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Bloodstream infection

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will usually prompt a repeat set of blood cultures to be drawn to confirm whether a contaminant or a real bacteremia is present. The patient's skin is typically cleaned with an alcohol-based product prior to drawing blood to prevent contamination. Blood cultures may be repeated at intervals to determine if persistent—rather than transient—bacteremia is present.
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important considerations include the patient's history of antibiotic use, the severity of the presenting symptoms, and any allergies to antibiotics. Empiric antibiotics should be narrowed, preferably to a single antibiotic, once the blood culture returns with a particular bacteria that has been isolated.
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Bacteremia may also be defined by the timing of bacteria presence in the bloodstream: transient, intermittent, or persistent. In transient bacteremia, bacteria are present in the bloodstream for minutes to a few hours before being cleared from the body, and the result is typically harmless in healthy
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bacteria in the blood. Asymptomatic bacteremia can occur in normal daily activities such as conducting oral hygiene and after minor medical procedures. In a healthy person, these clinically benign infections are transient and cause no further sequelae. However, when immune response mechanisms fail or
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coverage. Any patient presenting with signs or symptoms of bacteremia or a positive blood culture should be started on intravenous antibiotics. The choice of antibiotic is determined by the most likely source of infection and by the characteristic organisms that typically cause that infection. Other
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Bacteria can enter the bloodstream in a number of different ways. However, for each major classification of bacteria (gram negative, gram positive, or anaerobic) there are characteristic sources or routes of entry into the bloodstream that lead to bacteremia. Causes of bacteremia can additionally be
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Two blood cultures drawn from separate sites of the body are often sufficient to diagnose bacteremia. Two out of two cultures growing the same type of bacteria usually represents a real bacteremia, particularly if the organism that grows is not a common contaminant. One out of two positive cultures
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Luzzaro, F.; Viganò, E. F.; Fossati, D.; Grossi, A.; Sala, A.; Sturla, C.; Saudelli, M.; Toniolo, A.; AMCLI Lombardia Hospital Infectious Study Group (2002-12-01). "Prevalence and drug susceptibility of pathogens causing bloodstream infections in northern Italy: a two-year study in 16 hospitals".
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Any bacteria that incidentally find their way to the culture medium will also multiply. For example, if the skin is not adequately cleaned before needle puncture, contamination of the blood sample with normal bacteria that live on the surface of the skin can occur. For this reason, blood cultures
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The treatment of gram negative bacteremia is also highly dependent on the causative organism. Empiric antibiotic therapy should be guided by the most likely source of infection and the patient's past exposure to healthcare facilities. In particular, a recent history of exposure to a healthcare
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For healthcare-associated bacteremia due to intravenous catheters, the IDSA has published guidelines for catheter removal. Short term catheters (in place <14 days) should be removed if bacteremia is caused by any gram negative bacteria, staph aureus, enterococci or mycobacteria. Long term
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is the most common cause of healthcare-associated bacteremia in North and South America and is also an important cause of community-acquired bacteremia. Skin ulceration or wounds, respiratory tract infections, and IV drug use are the most important causes of community-acquired staph aureus
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Yang, Lu; Tang, Zhuang; Gao, Liang; Li, Tao; Chen, Yongji; Liu, Liangren; Han, Ping; Li, Xiang; Dong, Qiang (2016-08-01). "The augmented prophylactic antibiotic could be more efficacious in patients undergoing transrectal prostate biopsy: a systematic review and meta-analysis".
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are an increasingly important cause of bacteremia. Staphylococcus, streptococcus, and enterococcus species are the most important and most common species of gram-positive bacteria that can enter the bloodstream. These bacteria are normally found on the skin or in the
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The antibiotic treatment of choice for streptococcal and enteroccal infections differs by species. However, it is important to look at the antibiotic resistance pattern for each species from the blood culture to better treat infections caused by resistant organisms.
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in the bloodstream that are alive and capable of reproducing. It is a type of bloodstream infection. Bacteremia is defined as either a primary or secondary process. In primary bacteremia, bacteria have been directly introduced into the bloodstream.
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species are normal bacterial flora of the mouth. Viridans strep can cause temporary bacteremia after eating, toothbrushing, or flossing. More severe bacteremia can occur following dental procedures or in patients receiving chemotherapy. Finally,
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Deen, Jacqueline; von Seidlein, Lorenz; Andersen, Finn; Elle, Nelson; White, Nicholas J.; Lubell, Yoel (2012-06-01). "Community-acquired bacterial bloodstream infections in developing countries in south and southeast Asia: a systematic review".
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is the most common cause of community-acquired bacteremia accounting for approximately 75% of cases. E.coli bacteremia is usually the result of a urinary tract infection. Other organisms that can cause community-acquired bacteremia include
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Graff, Larissa R.; Franklin, Kristal K.; Witt, Lana; Cohen, Neal; Jacobs, Richard A.; Tompkins, Lucy; Guglielmo, B. Joseph (2002-02-15). "Antimicrobial therapy of gram-negative bacteremia at two university-affiliated medical centers".
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Biedenbach, Douglas J.; Moet, Gary J.; Jones, Ronald N. (2004-09-01). "Occurrence and antimicrobial resistance pattern comparisons among bloodstream infection isolates from the SENTRY Antimicrobial Surveillance Program (1997-2002)".
