Knowledge

Concussion

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step-wise. Prolonged complete mental or physical rest (beyond 24–48 hours after the accident that lead to the concussion) may worsen outcomes, however, rushing back to full school work load before the person is ready, has also been associated with longer-lasting symptoms and an extended recovery time. Students with a suspected concussion are required to see a doctor for an initial medical assessment and for suggestions on recovery, however, medical clearance is not required for a student to return to school. Since students may appear 'normal', continuing education of relevant school personnel may be needed to ensure appropriate accommodations are made such as part-days and extended deadlines. Accommodations should be based on the monitoring of symptoms that are present during the return-to-school transition including headaches, dizziness, vision problems, memory loss, difficulty concentrating, and abnormal behavior. Students must have completely resumed their school activities (without requiring concussion-related academic supports) before returning to full-contact or competitive sports.
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the concussion began), gradually and safely returning to the workplace with accommodations and support in place, should be prioritized over staying home and resting for long periods of time, to promote physical recovery and reduce the risk of people becoming socially isolated. The person should work with their employer to design a step-wise "return-to-work" plan. For those with a high-risk job, medical clearance may be required before resuming an activity that could lead to another head injury. Students should have completed the full return-to-school progression with no academic accommodations related to the concussion required before starting to return to part-time work.
1247:, memory and attention problems, sleep problems, and irritability. Rest, a previously recommended recovery technique, has limited effectiveness. A recommended treatment in both children and adults with symptoms beyond 4 weeks involves an active rehabilitation program with reintroduction of non-contact aerobic activity. Progressive physical exercise has been shown to reduce long-term post-concussive symptoms. Symptoms usually go away on their own within months but may last for years. The question of whether the syndrome is due to structural damage or other factors such as psychological ones, or a combination of these, has long been the subject of debate. 748:
certain symptoms such as visual disturbances, but other sets of symptoms, especially those of a psychological nature, are more likely to be caused by reversible pathophysiological changes in cellular function that occur after concussion, such as alterations in neurons' biochemistry. These reversible changes could also explain why dysfunction is frequently temporary. A task force of head injury experts called the Concussion In Sport Group met in 2001 and decided that "concussion may result in neuropathological changes but the acute clinical symptoms largely reflect a functional disturbance rather than structural injury."
1079:, for general cases this is not supported by current evidence. People may be released after assessment from their primary care medical clinic, hospital, or emergency room to the care of a trusted person with instructions to return if they display worsening symptoms or those that might indicate an emergent condition ("red flag symptoms") such as change in consciousness, convulsions, severe headache, extremity weakness, vomiting, new bleeding or deafness in either or both ears. Education about symptoms, their management, and their normal time course, may lead to an improved outcome. 776:, leading to local swelling. After this increase in glucose metabolism, there is a subsequent lower metabolic state which may persist for up to 4 weeks after injury. A completely separate pathway involves a large amount of calcium accumulating in cells, which may impair oxidative metabolism and begin further biochemical pathways that result in cell death. Again, both of these main pathways have been established from animal studies and the extent to which they apply to humans is still somewhat unclear. 1337: 1345:
how common the condition is. Estimates of the incidence of concussion may be artificially low, for example, due to under reporting. At least 25% of people with mTBI fail to get assessed by a medical professional. The WHO group reviewed studies on the epidemiology of mTBI and found a hospital treatment rate of 1–3 per 1000 people, but since not all concussions are treated in hospitals, they estimated that the rate per year in the general population is over 6 per 1000 people.
8206: 287:. Any of these symptoms may begin immediately, or appear days after the injury. Concussion should be suspected if a person indirectly or directly hits their head and experiences any of the symptoms of concussion. Symptoms of a concussion may be delayed by 1–2 days after the accident. It is not unusual for symptoms to last 2 weeks in adults and 4 weeks in children. Fewer than 10% of sports-related concussions among children are associated with loss of consciousness. 55: 1486: 390: 1053:
risk of repeat concussions. New "Head Impact Telemetry System" technology is being placed in helmets to study injury mechanisms and may generate knowledge that will potentially help reduce the risk of concussions among American Football players. Mouth guards have been put forward as a preventative measure, and there is mixed evidence supporting its use in preventing concussions but rather has support in preventing dental trauma.
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in turn resulting in sustained depolarization, impaired nerve activity and potential nerve damage. Human studies have failed to identify changes in glutamate concentration immediately post-mTBI, though disruptions have been seen 3 days to 2 weeks post-injury. In an effort to restore ion balance, the sodium-potassium ion pumps increase activity, which results in excessive ATP (
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physical damage, and this view continued to be widely held throughout the 18th century. The word "concussion" was used at the time to describe the state of unconsciousness and other functional problems that resulted from the impact, rather than a physiological condition. In 1839, Guillaume Dupuytren described brain contusions, which involve many small hemorrhages, as
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their injury. Self-reported concussion rates among U-20 and elite rugby union players in Ireland are 45–48%, indicating that many concussions go unreported. Changes to the rules or enforcing existing rules in sports, such as those against "head-down tackling", or "spearing", which is associated with a high injury rate, may also prevent concussions.
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to the head are also causes. A retrospective survey in 2005 suggested that more than 88% of concussions are unrecognized. Particularly, many younger athletes struggle with identifying their concussions, which often result in the non-disclosure of concussions and consequently under-representing the incidence of concussions in the context of sport.
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major component in concussion and its severity. As of 2007, studies with athletes have shown that the amount of force and the location of the impact are not necessarily correlated with the severity of the concussion or its symptoms, and have called into question the threshold for concussion previously thought to exist at around 70–75 
468:, which requires some form of structural brain damage, not just a momentary disruption in normal brain functioning. Concussive convulsions are thought to result from temporary loss or inhibition of motor function and are not associated either with epilepsy or with more serious structural damage. They are not associated with any particular 1228:
susceptible to another one, particularly if the new injury occurs before symptoms from the previous concussion have completely gone away. It is also a negative process if smaller impacts cause the same symptom severity. Repeated concussions may increase a person's risk in later life for dementia, Parkinson's disease, and depression.
1699:'simple' or 'complex' classification. However, the 2008 meeting in Zurich abandoned the simple versus complex terminology, although the participants did agree to keep the concept that most (80–90%) concussions resolve in a short period (7–10 days) and although the recovery time frame may be longer in children and adolescents. 1088:
contact, falling, or bumping the head should be avoided until the person has clearance from a doctor or nurse practitioner. Low-risk activities can be started even while a person has symptoms. Resting completely for longer than 24–48 hours following concussion has been shown to be associated with longer recovery.
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estimates that 300,000 sports-related concussions occur yearly in the U.S., but that number includes only athletes who lost consciousness. Since loss of consciousness is thought to occur in less than 10% of concussions, the CDC estimate is likely lower than the real number. Sports in which concussion
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Chronic traumatic encephalopathy, or "CTE", is an example of the cumulative damage that can occur as the result of multiple concussions or less severe blows to the head. The condition was previously referred to as "dementia pugilistica", or "punch drunk" syndrome, as it was first noted in boxers. The
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Concussion may be under-diagnosed because of the lack of the highly noticeable signs and symptoms while athletes may minimize their injuries to remain in the competition. Direct impact to the head is not required for a concussion diagnosis, as other bodily impacts with a subsequent force transmission
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and stretching forces disrupting the cell membrane of nerve cells through "mechanoporation". This results in potassium outflow from within the cell into the extracellular space with the subsequent release of excitatory neurotransmitters including glutamate which leads to enhanced potassium extrusion,
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The terms mild brain injury, mild traumatic brain injury (mTBI), mild head injury (MHI), and concussion may be used interchangeably; although the term "concussion" is still used in sports literature as interchangeable with "MHI" or "mTBI", the general clinical medical literature uses "mTBI" instead,
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Due to the lack of a consistent definition, the economic costs of mTBI are not known, but they are estimated to be very high. These high costs are due in part to the large percentage of hospital admissions for head injury that is due to mild head trauma, but indirect costs such as lost work time and
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Until the 17th century, a concussion was usually described by its clinical features, but after the invention of the microscope, more physicians began exploring underlying physical and structural mechanisms. However, the prevailing view in the 17th century was that the injury did not result from
1445:, and discusses loss of speech, hearing, and sight that can result from "commotion of the brain". This idea of disruption of mental function by "shaking of the brain" remained the widely accepted understanding of concussion until the 19th century. In the 10th century, the Persian physician 1190:
A person's recovery may be influenced by a variety of factors that include age at the time of injury, intellectual abilities, family environment, social support system, occupational status, coping strategies, and financial circumstances. Factors such as a previous head injury or a coexisting medical
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Physical and cognitive rest is recommended for the first 24–48 hours following a concussion after which injured persons should gradually start gentle low-risk physical and cognitive activities that do not make current symptoms worse or bring on new symptoms. Any activity for which there is a risk of
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Adults and children with a suspected concussion require a medical assessment with a doctor or nurse practitioner to confirm the diagnosis of concussion and rule out more serious head injuries. After life-threatening head injuries, injuries to the cervical spine, and neurological conditions are ruled
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Due to the incidence of concussion in sport, younger athletes often do not disclose concussions and their symptoms. Common reasons for non-disclosure include a lack of awareness of the concussion, the belief that the concussion was not serious enough, and not wanting to leave the game or team due to
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Most cases of traumatic brain injury are concussions. A World Health Organization (WHO) study estimated that between 70 and 90% of head injuries that receive treatment are mild. However, due to under reporting and to the widely varying definitions of concussion and mTBI, it is difficult to estimate
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The resumption of low-risk school activities should begin as soon as the student feels ready and has completed an initial period of cognitive rest of no more than 24–48 hours following the acute injury. Long absences from school are not suggested, however; the return to school should be gradual and
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Concussion symptoms vary between people and include physical, cognitive, and emotional symptoms. Symptoms may appear immediately or be delayed by 1–2 days. Delayed onset of symptoms may still be serious and require a medical assessment. Up to one-third of people with concussion experience longer or
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described concussion as brain "commotion", also recognizing a difference between concussion and other types of traumatic brain injury (though many of his contemporaries did not), and discussing the transience of post-concussion symptoms as a result of temporary loss of function from the injury. In
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Determining the ideal time for a person to return to work will depend on personal factors and job-related factors including the intensity of the job and the risk of falling or hitting one's head at work during recovery. After the required initial recovery period of complete rest (24–48 hours after
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Protective equipment such as helmets and other headgear and policy changes such as the banning of body checking in youth hockey leagues have been found to reduce the number and severity of concussions in athletes. Secondary prevention such as a Return to Play Protocol for an athlete may reduce the
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The debate over whether concussion is a functional or structural phenomenon is ongoing. Structural damage has been found in the mildly traumatically injured brains of animals, but it is not clear whether these findings would apply to humans. Such changes in brain structure could be responsible for
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in subcortical white matter tracts. Axonal damage has been found in the brains of concussion patients who died from other causes, but inadequate blood flow to the brain due to other injuries may have contributed. Findings from a study of the brains of deceased NFL athletes who received concussions
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No single definition of concussion, minor head injury, or mild traumatic brain injury is universally accepted. In 2001, the expert Concussion in Sport Group of the first International Symposium on Concussion in Sport defined concussion as "a complex pathophysiological process affecting the brain,
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Forces may cause linear, rotational, or angular movement of the brain or a combination of them. In rotational movement, the head turns around its center of gravity, and in angular movement, it turns on an axis, not through its center of gravity. The amount of rotational force is thought to be the
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supply. A thorough evaluation by a qualified medical provider working in their scope of practice (such as a physician or nurse practitioner) is required to rule out life-threatening head injuries, injuries to the cervical spine, and neurological conditions and to use information obtained from the
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At least 41 systems measure the severity, or grade, of a mild head injury, and there is little agreement about which is best. In an effort to simplify, the 2nd International Conference on Concussion in Sport, meeting in Prague in 2004, decided that these systems should be abandoned in favor of a
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Second-impact syndrome, in which the brain swells dangerously after a minor blow, may occur in very rare cases. The condition may develop in people who receive a second blow days or weeks after an initial concussion before its symptoms have gone away. No one is certain of the cause of this often
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such as the SCAT5/child SCAT5 may be suggested measure cognitive function. Such tests may be administered hours, days, or weeks after the injury, or at different times to demonstrate any trend. Some athletes are also being tested pre-season (pre-season baseline testing) to provide a baseline for
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As of 1999, cumulative effects of concussions were poorly understood, especially the effects on children. The severity of concussions and their symptoms may worsen with successive injuries, even if a subsequent injury occurs months or years after an initial one. Symptoms may be more severe and
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Worldwide, concussions are estimated to affect more than 3.5 per 1,000 people a year. Concussions are classified as mild traumatic brain injuries and are the most common type of TBIs. Males and young adults are most commonly affected. Outcomes are generally good. Another concussion before the
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was the first to write about concussion as distinct from other types of head injury. He may have been the first to use the term "cerebral concussion", and his definition of the condition, a transient loss of function with no physical damage, set the stage for the medical understanding of the
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Educational interventions, such as handouts, videos, workshops, and lectures, can improve concussion knowledge of diverse groups, particularly youth athletes and coaches. Strong concussion knowledge may be associated with greater recognition of concussion symptoms, higher rates of concussion
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may be present immediately or may develop over several minutes. A person may repeat the same questions, be slow to respond to questions or directions, have a vacant stare, or have slurred or incoherent speech. Other concussion symptoms include changes in sleeping patterns and difficulty with
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Diagnosis of concussion requires an assessment performed by a physician or nurse practitioner to rule out severe injuries to the brain and cervical spine, mental health conditions, or other medical conditions. Diagnosis is based on physical and neurological examination findings, duration of
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For unknown reasons, having had one concussion significantly increases a person's risk of having another. Having previously sustained a sports concussion has been found to be a strong factor increasing the likelihood of a concussion in the future. People who have had a concussion seem more
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is present, there is suspected increased risk for bleeding, age greater than 60, or less than 16. Most concussions, without complication, cannot be detected with MRI or CT scans. However, changes have been reported on MRI and SPECT imaging in those with concussion and normal CT scans, and
1021:) are not necessarily precluded in mTBI or mild head injury, as they are in concussion. mTBI associated with abnormal neuroimaging may be considered "complicated mTBI". "Concussion" can be considered to imply a state in which brain function is temporarily impaired and "mTBI" to imply a 1186:
The majority of children and adults fully recover from a concussion, however some may experience a prolonged recovery. There is no single physical test, blood test (or fluid biomarkers), or imaging test that can be used to determine when a person has fully recovered from concussion.
