linked transmission in a portion of the population. A
863:
Hamer, D.H.: Simian Virus 40 as a cloning vehicle in mammalian cells. In
Schultz, Jr. and Brada, Z. (Eds.): Genetic Manipulation as It Affects the Cancer Problem. Academic Press, New York, N.Y., 1977, pp.
400:
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previous work, suggest that genetic variation in each of these regions contributes to development of the important psychological trait of male sexual orientation." In August 2019, a
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analysis of DNA samples from these families showed that gay brothers had an increased probability of sharing polymorphic markers on the subtelomeric region of the long arm of the
599:, an animated short based on the Hawaiian term for intimate friends of the same sex. It won two Academy Award-qualifying film festival awards and was nationally distributed by
1994:
1400:
Lesch KP, Bengel D, Heils A, et al. (November 1996). "Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region".
211:. Hamer has won numerous awards including the Trinity College Thompson History Prize, Maryland Distinguished Young Scientist Award, Ariens Kappers Award for Neurobiology,
324:, is associated with mood and personality. This finding has been extensively replicated and extended and its activity has been confirmed by direct brain imaging studies.
883:
Furst P.; Hu S.; Hackett R.; Hamer D.H. (1988). "Copper activates metallothinonein gene expression by altering the conformation of a specific DNA binding protein".
812:
486:
Hamer turned to documentary filmmaking to address complex scientific and social issues often overlooked by the mainstream media. In 2005, he and partner
1453:"Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy"
1323:
1788:"In vivo evaluation of safety and toxicity of a Lactobacillus jensenii producing modified cyanovirin-N in a rhesus macaque vaginal challenge model"
327:
In 2004, Hamer used data from ongoing behavioral genetics studies in his lab to explore the possibility of genetic influences on spirituality. In
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1098:
Mustanski BS, Dupree MG, Nievergelt CM, Bocklandt S, Schork NJ, Hamer DH (March 2005). "A genomewide scan of male sexual orientation".
614:, the project aims to document and memorialize gender and sexual diversity across the multicultural landscape of the Hawaiian islands.
610:
In 2024, Hamer initiated a multimedia community engagement and storytelling effort on the "Queer
Histories of Hawai'i." Funded by the
2165:
570:, about transgender men in Samoa. These films became part of a campaign to decriminalize same-sex relationships across the Pacific.
566:, which documented the lives of transgender women in the conservative South Pacific Kingdom of Tonga. This was followed in 2019 by
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380:
2284:
2259:
1020:
Rice G, Anderson C, Risch N, Ebers G (April 1999). "Male homosexuality: absence of linkage to microsatellite markers at Xq28".
331:
he proposed that a quantitative measure of self-transcendence is partially heritable and may be correlated to a specific gene,
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Qwaves | Social issue films, animation & impact campaigns from Emmy award winning filmmakers Dean Hamer and Joe Wilson
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Qwaves | Social issue films, animation & impact campaigns from Emmy award winning filmmakers Dean Hamer and Joe Wilson
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sexual orientation has a strong positive influence on people's attitudes of acceptance and inclusion of LGBT people.
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829:
Hamer D.H.; Davoli D.; Thomas C.A., Jr; Fareed G.C. (1977). "Simian virus 40 carrying an E. coli suppressor gene".
1637:
Brooks, D. G.; Hamer, D. H.; Arlen, P. A.; Gao, L; Bristol, G; Kitchen, C. M.; Berger, E. A.; Zack, J. A. (2003).
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who first brought the healing arts from Tahiti to Hawaii. It premiered and won the
Special Jury Prize at the
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lives and voices and long tradition of acceptance of sexual and gender minorities. Their feature documentary
305:
200:
188:
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1995:"Kapaemahu by Hinaleimoana Wong-Kalu, Dean Hamer, Joe Wilson: 9780593530061 | PenguinRandomHouse.com: Books"
440:
1680:"Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide"
1549:
Hamer, D. H.; Bocklandt, S; McHugh, L; Chun, T. W.; Blumberg, P. M.; Sigano, D. M.; Marquez, V. E. (2003).
1375:
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based on the hidden history of four stones on
Waikiki Beach placed there as a tribute to four legendary
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396:
227:
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Hamer and colleagues also investigated the genetic roots of anxiety and found that a promoter region
204:
2199:
2019:
819:, The Great Lecture Library. Accessed October 2, 2015. "Dr. Dean Hamer was born in Montclair, N.J."
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263:
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389:
2090:"Honolulu tells story of healers with dual male and female spirit through new plaque in Waikiki"
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751:
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Hamer, Wilson and Wong-Kalu continued their collaboration in 2020 with the animated short film
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destroy the infected cells. They also collaborated with Osel, Inc. on a novel "live microbial
320:
in the gene for the serotonin transporter, which is the target of antidepressant drugs such as
317:
231:
196:
66:
1250:
1201:"Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior"
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685:
585:
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180:
54:
335:, involved in monamine metabolism. Hamer's speculations on the possible role of genetics in
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1409:
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184:
8:
1739:"Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus"
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Kenna GA, Roder-Hanna N, Leggio L, Zywiak WH, Clifford J, Edwards S, et al. (2012).