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species are responsible for approximately 24% of all cases of healthcare-associated bacteremia and 45% of all cases of community-acquired bacteremia. In general, gram negative bacteria enter the bloodstream from infections in the
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infection, despite mainly only resulting in gastroenteritis in the developed world, is a common cause of bacteremia in Africa. It principally affects children who lack antibodies to Salmonella and HIV+ patients of all ages.
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Bacteremia can travel through the blood stream to distant sites in the body and cause infection (hematogenous spread). Hematogenous spread of bacteria is part of the pathophysiology of certain infections of the heart
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Singer, Mervyn; Deutschman, Clifford S.; Seymour, Christopher Warren; Shankar-Hari, Manu; Annane, Djillali; Bauer, Michael; Bellomo, Rinaldo; Bernard, Gordon R.; Chiche, Jean-Daniel (2016-02-23).
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people. This can occur after manipulation of parts of the body normally colonized by bacteria, such as the mucosal surfaces of the mouth during tooth brushing, flossing, or dental procedures, or
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bacteremia with a 14-day course of intravenous vancomycin. Uncomplicated bacteremia is defined as having positive blood cultures for MRSA, but having no evidence of endocarditis, no implanted
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are especially vulnerable to infection from bacteremia. Prior to widespread use of vaccines, occult bacteremia was an important consideration in febrile children that appeared otherwise well.
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Forner, Lone; Larsen, Tove; Kilian, Mogens; Holmstrup, Palle (2006-06-01). "Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation".
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Mermel, Leonard A.; Allon, Michael; Bouza, Emilio; Craven, Donald E.; Flynn, Patricia; O'Grady, Naomi P.; Raad, Issam I.; Rijnders, Bart J. A.; Sherertz, Robert J. (2009-07-01).
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Liu, Catherine; Bayer, Arnold; Cosgrove, Sara E.; Daum, Robert S.; Fridkin, Scott K.; Gorwitz, Rachel J.; Kaplan, Sheldon L.; Karchmer, Adolf W.; Levine, Donald P. (2011-02-01).
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contaminated with bacteria may also lead to primary bacteremia. Secondary bacteremia occurs when bacteria have entered the body at another site, such as the cuts in the skin, or
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catheters (>14 days) should be removed if the patient is developing signs or symptoms of sepsis or endocarditis, or if blood cultures remain positive for more than 72 hours.
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Prior to drawing blood cultures, a thorough patient history should be taken with particular regard to presence of both fevers and chills, other focal signs of infection such as
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are an important cause of healthcare-associated bacteremia. These bacteria commonly live in the gastrointestinal tract and female genital tract. Intravenous catheters,
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that promotes bacterial growth. If bacteria are present in the bloodstream at the time the sample is obtained, the bacteria will multiply and can thereby be detected.
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Cervera, Carlos; Almela, Manel; Martínez-Martínez, José A.; Moreno, Asunción; Miró, José M. (2009-01-01). "Risk factors and management of Gram-positive bacteraemia".
914:. Intermittent bacteremia is characterized by periodic seeding of the same bacteria into the bloodstream by an existing infection elsewhere in the body, such as an 563:
bacteremia. In healthcare settings, intravenous catheters, urinary tract catheters, and surgical procedures are the most common causes of staph aureus bacteremia.
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Coburn, Bryan; Morris, Andrew M.; Tomlinson, George; Detsky, Allan S. (2012-08-01). "Does This Adult Patient With Suspected Bacteremia Require Blood Cultures?".
1245:"Five years of nosocomial Gram-negative bacteremia in a general intensive care unit: epidemiology, antimicrobial susceptibility patterns, and outcomes" 3081: 1591: 405: 3130: 258:
become overwhelmed, bacteremia becomes a bloodstream infection that can evolve into many clinical spectrums and is differentiated as septicemia.
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almost never represent a contamination of the sample. On the other hand, contamination may be more highly suspected if organisms like
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There are several risk factors that increase the likelihood of developing bacteremia from any type of bacteria. These include:
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Agarwal, Anil; Aggarwal, Aditya N. (2016-08-01). "Bone and Joint Infections in Children: Acute Hematogenous Osteomyelitis".
3074: 643:. Gram-negative bacteremia occurs more frequently in elderly populations (65 years or older) and is associated with higher 392:
species; candidemia is also among the most common bloodstream infections of any kind. Infections by other fungi, including
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must be drawn with great attention to sterile process. The presence of certain bacteria in the blood culture, such as
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species can cause bacteremia in patients who have had long hospital stays or frequent antibiotic use in the past (see
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Among healthcare-associated cases of bacteremia, gram negative organisms are an important cause of bacteremia in the
612: 1161: 535: 3067: 3267: 2591:"The Clinical Importance of Microbiological Findings in the Diagnosis and Management of Bloodstream Infections" 845: 491:. They are usually contracted by either an insect vector or by contact with an infected substance or surface. 1079: 2262:
Brigden, M. L. (2001-02-01). "Detection, education and management of the asplenic or hyposplenic patient".
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Gaynes, Robert; Edwards, Jonathan R.; National Nosocomial Infections Surveillance System (2005-09-15).