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out, exclusion of neck or head injury, observation should be continued for several hours. If repeated vomiting, worsening headache, dizziness, seizure activity, excessive drowsiness, double vision, slurred speech, unsteady walk, or weakness or numbness in arms or legs, or signs of
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In post-concussion syndrome, symptoms do not resolve for weeks, months, or years after a concussion, and may occasionally be permanent. About 10% to 20% of people have persisting concussion symptoms for more than a month. Symptoms may include headaches, dizziness, fatigue,
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events. As one example, in animal models, after an initial increase in glucose metabolism, there is a subsequent reduced metabolic state which may persist for up to four weeks after injury. Though these events are thought to interfere with neuronal and brain function, the
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develop, immediate assessment in an emergency department is needed. Observation to monitor for worsening condition is an important part of treatment. While it is common advice that someone who is concussed should not be allowed to fall asleep in case they go into a
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Guskiewicz KM, Mihalik JP, Shankar V, Marshall SW, Crowell DH, Oliaro SM, et al. (December 2007). "Measurement of head impacts in collegiate football players: relationship between head impact biomechanics and acute clinical outcome after concussion".
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Stage 1 (Immediately after injury): 24–48 hours (maximum) of relative physical and cognitive rest. This can include gentle daily activities such as walking in the house, gentle housework, and light school work that do not make symptoms worse. No sports
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review article stated that there is debate whether the brain swelling is due to two separate hits or to just one hit, but in either case, catastrophic football head injuries are three times more likely in high school athletes than in college athletes.
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can occur with the third and subsequent concussions. As of 2006, studies had conflicting findings on whether athletes have longer recovery times after repeat concussions and whether cumulative effects such as impairment in cognition and memory occur.
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of mTBI is lower in older age groups (graph at right). Studies suggest males develop mTBI at about twice the rate of their female counterparts. However, female athletes may be at a higher risk of sustaining a concussion than their male counterparts.
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Concussion falls under the classification of mild TBI, but it is not clear whether concussion is implied in mild brain injury or mild head injury. "mTBI" and "concussion" are often treated as synonyms in medical literature but other injuries such as
421:, which is defined as concussion symptoms lasting for 4 weeks or longer in children and adolescents, and symptoms lasting for more than 14 days in an adult. The severity of the initial symptoms is the strongest predictor of recovery time in adults. 1129:
At each step, the person should not have worsening or new symptoms for at least 24 hours before progressing to the next. If symptoms worsen or new symptoms begin, athletes should drop back to the previous level for at least another 24 hours.
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state, but in practice, few researchers and clinicians distinguish between the terms. Descriptions of the condition, including the severity and the area of the brain affected, are now used more often than "concussion" in clinical neurology.
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including crankiness, loss of interest in favorite activities or items, tearfulness, and displays of emotion that are inappropriate to the situation. Common symptoms in concussed children include restlessness, lethargy, and irritability.
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unconsciousness (usually less than 30 minutes) and post-traumatic amnesia (usually less than 24 hours), and the Glasgow Coma Scale (people with mTBI have scores of 13 to 15). A CT scan or MRI is not required to diagnose concussion.
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Kerr ZY, Register-Mihalik JK, Marshall SW, Evenson KR, Mihalik JP, Guskiewicz KM (July 2014). "Disclosure and non-disclosure of concussion and concussion symptoms in athletes: review and application of the socio-ecological framework".
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in cars, and protective equipment such as helmets for high-risk sports. Older people are encouraged to reduce fall risk by keeping floors free of clutter and wearing thin, flat shoes with hard soles that do not interfere with balance.
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Concussions may also be common and occur in the workplace. According to the US Bureau of Labour Statistics, the most common causes of mTBI-related hospitalizations and deaths from the workplace are falls, force of heavy objects, and
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often carry the most risk. Despite these findings, there still remain important gaps in data compilation on workplace-related mTBIs, which has raised questions about increased concussion surveillance and preventive measures in
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that have not been approved by a doctor as they can impede healing. Activation database-guided EEG biofeedback has been shown to return the memory abilities of the concussed individual to levels better than the control group.
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Schneider DK, Grandhi RK, Bansal P, Kuntz GE, Webster KE, Logan K, et al. (October 2017). "Current state of concussion prevention strategies: a systematic review and meta-analysis of prospective, controlled studies".
346:. Treatment includes physical and mental rest for 1–2 days, with a gradual step-wise return to activities, school, and work. Prolonged periods of rest may slow recovery and result in greater depression and anxiety. 1383:", i.e. give a mild traumatic brain injury to, the opponent). The injury is so common in the latter that several medical groups have called for a ban on the sport, including the American Academy of Neurology, the 928:
Diagnosis can be complex because concussion shares symptoms with other conditions. For example, persisting concussion symptoms such as cognitive problems may be misattributed to brain injury when, in fact, due to
4326:"Summary and agreement statement of the First International Conference on Concussion in Sport, Vienna 2001. Recommendations for the improvement of safety and health of athletes who may suffer concussive injuries" 8296: 8281: 8266: 8251: 1614:
In the past, the decision to allow athletes to return to participation was frequently based on the grade of concussion. However, current research and recommendations by professional organizations including the
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If the Glasgow coma scale is less than 15 at two hours or less than 14 at any time, a CT is recommended. In addition, a CT scan is more likely to be performed if observation after discharge is not assured or
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Emery CA, Black AM, Kolstad A, Martinez G, Nettel-Aguirre A, Engebretsen L, et al. (June 2017). "What strategies can be used to effectively reduce the risk of concussion in sport? A systematic review".
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readings. A blood test known as the Brain Trauma Indicator was approved in the United States in 2018 and may be able to rule out the risk of intracranial bleeding and thus the need for a CT scan for adults.
1412:) have more elevated mTBI incidence rates ranging from 10 to 20 cases per 100,000 workers. In particular, as vehicular collisions are the leading cause of workplace mTBI-related injuries, workers from the 1619:
recommend against such use of these grading systems. Currently, injured athletes are prohibited from returning to play before they are symptom-free during both rest and exertion and until results of the
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suggest that lasting damage is done by such injuries. This damage, the severity of which increases with the cumulative number of concussions sustained, can lead to a variety of other health issues.
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Lumba-Brown A, Yeates KO, Sarmiento K, Breiding MJ, Haegerich TM, Gioia GA, et al. (November 2018). "Diagnosis and Management of Mild Traumatic Brain Injury in Children: A Systematic Review".
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Mouzon BC, Bachmeier C, Ferro A, Ojo JO, Crynen G, Acker CM, et al. (February 2014). "Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model".
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players with a history of three or more concussions than for those with no concussion history. An experience of three or more concussions is associated with a fivefold greater chance of developing
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and a prior history of concussion. The mechanism of injury involves either a direct blow to the head or forces elsewhere on the body that are transmitted to the head. This is believed to result in
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athletes, are typically followed closely by team athletic trainers during this period but others may not have access to this level of health care and may be sent home with minimal monitoring.
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occurs. This debate resurfaces in some of the best-known concussion grading scales, in which those episodes involving loss of consciousness are graded as being more severe than those without.
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Patricios JS, Schneider KJ, Dvorak J, Ahmed OH, Blauwet C, Cantu RC, Davis GA, Echemendia RJ, Makdissi M, McNamee M, Broglio S, Emery CA, Feddermann-Demont N, Fuller GW, Giza CC (2023).
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located in these areas and that this disruption produces the loss of consciousness often seen in concussion. Other areas of the brain that may be affected include the upper part of the
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induced by traumatic biomechanical forces." It was agreed that concussion typically involves temporary impairment of neurological function that heals by itself within time, and that
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Vuu S, Barr CJ, Killington M, Jill G, van den Berg ME (2022). "Physical exercise for people with mild traumatic brain injury: A systematic review of randomized controlled trials".
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condition have been found to predict longer-lasting persisting concussion symptoms. Other factors that may lengthen recovery time after mTBI include psychological problems such as
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early retirement account for the bulk of the costs. These direct and indirect costs cause the expense of mild brain trauma to rival that of moderate and severe head injuries.
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comparison in the event of an injury, though this may not reduce risk or affect return to play and baseline testing is not required or suggested for most children and adults.
