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On May 10, 1989, a flash fire destroyed the
Morrell Park mouse production facility. The fire lasted for five hours, requiring over 100 firefighters from 15 companies and a total of 16 trucks for the fire to be contained. Four workers of the Colwell Construction Company who were installing fiberglass
651:
The
Jackson Laboratory Cancer Center has a single program, Genetic Models for Precision Cancer Medicine, composed of three biological themes: cancer cell robustness, genomic and genetic complexity, and progenitor cell biology. The themes emphasize the systems genetics of cancer and translational
661:
wallboard in the room where the fire broke out were injured, one with burns over 15 percent of his body. While none of the foundation strains were lost, 300,000 production mice (about 50% of their stock) died, resulting in a national shortage of laboratory mice and the layoff of 60 employees.
1257:
Hollander, Anneke I. den; Nishina, Patsy M.; Hoyng, Carel B.; Peachey, Neal S.; Leroy, Bart P.; Roepman, Ronald; Boon, Camiel J. F.; Cremers, Frans P. M.; Simonelli, Francesca; Banfi, Sandro; Walraedt, Sophie; Baere, Elfride De; Abu-Ltaif, Sleiman; Moorsel, Tamara W. van; Neveling, Kornelia;
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Office for
Laboratory Animal Welfare. The worker accused the laboratory of "allowing mice to suffer and then die in their cages instead of euthanizing them" and of cutting off the toes of mice to identify them. Jackson Laboratory denied the allegations and stated the worker was fired for her
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and The
Jackson Laboratory now provides a high proportion of the mice used in biomedical research In particular, the C57BL/6J strain, which is widely used and cited is maintained at The Jackson Laboratory. The demand for mice generated at The Jackson Lab increased in 1937 when the
647:
The
Jackson Laboratory Cancer Center (JAXCC) first received its National Cancer Institute designation in 1983 in recognition of the foundational cancer research conducted there. The JAXCC is one of seven NCI-designated Cancer Centers with a focus on basic research.
452:
Cancer: The
Jackson Laboratory Cancer Center (JAXCC) has a National Cancer Institute-designated Cancer Center. Cancer areas of focus include: brain, leukemia, lung, lymphoma, prostate, breast; cancer initiation and progression; cancer prevention and
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This was the second fire to severely affect the laboratory; the 1947 fire that burned most of the island destroyed most of the laboratory, and its mice. Worldwide donations of funds and mice allowed the lab to resume operations in 1948.
584:, central to obesity and diabetes research, earning him the Shaw Prize, the Albert Lasker Award, the Gairdner International Award, Frontiers of Knowledge Award in Biomedicine, and the King Faisal International Prize in Medicine.
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as a public charity. According to organization literature, revenue comes primarily from the sale of materials and services (~70%) and from government support (~25%). Less than 5% of 2012 revenue came from charitable donations.
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located in
Farmington, Connecticut. Each campus maintains affiliations with a variety of other academic institutions. In the Bar Harbor location, cooperative Ph.D. training is offered in conjunction with the
1258:
Letteboer, Stef J.; Charette, Jeremy R.; Collin, Gayle B.; Rowe, Lucy; Shi, Lanying; Yu, Minzhong; Hicks, Wanda; Schoenmaker-Koller, Frederieke E.; Krebs, Mark P.; Saksens, Nicole T. M. (1 February 2016).
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to the lab that made mice produced there a de facto industry standard due to federal standardization requirements because it was the only large-scale mouse provider before World War II.
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Recent research has provided insight into cancer stem cells and treatments for leukemia; progress with type 1 diabetes and lupus; and a breakthrough in extending mammalian life span.
517:, for whom the institution is named. As well as providing funds for the first laboratory building, Roscoe B. Jackson provided support for the first five years of operation.
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genetics. The stated mission of The
Jackson Laboratory is "to discover the genetic basis for preventing, treating and curing human diseases, and to enable research and
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2018:
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cancer genomics, and all are supported by the JAX Cancer Center's technological initiatives in mouse modeling, genome analytics and quantitative cell biology.
2013:
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with the purpose of discovering the causes of cancer and other diseases through research on mammals. The campus was built on 13 acres of land donated by
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protection law when they fired an employee who claimed to have been terminated after reporting her concerns about the treatment of animals to the
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448:. There are more than 60 faculty members maintaining independent labs across these campuses, who perform research in six primary areas:
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Immunology: HIV/AIDS, anemia, autoimmunity, cancer immunology, immune system disorders, lupus, tissue transplant rejection, vaccines
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Studies in
History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
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performed the first bone marrow transplants in a mammal, leading to new treatments for blood and immunological diseases.