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enter the bloodstream. The name comes from combining the word "virus" with the Greek word for "blood" (
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Bacteremia can have several important health consequences. Immune responses to the bacteria can cause
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Guay, David R. (2012-02-01). "Antimicrobial prophylaxis in noncardiac prosthetic device recipients".
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Diekema, D. J.; Beekmann, S. E.; Chapin, K. C.; Morel, K. A.; Munson, E.; Doern, G. V. (2003-08-01).
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and surgical wounds are all risk factors for developing bacteremia from enterococcal species.
3197: 853: 807: 726: 662: 588: 558: 410: 78: 898:, or genitals. Bacteria that have infected the body at these sites may then spread into the 3344: 966: 636: 3014: 8: 3317: 3177: 3149: 3120: 3102: 3024: 2727:– via accessmedicine.mhmedical.com/content.aspx?bookid=1130&Sectionid=79736907. 2702:– via accessmedicine.mhmedical.com/content.aspx?bookid=1020&Sectionid=56968846. 2678:– via accessmedicine.mhmedical.com/content.aspx?bookid=1551&Sectionid=94106209. 993: 833: 683: 595: 3054: 3405: 3202: 2947: 2914: 2692:. New York: McGraw-Hill. 2014. pp. Infectious Diseases: Syndromes and Etiologies. 2557: 2532: 2508: 2475: 2381: 2330: 2195: 2162: 2133: 2108: 2045: 1667: 1585: 1429: 1372: 1339: 1295:
Perez-Chaparro, P. J.; Meuric, V.; De Mello, G.; Bonnaure-Mallet, M. (2011-11-01). "".
1220: 1187: 1137: 1110: 468: 3029: 2642:"IDP200 Pathophysiology of Infectious Diseases, Fall 2004/2005 - Tufts OpenCourseWare" 2232: 2077: 1960: 1927: 1623: 1340:"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)" 3163: 3059: 2952: 2934: 2890: 2862: 2854: 2808: 2763: 2755: 2751: 2718: 2693: 2669: 2620: 2612: 2562: 2513: 2495: 2445: 2437: 2373: 2365: 2322: 2314: 2279: 2271: 2244: 2236: 2200: 2182: 2138: 2089: 2081: 2037: 2029: 1991: 1965: 1947: 1908: 1900: 1857: 1832: 1807: 1782: 1750: 1722: 1714: 1679: 1671: 1635: 1627: 1530: 1502: 1475: 1467: 1421: 1413: 1377: 1359: 1320: 1312: 1274: 1266: 1225: 1207: 1142: 950:. Left untreated, conditions causing persistent bacteremia can be potentially fatal. 887: 768: 714: 668: 632: 616: 419: 45: 2385: 2049: 1943: 3262: 3252: 3231: 2942: 2926: 2844: 2747: 2602: 2552: 2544: 2503: 2487: 2429: 2357: 2334: 2306: 2228: 2190: 2174: 2128: 2120: 2073: 2021: 1955: 1939: 1890: 1706: 1663: 1619: 1459: 1433: 1405: 1367: 1351: 1304: 1256: 1215: 1199: 1132: 1122: 899: 821: 648: 415: 388: 117: 1928:"Epidemiology and outcome of nosocomial and community-onset bloodstream infection" 1127: 794:, in which a sample of blood drawn from the vein by needle puncture is allowed to 3441: 3300: 3135: 3125: 3040: 2641: 1308: 935: 883: 513: 147:). Transient bacteremia can result after dental procedures or brushing of teeth. 98: 2783:"Systemic Inflammatory Response Syndrome: Background, Pathophysiology, Etiology" 2124: 1710: 1494: 1261: 1244: 982: 895: 875: 737: 488: 186:
Bacteremia is typically transient and is quickly removed from the blood by the
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Based on type of causative microbe, bloodstream infections are of many types:
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may lead to primary bacteremia. In the hospital setting, use of blood vessel
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Fan, Shu-Ling; Miller, Nancy S.; Lee, John; Remick, Daniel G. (2016-09-01).
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The presence of bacteria in the blood almost always requires treatment with
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Ultrasound of the heart is recommended in all those with bacteremia due to
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coverage or broader coverage for resistant organisms. Extended generation
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For the systemic immune response to bacterial infection in the blood, see
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Kurtz, Jonathan R; Goggins, J. Alan; McLachlan, James B. (October 2017).
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are the most important causes of gram negative bacteremia in the ICU.
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Bacteremia frequently evokes a response from the immune system called
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Lowy, Franklin D. (1998-08-20). "Staphylococcus aureus Infections".
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and gain access to the bloodstream, where further spread can occur.
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European Journal of Clinical Microbiology & Infectious Diseases
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are frequently used for the treatment of gram negative bacteremia.
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Scott, Michael C. (2017-02-01). "Defining and Diagnosing Sepsis".
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Sligl, Wendy; Taylor, Geoffrey; Brindley, Peter G. (2006-07-01).
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Clinica Chimica Acta; International Journal of Clinical Chemistry
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and hence have access to the rest of the body. It is similar to
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is a common cause of bacteremia in patients with colon cancer.