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capability shows a moving object in a predictive pattern for the person to follow with their eyes. People without brain injury will be able to track the moving object with
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Mannix R, Levy R, Zemek R, Yeates KO, Arbogast K, Meehan WP, et al. (October 2020). "Fluid Biomarkers of Pediatric Mild Traumatic Brain Injury: A Systematic Review".
1474:. In the 16th-century, the term "concussion" came into use, and symptoms such as confusion, lethargy, and memory problems were described. The 16th century physician 542:, which protects it from light trauma. More severe impacts, or the forces associated with rapid acceleration, may not be absorbed by this cushion. Concussions, and other 8381: 1353:
Young children have the highest concussion rate among all age groups. However, most people with a concussion are young adults. A Canadian study found that the yearly
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may be suggested, but should be avoided unless there are progressive neurological symptoms, focal neurological findings, or concern of skull fracture on exam.
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Satz P, Zaucha K, McCleary C, Light R, Asarnow R, Becker D (September 1997). "Mild head injury in children and adolescents: a review of studies (1970-1995)".
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such as an intracranial hemorrhage or other serious head or neck injuries. This includes the "ABCs" (airway, breathing, circulation) and stabilization of the
8374: 985: 957: 878:. Those with such symptoms, or those who are at higher risk of a more serious brain injury, require an emergency medical assessment. Brain imaging such as a 331:. Diagnostic imaging such as a CT scan or an MRI may be required to rule out severe head injuries. Routine imaging is not required to diagnose concussion. 6325:"What factors must be considered in 'return to school' following concussion and what strategies or accommodations should be followed? A systematic review" 5758:"Primary prevention of contact sports-related concussions in amateur athletes: a systematic review from the Eastern Association for the Surgery of Trauma" 3032:
Erlanger DM, Kutner KC, Barth JT, Barnes R (May 1999). "Neuropsychology of sports-related head injury: Dementia Pugilistica to Post Concussion Syndrome".
1851:"Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury" 8697: 6714: 1207:
Most children recover completely from concussion in less than four weeks, however 15–30% of youth may experience symptoms that last longer than a month.
7723:"Non-surgical intervention and cost for mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury" 6799:
Zemek RL, Farion KJ, Sampson M, McGahern C (March 2013). "Prognosticators of persistent symptoms following pediatric concussion: a systematic review".
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Murray ED, Buttner N, Price BH (2012). "Depression and Psychosis in Neurological Practice". In Bradley WG, Daroff RB, Fenichel GM, Jankovic J (eds.).
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Delaney JS, Abuzeyad F, Correa JA, Foxford R (August 2005). "Recognition and characteristics of concussions in the emergency department population".
1296:, speech and memory problems, slowed mental processing, tremor, depression, and inappropriate behavior. It shares features with Alzheimer's disease. 5493:
Petchprapai N, Winkelman C (October 2007). "Mild traumatic brain injury: determinants and subsequent quality of life. A review of the literature".
3396:"Concussion in professional football: summary of the research conducted by the National Football League's Committee on Mild Traumatic Brain Injury" 7648: 2434: 327:
score 13 to 15, loss of consciousness for less than 30 minutes, and memory loss for less than 24 hours may be used to rule out moderate or severe
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At the same time, cerebral blood flow is relatively reduced for unknown reasons, though the reduction in blood flow is not as severe as it is in
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symptoms of a prior concussion have resolved is associated with worse outcomes. Repeated concussions may also increase the risk in later life of
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McKeever CK, Schatz P (2003). "Current issues in the identification, assessment, and management of concussions in sports-related injuries".
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King D, Brughelli M, Hume P, Gissane C (April 2014). "Assessment, management and knowledge of sport-related concussion: systematic review".
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For persons participating in athletics, it is suggested that participants progress through a series of graded steps. These steps include:
4631:"Diagnostic procedures in mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury" 3247: 7641:"Report to Congress on Traumatic Brain Injury Epidemiology and Rehabilitation | Concussion | Traumatic Brain Injury | CDC Injury Center" 7587: 4045: 2727: 2072: 1616: 1606:
National and international clinical practice guidelines do not recommend a concussion grading system for use by medical professionals.
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Rousseau P, Post A, Hoshizaki TB (2009). "The effects of impact management materials in ice hockey helmets on head injury criteria".
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Mild traumatic brain injury recovery time in people over age 65 may have increased complications due to elevated health concerns, or
6843:"Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children" 6513: 936:
There are no fluid biomarkers (i.e., blood or urine tests) that are validated for diagnosing concussion in children or adolescents.
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McCrory PR, Berkovic SF (December 2001). "Concussion: the history of clinical and pathophysiological concepts and misconceptions".
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Comper P, Bisschop SM, Carnide N, Tricco A (October 2005). "A systematic review of treatments for mild traumatic brain injury".
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Bowen AP (June 2003). "Second impact syndrome: a rare, catastrophic, preventable complication of concussion in young athletes".
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Measurement of predictive visual tracking is being studied as a screening technique to identify mild traumatic brain injury. A
739:
in which rodents were concussed have revealed lifelong neuropathological consequences such as ongoing axonal degeneration and
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McAllister TW, Sparling MB, Flashman LA, Saykin AJ (December 2001). "Neuroimaging findings in mild traumatic brain injury".
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6184:"Guideline for Concussion/Mild Traumatic Brain Injury and Persistent Symptoms: 3rd Edition (for Adults 18+ years of age)" 6075: 4859: 3311: 488:. Loss of consciousness may occur, but is not necessarily correlated with the severity of the concussion if it is brief. 952:
However, although no structural brain damage occurs according to the classic definition, some researchers have included
4471: 4432:
Barkhoudarian G, Hovda DA, Giza CC (May 2016). "The Molecular Pathophysiology of Concussive Brain Injury - an Update".
3740: 2948:"Posttraumatic Retrograde and Anterograde Amnesia: Pathophysiology and Implications in Grading and Safe Return to Play" 785:
Red flags are warning signs that may indicate a more serious problem and require immediate emergency medical attention
631:
In both animals and humans, mTBI can alter the brain's physiology for hours to years, setting into motion a variety of
8193: 760:) consumption and glucose utilization, quickly depleting glucose stores within the cells. Simultaneously, inefficient 6273:"Effectiveness of return to activity and return to school protocols for children postconcussion: a systematic review" 6135:"Effectiveness of return to activity and return to school protocols for children postconcussion: a systematic review" 4976:"Press Announcements – FDA authorizes marketing of first blood test to aid in the evaluation of concussion in adults" 3067:
McCrory PR, Berkovic SF (February 1998). "Concussive convulsions. Incidence in sport and treatment recommendations".
2351:"Living Concussion Guidelines: Guideline for Concussion & Prolonged Symptoms for Adults 18 years of Age or Older" 4740: 3203: 1441:
The Hippocratic Corpus, a collection of medical works from ancient Greece, mentions concussion, later translated to
8632: 7616: 7224: 3272: 1708: 1265: 980: 375: 119: 6442: 5650:
Savitsky EA, Votey SR (January 2000). "Current controversies in the management of minor pediatric head injuries".
5370:
Head Injury: Triage, Assessment, Investigation and Early Management of Head Injury in Infants, Children and Adults
8667: 2034: 1446: 1276:. For example, the risk of developing clinical depression has been found to be significantly greater for retired 667:
that serve to stimulate nerve cells, are released in excessive amounts. The resulting cellular excitation causes
4891:
Binder LM (August 1986). "Persisting symptoms after mild head injury: a review of the postconcussive syndrome".
1976: 1748: 1540:
report outlined it as an important strategy. In this article, "concussion" and "mTBI" are used interchangeably.
1466:
pointed out the relatively good prognosis of concussion as compared to more severe types of head trauma such as
1219:. This often results in longer hospitalization duration, poorer cognitive outcomes, and higher mortality rates. 7020: 2064: 1624:
have returned to pre-injury levels. Three grading systems have been most widely followed: by Robert Cantu, the
930: 724: 1941: 1636:
Comparison of historic concussion grading scales – not currently recommended for use by medical professionals
1315:
lose the ability to regulate their diameter, causing a loss of control over cerebral blood flow. As the brain
1057:
reporting behaviors, and reduced body checking-related penalties and injuries, thereby lowering risk of mTBI.
8366: 3112:"Concussive convulsions: emergency department assessment and management of a frequently misunderstood entity" 1629: 3804:
Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology
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Mahooti N (January 2018). "Sports-Related Concussion: Acute Management and Chronic Postconcussive Issues".
1585: 1157:
is preferred to minimize the risk of intracranial hemorrhage. Concussed individuals are advised not to use
913: 563: 359: 7832: 8570: 8565: 8079:"Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004" 6841:
Lumba-Brown A, Yeates KO, Sarmiento K, Breiding MJ, Haegerich TM, Gioia GA, et al. (November 2018).
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Marshall S, Bayley M, McCullagh S, Berrigan L, Fischer L, Ouchterlony D, Rockwell C, Velikonja D (2018).
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Harrison, Emily A. "The first concussion crisis: head injury and evidence in early American football."
2426: 2204:"American Academy of Pediatrics. Clinical report--sport-related concussion in children and adolescents" 1713: 1601: 456:, or a ringing in the ears, is also commonly reported. In one in about seventy concussions, concussive 3527:
Poirier MP (2003). "Concussions: Assessment, management, and recommendations for return to activity".
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Harmon KG, Drezner JA, Gammons M, Guskiewicz KM, Halstead M, Herring SA, et al. (January 2013).
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For a period of minutes to days after a concussion, the brain is especially vulnerable to changes in
363: 8672: 6506:"Symptoms of Traumatic Brain Injury (TBI) | Concussion | Traumatic Brain Injury | CDC Injury Center" 5607:
van der Naalt J (December 2001). "Prediction of outcome in mild to moderate head injury: a review".
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Flanagan SR, Hibbard MR, Gordon WA (February 2005). "The impact of age on traumatic brain injury".
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Silverberg ND, Iverson GL, Cogan A, Dams-O'Connor K, Delmonico R, Graf MJ, et al. (May 2023).
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Moser RS, Iverson GL, Echemendia RJ, Lovell MR, Schatz P, Webbe FM, et al. (November 2007).
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Schulz MR, Marshall SW, Mueller FO, Yang J, Weaver NL, Kalsbeek WD, Bowling JM (November 2004).
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Campbell KR, Marshall SW, Luck JF, Pinton GF, Stitzel JD, Boone JS, et al. (October 2020).
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Lee LK (August 2007). "Controversies in the sequelae of pediatric mild traumatic brain injury".
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Mild brain injury, mild traumatic brain injury (mTBI), mild head injury (MHI), minor head trauma
8748: 8738: 8622: 8549: 3585: 2203: 2147: 1418: 1305: 1281: 1071: 994: 917: 900: 757: 736: 489: 461: 379: 328: 123: 8340: 8260: 7084:
Willer B, Leddy JJ (September 2006). "Management of concussion and post-concussion syndrome".
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Aubry M, Cantu R, Dvorak J, Graf-Baumann T, Johnston K, Kelly J, et al. (February 2002).
3231: 3154:
Cantu RC, Aubry M, Dvorak J, Graf-Baumann T, Johnston K, Kelly J, et al. (October 2006).
2546:"The International Incidence of Traumatic Brain Injury: A Systematic Review and Meta-Analysis" 354:
may be recommended to help with a headache. Prescribed aerobic exercise may improve recovery.