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Neurobiology: blindness, Alzheimer's, deafness, epilepsy, glaucoma, macular degeneration, neurodegenerative diseases
1210:"National Institute on Aging funds new Alzheimer's disease center at Indiana University and The Jackson Laboratory"
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1511:; Bult, Carol J.; Kadin, James A.; Richardson, Joel E.; Eppig, Janan T.; The Mouse Genome Database Group (2011).
1260:"Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity"
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444:. At the Jackson Laboratory for Genomic Medicine, cooperative Ph.D. training is offered in conjunction with the
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funds the development of new computational tools to understand how multiple genes interact in complex diseases.
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Use of cancer avatars â mice with implanted human tumors â to test targeted therapies for cancer patients.
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via research, resources, or educational programming. Some notable findings from the institution include:
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Established that cancer is a genetic disorder, a novel concept before the
Laboratory's founding in 1929.
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1513:"The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics"
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Metabolic diseases: atherosclerosis, cardiovascular disease, diabetes, high blood pressure, obesity
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906:"Personalized Medicine Coalition â Advocates for precision medicine : The Jackson Laboratory"
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Ribbon cutting at the Jackson Laboratory for Genomic Medicine dedication ceremony in October 2014
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won the Nobel Prize in 1980 for providing an in-depth understanding of the immune system's major
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Researchers link mutations to butterfly-shaped pigment dystrophy, an inherited macular disease.
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provides $ 25 million to develop new treatments, future therapies based on precision modeling.
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The Jackson Laboratory for Genomic Medicine opens in Farmington, Connecticut in October 2014.
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971:"GSBSE @ JAX â Graduate School of Biomedical Science and Engineering â University of Maine"
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Griesemer, James R.; Gerson, Elihu M. (1 June 2006). "Of mice and men and low unit cost".
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first described cells that can develop into different tissues â today known as stem cells.
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1627:"Former worker who accused Jackson Lab of mistreating mice loses whistleblower lawsuit"
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Development/reproductive biology: birth defects, Down syndrome, osteoporosis, fertility
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626:(NIH) funds phase 2 of the Knockout Mouse Production and Phenotyping Project (KOMP2).
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database, and an international hub for scientific courses, conferences, training and
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In 2013, a jury in Maine found that Jackson Laboratory did not violate that state's
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1308:"Jackson Laboratory researchers discover mutation involved in neurodegeneration"
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The research performed at The Jackson Laboratory is associated with at least 26
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In October 2020, it received a $ 11.8M USD grant from Harold Alfond Foundation.
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Jackson Laboratory researchers discover mutation involved in neurodegeneration.
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In October 2021, Jackson Lab bought Japan-based research animal business from
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in 68 countries around the world. Additionally, JAX is the home of the
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1007:"Mammalian Genetics at JAX | Graduate School of Biomedical Sciences"
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1358:"Jackson Lab to get 11.8 million dollar grant for cancer research"
870:"Find an NCI-Designated Cancer Center â National Cancer Institute"
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1491:"Jackson Lab buys Japan-based research animal business for $ 63M"
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Aerial view of The Jackson Laboratory campus in Bar Harbor, Maine
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1026:"JAX Labs uses biomolecular modeling to advance patient health"
924:"JAX Mice and Research Services Provided Through Charles River"
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834:"Jackson Lab to remove founder's name from conference center"
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Johnson, Mary (8 July 2022). "Laboratory Mice and Rats".
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for improperly handling and storing hazardous materials.
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The laboratory also provides more than 13,000 strains of
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1043:"Jackson Laboratory | Bar Harbor, ME â Official Website"
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Neurobehavioral disorders: autism, addiction, depression
989:"Neuro at JAX | Graduate School of Biomedical Sciences"
642:
1333:"Jackson Lab Opens To Big Hopes for Bioscience Growth"
501:. Initial funding for the laboratory campus came from
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The Jackson Laboratory has two research campuses, the
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Graduate School of Biomedical Science and Engineering
53:, and by adding encyclopedic content written from a
1440:"Debris Cleared, Jackson Begins Recovery From Fire"
771:In 2009, Jackson Laboratory was fined $ 161,680 by
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1999:Medical research institutes in the United States
1980:
1061:"The Jackson Laboratory Milestones: 1900 â 1929"
2019:Medical and health organizations based in Maine
2004:Cancer organizations based in the United States
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1650:"Jackson Laboratory to pay $ 161,680 EPA fine"
1466:"The Jackson Laboratory Milestones: 1940â1949"
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610:National Institute of General Medical Sciences
1994:Buildings and structures in Bar Harbor, Maine
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2014:Scientific organizations established in 1929
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1412:"Probable causes given for Jackson Lab fire"
1386:"The Jackson Laboratory Cancer Center â NCI"
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699:The Jackson Laboratory is recognized by the
348:in 1929. It employs over 3,000 employees in
573:complex, making organ transplants possible.