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Bacteria can enter the bloodstream as a severe complication of
90: 20: 318:). It usually lasts for 4 to 5 days in the primary condition. 3207: 2668:. New York: McGraw-Hill Education. 2016. pp. Chapter 9. 962: 368: 364: 351: 328: 301: 297: 288: 198: 137: 74: 2163:"Hospital-Acquired Infections Due to Gram-Negative Bacteria" 2062: 1740: 1738: 1736: 2737: 2419: 2010: 1925: 253:
Bacteremia, in the strictest sense, refers to presence of
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Holland, TL; Arnold, C; Fowler VG, Jr (1 October 2014).
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Harrison's Principles of Internal Medicine 19th Edition
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response from the body, often causing abnormalities in
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caused by organisms formerly classified in the kingdom
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setting may necessitate the need for antibiotics with
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central line-associated bloodstream infection (CLABSI)
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Revue de Stomatologie et de Chirurgie Maxillo-Faciale
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Abnormal clinical and laboratory findings for blood
1652: 1242: 2793: 2149: 1185: 965:, heart rate, breathing rate, blood pressure, and 2873: 2573: 1772: 1770: 1768: 1766: 1605: 1603: 1601: 1111:"Bloodstream Infections: The peak of the iceberg" 1059: 3423: 2908: 2906: 2161:Peleg, Anton Y.; Hooper, David C. (2010-05-13). 1162:"Blood Cultures for the Detection of Bacteremia" 40:Blood infection, toxemia, bacteremia, septicemia 3131:Fluorescent treponemal antibody absorption test 2889:. New York: McGraw Hill. pp. Chapter 186. 2807:. New York: McGraw Hill. pp. Chapter 170. 2717:. New York: McGraw-Hill. pp. Chapter 201. 2715:Harrison's Principles of Internal Medicine, 19e 2476:"Updated Review of Blood Culture Contamination" 2469: 2467: 2465: 2463: 2461: 2459: 2296: 1990:. New York: McGraw Hill. pp. Chapter 125. 1831:. New York: McGraw Hill. pp. Chapter 174. 1806:. New York: McGraw Hill. pp. Chapter 110. 1781:. New York: McGraw Hill. pp. Chapter 201. 1501:, Treasure Island (FL): StatPearls Publishing, 2712: 1988:Geriatric Medicine and Gerontology 7th Edition 1856:. New York: McGraw Hill. pp. Chapter 87. 1776: 1763: 1749:. New York: McGraw Hill. pp. Chapter 33. 1656:Diagnostic Microbiology and Infectious Disease 1598: 992:The treatment of bacteremia should begin with 3075: 2903: 2826: 2824: 2474:Hall, Keri K.; Lyman, Jason A. (2016-12-16). 1981: 1979: 1612:International Journal of Antimicrobial Agents 1394: 1024: 1000: 116:), during surgery (especially when involving 2456: 1747:Current Medical Diagnosis and Treatment 2017 1590:: CS1 maint: multiple names: authors list ( 1569: 1492: 1249:International Journal of Infectious Diseases 85:in the blood (most commonly accomplished by 2160: 1452:Emergency Medicine Clinics of North America 1445: 1443: 622: 541: 404:(as in aspergillemia, also called invasive 3082: 3068: 2821: 2780: 1976: 1529:(4th ed.). McGraw Hill. p. 881. 1493:Smith, David A.; Nehring, Sara M. (2023), 700: 433:patients, or in patients with intravenous 55: 3116:Venereal Disease Research Laboratory test 2946: 2848: 2606: 2556: 2507: 2473: 2415: 2413: 2194: 2132: 1959: 1894: 1371: 1260: 1219: 1136: 1126: 1011:methicillin resistant staph aureus (MRSA) 1009:(IDSA) recommends treating uncomplicated 790:Bacteremia is most commonly diagnosed by 778:Prosthetic cardiac implants (for example 1744: 1440: 2636: 2634: 2588: 2261: 1524: 1518: 1108: 953:Bacteremia is clinically distinct from 582:is an important cause of bacteremia in 3424: 2802: 2410: 1851: 1576:Wiley, Sandman, Wood, K, J, D (2020). 1102: 371:. The most common type, also known as 178:can be given in high risk situations. 16:Bacterial or fungal infection of blood 3063: 2884: 1826: 1801: 1449: 1159: 1007:Infectious Disease Society of America 586:, often immediately following birth. 