8682: 8677: 8639: 7721:
Borg J, Holm L, Peloso PM, Cassidy JD, Carroll LJ, von Holst H, et al. (February 2004).
7571: 6534:
Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK, Solomon GS (June 2017).
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The Canadian Journal of Neurological Sciences. Le Journal Canadien des Sciences Neurologiques
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Cassidy JD, Carroll LJ, Peloso PM, Borg J, von Holst H, Holm L, et al. (February 2004).
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Bryant RA (January 2008). "Disentangling mild traumatic brain injury and stress reactions".
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Nguyen R, Fiest KM, McChesney J, Kwon CS, Jette N, Frolkis AD, et al. (November 2016).
1509:
and that due to concussion, without such injury. In 1941, animal experiments showed that no
1311:
fatal complication, but it is commonly thought that the swelling occurs because the brain's
1169:
About one percent of people who receive treatment for mTBI need surgery for a brain injury.
8784: 8779: 8627: 8518: 8415: 8002: 7915: 7140: 4727: 4629:
Borg J, Holm L, Cassidy JD, Peloso PM, Carroll LJ, von Holst H, Ericson K (February 2004).
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Mouzon BC, Bachmeier C, Ojo JO, Acker CM, Ferguson S, Paris D, et al. (January 2018).
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can occur when the head is struck by an object or surface (a 'direct impact'), or when the
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McCrory P, Johnston K, Meeuwisse W, Aubry M, Cantu R, Dvorak J, et al. (April 2005).
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Kraus JF, Chu LD (2005). "Epidemiology". In Silver JM, McAllister TW, Yudofsky SC (eds.).
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Stage 6: Return to full-contact sport or high-risk activities (requires medical clearance)
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McCrory P, Meeuwisse WH, Aubry M, Cantu RC, DvoΕ™Γ‘k J, Echemendia RJ, et al. (2013).
6931:
McCrory P, Meeuwisse W, Johnston K, Dvorak J, Aubry M, Molloy M, Cantu R (Jul–Aug 2009).
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McCrory P, Meeuwisse W, DvoΕ™Γ‘k J, Aubry M, Bailes J, Broglio S, et al. (June 2017).
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Loss of consciousness <5 minutes or amnesia lasting 30 minutes–24 hours
1489: 1196: 1134: 656: 539: 501: 492:, in which events following the injury cannot be recalled, is a hallmark of concussions. 8183: 7919: 7795: 7424: 7144: 5368: 4046:"Concussion (mild traumatic brain injury) and the team physician: a consensus statement" 2812: 2787: 2427:"CDC Pediatric mTBI Guideline | Concussion | Traumatic Brain Injury | CDC Injury Center" 949:
normally shows no gross structural changes to the brain as the result of the condition.
8659: 8602: 8479: 8152: 8127: 8103: 8078: 8054: 8029: 7984: 7936: 7903: 7879: 7854: 7853:
Toledo E, Lebel A, Becerra L, Minster A, Linnman C, Maleki N, et al. (July 2012).
7695: 7670: 7517: 7471: 7330: 7287: 7240: 7109: 7012: 6957: 6932: 6867: 6842: 6614: 6560: 6535: 6473: 6397: 6354: 6297: 6272: 6248: 6159: 6134: 6028: 5976: 5943: 5919: 5894: 5834: 5782: 5757: 5713: 5632: 5561: 5518: 5468: 5350: 5307: 5224: 5143: 4952: 4927: 4840: 4569: 4526: 4404: 4379: 4350: 4325: 4303: 4198: 4173: 4064: 4022: 4010: 3962: 3914: 3889: 3870: 3827: 3654: 3642: 3603: 3506: 3460: 3128: 3111: 3092: 2521: 2403: 1434: 1405: 1376: 1316: 998: 871: 752: 676: 433: 324: 295: 153: 94: 83: 7821:"Current concepts in concussion diagnosis and management in sports: A clinical review" 7548: 7152: 7128: 5854:"American Medical Society for Sports Medicine position statement: concussion in sport" 5663: 4687: 4670: 4147: 4111: 4094: 3540: 3448: 2964: 2947: 2648:
Sports-related concussions in youth : improving the science, changing the culture
1505:
and showed the difference between unconsciousness associated with damage to the brain
690:. Thus cells get less glucose than they normally do, which causes an "energy crisis". 472:
and have the same high rate of favorable outcomes as concussions without convulsions.
460:
occur, but seizures that take place during or immediately after a concussion are not "
432:
are the most common mTBI symptom. Others include dizziness, vomiting, nausea, lack of
8753: 8585: 8580: 8157: 8108: 8059: 7976: 7972: 7941: 7927: 7884: 7767: 7744: 7700: 7613:"Nonfatal cases involving days away from work: Selected characteristics. (2003–2010)" 7577: 7552: 7509: 7505: 7463: 7428: 7390: 7386: 7322: 7279: 7244: 7191: 7101: 7062: 7058: 7004: 6962: 6910: 6872: 6858: 6816: 6778: 6726: 6680: 6637: 6618: 6606: 6565: 6465: 6389: 6346: 6302: 6252: 6240: 6164: 6020: 5981: 5963: 5924: 5875: 5826: 5787: 5736: 5705: 5667: 5636: 5624: 5587: 5553: 5510: 5506: 5460: 5420: 5377: 5354: 5342: 5299: 5259: 5228: 5216: 5181: 5147: 5135: 5096: 5050: 5017: 4957: 4943: 4908: 4832: 4791: 4732: 4692: 4652: 4561: 4518: 4513: 4496: 4449: 4409: 4355: 4307: 4295: 4203: 4151: 4116: 4068: 4014: 3954: 3919: 3862: 3831: 3819: 3784: 3732: 3646: 3510: 3498: 3452: 3417: 3369: 3327: 3237: 3177: 3133: 3084: 3080: 3049: 3011: 2969: 2923: 2875: 2817: 2652: 2567: 2525: 2513: 2478: 2407: 2395: 2308: 2225: 2175: 2167: 2125: 2120: 2103: 1920: 1872: 1814: 1454: 1397: 1277: 1018: 1014: 867: 740: 713: 648: 522: 437: 303: 193: 181: 161: 127: 78: 8305: 7988: 7870: 7855:"The young brain and concussion: imaging as a biomarker for diagnosis and prognosis" 7521: 7475: 7411:
Gordon KE, Dooley JM, Wood EP (May 2006). "Descriptive epidemiology of concussion".
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Boake C, McCauley SR, Levin HS, Pedroza C, Contant CF, Song JX, et al. (2005).
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Kamins J, Bigler E, Covassin T, Henry L, Kemp S, Leddy JJ, et al. (June 2017).
6401: 5838: 5717: 5565: 5522: 5472: 5311: 4844: 4573: 4530: 4026: 3966: 3874: 3658: 3607: 3464: 3096: 8597: 8458: 8351: 8147: 8139: 8098: 8090: 8049: 8041: 7968: 7931: 7923: 7874: 7866: 7734: 7690: 7686: 7682: 7544: 7501: 7455: 7420: 7382: 7314: 7271: 7236: 7148: 7093: 7054: 6996: 6952: 6944: 6902: 6862: 6854: 6808: 6768: 6670: 6596: 6555: 6547: 6477: 6457: 6381: 6358: 6336: 6292: 6284: 6230: 6154: 6146: 6032: 6012: 5971: 5955: 5914: 5906: 5895:"Head Impact Telemetry System's Video-based Impact Detection and Location Accuracy" 5865: 5818: 5777: 5769: 5756:
Enniss TM, Basiouny K, Brewer B, Bugaev N, Cheng J, Danner OK, et al. (2018).
5697: 5659: 5616: 5545: 5502: 5452: 5334: 5291: 5251: 5208: 5173: 5127: 5092: 5088: 4947: 4939: 4900: 4822: 4781: 4722: 4682: 4642: 4553: 4508: 4441: 4399: 4391: 4345: 4337: 4287: 4239:. Boston University: Center for the Study of Traumatic Encephalopathy. 2009-01-27. 4193: 4185: 4143: 4106: 4060: 4006: 3946: 3909: 3901: 3854: 3811: 3774: 3722: 3638: 3595: 3536: 3490: 3444: 3407: 3361: 3167: 3123: 3076: 3041: 3003: 2959: 2915: 2865: 2807: 2799: 2557: 2505: 2468: 2387: 2298: 2288: 2215: 2159: 2115: 1912: 1862: 1806: 1570: 1320: 1273: 961: 751:
Using animal studies, the pathology of a concussion seems to start with mechanical
668: 660: 647:
Included in the cascade of events unleashed in the brain by concussion is impaired
493: 6585:"What is the physiological time to recovery after concussion? A systematic review" 6415: 3763:"Neuropsychology and clinical neuroscience of persistent post-concussive syndrome" 1475: 8316: 7786: 7000: 6601: 6584: 6551: 6341: 6324: 6016: 5910: 5870: 5853: 5822: 5701: 5549: 5456: 5131: 4827: 4810: 4600: 4596: 2870: 2853: 2293: 2276: 2163: 1493: 1463: 1269: 1257: 1192: 1145:
Medications may be prescribed to treat headaches, sleep problems and depression.
1119:
Stage 4: Non-contact training drills (exercise, coordination, and cognitive load)
1022: 965: 604: 600: 8354: 7275: 6636:. Vol. 1 (6th ed.). Philadelphia, PA: Elsevier/Saunders. p. 111. 5255: 3890:"Chronic neuropathologies of single and repetitive TBI: substrates of dementia?" 3197:"Practice Parameter: The Management of Concussion in Sports (Summary Statement)" 2854:"Mild traumatic brain injury: toward understanding manifestations and treatment" 2646: 977:
International Statistical Classification of Diseases and Related Health Problems
640:
processes that follow concussion are reversible in a large majority of affected
221:
Physical and cognitive rest for a day or two with a gradual return to activities
6948: 6659:"Definition, diagnosis, and forensic implications of postconcussional syndrome" 6288: 6183: 6150: 5620: 5038: 4395: 3950: 3045: 3007: 2994:
Rees PM (December 2003). "Contemporary issues in mild traumatic brain injury".
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Marshall S, Lithopoulos A, Curran D, Fischer L, Velikonja D, Bayley M (2023).
1867: 1850: 1810: 971:
Definitions of mild traumatic brain injury (mTBI) were inconsistent until the
18:
For concussion (mild traumatic brain injury) in children and adolescents, see
8768: 8428: 8094: 6730: 5967: 5959: 5346: 4467: 3905: 3823: 3677: 3599: 3412: 3395: 2171: 1592:
while it is hypothesized that those with mild traumatic brain injury cannot.
1367: 1216: 862:
is not a sign of concussion and can be a sign of a more serious brain injury.
694: 608: 383: 355: 103: 8223: 7199: 4586: 3710: 3195:
Quality Standards Subcommittee of the American Academy of Neurology (1997).
3172: 3155: 1116:
Stage 3: Sport-specific activities such as running drills and skating drills
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Jordan BD (2000). "Chronic traumatic brain injury associated with boxing".