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429:Jackson Laboratory for Mammalian Genetics
73:Learn how and when to remove this message
2009:Companies based in Hancock County, Maine
675:Charles River Laboratories International
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446:University of Connecticut Health Center
433:Jackson Laboratory for Genomic Medicine
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1981:
1331:STURDEVANT, MATTHEW (2 October 2014).
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542:Nobel Prizes in Physiology or Medicine
524:began in 1933 with early sales to the
477:The Jackson Laboratory was founded by
431:located in Bar Harbor, Maine, and the
34:contains content that is written like
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495:Roscoe B. Jackson Memorial Laboratory
1468:. Jackson Laboratory. Archived from
1420:(Hancock County ed.). p. 8
1067:. Jackson Laboratory. Archived from
888:"Nathan Shock Centers of Excellence"
643:The Jackson Laboratory Cancer Center
18:
1561:"Exempt Organizations Select Check"
1523:(Database issue). England: D842-8.
526:United States Public Health Service
384:Centers of Excellence in aging and
13:
2034:Research institutes in Connecticut
1410:Harbour, Kathy (August 21, 1989).
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380:-designated Cancer Center and has
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2029:Research institutes in California
1936:Maine Public Broadcasting Network
1438:Mathewson, Judy (June 26, 1989).
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344:institution which was founded by
953:"Our Campuses & Communities"
340:) is an independent, non-profit
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1730:Fay Hyland Botanical Plantation
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1234:"Knockout Mouse Project (KOMP)"
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1186:"LittleSis: Jackson Laboratory"
1065:The Jackson Laboratory Timeline
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16:Biomedical research institution
1868:The Senior Skull Honor Society
1648:Trotter, Bill (2 April 2009).
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862:
848:"About The Jackson Laboratory"
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826:
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1:
1745:Maynard F. Jordan Observatory
1625:Trotter, Bill (3 June 2013).
910:personalizedmedicinecoalition
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765:National Institutes of Health
624:National Institutes of Health
594:
2024:Research institutes in Maine
7:
1750:Page Farm & Home Museum
1725:Collins Center for the Arts
1169:10.1016/j.shpsc.2006.03.005
892:National Institute on Aging
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617:National Institute on Aging
10:
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1760:University of Maine system
768:confrontational demeanor.
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1889:Black Bear Sports Network
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1047:barharbormaine government
535:National Cancer Institute
513:, a one-time head of the
378:National Cancer Institute
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688:Mouse Genome Informatics
515:Hudson Motor Car Company
413:Mouse Genome Informatics
1856:Organizations and Greek
1093:"85 Years of Discovery"
580:discovered the hormone
533:supported a grant from
376:. The institution is a
358:Farmington, Connecticut
172:Farmington, Connecticut
1312:The Jackson Laboratory
1238:The Jackson Laboratory
1214:The Jackson Laboratory
957:The Jackson Laboratory
820:The Jackson Laboratory
604:
489:president, in 1929 in
487:University of Michigan
354:Sacramento, California
336:(often abbreviated as
179:Sacramento, California
144:Nonprofit organization
117:; 95 years ago
86:The Jackson Laboratory
1863:Francis Crowe Society
1833:Alfond Sports Stadium
1118:Materials and Methods
656:The Morrell Park fire
602:
275:Computational biology
55:neutral point of view
1902:The Maine Stein Song
1594:"2012 Annual Report"
1095:. Jackson Laboratory
1011:gsbs tufts education
993:gsbs tufts education
850:. Jackson Laboratory
677:for US$ 63 million.
479:Clarence Cook Little
423:Major research areas
346:Clarence Cook Little
1989:Mount Desert Island
1965:44.3655°N 68.1965°W
1961: /
1828:Alfond Sports Arena
1821:Arenas and stadiums
1700:University of Maine
1652:. Bangor Daily News
1529:10.1093/nar/gkq1008
1362:newscentermaine.com
708:Notable researchers
522:mouse animal models
483:University of Maine
438:University of Maine
407:to more than 2,400
342:biomedical research
265:Alzheimer's disease
87:
47:promotional content
1931:Jackson Laboratory
1843:Memorial Gymnasium
1812:Women's ice hockey
1797:Women's basketball
1606:on October 1, 2013
1563:(search results).
681:Research resources
605:
578:Douglas L. Coleman
571:histocompatibility
334:Jackson Laboratory
242:Laboratory Animals
147:Research institute
85:
49:and inappropriate
1970:44.3655; -68.1965
1944:
1943:
1851:
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1517:Nucleic Acids Res
1417:Bangor Daily News
1133:Missing or empty
876:. 13 August 2012.
874:cancer government
744:Elizabeth Russell
608:A grant from the
560:Elizabeth Russell
511:Roscoe B. Jackson
491:Bar Harbor, Maine
350:Bar Harbor, Maine
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1807:Men's ice hockey
1792:Men's basketball
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1599:. Archived from
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1337:Courant.com
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503:Edsel Ford
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