197:, which consists of symptoms such as 181: 2631: 2347: 1985: 1696: 1398:International Urology and Nephrology 2167:The New England Journal of Medicine 570:species that can cause bacteremia. 456:(blood-borne protozoal infections) 212:multiple organ dysfunction syndrome 170:. Treatment for bacteremia is with 101:of the host organism to pathogens. 93:, which is characterized by severe 13: 2740:Journal of Clinical Periodontology 1668:10.1016/j.diagmicrobio.2004.05.003 1160:Doern, Gary (September 13, 2016). 767:), and tuberculosis of the spine ( 566:There are many different types of 14: 3453: 2967: 981:. This is because there are high 647:and mortality in this population. 3055:Bacteremia at Medscape eMedicine 2781:Kaplan, MD, Lewis (2016-08-16). 2752:10.1111/j.1600-051X.2006.00924.x 2690:Sherris Medical Microbiology, 6e 2221:The American Journal of Medicine 1932:Journal of Clinical Microbiology 763:), structures around the brain ( 2774: 2731: 2706: 2682: 2658: 2524: 2392: 2341: 2290: 2255: 2211: 2100: 2066:The Lancet. Infectious Diseases 2056: 2004: 1944:10.1128/JCM.41.8.3655-3660.2003 1919: 1870: 1845: 1820: 1795: 1699:New England Journal of Medicine 1690: 1646: 1543: 215:, which are potentially fatal. 3268:Orthopoxvirus inclusion bodies 2713:Cohen-Poradosu, Ronit (2015). 2589:Seifert, Harald (2009-05-15). 1777:Cohen-Poradosu, Ronit (2015). 1525:Ryan KJ, Ray CG, eds. (2004). 1486: 1388: 1331: 1236: 1179: 1153: 1060:Catheter-associated infections 908:instrumentation of the bladder 869:Bacteremia is the presence of 229:Type of blood-borne infection 1: 2480:Clinical Microbiology Reviews 2233:10.1016/s0002-9343(01)01092-0 2078:10.1016/S1473-3099(12)70028-2 1854:Harrison's Manual of Medicine 1624:10.1016/S0924-8579(09)70562-X 1128:10.1080/21505594.2016.1152440 1095: 1080:Dental antibiotic prophylaxis 890:tract), mouth or intestines ( 864: 639:, gastrointestinal tract, or 296:is a medical condition where 2919:Clinical Infectious Diseases 2837:Clinical Infectious Diseases 2595:Clinical Infectious Diseases 2299:Indian Journal of Pediatrics 1883:Clinical Infectious Diseases 1527:Sherris Medical Microbiology 1309:10.1016/j.stomax.2011.08.012 989:if antibiotics are delayed. 972: 785: 753: 7: 2601:(Supplement 4): S238–S245. 2125:10.1016/j.imlet.2017.07.006 1711:10.1056/NEJM199808203390806 1109:Viscoli, C (2 April 2016). 1068: 837:grow in the blood culture. 10: 3458: 1262:10.1016/j.ijid.2005.07.003 846:in the skin or soft tissue 828:Staphylococcus epidermidis 443:, aspergillemia (invasive 18: 3398: 3360: 3316: 3220:Heterophile antibody test 3188: 3101: 2975: 2666:Medical Microbiology, 27e 2311:10.1007/s12098-015-1806-3 2264:American Family Physician 2026:10.1007/s10096-002-0837-7 1464:10.1016/j.emc.2016.08.002 1410:10.1007/s11255-016-1299-7 1204:10.1016/j.cca.2016.07.002 528: 44: 36: 31: 1745:Schwartz, Brian (2016). 1580:. McGraw-Hill Education. 1050:beta lactamase inhibitor 1025:Gram negative bacteremia 1001:Gram positive bacteremia 816:Streptococcus pneumoniae 780:artificial heart valves) 623:Gram negative bacteremia 609:urinary tract infections 542:Gram positive bacteremia 218: 1852:Kasper, Dennis (2015). 1578:Prescott's Microbiology 1054:piperacillin-tazobactam 896:bladder (urinary tract) 859:infectious endocarditis 701:Bacteremia risk factors 628:Gram negative bacterial 264:Meningitis, pneumonia, 3362:Bloodstream infections 3331:Sabin–Feldman dye test 3246:Warthin–Finkeldey cell 2885:Russo, Thomas (2016). 2803:Hooper, David (2016). 2549:10.1001/jama.2014.9743 2434:10.1001/jama.2012.8262 2362:10.3810/hp.2012.02.947 1802:Mayer, Robert (2015). 1356:10.1001/jama.2016.0287 1075:Antibiotic prophylaxis 1033:pseudomonas aeruginosa 967:white blood cell count 657:Pseudomonas aeruginosa 613:Resistant enterococcal 552:gastrointestinal tract 547:Gram positive bacteria 487:(SAR supergroup), and 176:antibiotic prophylaxis 174:, and prevention with 122:gastrointestinal tract 67:Bloodstream infections 32:Bloodstream infections 2179:10.1056/NEJMra0904124 1827:Arias, Cesar (2015). 