7248: 7195: 7105: 7066: 7008: 6966: 6914: 6876: 6820: 6782: 6684: 6610: 6569: 6469: 6350: 6306: 6244: 6168: 6024: 5985: 5928: 5879: 5830: 5791: 5709: 5671: 5628: 5557: 5514: 5464: 5413:"Postconcussional disorder: Background to DSM-IV and future considerations" 5303: 5220: 5185: 5139: 5100: 5054: 4961: 4836: 4795: 4736: 4696: 4656: 4565: 4522: 4453: 4413: 4359: 4299: 4291: 4207: 4155: 4120: 4072: 4018: 3958: 3923: 3866: 3815: 3788: 3736: 3650: 3502: 3456: 3421: 3373: 3331: 3181: 3137: 3053: 3015: 2973: 2927: 2821: 2571: 2517: 2482: 2473: 2456: 2399: 2312: 2229: 2220: 2179: 2129: 1924: 1876: 1818: 1581: 1336: 1293: 946: 717: 612: 584: 284: 107: 70: 62: 7556: 7283: 6393: 5338: 5263: 5212: 4912: 3088: 2879: 2098: 2096: 2094: 2092: 2090: 768:
of glucose and increased lactate accumulation. There is a resultant local
8702: 8398: 8335: 7794:. Atlanta, GA: Centers for Disease Control and Prevention. Archived from 6773: 6756: 6108:. National Institute for Health and Clinical Excellence. September 2007. 4710: 4544:
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can deliver more rotational force to the head than the typical impact in
441: 347: 343: 264: 231: 168: 8205: 7318: 5177: 4341: 3312:"[Contemporary view on mild brain injuries in adult population]" 3233:
Foundations of Athletic Training: Prevention, Assessment, and Management
2919: 2007:"Brain Injury Safety Tips and Prevention | Heads Up | CDC Injury Center" 960:
definition includes physiological or physical disruption in the brain's
440:, or other problems with movement or sensation. Visual symptoms include 8687: 8453: 7612: 6794: 6792: 6712: 6385: 2803: 2509: 2370: 2087: 1589: 1506: 875: 866:
Head trauma recipients are initially assessed to exclude a more severe
859: 799: 641: 637: 596: 457: 226: 54: 8243: 8228: 7349:"Second Impact Syndrome: the Dangerous Effect of Multiple Concussions" 6536:"Predictors of clinical recovery from concussion: a systematic review" 5016:. Hillsdale, New Jersey: Lawrence Erlbaum Associates. pp. 85–86. 3858: 3727: 2759: 2757: 2755: 2753: 2751: 2749: 2747: 2745: 2303: 1903:
Ropper AH, Gorson KC (January 2007). "Clinical practice. Concussion".
1686:
Confusion, symptoms last <15 minutes, no loss of consciousness
1664:
Loss of consciousness >5 minutes or amnesia >24 hours
1485: 358:
may be useful for persisting balance problems, headache, or whiplash;
8448: 8438: 8346: 8285: 5944:"Counseling Athletes on the Risk of Chronic Traumatic Encephalopathy" 4189: 1977:"How do health care providers diagnose traumatic brain injury (TBI)?" 1492:
distinguished between concussion and unconsciousness associated with
1413: 1312: 1150: 1146: 1113:
Stage 2: Light aerobic activity such as walking or stationary cycling
1082: 1041: 664: 632: 485: 339: 207: 185: 87: 6984: 6789: 1658:
Post-traumatic amnesia <30 minutes, no loss of consciousness
1482:, as well as "shaking of the brain", "commotion", and "concussion". 65:(g-forces) can exert rotational forces in the brain, especially the 8003:"Returning to Sports and Activities | HEADS UP | CDC Injury Center" 7606: 7604: 5419:. Hillsdale, New Jersey: Lawrence Erlbaum Associates. p. 320. 5116: 5039:"Current Concepts in Concussion: Initial Evaluation and Management" 3997:
Iverson GL (May 2005). "Outcome from mild traumatic brain injury".
2742: 1692:
Loss of consciousness (IIIa, coma lasts seconds, IIIb for minutes)
1632:. Each employs three grades, as summarized in the following table: 1380: 1375:
is particularly common include American football, the rugby codes,
832: 819: 807: 769: 687: 623:/s are estimated to have 25, 50, or 80% risk of mTBI respectively. 587:. It is thought that the forces from the injury disrupt the normal 580: 453: 449: 429: 276: 99: 66: 7958: 7225:"Chronic traumatic encephalopathy in the National Football League" 6840: 4711:"Sport concussion assessment tool for children ages 5 to 12 years" 1429: 579:
The parts of the brain most affected by rotational forces are the
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Hardman JM, Manoukian A (May 2002). "Pathology of head trauma".
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disease can lead to cognitive and physical disabilities such as
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Masferrer R, Masferrer M, Prendergast V, Harrington TR (2000).
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Cook RS, Schweer L, Shebesta KF, Hartjes K, Falcone RA (2006).
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may be useful for mood changes. Evidence to support the use of
351: 335: 311: 279:; difficulty with thinking, concentration, or balance; nausea; 235: 211: 8510: 8224:"Facts about Concussion and Brain Injury and Where to Get Help 6930: 6217:
Zimmerman SD, Vernau BT, Meehan WP, Master CL (January 2021).
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reasoning, concentrating, and performing everyday activities.
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McCrory P (July 2001). "Does second impact syndrome exist?".
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Physical Medicine and Rehabilitation Clinics of North America
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Symptoms may include 8749:Brachial plexus injury 8739:Wallerian degeneration 8673:Brown-SΓ©quard syndrome 8623:Second-impact syndrome 8550:Traumatic brain injury 5244:Psychological Bulletin 5201:Journal of Neurotrauma 4292:10.1212/WNL.57.12.2283 3816:10.1243/17543371JSET36 3320:Casopis Lekaru Ceskych 2474:10.1542/peds.2018-3074 2221:10.1542/peds.2010-2005 2114:(11): 872. June 2017. 1497: 1438: 1366:Up to five percent of 1348: 1341: 1306:Second-impact syndrome 1300:Second-impact syndrome 1072:basilar skull fracture 995:post-traumatic amnesia 863: 758:adenosine triphosphate 546:, occur when external 526: 490:Post-traumatic amnesia 404: 290:Common causes include 106:; sleep disturbances; 8683:Central cord syndrome 8678:Cauda equina syndrome 8640:Diffuse axonal injury 8192:1.3 (2012): 170-184. 7307:Seminars in Neurology 5339:10.1007/s003290050153 5213:10.1089/neu.2019.6956 1719:Head injury criterion 1488: 1437:mentioned concussion. 1432: 1414:transportation sector 1339: 1270:psychiatric disorders 991:loss of consciousness 966:loss of consciousness 858: 774:membrane permeability 729:diffuse axonal injury 710:intracranial pressure 617:Angular accelerations 544:head-related injuries 516: 402: 273:loss of consciousness 8628:Dementia pugilistica 8210:Share your views on 8046:10.1093/pch/19.3.153 6374:Neurosurgical Review 4221:. December 14, 2017. 2563:10.1017/cjn.2016.290 1917:10.1056/NEJMcp064645 1578:head-mounted display 1398:vehicular collisions 1203:Pediatric concussion 1011:intra-axial hematoma 766:anaerobic metabolism 762:oxidative metabolism 723:Concussion involves 699:anaerobic metabolism 663:, chemicals such as 368:chiropractic therapy 25:For other uses, see 20:Pediatric concussion 8645:Abusive head trauma 8608:Cerebral laceration 8229:Concussion Alliance 7920:2010NYASA1208...58M 7733:(43 Suppl): 76–83. 7413:Pediatric Neurology 7319:10.1055/s-2000-9826 7145:2017NewSc.236...10K 5178:10.1056/NEJMe078235 4809:Randolph C (2011). 4641:(43 Suppl): 61–75. 4342:10.1136/bjsm.36.1.6 3847:Annals of Neurology 3577:Practical Neurology 3400:Neurosurgical Focus 3360:(3): 655–78, viii. 3160:Neurosurgical Focus 2920:10.1067/men.2003.90 2498:NeuroRehabilitation 1861:(43 Suppl): 28–60. 1637: 1517:Society and culture 1490:Guillaume Dupuytren 1282:Alzheimer's disease 1197:clinical depression 1133:Intercollegiate or 786: 657:cerebral blood flow 540:cerebrospinal fluid 380:Parkinson's disease 350:(acetaminophen) or 124:Parkinson's disease 8660:Spinal cord injury 8603:Cerebral contusion 8480:Perforated eardrum 8327:External resources 8190:Kinesiology Review 8009:. 12 February 2019 7825:BC Medical Journal 7190:(3): 887–92, 894. 6774:10.1093/aje/kwh304 6386:10.1007/BF02352062 4142:(2): 175–87, vii. 3715:European Neurology 3709:Pearce JM (2007). 2852:Kushner D (1998). 