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1876:(Documentary, Comedy, Family), C. J. Bills, Diane Granley, Linda Henderson, qWaves.com
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234:. This approach was used to produce a variety of biomedical products including human
203:
for 35 years, where he was the Chief of Gene
Structure and Regulation Section at the
1737:
Lagenaur LA, Sanders-Beer BE, Brichacek B, Pal R, Liu X, Liu Y, et al. (2011).
1437:
975:"Linkage between sexual orientation and chromosome Xq28 in males but not in females"
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Hamer invented the first method for introducing new genes into animal cells using
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1551:"Rational design of drugs that induce human immunodeficiency virus replication"
928:"A linkage between DNA markers on the X chromosome and male sexual orientation"
668:
235:
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555:
In 2017, Hamer and Wilson, with
Hinaleimoana Wong-Kalu as producer, released
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1615:
1600:"Can HIV be Cured? Mechanisms of HIV persistence and strategies to combat it"
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Brichacek, B; Lagenaur, L. A.; Lee, P. P.; Venzon, D; Hamer, D. H. (2013).
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1324:"Massive Study Finds No Single Genetic Cause of Same-Sex Sexual Behavior"
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526:
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239:
192:
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1639:"Molecular characterization, reactivation, and depletion of latent HIV"
1063:
Hamer, D. H. (August 6, 1999). "Genetics and Male Sexual
Orientation".
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644:
617:
Hamer is a frequent guest on TV documentaries and news shows including
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512:
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Hamer, D.H.: Metallothionein. Annu. Rev. Biochem. 55: 913‑951, 1986.
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266:, which led to the first molecular evidence for genes that influence
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2021:
Pacific Heartbeat | The Healer Stones of Kapaemahu | Season 11 | PBS
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and was shortlisted for an Oscar as Best Animated Short Film at the
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761:(Dir Dean Hamer, Joe Wilson, Prod Hinaleimoana Wong-Kalu, 2018).
672:
257:
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671:, Hamer's works have been cited over 27,000 times and he has an
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Hu S, Pattatucci AM, Patterson C, et al. (November 1995).
321:
243:
164:
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Hamer DH, Hu S, Magnuson VL, Hu N, Pattatucci AM (July 1993).
410:
from the article and its talk page, especially if potentially
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32:
1846:"Qwaves | Films and Impact Campaign focusing on the Pacific"
1450:
772:(Dir Hinaleimoana Wong-Kalu, Dean Hamer, Joe Wilson, 2020).
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Living with Our Genes: Why They Matter More Than You Think
1969:
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688:: The Search for the Gay Gene and the Biology of Behavior
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that were moderately linked to male sexual orientation.
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773:
2065:"Convention center unveils Hawaiian cultural exhibits"
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329:
The God Gene: How Faith is Hardwired into our Genes,
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714:
The God Gene: How Faith Is Hardwired into our Genes
148:
142:
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1678:Rao S, Hu S, McHugh L, et al. (August 2005).
925:
270:. His research group's first paper, published in
2251:
2042:"THE HEALER STONES OF KAPAEMAHU - Bishop Museum"
1399:
1149:
1147:
537:, Pacific Islanders in Communications and the
258:Human sexual orientation and behavior genetics
543:GLAAD Media Award for Outstanding Documentary
249:At NIH, Hamerʻs lab initially focused on the
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1671:
1542:
1495:
1444:
1144:
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215:book-of-the year author, and an Emmy Award.
207:; upon retirement in 2011 he was designated
1870:Hamer, Dean; Wilson, Joe (August 5, 2009),
1869:
1677:
1393:
1255:: CS1 maint: numeric names: authors list (
1013:
2233:D.C. scientist breaks new lead on gay gene
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529:native Hawaiian teacher and cultural icon
403:about living persons that is unsourced or
199:. He was an independent researcher at the
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474:Learn how and when to remove this message
218:
1504:"Genetics. Rethinking behavior genetics"
262:In the 1990s Hamer began studies on the
1501:
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174:
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662:
2062:
1597:
1349:
1062:
750:(Dir. Dean Hamer, Joe Wilson, 2014).
738:(Dir Joe Wilson, Dean Hamer, 2009).
365:
159:; born May 29, 1951) is an American
2063:Dower, Linsey (February 17, 2023).
703:with Peter Copeland (Anchor, 1999)
511:In 2011, Hamer and Wilson moved to
13:
2315:21st-century American LGBTQ people
1567:10.1128/jvi.77.19.10227-10236.2003
1071:(5429). Sciencemag.org: 803a–803.