854:Staphylococcus aureus 663:Klebsiella pneumoniae 589:Viridans streptococci 579:Group B streptococcus 573:Group A streptococcus 559:Staphylococcus aureus 536:healthcare-associated 79:blood-borne pathogens 3345:Diagnosis of malaria 2492:10.1128/CMR.00062-05 1986:High, Kevin (2017). 1555:Invasive Candidiasis 1052:antibiotics such as 985:from progression to 948:bacterial meningitis 928:infected heart valve 884:the mucous membranes 810:taphylococcus aureus 732:Stem cell transplant 641:hepatobiliary system 465:Protozoan infections 310:, a condition where 73:) are infections of 3318:Protozoan infection 3178:Anti-streptolysin O 3121:rapid plasma reagin 3103:Bacterial infection 2270:(3): 499–506, 508. 1618:(Suppl 4): S26–30. 834:Cutibacterium acnes 637:genitourinary tract 596:Streptococcus bovis 359:is the presence of 81:. The detection of 51:Infectious diseases 3432:Bacterial diseases 3406:C-reactive protein 3215:Epstein–Barr virus 3203:Branched DNA assay 3095:infectious disease 2850:10.1093/cid/ciq146 2113:Immunology Letters 994:empiric antibiotic 936:blood vessel graft 876:Injection drug use 469:parasitic diseases 232:Causative microbe 182:Signs and symptoms 158:, which have high 140:(including during 3419: 3418: 3164:HelicoCARE direct 3050: 3049: 2896:978-0-07-180215-4 2814:978-0-07-180215-4 2724:978-0-07-180215-4 2699:9780-0-7-181821-6 2675:9780-0-71-82498-9 2350:Hospital Practice 2173:(19): 1804–1813. 1997:978-0-07-183345-5 1863:978-0-07-182852-9 1838:978-0-07-180215-4 1813:978-0-07-180215-4 1788:978-0-07-180215-4 1756:978-1-25-958511-1 1536:978-0-8385-8529-0 715:Diabetes Mellitus 669:Proteus mirabilis 633:respiratory tract 617:antibiotic misuse 526: 525: 420:immunocompromised 64: 63: 26:Medical condition 3449: 3350:SchĂĽffner's dots 3263:B type inclusion 3253:Inclusion bodies 3232:NS1 antigen test 3084: 3077: 3070: 3061: 3060: 2973: 2972: 2961: 2960: 2950: 2910: 2901: 2900: 2882: 2871: 2870: 2852: 2828: 2819: 2818: 2800: 2791: 2790: 2778: 2772: 2771: 2735: 2729: 2728: 2710: 2704: 2703: 2686: 2680: 2679: 2662: 2656: 2655: 2653: 2652: 2638: 2629: 2628: 2610: 2586: 2571: 2570: 2560: 2528: 2522: 2521: 2511: 2471: 2454: 2453: 2417: 2408: 2407: 2404:www.uptodate.com 2396: 2390: 2389: 2345: 2339: 2338: 2294: 2288: 2287: 2259: 2253: 2252: 2215: 2209: 2208: 2198: 2158: 2147: 2146: 2136: 2104: 2098: 2097: 2060: 2054: 2053: 2008: 2002: 2001: 1983: 1974: 1973: 1963: 1938:(8): 3655–3660. 1923: 1917: 1916: 1898: 1874: 1868: 1867: 1849: 1843: 1842: 1824: 1818: 1817: 1799: 1793: 1792: 1774: 1761: 1760: 1742: 1731: 1730: 1694: 1688: 1687: 1650: 1644: 1643: 1607: 1596: 1595: 1589: 1581: 1573: 1567: 1566: 1564: 1562: 1547: 1541: 1540: 1522: 1516: 1515: 1514: 1513: 1490: 1484: 1483: 1447: 1438: 1437: 1404:(8): 1197–1207. 1392: 1386: 1385: 1375: 1335: 1329: 1328: 1292: 1283: 1282: 1264: 1240: 1234: 1233: 1223: 1183: 1177: 1176: 1174: 1172: 1157: 1151: 1150: 1140: 1130: 1106: 963:body temperature 900:lymphatic system 892:gastrointestinal 822:Escherichia coli 727:organ transplant 416:immunosuppressed 226: 225: 118:mucous membranes 99:immune responses 60: 59: 29: 28: 3457: 3456: 3452: 3451: 3450: 3448: 3447: 3446: 3422: 3421: 3420: 3415: 3394: 3356: 3312: 3301:Councilman body 3190:Viral infection 3184: 3150:Weil–Felix test 3136:Abelin reaction 3126:Wassermann test 3097: 3088: 3051: 3046: 3045: 2984: 2970: 2965: 2964: 2911: 2904: 2897: 2883: 2874: 2829: 2822: 2815: 2801: 2794: 2779: 2775: 2736: 2732: 2725: 2711: 2707: 2700: 2688: 2687: 2683: 2676: 2664: 2663: 2659: 2650: 2648: 2640: 2639: 2632: 2587: 2574: 2543:(13): 1330–41. 2529: 2525: 2472: 2457: 2418: 2411: 2398: 2397: 2393: 2346: 2342: 2295: 2291: 2260: 2256: 2216: 2212: 2159: 2150: 2105: 2101: 2061: 2057: 2020:(12): 849–855. 