2804:10.1002/pmrj.12884 2510:10.3233/NRE-220044 1942:"What causes TBI?" 1635: 1498: 1439: 1435:Hippocratic Corpus 1342: 1251:Cumulative effects 1023:pathophysiological 999:Glasgow Coma Scale 876:unequal pupil size 864: 860:Unequal pupil size 712:, blood flow, and 591:activities in the 527: 434:motor coordination 408:Signs and symptoms 405: 325:Glasgow coma scale 255:, also known as a 174:Physical violences 84:Emergency medicine 8775:Athletic training 8762: 8761: 8754:Traumatic neuroma 8714:Peripheral nerves 8586:Epidural hematoma 8581:Subdural hematoma 8508: 8507: 8488: 8487: 8364: 8363: 7773:978-1-58562-105-7 7583:978-0-7360-6008-0 6643:978-1-4377-0434-1 6011:(20): 1473–1482. 5905:(10): 2198–2206. 5742:978-0-521-62960-7 5593:978-0-19-505301-2 5426:978-0-8058-2394-3 5383:978-0-9549760-5-7 5207:(19): 2029–2044. 5023:978-0-8058-2394-3 4590:(24 April 2014), 4286:(12): 2283–2289. 4212:*Lay summary in: 3859:10.1002/ana.24064 3728:10.1159/000111872 3243:978-0-7817-5001-1 3002:(12): 1885–1894. 2864:(15): 1617–1624. 2798:(12): 1509–1513. 2658:978-0-309-28800-2 2039:www.nichd.nih.gov 1981:www.nichd.nih.gov 1946:www.nichd.nih.gov 1696: 1695: 1455:Lanfranc of Milan 1278:American football 1223:Repeat concussion 1019:subdural hematoma 1015:epidural hematoma 853: 852: 741:neuroinflammation 661:neurotransmitters 649:neurotransmission 538:is surrounded by 523:American football 442:light sensitivity 400: 304:bicycle accidents 269:brain functioning 249: 248: 234:(acetaminophen), 198:Based on symptoms 194:Diagnostic method 182:American football 162:bicycle accidents 34:Medical condition 8792: 8598:Brain herniation 8535: 8528: 8521: 8512: 8511: 8459:Corneal abrasion 8434: 8433: 8391: 8384: 8377: 8368: 8367: 8235: 8234: 8214:with Wikiversity 8208: 8166: 8165: 8155: 8123: 8117: 8116: 8106: 8074: 8068: 8067: 8057: 8025: 8019: 8018: 8016: 8014: 7999: 7993: 7992: 7956: 7950: 7949: 7939: 7899: 7893: 7892: 7882: 7865:(6): 1510–1531. 7850: 7844: 7843: 7841: 7840: 7816: 7810: 7809: 7807: 7806: 7800: 7793: 7784: 7778: 7777: 7759: 7753: 7752: 7742: 7718: 7709: 7708: 7698: 7666: 7660: 7659: 7657: 7656: 7637: 7628: 7627: 7625: 7624: 7608: 7599: 7598: 7596: 7595: 7567: 7561: 7560: 7532: 7526: 7525: 7489: 7480: 7479: 7443: 7437: 7436: 7408: 7399: 7398: 7370: 7364: 7363: 7361: 7359: 7345: 7339: 7338: 7302: 7296: 7295: 7259: 7253: 7252: 7220: 7211: 7210: 7208: 7207: 7198:. Archived from 7175: 7169: 7168: 7166: 7164: 7124: 7118: 7117: 7081: 7075: 7074: 7069:. Archived from 7038: 7032: 7031: 7029: 7028: 6980: 6971: 6970: 6960: 6928: 6919: 6918: 6890: 6881: 6880: 6870: 6838: 6825: 6824: 6796: 6787: 6786: 6776: 6752: 6746: 6745: 6743: 6742: 6733:. Archived from 6710: 6689: 6688: 6678: 6654: 6648: 6647: 6629: 6623: 6622: 6604: 6580: 6574: 6573: 6563: 6531: 6525: 6524: 6522: 6521: 6502: 6496: 6495: 6493: 6492: 6486: 6447: 6438: 6432: 6431: 6429: 6427: 6412: 6406: 6405: 6369: 6363: 6362: 6344: 6320: 6311: 6310: 6300: 6268: 6257: 6256: 6238: 6214: 6199: 6198: 6196: 6195: 6179: 6173: 6172: 6162: 6130: 6124: 6123: 6121: 6120: 6114: 6107: 6099: 6093: 6092: 6090: 6088: 6071: 6065: 6064: 6062: 6060: 6043: 6037: 6036: 5999: 5990: 5989: 5979: 5939: 5933: 5932: 5922: 5890: 5884: 5883: 5873: 5849: 5843: 5842: 5805: 5796: 5795: 5785: 5753: 5747: 5746: 5728: 5722: 5721: 5685: 5676: 5675: 5647: 5641: 5640: 5604: 5598: 5597: 5584:Mild Head Injury 5579: 5570: 5569: 5533: 5527: 5526: 5490: 5477: 5476: 5440: 5431: 5430: 5408: 5402: 5401: 5399: 5398: 5392: 5375: 5365: 5359: 5358: 5322: 5316: 5315: 5279: 5268: 5267: 5239: 5233: 5232: 5196: 5190: 5189: 5161: 5152: 5151: 5126:(8): 1009–1021. 5114: 5105: 5104: 5076: 5070: 5069: 5067: 5066: 5034: 5028: 5027: 5005: 4996: 4995: 4993: 4991: 4972: 4966: 4965: 4955: 4923: 4917: 4916: 4888: 4882: 4881: 4879: 4877: 4871: 4864: 4855: 4849: 4848: 4830: 4806: 4800: 4799: 4789: 4765: 4752: 4751: 4749: 4748: 4730: 4707: 4701: 4700: 4690: 4667: 4661: 4660: 4650: 4626: 4617: 4616: 4615: 4613: 4584: 4578: 4577: 4552:(9): 1210–1220. 4541: 4535: 4534: 4516: 4492: 4483: 4482: 4480: 4479: 4464: 4458: 4457: 4429: 4418: 4417: 4407: 4375: 4364: 4363: 4353: 4321: 4312: 4311: 4275: 4252: 4251: 4249: 4248: 4229: 4223: 4222: 4211: 4201: 4190:10.1002/acn3.510 4169: 4160: 4159: 4131: 4125: 4124: 4114: 4090: 4084: 4083: 4081: 4075:. Archived from 4050: 4042: 4031: 4030: 3994: 3971: 3970: 3934: 3928: 3927: 3917: 3885: 3879: 3878: 3842: 3836: 3835: 3799: 3793: 3792: 3782: 3758: 3752: 3751: 3749: 3748: 3730: 3721:(3–4): 113–119. 3706: 3693: 3692: 3690: 3689: 3669: 3663: 3662: 3625: 3619: 3618: 3616: 3610:. Archived from 3593: 3573: 3564: 3545: 3544: 3524: 3515: 3514: 3478: 3469: 3468: 3432: 3426: 3425: 3415: 3391: 3378: 3377: 3349: 3343: 3342: 3340: 3334:. Archived from 3317: 3307: 3288: 3287: 3285: 3284: 3268: 3259: 3258: 3256: 3255: 3227: 3218: 3217: 3215: 3214: 3208: 3201: 3192: 3186: 3185: 3175: 3151: 3142: 3141: 3131: 3107: 3101: 3100: 3064: 3058: 3057: 3029: 3020: 3019: 2991: 2978: 2977: 2967: 2943: 2932: 2931: 2903: 2884: 2883: 2873: 2849: 2826: 2825: 2815: 2783: 2777: 2776: 2774: 2772: 2761: 2740: 2739: 2737: 2735: 2716: 2710: 2709: 2707: 2706: 2686: 2675: 2674: 2672: 2670: 2642: 2636: 2635: 2633: 2631: 2612: 2606: 2605: 2603: 2601: 2592:. October 2013. 2582: 2576: 2575: 2565: 2541: 2530: 2529: 2493: 2487: 2486: 2476: 2467:(6): e20183074. 2452: 2446: 2445: 2443: 2442: 2423: 2412: 2411: 2386:(8): 1343–1355. 2377: 2368: 2362: 2361: 2359: 2357: 2346: 2317: 2316: 2306: 2296: 2272: 2245: 2244: 2242: 2241: 2223: 2199: 2184: 2183: 2143: 2134: 2133: 2123: 2100: 2085: 2084: 2082: 2080: 2061: 2055: 2054: 2052: 2050: 2031: 2022: 2021: 2019: 2018: 2003: 1997: 1996: 1994: 1992: 1973: 1962: 1961: 1959: 1957: 1938: 1929: 1928: 1900: 1881: 1880: 1870: 1846: 1823: 1822: 1794: 1769: 1768: 1766: 1764: 1745: 1641:Guidelines  1638: 1634: 1571:N-acetylcysteine 1503:contusio cerebri 1480:commotio cerebri 1443:commotio cerebri 1419:private industry 1274:long-term memory 1092:Return-to-school 787: 783: 401: 57: 37: 36: 8800: 8799: 8795: 8794: 8793: 8791: 8790: 8789: 8765: 8764: 8763: 8758: 8708: 8654: 8544: 8539: 8509: 8504: 8484: 8463: 8427: 8421: 8402: 8395: 8365: 8360: 8359: 8322: 8321: 8246: 8202: 8175: 8173:Further reading 8170: 8169: 8124: 8120: 8075: 8071: 8026: 8022: 8012: 8010: 8001: 8000: 7996: 7967:(11): e182847. 7961:JAMA Pediatrics 7957: 7953: 7900: 7896: 7851: 7847: 7838: 7836: 7817: 7813: 7804: 7802: 7798: 7791: 7785: 7781: 7774: 7760: 7756: 7719: 7712: 7667: 7663: 7654: 7652: 7639: 7638: 7631: 7622: 7620: 7609: 7602: 7593: 7591: 7584: 7568: 7564: 7533: 7529: 7490: 7483: 7444: 7440: 7409: 7402: 7371: 7367: 7357: 7355: 7347: 7346: 7342: 7303: 7299: 7260: 7256: 7221: 7214: 7205: 7203: 7176: 7172: 7162: 7160: 7125: 7121: 7082: 7078: 7039: 7035: 7026: 7024: 6981: 6974: 6929: 6922: 6891: 6884: 6853:(11): e182853. 6847:JAMA Pediatrics 6839: 6828: 6801:JAMA Pediatrics 6797: 6790: 6767:(10): 937–944. 6753: 6749: 6740: 6738: 6711: 6692: 6655: 6651: 6644: 6630: 6626: 6595:(12): 935–940. 6581: 6577: 6546:(12): 941–948. 6532: 6528: 6519: 6517: 6504: 6503: 6499: 6490: 6488: 6484: 6445: 6439: 6435: 6425: 6423: 6413: 6409: 6370: 6366: 6321: 6314: 6269: 6260: 6215: 6202: 6193: 6191: 6180: 6176: 6131: 6127: 6118: 6116: 6112: 6105: 6101: 6100: 6096: 6086: 6084: 6072: 6068: 6058: 6056: 6044: 6040: 6000: 5993: 5940: 5936: 5891: 5887: 5850: 5846: 5817:(12): 978–984. 5806: 5799: 5754: 5750: 5743: 5729: 5725: 5686: 5679: 5648: 5644: 5605: 5601: 5594: 5580: 5573: 5534: 5530: 5491: 5480: 5441: 5434: 5427: 5409: 5405: 5396: 5394: 5390: 5384: 5373: 5367: 5366: 5362: 5323: 5319: 5290:(11): 863–880. 