361:
339:were featured in a cover story in
14:
2326:
2305:People from Montclair, New Jersey
2221:
1322:Reardon, Sara (August 29, 2019).
515:to begin a series of films about
501:Sundance Documentary Film Program
349:HIV/AIDS treatment and prevention
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595:The team's most recent film is
16:American geneticist (born 1951)
1974:The Healer Stones of Kapaemahu
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876:
867:
857:
822:
803:
786:Biology and sexual orientation
297:single-nucleotide polymorphism
205:U.S. National Cancer Institute
1:
2285:Harvard Medical School alumni
2260:American LGBTQ film directors
2200:"Dean Hamer - Google Scholar"
1656:10.1016/s1074-7613(03)00236-x
1422:10.1126/science.274.5292.1527
1077:10.1126/science.285.5429.803a
843:10.1016/s0022-2836(77)80137-x
796:
306:genome-wide association study
201:National Institutes of Health
115:National Institutes of Health
2300:LGBTQ people from New Jersey
2141:"Queer Histories of Hawai'i"
1813:10.1371/journal.pone.0078817
1684:Proc. Natl. Acad. Sci. U.S.A
1042:10.1126/science.284.5414.665
897:10.1016/0092-8674(88)90229-2
381:biography of a living person
230:while a graduate student at
7:
1895:"Out in the Silence | Home"
779:
690:(Simon and Schuster, 1994)
653:, and has been profiled in
408:must be removed immediately
10:
2331:
2145:Queer Histories of Hawai'i
264:genetics of human behavior
2295:American LGBTQ scientists
1169:10.1017/S0033291714002451
1112:10.1007/s00439-004-1241-4
675:of 72 as of August 2020.
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2069:Honolulu Star-Advertiser
1616:10.2174/1570162043484915
1502:Hamer D (October 2002).
815:October 3, 2015, at the
727:
678:
635:. He is featured in the
268:human sexual orientation
2290:Writers on LGBTQ topics
1705:10.1073/pnas.0504881102
1520:10.1126/science.1077582
1380:The Scientist Magazine®
1285:10.1126/science.aba2941
1217:10.1126/science.aat7693
952:10.1126/science.8332896
2310:American LGBTQ writers
2238:June 19, 2006, at the
1999:PenguinRandomhouse.com
1457:Pharmgenomics Pers Med
1376:"Going Beyond the Lab"
1354:. Simon and Schuster.
1157:Psychological Medicine
774:Kanak Pakipika website
632:The Oprah Winfrey Show
531:Hinaleimoana Wong-Kalu
395:Please help by adding
299:markers confirmed the
232:Harvard Medical School
219:Biotechnology research
197:Harvard Medical School
67:Harvard Medical School
1598:Hamer, D. H. (2004).
1352:The Science of Desire
791:Serotonin transporter
686:The Science of Desire
586:Tribeca Film Festival
183:, Hamer obtained his
181:Montclair, New Jersey
55:Montclair, New Jersey
2280:American geneticists
2245:Is God In Our Genes?
2228:Dean Hamer's website
1604:Current HIV Research
1350:Hamer, Dean (1994).
620:Good Morning America
401:Contentious material
337:religious experience
242:, resulting in 4 US
175:Education and career
2166:"Mellon Foundation"
1945:"Leitis in Waiting"
1804:2013PLoSO...878817B
1696:2005PNAS..10211993R
1555:Journal of Virology
1470:10.2147/PGPM.S23462
1414:1996Sci...274.1527L
1329:Scientific American
1034:1999Sci...284..665R
944:1993Sci...261..321H
663:Scholarly influence
590:93rd Academy Awards
533:, was supported by
195:, and his PhD from
2275:American agnostics
2204:scholar.google.com
2096:. October 25, 2023
2044:. February 2, 2022
1873:Out in the Silence
1755:10.1038/mi.2011.30
1279:(6536): eaba2941.
1211:(6456): eaat7693.
991:10.1038/ng1195-248
735:Out in the Silence
716:(Doubleday, 2004)
549:Audience Award on
496:Out in the Silence
379:This section of a
238:and a vaccine for
209:Scientist Emeritus
119:Sundance Institute
106:, documentary film
86:Out in the Silence
2189:71,139036,00.html
1949:Leitis in Waiting
1408:(5292): 1527–31.
758:Leitis in Waiting
612:Mellon Foundation
558:Leitis in Waiting
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384:needs additional
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517:Pacific Islander
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810:Dr. Dean Hamer
801:
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2150:January 9,
2125:January 9,
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797:References
659:magazine.
650:Religulous
645:Bill Maher
639:' special
607:platform.
601:Conde Nast
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505:Emmy Award
488:Joe Wilson
434:newspapers
345:magazine.
161:geneticist
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545:and the
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412:libelous
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104:Genetics
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2094:AP News
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1800:Bibcode
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