2009: 2005: 1998: 1984: 1977: 1924: 1920: 1875: 1871: 1864: 1850: 1846: 1839: 1825: 1821: 1814: 1800: 1796: 1789: 1775: 1764: 1757: 1743: 1734: 1695: 1691: 1651: 1647: 1608: 1599: 1583: 1582: 1574: 1570: 1560: 1558: 1549: 1548: 1544: 1537: 1523: 1519: 1511: 1509: 1491: 1487: 1448: 1441: 1393: 1389: 1336: 1332: 1293: 1286: 1241: 1237: 1184: 1180: 1170: 1168: 1158: 1154: 1107: 1103: 1098: 1071: 1062: 1027: 1003: 983:mortality rates 975: 867: 788: 756: 738:glucocorticoids 736:Treatment with 703: 625: 544: 531: 522: 514:trypanosomiasis 455: 386:, is caused by 341: 278: 221: 184: 160:mortality rates 54: 27: 24: 17: 12: 11: 5: 3455: 3445: 3444: 3439: 3434: 3417: 3416: 3414: 3413: 3408: 3402: 3400: 3396: 3395: 3393: 3392: 3387: 3382: 3377: 3372: 3366: 3364: 3358: 3357: 3355: 3354: 3353: 3352: 3347: 3335: 3334: 3333: 3322: 3320: 3314: 3313: 3311: 3310: 3305: 3304: 3303: 3291: 3286: 3285: 3284: 3272: 3271: 3270: 3265: 3260: 3250: 3249: 3248: 3236: 3235: 3234: 3224: 3223: 3222: 3212: 3211: 3210: 3205: 3194: 3192: 3186: 3185: 3183: 3182: 3181: 3180: 3168: 3167: 3166: 3154: 3153: 3152: 3140: 3139: 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787: 784: 769:Pott's disease 755: 752: 751: 750: 745: 740: 734: 729: 723: 717: 712: 702: 699: 624: 621: 543: 540: 530: 527: 524: 523: 521: 520: 494: 492: 489:Archaeplastida 462: 457: 449: 448: 438: 406:aspergillosiis 354: 349: 343: 342: 340: 339: 321: 319: 291: 286: 280: 279: 277: 276: 261: 259: 251: 246: 240: 239: 236: 233: 230: 220: 217: 201:, chills, and 183: 180: 130:foreign bodies 87:blood cultures 62: 61: 48: 42: 41: 38: 34: 33: 25: 15: 9: 6: 4: 3: 2: 3454: 3443: 3440: 3438: 3435: 3433: 3430: 3429: 3427: 3412: 3411:Procalcitonin 3409: 3407: 3404: 3403: 3401: 3397: 3391: 3388: 3386: 3383: 3381: 3378: 3376: 3373: 3371: 3370:Blood culture 3368: 3367: 3365: 3363: 3359: 3351: 3348: 3346: 3343: 3342: 3341: 3340: 3336: 3332: 3329: 3328: 3327: 3326:toxoplasmosis 3324: 3323: 3321: 3319: 3315: 3309: 3306: 3302: 3299: 3298: 3297: 3296: 3292: 3290: 3289:Cowdry bodies 3287: 3283: 3280: 3279: 3278: 3277: 3273: 3269: 3266: 3264: 3261: 3259: 3258:Downie bodies 3256: 3255: 3254: 3251: 3247: 3244: 3243: 3242: 3241: 3237: 3233: 3230: 3229: 3228: 3225: 3221: 3218: 3217: 3216: 3213: 3209: 3206: 3204: 3201: 3200: 3199: 3196: 3195: 3193: 3191: 3187: 3179: 3176: 3175: 3174: 3173: 3172:Streptococcus 3169: 3165: 3162: 3161: 3160: 3159: 3155: 3151: 3148: 3147: 3146: 3145: 3141: 3137: 3134: 3132: 3129: 3127: 3124: 3122: 3119: 3117: 3114: 3113: 3112: 3109: 3108: 3106: 3104: 3100: 3096: 3092: 3085: 3080: 3078: 3073: 3071: 3066: 3065: 3062: 3056: 3053: 3052: 3042: 3038: 3037: 3033: 3031: 3027: 3026: 3022: 3018: 3016: 3012: 3011: 3007: 3003: 3000: 2996: 2995: 2991: 2987: 2986: 2983: 2978: 2974: 2958: 2954: 2949: 2944: 2940: 2936: 2932: 2928: 2924: 2920: 2916: 2909: 2907: 2898: 2892: 2888: 2881: 2879: 2877: 2868: 2864: 2860: 2856: 2851: 2846: 2843:(3): e18–55. 2842: 2838: 2834: 2827: 2825: 2816: 2810: 2806: 2799: 2797: 2788: 2784: 2777: 2769: 2765: 2761: 2757: 2753: 2749: 2745: 2741: 2734: 2726: 2720: 2716: 2709: 2701: 2695: 2691: 2685: 2677: 2671: 2667: 2661: 2647: 2646:ocw.tufts.edu 2643: 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432: 428: 424: 421: 417: 413: 412: 407: 403: 402: 397: 396: 395:Saccharomyces 391: 390: 385: 384: 378: 374: 370: 366: 362: 358: 355: 353: 350: 348: 345: 344: 338: 334: 330: 326: 323: 322: 320: 317: 313: 309: 308: 303: 299: 295: 292: 290: 287: 285: 282: 281: 275: 271: 267: 263: 262: 260: 256: 252: 250: 247: 245: 242: 241: 237: 234: 231: 228: 227: 224: 216: 214: 213: 208: 204: 200: 196: 191: 189: 188:immune system 179: 177: 173: 169: 168:osteomyelitis 165: 161: 157: 153: 148: 146: 143: 139: 135: 132:entering the 131: 127: 124:), or due to 123: 119: 115: 111: 107: 102: 100: 96: 92: 88: 84: 80: 76: 72: 68: 58: 52: 49: 47: 43: 39: 35: 30: 22: 3337: 3295:yellow fever 3293: 3282:Negri bodies 3274: 3238: 3227:Dengue fever 3170: 3158:Helicobacter 3156: 3142: 3034: 3019: 3004: 2988: 2922: 2918: 2886: 2840: 2836: 2804: 2786: 2776: 2743: 2739: 2733: 2714: 2708: 2689: 2684: 2665: 2660: 2649:. Retrieved 2645: 2598: 2594: 2540: 2536: 2526: 2483: 2479: 2425: 2421: 2403: 2394: 2356:(1): 44–74. 