5280: 5271: 5240: 5236: 5197: 5193: 5162: 5155: 5115: 5108: 5077: 5073: 5064: 5062: 5035: 5031: 5024: 5006: 4999: 4989: 4987: 4974: 4973: 4969: 4924: 4920: 4889: 4885: 4875: 4873: 4869: 4862: 4856: 4852: 4807: 4803: 4766: 4755: 4746: 4744: 4709: 4708: 4704: 4669: 4668: 4664: 4627: 4620: 4611: 4609: 4601:ABIM Foundation 4597:Choosing Wisely 4585: 4581: 4542: 4538: 4493: 4486: 4477: 4475: 4466: 4465: 4461: 4430: 4421: 4376: 4367: 4322: 4315: 4276: 4255: 4246: 4244: 4231: 4230: 4226: 4213: 4170: 4163: 4132: 4128: 4091: 4087: 4079: 4048: 4044: 4043: 4034: 3995: 3974: 3935: 3931: 3886: 3882: 3843: 3839: 3800: 3796: 3759: 3755: 3746: 3744: 3707: 3696: 3687: 3685: 3670: 3666: 3626: 3622: 3614: 3591:10.1.1.536.9655 3571: 3565: 3548: 3525: 3518: 3483:Sports Medicine 3479: 3472: 3433: 3429: 3392: 3381: 3350: 3346: 3338: 3315: 3308: 3291: 3282: 3280: 3275:. Mayo Clinic. 3269: 3262: 3253: 3251: 3244: 3228: 3221: 3212: 3210: 3206: 3199: 3193: 3189: 3152: 3145: 3108: 3104: 3069:Sports Medicine 3065: 3061: 3030: 3023: 2992: 2981: 2944: 2935: 2904: 2887: 2850: 2829: 2784: 2780: 2770: 2768: 2762: 2743: 2733: 2731: 2718: 2717: 2713: 2704: 2702: 2687: 2678: 2668: 2666: 2659: 2643: 2639: 2629: 2627: 2614: 2613: 2609: 2599: 2597: 2584: 2583: 2579: 2542: 2533: 2494: 2490: 2453: 2449: 2440: 2438: 2425: 2424: 2415: 2375: 2369: 2365: 2355: 2353: 2347: 2320: 2287:(11): 838–847. 2273: 2248: 2239: 2237: 2200: 2187: 2158:(11): 695–711. 2144: 2137: 2102: 2101: 2088: 2078: 2076: 2063: 2062: 2058: 2048: 2046: 2033: 2032: 2025: 2016: 2014: 2009:. 6 July 2021. 2005: 2004: 2000: 1990: 1988: 1975: 1974: 1965: 1955: 1953: 1940: 1939: 1932: 1901: 1884: 1847: 1826: 1795: 1772: 1762: 1760: 1747: 1746: 1737: 1732: 1705: 1650:Grade III 1612: 1604: 1598: 1596:Grading systems 1560: 1533: 1524: 1519: 1494:brain contusion 1468:skull fractures 1464:Guy de Chauliac 1427: 1393: 1368:sports injuries 1364: 1351: 1334: 1308: 1302: 1258:neurophysiology 1253: 1240: 1234: 1225: 1213: 1205: 1193:substance abuse 1184: 1175: 1143: 1103: 1101:Return-to-sport 1094: 1085: 1067: 1038: 1032: 942: 782: 716:. According to 669:neurons to fire 629: 627:Pathophysiology 605:corpus callosum 532: 511: 478: 427: 410: 389: 300:sports injuries 275:; memory loss; 158:sports injuries 35: 30: 23: 12: 11: 5: 8798: 8788: 8787: 8782: 8777: 8760: 8759: 8757: 8756: 8751: 8746: 8741: 8736: 8735: 8734: 8732:classification 8729: 8718: 8716: 8710: 8709: 8707: 8706: 8705:(Quadriplegia) 8700: 8695: 8690: 8685: 8680: 8675: 8670: 8664: 8662: 8656: 8655: 8653: 8652: 8647: 8642: 8637: 8636: 8635: 8630: 8625: 8620: 8610: 8605: 8600: 8595: 8594: 8593: 8588: 8583: 8575: 8574: 8573: 8568: 8560: 8554: 8552: 8546: 8545: 8538: 8537: 8530: 8523: 8515: 8506: 8505: 8503: 8502: 8496: 8494: 8490: 8489: 8486: 8485: 8483: 8482: 8476: 8474: 8465: 8464: 8462: 8461: 8456: 8451: 8445: 8443: 8431: 8423: 8422: 8420: 8419: 8410: 8408: 8404: 8403: 8394: 8393: 8386: 8379: 8371: 8362: 8361: 8358: 8357: 8343: 8331: 8330: 8328: 8324: 8323: 8320: 8319: 8308: 8293: 8278: 8263: 8247: 8242: 8241: 8239: 8238:Classification 8232: 8231: 8226: 8201: 8200:External links 8198: 8197: 8196: 8186: 8174: 8171: 8168: 8167: 8138:(4): 554–575. 8118: 8089:(4): 196–204. 8069: 8040:(3): 153–165. 8020: 7994: 7951: 7894: 7845: 7811: 7779: 7772: 7754: 7710: 7661: 7647:. 2019-01-31. 7629: 7600: 7582: 7562: 7527: 7500:(5): 375–378. 7481: 7438: 7419:(5): 376–378. 7400: 7381:(3): 144–149. 7365: 7340: 7313:(2): 179–185. 7297: 7270:(3): 249–262. 7254: 7235:(2): 223–225. 7212: 7170: 7119: 7092:(5): 415–426. 7076: 7073:on 2006-10-06. 7053:(3): 350–356. 7033: 6995:(4): 310–316. 6972: 6943:(4): 434–448. 6920: 6901:(1): 163–177. 6882: 6826: 6807:(3): 259–265. 6788: 6747: 6690: 6669:(3): 195–202. 6663:Psychosomatics 6649: 6642: 6624: 6575: 6526: 6512:. 2019-03-11. 6497: 6456:(2): 101–124. 6433: 6407: 6364: 6312: 6283:(1): e000667. 6258: 6229:(1): 147–158. 6200: 6174: 6145:(1): e000667. 6125: 6094: 6066: 6038: 5991: 5954:(5): 396–401. 5934: 5885: 5844: 5797: 5768:(1): e000153. 5748: 5741: 5723: 5696:(3): 119–135. 5677: 5642: 5615:(6): 837–851. 5599: 5592: 5571: 5528: 5501:(5): 260–272. 5478: 5451:(5): 262–267. 5432: 5425: 5403: 5382: 5360: 5317: 5269: 5250:(2): 107–131. 5234: 5191: 5172:(5): 525–527. 5153: 5106: 5087:(2): 189–197. 5071: 5049:(7): 426–434. 5029: 5022: 4997: 4967: 4918: 4899:(4): 323–346. 4883: 4850: 4801: 4780:(8): 909–916. 4753: 4702: 4662: 4618: 4579: 4536: 4484: 4459: 4440:(2): 373–393. 4419: 4390:(2): 105–116. 4365: 4313: 4253: 4224: 4161: 4126: 4105:(3): 228–235. 4085: 4082:on 2008-02-28. 4032: 4005:(3): 301–317. 3972: 3945:(6): 775–791. 3929: 3900:(4): 211–221. 3880: 3853:(2): 241–254. 3837: 3794: 3753: 3694: 3664: 3620: 3617:on 2007-07-01. 3546: 3516: 3489:(4): 449–471. 3470: 3443:(4): 281–344. 3427: 3379: 3344: 3341:on 2008-02-27. 3289: 3260: 3242: 3219: 3187: 3143: 3122:(3): 296–298. 3102: 3075:(2): 131–136. 3059: 3040:(2): 193–209. 3021: 2979: 2958:(3): 244–248. 2933: 2914:(3): 287–289. 2885: 2827: 2778: 2741: 2711: 2676: 2657: 2637: 2607: 2577: 2556:(6): 774–785. 2531: 2504:(2): 185–200. 2488: 2447: 2433:. 2020-07-28. 2413: 2363: 2318: 2246: 2214:(3): 597–615. 2185: 2135: 2086: 2056: 2023: 1998: 1963: 1930: 1911:(2): 166–172. 1882: 1824: 1770: 1734: 1733: 1731: 1728: 1727: 1726: 1721: 1716: 1711: 1704: 1701: 1694: 1693: 1690: 1687: 1684: 1680: 1679: 1676: 1673: 1670: 1666: 1665: 1662: 1659: 1656: 1652: 1651: 1648: 1645: 1642: 1611: 1608: 1600:Main article: 1597: 1594: 1559: 1556: 1532: 1529: 1523: 1520: 1518: 1515: 1478:used the term 1459:Chiurgia Magna 1426: 1423: 1392: 1389: 1363: 1360: 1350: 1347: 1333: 1330: 1304:Main article: 1301: 1298: 1252: 1249: 1236:Main article: 1233: 1230: 1224: 1221: 1212: 1209: 1204: 1201: 1183: 1180: 1174: 1173:Return to work 1171: 1142: 1139: 1127: 1126: 1123: 1120: 1117: 1114: 1111: 1102: 1099: 1093: 1090: 1084: 1081: 1066: 1063: 1034:Main article: 1031: 1028: 941: 940:Classification 938: 872:cervical spine 851: 850: 846: 845: 841: 840: 836: 835: 828: 827: 823: 822: 816: 815: 811: 810: 803: 802: 792: 791: 781: 778: 737:Animal studies 681:excitotoxicity 628: 625: 531: 528: 510: 507: 482:disorientation 477: 474: 446:blurred vision 426: 423: 409: 406: 281:blurred vision 247: 246: 243: 239: 238: 229: 223: 222: 219: 215: 214: 204: 200: 199: 196: 190: 189: 171: 165: 164: 147: 143: 142: 139: 135: 134: 117: 111: 110: 97: 91: 90: 81: 75: 74: 59: 58: 50: 49: 46: 42: 41: 33: 9: 6: 4: 3: 2: 8797: 8786: 8783: 8781: 8778: 8776: 8773: 8772: 8770: 8755: 8752: 8750: 8747: 8745: 8742: 8740: 8737: 8733: 8730: 8728: 8725: 8724: 8723: 8720: 8719: 8717: 8715: 8711: 8704: 8701: 8699: 8696: 8694: 8691: 8689: 8686: 8684: 8681: 8679: 8676: 8674: 8671: 8669: 8666: 8665: 8663: 8661: 8657: 8651: 8648: 8646: 8643: 8641: 8638: 8634: 8631: 8629: 8626: 8624: 8621: 8619: 8616: 8615: 8614: 8611: 8609: 8606: 8604: 8601: 8599: 8596: 8592: 8589: 8587: 8584: 8582: 8579: 8578: 8576: 8572: 8569: 8567: 8564: 8563: 8561: 8559: 8556: 8555: 8553: 8551: 8547: 8543: 8536: 8531: 8529: 8524: 8522: 8517: 8516: 8513: 8501: 8498: 8497: 8495: 8491: 8481: 8478: 8477: 8475: 8473: 8471: 8466: 8460: 8457: 8455: 8452: 8450: 8447: 8446: 8444: 8442: 8440: 8435: 8432: 8430: 8429:facial trauma 8426:Extracranial/ 8424: 8418: 8417: 8412: 8411: 8409: 8405: 8400: 8392: 8387: 8385: 8380: 8378: 8373: 8372: 8369: 8356: 8353: 8349: 8348: 8344: 8342: 8338: 8337: 8333: 8332: 8329: 8325: 8318: 8314: 8313: 8309: 8307: 8303: 8302: 8298: 8294: 8292: 8288: 8287: 8283: 8279: 8277: 8273: 8272: 8268: 8264: 8262: 8258: 8257: 8253: 8249: 8248: 8245: 8240: 8236: 8230: 8227: 8225: 8221: 8218: 8217: 8216: 8215: 8213: 8207: 8195: 8191: 8187: 8185: 8181: 8177: 8176: 8163: 8159: 8154: 8149: 8145: 8141: 8137: 8133: 8129: 8122: 8114: 8110: 8105: 8100: 8096: 8092: 8088: 8084: 8080: 8073: 8065: 8061: 8056: 8051: 8047: 8043: 8039: 8035: 8031: 8024: 8008: 8004: 7998: 7990: 7986: 7982: 7978: 7974: 7970: 7966: 7962: 7955: 7947: 7943: 7938: 7933: 7929: 7925: 7921: 7917: 7913: 7909: 7905: 7898: 7890: 7886: 7881: 7876: 7872: 7868: 7864: 7860: 7856: 7849: 7834: 7831:(9): 453–59. 