2353: 2349: 2343: 2302: 2298: 2292: 2267: 2263: 2257: 2224: 2220: 2213: 2170: 2166: 2116: 2112: 2102: 2069: 2065: 2058: 2017: 2013: 2006: 1987: 1935: 1931: 1921: 1886: 1882: 1872: 1853: 1847: 1828: 1822: 1803: 1797: 1778: 1746: 1702: 1698: 1692: 1662:(1): 59–69. 1659: 1655: 1648: 1615: 1611: 1577: 1571: 1559:. Retrieved 1554: 1551:"Statistics" 1545: 1526: 1520: 1510:, retrieved 1498: 1495:"Bacteremia" 1488: 1455: 1451: 1401: 1397: 1390: 1347: 1343: 1333: 1300: 1296: 1252: 1248: 1238: 1195: 1191: 1181: 1169:. Retrieved 1166:uptodate.com 1165: 1155: 1118: 1114: 1104: 1063: 1031: 1028: 1019: 1004: 991: 976: 959:inflammatory 952: 904: 868: 857:to rule out 852: 850: 843: 839: 832: 826: 820: 814: 809: 804: 789: 777: 761:endocarditis 757: 721:hemodialysis 704: 693:Enterobacter 692: 687: 681: 673: 667: 661: 655: 649: 626: 603: 601: 594: 587: 578: 572: 565: 557: 556: 545: 532: 464: 425:with severe 411:Cryptococcus 409: 399: 393: 387: 380: 376: 372: 356: 315: 305: 293: 274:endocarditis 235:Description 222: 210: 207:septic shock 192: 185: 164:endocarditis 156:septic shock 149: 120:such as the 103: 95:inflammatory 70: 66: 65: 3385:Parasitemia 3308:Tzanck test 3198:HIV testing 3091:Blood tests 2925:(1): 1–45. 1561:24 December 1198:: 203–210. 1171:December 1, 1046:beta lactam 1042:ceftriaxone 979:antibiotics 944:brucellosis 888:respiratory 688:Pseudomonas 604:Enterococci 453:Protozoemia 427:neutropenia 401:Aspergillus 383:candidiasis 337:hepatitis C 333:hepatitis B 302:bloodstream 270:brucellosis 244:Bacteremias 203:hypotension 172:antibiotics 142:intravenous 37:Other names 3426:Categories 3144:Rickettsia 2651:2016-12-07 2400:"UpToDate" 1512:2023-12-15 1499:StatPearls 1458:(1): 1–9. 1096:References 1015:prostheses 865:Definition 765:meningitis 675:Salmonella 510:babesiosis 441:Candidemia 377:candedemia 373:candidemia 307:bacteremia 300:enter the 145:drug abuse 128:and other 114:meningitis 106:infections 77:caused by 2939:1537-6591 2859:1537-6591 2760:1600-051X 2617:1058-4838 2500:0893-8512 2442:0098-7484 2370:2154-8331 2319:0973-7693 2276:0002-838X 2241:0002-9343 2187:0028-4793 2119:: 42–50. 2086:1474-4457 2034:0934-9723 1952:0095-1137 1905:1537-6591 1719:0028-4793 1676:0732-8893 1632:1872-7913 1586:cite book 1472:1558-0539 1418:1573-2584 1364:1538-3598 1317:1776-257X 1271:1201-9712 1212:1873-3492 1115:Virulence 973:Treatment 920:pneumonia 880:catheters 786:Diagnosis 754:Mechanism 645:morbidity 481:Amoebozoa 435:catheters 381:systemic 347:Fungemias 238:Examples 126:catheters 110:pneumonia 46:Specialty 3390:Algaemia 3380:Fungemia 3111:syphilis 2957:19489710 2867:21208910 2787:Medscape 2768:16677328 2625:19374579 2567:25268440 2518:17041144 2450:22851117 2386:10854052 2378:22406882 2327:26096866 2284:11272299 2249:11893347 2205:20463340 2143:28720334 2094:22632186 2050:13043807 2042:12525919 1970:12904371 1913:16107985 1684:15380279 1640:19931813 1507:28723008 1480:27908326 1426:27160220 1382:26903338 1325:21940028 1279:16460982 1230:27387712 1147:26890622 1085:Fungemia 1069:See also 1040:such as 894:tract), 871:bacteria 796:incubate 748:Asplenia 719:Chronic 584:neonates 477:Excavata 473:Protozoa 460:Protozoa 423:patients 357:Fungemia 325:HIV-AIDS 312:bacteria 284:Viremias 266:syphilis 249:Bacteria 134:arteries 83:microbes 3399:General 3375:Viremia 3339:malaria 3240:measles 3041:D016470 2948:4039170 2558:4263314 2509:1592696 2335:1561868 2196:3107499 2134:5918639 1727:9709046 1434:6566177 1373:4968574 1221:4980259 1138:4871637 1090:Viremia 916:abscess 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Index

sepsis
Specialty
Infectious diseases
Edit this on Wikidata
blood
blood-borne pathogens
microbes
blood cultures
sepsis
inflammatory
immune responses
infections
pneumonia
meningitis
mucous membranes
gastrointestinal tract
catheters
foreign bodies
arteries
veins
intravenous
drug abuse
sepsis
septic shock
mortality rates
endocarditis
osteomyelitis
antibiotics
antibiotic prophylaxis
immune system

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