7830: 7826: 7822: 7815: 7801:on 2008-02-28 7797: 7790: 7783: 7775: 7769: 7765: 7758: 7750: 7746: 7741: 7736: 7732: 7728: 7724: 7717: 7715: 7706: 7702: 7697: 7692: 7688: 7684: 7680: 7676: 7672: 7665: 7650: 7646: 7642: 7636: 7634: 7618: 7614: 7607: 7605: 7589: 7585: 7579: 7575: 7574: 7566: 7558: 7554: 7550: 7546: 7542: 7538: 7531: 7523: 7519: 7515: 7511: 7507: 7503: 7499: 7495: 7488: 7486: 7477: 7473: 7469: 7465: 7461: 7457: 7453: 7449: 7442: 7434: 7430: 7426: 7422: 7418: 7414: 7407: 7405: 7396: 7392: 7388: 7384: 7380: 7376: 7369: 7354: 7353:Revere Health 7350: 7344: 7336: 7332: 7328: 7324: 7320: 7316: 7312: 7308: 7301: 7293: 7289: 7285: 7281: 7277: 7273: 7269: 7265: 7258: 7250: 7246: 7242: 7238: 7234: 7230: 7226: 7219: 7217: 7202:on 2021-03-04 7201: 7197: 7193: 7189: 7185: 7181: 7174: 7158: 7154: 7150: 7146: 7142: 7138: 7134: 7133:New Scientist 7130: 7123: 7115: 7111: 7107: 7103: 7099: 7095: 7091: 7087: 7080: 7072: 7068: 7064: 7060: 7056: 7052: 7048: 7044: 7037: 7022: 7018: 7014: 7010: 7006: 7002: 6998: 6994: 6990: 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6205: 6189: 6185: 6178: 6170: 6166: 6161: 6156: 6152: 6148: 6144: 6140: 6136: 6129: 6111: 6104: 6098: 6083: 6082: 6077: 6070: 6055: 6054: 6049: 6042: 6034: 6030: 6026: 6022: 6018: 6014: 6010: 6006: 5998: 5996: 5987: 5983: 5978: 5973: 5969: 5965: 5961: 5957: 5953: 5949: 5945: 5938: 5930: 5926: 5921: 5916: 5912: 5908: 5904: 5900: 5896: 5889: 5881: 5877: 5872: 5867: 5863: 5859: 5855: 5848: 5840: 5836: 5832: 5828: 5824: 5820: 5816: 5812: 5804: 5802: 5793: 5789: 5784: 5779: 5775: 5771: 5767: 5763: 5759: 5752: 5744: 5738: 5734: 5727: 5719: 5715: 5711: 5707: 5703: 5699: 5695: 5691: 5684: 5682: 5673: 5669: 5665: 5661: 5658:(1): 96–101. 5657: 5653: 5646: 5638: 5634: 5630: 5626: 5622: 5618: 5614: 5610: 5603: 5595: 5589: 5585: 5578: 5576: 5567: 5563: 5559: 5555: 5551: 5547: 5543: 5539: 5532: 5524: 5520: 5516: 5512: 5508: 5504: 5500: 5496: 5489: 5487: 5485: 5483: 5474: 5470: 5466: 5462: 5458: 5454: 5450: 5446: 5439: 5437: 5428: 5422: 5418: 5414: 5407: 5389: 5385: 5379: 5372: 5371: 5364: 5356: 5352: 5348: 5344: 5340: 5336: 5333:(6): 335–39. 5332: 5328: 5321: 5313: 5309: 5305: 5301: 5297: 5293: 5289: 5285: 5278: 5276: 5274: 5265: 5261: 5257: 5253: 5249: 5245: 5238: 5230: 5226: 5222: 5218: 5214: 5210: 5206: 5202: 5195: 5187: 5183: 5179: 5175: 5171: 5167: 5160: 5158: 5149: 5145: 5141: 5137: 5133: 5129: 5125: 5121: 5113: 5111: 5102: 5098: 5094: 5090: 5086: 5082: 5075: 5060: 5056: 5052: 5048: 5044: 5040: 5033: 5025: 5019: 5015: 5011: 5004: 5002: 4985: 4981: 4977: 4971: 4963: 4959: 4954: 4949: 4945: 4941: 4937: 4933: 4929: 4922: 4914: 4910: 4906: 4902: 4898: 4894: 4887: 4868: 4861: 4854: 4846: 4842: 4838: 4834: 4829: 4824: 4820: 4816: 4812: 4805: 4797: 4793: 4788: 4783: 4779: 4775: 4771: 4764: 4762: 4760: 4758: 4742: 4738: 4734: 4729: 4724: 4720: 4716: 4712: 4706: 4698: 4694: 4689: 4684: 4680: 4676: 4672: 4666: 4658: 4654: 4649: 4644: 4640: 4636: 4632: 4625: 4623: 4607: 4603: 4602: 4598: 4593: 4589: 4583: 4575: 4571: 4567: 4563: 4559: 4555: 4551: 4547: 4540: 4532: 4528: 4524: 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3776: 3772: 3768: 3764: 3757: 3742: 3738: 3734: 3729: 3724: 3720: 3716: 3712: 3705: 3703: 3701: 3699: 3683: 3679: 3678:MedPage Today 3675: 3668: 3660: 3656: 3652: 3648: 3644: 3640: 3636: 3632: 3624: 3613: 3609: 3605: 3601: 3597: 3592: 3587: 3584:(6): 342–57. 3583: 3579: 3578: 3570: 3563: 3561: 3559: 3557: 3555: 3553: 3551: 3542: 3538: 3535:(3): 179–85. 3534: 3530: 3523: 3521: 3512: 3508: 3504: 3500: 3496: 3492: 3488: 3484: 3477: 3475: 3466: 3462: 3458: 3454: 3450: 3446: 3442: 3438: 3431: 3423: 3419: 3414: 3409: 3405: 3401: 3397: 3390: 3388: 3386: 3384: 3375: 3371: 3367: 3363: 3359: 3355: 3348: 3337: 3333: 3329: 3325: 3322:(in Slovak). 3321: 3313: 3306: 3304: 3302: 3300: 3298: 3296: 3294: 3278: 3274: 3267: 3265: 3249: 3245: 3239: 3235: 3234: 3226: 3224: 3209:on 2008-02-28 3205: 3198: 3191: 3183: 3179: 3174: 3169: 3165: 3161: 3157: 3150: 3148: 3139: 3135: 3130: 3125: 3121: 3117: 3113: 3106: 3098: 3094: 3090: 3086: 3082: 3078: 3074: 3070: 3063: 3055: 3051: 3047: 3043: 3039: 3035: 3028: 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1541: 1539: 1536:since a 2003 1528: 1514: 1512: 1508: 1504: 1495: 1491: 1487: 1483: 1481: 1477: 1476:Ambroise ParΓ© 1473: 1469: 1465: 1460: 1456: 1451: 1448: 1444: 1436: 1431: 1422: 1420: 1415: 1411: 1407: 1403: 1399: 1388: 1386: 1382: 1378: 1373: 1369: 1359: 1356: 1346: 1338: 1329: 1326: 1322: 1318: 1314: 1307: 1297: 1295: 1289: 1287: 1283: 1279: 1275: 1271: 1267: 1262: 1259: 1248: 1246: 1239: 1229: 1220: 1218: 1217:comorbidities 1208: 1200: 1198: 1194: 1188: 1179: 1170: 1167: 1164: 1160: 1156: 1152: 1148: 1138: 1136: 1131: 1124: 1121: 1118: 1115: 1112: 1108: 1107: 1106: 1098: 1089: 1080: 1078: 1073: 1062: 1058: 1054: 1050: 1047: 1043: 1037: 1027: 1024: 1020: 1016: 1012: 1008: 1002: 1000: 996: 992: 988: 987: 982: 978: 974: 969: 967: 963: 959: 955: 950: 948: 937: 934: 932: 926: 922: 919: 915: 911: 907: 902: 896: 893: 887: 885: 881: 877: 873: 869: 861: 857: 848: 847: 843: 842: 838: 837: 834: 830: 829: 825: 824: 821: 820:Seeing double 818: 817: 813: 812: 809: 805: 804: 801: 797: 794: 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Excitatory 658: 654: 650: 645: 643: 639: 634: 624: 622: 618: 614: 610: 609:temporal lobe 606: 602: 598: 594: 590: 586: 582: 577: 575: 574: 567: 565: 561: 557: 553: 549: 545: 541: 537: 524: 520: 515: 506: 503: 498: 495: 491: 487: 483: 473: 471: 467: 463: 459: 455: 451: 450:double vision 447: 443: 439: 436:, difficulty 435: 431: 422: 420: 416: 387: 385: 381: 377: 371: 369: 365: 361: 357: 356:Physiotherapy 353: 349: 345: 341: 337: 332: 330: 326: 321: 317: 313: 309: 305: 301: 297: 293: 288: 286: 282: 278: 274: 270: 266: 262: 258: 254: 244: 240: 237: 233: 230: 228: 224: 220: 216: 213: 209: 205: 201: 197: 195: 191: 187: 183: 179: 175: 172: 170: 166: 163: 159: 155: 151: 148: 144: 141:Up to 4 weeks 140: 136: 133: 129: 125: 121: 118: 116: 115:Complications 112: 109: 105: 104:blurry vision 101: 98: 96: 92: 89: 85: 82: 80: 76: 72: 68: 64: 60: 56: 51: 47: 43: 38: 32: 28: 21: 16: 8722:Nerve injury 8612: 8577:Extra-axial 8562:Intra-axial 8468: 8437: 8413: 8407:Intracranial 8345: 8334: 8310: 8295: 8280: 8265: 8250: 8211: 8203: 8189: 8179: 8135: 8131: 8121: 8086: 8082: 8072: 8037: 8033: 8023: 8011:. Retrieved 8006: 7997: 7964: 7960: 7954: 7914:(1): 58–66. 7911: 7907: 7897: 7862: 7858: 7848: 7837:. Retrieved 7828: 7824: 7814: 7803:. Retrieved 7796:the original 7782: 7763: 7757: 7730: 7726: 7678: 7674: 7664: 7653:. Retrieved 7644: 7621:. Retrieved 7592:. Retrieved 7572: 7565: 7543:(1): 37–44. 7540: 7536: 7530: 7497: 7493: 7451: 7447: 7441: 7416: 7412: 7378: 7374: 7368: 7356:. Retrieved 7352: 7343: 7310: 7306: 7300: 7267: 7263: 7257: 7232: 7229:Neurosurgery 7228: 7204:. Retrieved 7200:the original 7187: 7183: 7173: 7163:November 11, 7161:. Retrieved 7139:(3151): 10. 7136: 7132: 7122: 7089: 7085: 7079: 7071:the original 7050: 7046: 7036: 7025:. Retrieved 6992: 6988: 6940: 6936: 6898: 6894: 6850: 6846: 6804: 6800: 6764: 6760: 6750: 6739:. Retrieved 6735:the original 6722: 6718: 6666: 6662: 6652: 6633: 6627: 6592: 6588: 6578: 6543: 6539: 6529: 6518:. Retrieved 6509: 6500: 6489:. Retrieved 6453: 6449: 6436: 6426:September 9, 6424:. Retrieved 6410: 6380:(1): 21–25. 6377: 6373: 6367: 6332: 6328: 6280: 6276: 6226: 6222: 6192:. Retrieved 6177: 6142: 6138: 6128: 6117:. Retrieved 6097: 6085:. Retrieved 6079: 6069: 6057:. Retrieved 6051: 6041: 6008: 6004: 5951: 5947: 5937: 5902: 5898: 5888: 5864:(1): 15–26. 5861: 5857: 5847: 5814: 5810: 5765: 5761: 5751: 5732: 5726: 5693: 5689: 5655: 5651: 5645: 5612: 5608: 5602: 5583: 5541: 5537: 5531: 5498: 5494: 5448: 5444: 5416: 5406: 5395:. Retrieved 5369: 5363: 5330: 5326: 5320: 5287: 5284:Brain Injury 5283: 5247: 5243: 5237: 5204: 5200: 5194: 5169: 5165: 5123: 5120:Brain Injury 5119: 5084: 5080: 5074: 5063:. Retrieved 5046: 5042: 5032: 5013: 4988:. Retrieved 4979: 4970: 4935: 4931: 4921: 4896: 4892: 4886: 4874:. Retrieved 4853: 4821:(1): 21–26. 4818: 4814: 4804: 4777: 4773: 4745:. Retrieved 4718: 4714: 4705: 4678: 4674: 4665: 4638: 4634: 4610:, retrieved 4595: 4582: 4549: 4545: 4539: 4507:(2): 58–65. 4504: 4500: 4476:. 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